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Stephen B. Howell
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Journal Articles

Abstract 25: CG′806, a first-in-class FLT3/BTK inhibitor, exerts superior potency against AML cells harboring ITD, TKD and gatekeeper mutated FLT3 or wild-type FLT3

Weiguo Zhang, Hongying Zhang, Andrea Local, William G. Rice, Charlie J. Ly, Guopan Yu, Stephen B. Howell, Michael Andreeff
Journal: Clinical Cancer Research
Clin Cancer Res (2017) 23 (24_Supplement): 25.
https://doi.org/10.1158/1557-3265.HEMMAL17-25
Published: 14 December 2017
View article titled, Abstract 25: CG′806, a first-in-class FLT3/BTK inhibitor, exerts superior potency against AML cells harboring ITD, TKD and gatekeeper mutated FLT3 or wild-type FLT3
Journal Articles

Abstract 44: CG′806, a first-in-class FLT3/BTK inhibitor, exhibits potent activity against AML patient samples with mutant or wild type FLT3, as well as other hematologic malignancy subtypes

Stephen E. Kurtz, Beth Wilmot, Shannon McWeeney, Avanish Vellanki, Andrea Local, Khalid Benbatoul, Peter Folger, Susan Sheng, Hongying Zhang, Stephen B. Howell, William G. Rice, Brian J. Druker, Jeffrey W. Tyner
Journal: Clinical Cancer Research
Clin Cancer Res (2017) 23 (24_Supplement): 44.
https://doi.org/10.1158/1557-3265.HEMMAL17-44
Published: 14 December 2017
View article titled, Abstract 44: CG′806, a first-in-class FLT3/BTK inhibitor, exhibits potent activity against AML patient samples with mutant or wild type FLT3, as well as other hematologic malignancy subtypes
Journal Articles

Abstract POSTER-BIOL-1318: Claudin 4 controls the receptor tyrosine kinase EphA2 pro-oncogenic switch through β-catenin

Xiying Shang, MD, PhD, Xinjian Lin, MD, Stephen B. Howell, MD
Journal: Clinical Cancer Research
Clin Cancer Res (2015) 21 (16_Supplement): POSTER-BIOL-1318.
https://doi.org/10.1158/1557-3265.OVCASYMP14-POSTER-BIOL-1318
Published: 15 August 2015
View article titled, Abstract POSTER-BIOL-1318: Claudin 4 controls the receptor tyrosine kinase EphA2 pro-oncogenic switch through β-catenin
Journal Articles

Copper Transporter 2 Regulates the Cellular Accumulation and Cytotoxicity of Cisplatin and Carboplatin

Brian G. Blair, Christopher A. Larson, Roohangiz Safaei, Stephen B. Howell
Journal: Clinical Cancer Research
Clin Cancer Res (2009) 15 (13): 4312–4321.
https://doi.org/10.1158/1078-0432.CCR-09-0311
Published: 01 July 2009
View article titled, Copper Transporter 2 Regulates the Cellular Accumulation and Cytotoxicity of Cisplatin and Carboplatin
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Journal Articles

Enhanced Delivery of Cisplatin to Intraperitoneal Ovarian Carcinomas Mediated by the Effects of Bortezomib on the Human Copper Transporter 1

Danielle D. Jandial, Salman Farshchi-Heydari, Christopher A. Larson, Gregory I. Elliott, Wolfgang J. Wrasidlo, Stephen B. Howell
Journal: Clinical Cancer Research
Clin Cancer Res (2009) 15 (2): 553–560.
https://doi.org/10.1158/1078-0432.CCR-08-2081
Published: 15 January 2009
View article titled, Enhanced Delivery of Cisplatin to Intraperitoneal Ovarian Carcinomas Mediated by the Effects of Bortezomib on the Human Copper Transporter 1
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Journal Articles

Preclinical Efficacy and Pharmacokinetics of AP5346, A Novel Diaminocyclohexane-Platinum Tumor-Targeting Drug Delivery System

John R. Rice, Jennifer L. Gerberich, David P. Nowotnik, Stephen B. Howell
Journal: Clinical Cancer Research
Clin Cancer Res (2006) 12 (7): 2248–2254.
https://doi.org/10.1158/1078-0432.CCR-05-2169
Published: 11 April 2006
View article titled, Preclinical Efficacy and Pharmacokinetics of AP5346, A Novel Diaminocyclohexane-Platinum Tumor-Targeting Drug Delivery System
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Journal Articles

DNA Polymerase ζ Accounts for the Reduced Cytotoxicity and Enhanced Mutagenicity of Cisplatin in Human Colon Carcinoma Cells That Have Lost DNA Mismatch Repair

Xinjian Lin, Julie Trang, Tsuyoshi Okuda, Stephen B. Howell
Journal: Clinical Cancer Research
Clin Cancer Res (2006) 12 (2): 563–568.
https://doi.org/10.1158/1078-0432.CCR-05-1380
Published: 20 January 2006
View article titled, DNA Polymerase ζ Accounts for the Reduced Cytotoxicity and Enhanced Mutagenicity of Cisplatin in Human Colon Carcinoma Cells That Have Lost DNA Mismatch Repair
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Journal Articles

Intracellular Localization and Trafficking of Fluorescein-Labeled Cisplatin in Human Ovarian Carcinoma Cells

Roohangiz Safaei, Kuniyuki Katano, Barrett J. Larson, Goli Samimi, Alison K. Holzer, Wiltrud Naerdemann, Mika Tomioka, Murray Goodman, Stephen B. Howell
Journal: Clinical Cancer Research
Clin Cancer Res (2005) 11 (2): 756–767.
https://doi.org/10.1158/1078-0432.756.11.2
Published: 08 February 2005
View article titled, Intracellular Localization and Trafficking of Fluorescein-Labeled Cisplatin in Human Ovarian Carcinoma Cells
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Journal Articles

