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Simone Detre
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Journal Articles

Antiproliferative Effect of Lapatinib in HER2-Positive and HER2-Negative/HER3-High Breast Cancer: Results of the Presurgical Randomized MAPLE Trial (CRUK E/06/039)

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Alexandra Leary, Abigail Evans, Stephen R.D. Johnston, Roger A'Hern, Judith M. Bliss, Rashmita Sahoo, Simone Detre, Benjamin P. Haynes, Margaret Hills, Catherine Harper-Wynne, Nigel Bundred, Gill Coombes, Ian Smith, Mitch Dowsett
Journal: Clinical Cancer Research
Series: Author Choice
Clin Cancer Res (2015) 21 (13): 2932–2940.
https://doi.org/10.1158/1078-0432.CCR-14-1428
Published: 30 June 2015
View articletitled, Antiproliferative Effect of Lapatinib in HER2-Positive and HER2-Negative/HER3-High Breast Cancer: Results of the Presurgical Randomized MAPLE Trial (CRUK E/06/039)
Open the PDF for Antiproliferative Effect of Lapatinib in HER2-Positive and HER2-Negative/HER3-High Breast Cancer: Results of the Presurgical Randomized MAPLE Trial (CRUK E/06/039) in another window
Includes: Supplementary data
Journal Articles

Close and Stable Relationship between Proliferation and a Hypoxia Metagene in Aromatase Inhibitor–Treated ER-Positive Breast Cancer

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Zara Ghazoui, Francesca M. Buffa, Anita K. Dunbier, Helen Anderson, Tim Dexter, Simone Detre, Janine Salter, Ian E. Smith, Adrian L. Harris, Mitchell Dowsett
Journal: Clinical Cancer Research
Clin Cancer Res (2011) 17 (9): 3005–3012.
https://doi.org/10.1158/1078-0432.CCR-10-1704
Published: 01 May 2011
View articletitled, Close and Stable Relationship between Proliferation and a Hypoxia Metagene in Aromatase Inhibitor–Treated ER-Positive Breast Cancer
Open the PDF for Close and Stable Relationship between Proliferation and a Hypoxia Metagene in Aromatase Inhibitor–Treated ER-Positive Breast Cancer in another window
Includes: Supplementary data
Journal Articles

Biological Evidence for Dual Antiangiogenic-Antiaromatase Activity of the VEGFR Inhibitor PTK787/ZK222584 In vivo

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Susana Banerjee, Roger A'Hern, Simone Detre, Amanda J. Littlewood-Evans, Dean B. Evans, Mitchell Dowsett, Lesley-Ann Martin
Journal: Clinical Cancer Research
Clin Cancer Res (2010) 16 (16): 4178–4187.
https://doi.org/10.1158/1078-0432.CCR-10-0456
Published: 11 August 2010
View articletitled, Biological Evidence for Dual Antiangiogenic-Antiaromatase Activity of the VEGFR Inhibitor PTK787/ZK222584 In vivo
Open the PDF for Biological Evidence for Dual Antiangiogenic-Antiaromatase Activity of the VEGFR Inhibitor PTK787/ZK222584 In vivo in another window
Includes: Supplementary data
Journal Articles

Lapatinib Restores Hormone Sensitivity with Differential Effects on Estrogen Receptor Signaling in Cell Models of Human Epidermal Growth Factor Receptor 2–Negative Breast Cancer with Acquired Endocrine Resistance

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Alexandra F. Leary, Suzanne Drury, Simone Detre, Sunil Pancholi, Anne E. Lykkesfeldt, Lesley-Ann Martin, Mitch Dowsett, Stephen R.D. Johnston
Journal: Clinical Cancer Research
Clin Cancer Res (2010) 16 (5): 1486–1497.
https://doi.org/10.1158/1078-0432.CCR-09-1764
Published: 28 February 2010
View articletitled, Lapatinib Restores Hormone Sensitivity with Differential Effects on Estrogen Receptor Signaling in Cell Models of Human Epidermal Growth Factor Receptor 2–Negative Breast Cancer with Acquired Endocrine Resistance
Open the PDF for Lapatinib Restores Hormone Sensitivity with Differential Effects on Estrogen Receptor Signaling in Cell Models of Human Epidermal Growth Factor Receptor 2–Negative Breast Cancer with Acquired Endocrine Resistance in another window
Includes: Supplementary data
Journal Articles