Cisplatin Rapidly Down-regulates Its Own Influx Transporter hCTR1 in Cultured Human Ovarian Carcinoma Cells

Alison K. Holzer, Kuniyuki Katano, Leo W. J. Klomp, Stephen B. Howell
Journal: Clinical Cancer Research
Clin Cancer Res (2004) 10 (19): 6744–6749.
https://doi.org/10.1158/1078-0432.CCR-04-0748
Published: 08 October 2004
View article titled, Cisplatin Rapidly Down-regulates Its Own Influx Transporter hCTR1 in Cultured Human Ovarian Carcinoma Cells
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Journal Articles

Increased Expression of the Copper Efflux Transporter ATP7A Mediates Resistance to Cisplatin, Carboplatin, and Oxaliplatin in Ovarian Cancer Cells

Goli Samimi, Roohangiz Safaei, Kuniyuki Katano, Alison K. Holzer, Myriam Rochdi, Mika Tomioka, Murray Goodman, Stephen B. Howell
Journal: Clinical Cancer Research
Clin Cancer Res (2004) 10 (14): 4661–4669.
https://doi.org/10.1158/1078-0432.CCR-04-0137
Published: 21 July 2004
View article titled, Increased Expression of the Copper Efflux Transporter ATP7A Mediates Resistance to Cisplatin, Carboplatin, and Oxaliplatin in Ovarian Cancer Cells
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Journal Articles

Confocal Microscopic Analysis of the Interaction between Cisplatin and the Copper Transporter ATP7B in Human Ovarian Carcinoma Cells

Kuniyuki Katano, Roohangiz Safaei, Goli Samimi, Alison Holzer, Mika Tomioka, Murray Goodman, Stephen B. Howell
Journal: Clinical Cancer Research
Clin Cancer Res (2004) 10 (13): 4578–4588.
https://doi.org/10.1158/1078-0432.CCR-03-0689
Published: 06 July 2004
View article titled, Confocal Microscopic Analysis of the Interaction between Cisplatin and the Copper Transporter ATP7B in Human Ovarian Carcinoma Cells
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Journal Articles

A Phase I and Pharmacological Study of the Platinum Polymer AP5280 Given as an Intravenous Infusion Once Every 3 Weeks in Patients with Solid Tumors

Jeany M. Rademaker-Lakhai, Catherine Terret, Stephen B. Howell, Christiane M. Baud, Richard F. de Boer, Dick Pluim, Jos H. Beijnen, Jan H. M. Schellens, Jean-Pierre Droz
Journal: Clinical Cancer Research
Clin Cancer Res (2004) 10 (10): 3386–3395.
https://doi.org/10.1158/1078-0432.CCR-03-0315
Published: 24 May 2004
View article titled, A Phase I and Pharmacological Study of the Platinum Polymer AP5280 Given as an Intravenous Infusion Once Every 3 Weeks in Patients with Solid Tumors
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Journal Articles

Increase in Expression of the Copper Transporter ATP7A during Platinum Drug-Based Treatment Is Associated with Poor Survival in Ovarian Cancer Patients

Goli Samimi, Nissi M. Varki, Sharon Wilczynski, Roohangiz Safaei, David S. Alberts, Stephen B. Howell
Journal: Clinical Cancer Research
Clin Cancer Res (2003) 9 (16): 5853–5859.
Published: 15 December 2003
View article titled, Increase in Expression of the Copper Transporter ATP7A during Platinum Drug-Based Treatment Is Associated with Poor Survival in Ovarian Cancer Patients
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Journal Articles

Analysis of MLH1 and MSH2 Expression in Ovarian Cancer before and after Platinum Drug-based Chemotherapy

Goli Samimi, Daniel Fink, Nissi M. Varki, Amreen Husain, William J. Hoskins, David S. Alberts, Stephen B. Howell
Journal: Clinical Cancer Research
Clin Cancer Res (2000) 6 (4): 1415–1421.
Published: 01 April 2000
View article titled, Analysis of MLH1 and MSH2 Expression in Ovarian Cancer before and after Platinum Drug-based Chemotherapy
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Journal Articles

A Randomized Controlled Trial Comparing Intrathecal Sustained-release Cytarabine (DepoCyt) to Intrathecal Methotrexate in Patients with Neoplastic Meningitis from Solid Tumors

Michael J. Glantz, Kurt A. Jaeckle, Marc C. Chamberlain, Surasak Phuphanich, Lawrence Recht, Lode J. Swinnen, Bernard Maria, Susan LaFollette, G. Berry Schumann, Bernard F. Cole, Stephen B. Howell
Journal: Clinical Cancer Research
Clin Cancer Res (1999) 5 (11): 3394–3402.
Published: 01 November 1999
View article titled, A Randomized Controlled Trial Comparing Intrathecal Sustained-release Cytarabine (DepoCyt) to Intrathecal Methotrexate in Patients with Neoplastic Meningitis from Solid Tumors
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Journal Articles

Quantitation of the Change in GADD153 Messenger RNA Level as a Molecular Marker of Tumor Response in Head and Neck Cancer

Gerrit Los, Khalid Benbatoul, Dennis P. Gately, Racine Barton, Randolph Christen, K. Thomas Robbins, Daniel Vicario, Saeeda Kirmani, Lisa A. Orloff, Robert Weisman, Stephen B. Howell
Journal: Clinical Cancer Research
Clin Cancer Res (1999) 5 (7): 1610–1618.
Published: 01 July 1999
View article titled, Quantitation of the Change in <em>GADD153</em> Messenger RNA Level as a Molecular Marker of Tumor Response in Head and Neck Cancer
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