Short-Term Changes in Ki-67 during Neoadjuvant Treatment of Primary Breast Cancer with Anastrozole or Tamoxifen Alone or Combined Correlate with Recurrence-Free Survival

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Mitch Dowsett, Ian E. Smith, Steve R. Ebbs, J. Michael Dixon, Anthony Skene, Clive Griffith, Irene Boeddinghaus, Janine Salter, Simone Detre, Margaret Hills, Susan Ashley, Stephen Francis, Geraldine Walsh, on behalf of the IMPACT Trialists
Journal: Clinical Cancer Research
Clin Cancer Res (2005) 11 (2): 951s–958s.
https://doi.org/10.1158/1078-0432.951s.11.2
Published: 01 September 2009
View articletitled, Short-Term Changes in Ki-67 during Neoadjuvant Treatment of Primary Breast Cancer with Anastrozole or Tamoxifen Alone or Combined Correlate with Recurrence-Free Survival
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Journal Articles

Proliferation and Apoptosis as Markers of Benefit in Neoadjuvant Endocrine Therapy of Breast Cancer

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Mitch Dowsett, Ian E. Smith, Steve R. Ebbs, J. Michael Dixon, Anthony Skene, Clive Griffith, Irene Boeddinghaus, Janine Salter, Simone Detre, Margaret Hills, Susan Ashley, Stephen Francis, Geraldine Walsh, Roger A'Hern
Journal: Clinical Cancer Research
Clin Cancer Res (2006) 12 (3): 1024s–1030s.
https://doi.org/10.1158/1078-0432.CCR-05-2127
Published: 07 February 2006
View articletitled, Proliferation and Apoptosis as Markers of Benefit in Neoadjuvant Endocrine Therapy of Breast Cancer
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Journal Articles

Integration of Signal Transduction Inhibitors with Endocrine Therapy: An Approach to Overcoming Hormone Resistance in Breast Cancer

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Stephen R. D. Johnston, Julia Head, Sunil Pancholi, Simone Detre, Lesley-Ann Martin, Ian E. Smith, Mitch Dowsett
Journal: Clinical Cancer Research
Clin Cancer Res (2003) 9 (1): 524s–532s.
Published: 01 January 2003
View articletitled, Integration of Signal Transduction Inhibitors with Endocrine Therapy: An Approach to Overcoming Hormone Resistance in Breast Cancer
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Journal Articles

Preclinical Antitumor Activity and Pharmacodynamic Studies with the Farnesyl Protein Transferase Inhibitor R115777 in Human Breast Cancer

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Lloyd R. Kelland, Vicki Smith, Melanie Valenti, Lisa Patterson, Paul A. Clarke, Simone Detre, Dave End, Angela J. Howes, Mitch Dowsett, Paul Workman, Stephen R. D. Johnston
Journal: Clinical Cancer Research
Clin Cancer Res (2001) 7 (11): 3544–3550.
Published: 01 November 2001
View articletitled, Preclinical Antitumor Activity and Pharmacodynamic Studies with the Farnesyl Protein Transferase Inhibitor R115777 in Human Breast Cancer
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Journal Articles

Influence of Neoadjuvant Anastrozole (Arimidex) on Intratumoral Estrogen Levels and Proliferation Markers in Patients with Locally Advanced Breast Cancer

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Jürgen Geisler, Simone Detre, Hildegunn Berntsen, Lars Ottestad, Bernt Lindtjørn, Mitch Dowsett, Per Eystein Lønning
Journal: Clinical Cancer Research
Clin Cancer Res (2001) 7 (5): 1230–1236.
Published: 01 May 2001
View articletitled, Influence of Neoadjuvant Anastrozole (Arimidex) on Intratumoral Estrogen Levels and Proliferation Markers in Patients with Locally Advanced Breast Cancer
Open the PDF for Influence of Neoadjuvant Anastrozole (Arimidex) on Intratumoral Estrogen Levels and Proliferation Markers in Patients with Locally Advanced Breast Cancer in another window