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Shelley Orwick
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Journal Articles

Targeting DNA Damage Repair Functions of Two Histone Deacetylases, HDAC8 and SIRT6, Sensitizes Acute Myeloid Leukemia to NAMPT Inhibition

Pu Zhang, Lindsey T. Brinton, Katie Williams, Steven Sher, Shelley Orwick, Lai Tzung-Huei, Alice S. Mims, Christopher C. Coss, Samuel K. Kulp, Youssef Youssef, Wing Keung Chan, Shaneice Mitchell, Allison Mustonen, Matthew Cannon, Hannah Phillips, Amy M. Lehman, Tierney Kauffman, Larry Beaver, Daniel Canfield, Nicole R. Grieselhuber, Lapo Alinari, Deepa Sampath, Pearlly Yan, John C. Byrd, James S. Blachly, Rosa Lapalombella
Journal: Clinical Cancer Research
Clin Cancer Res (2021) 27 (8): 2352–2366.
https://doi.org/10.1158/1078-0432.CCR-20-3724
Published: 15 April 2021
View article titled, Targeting DNA Damage Repair Functions of Two Histone Deacetylases, HDAC8 and SIRT6, Sensitizes Acute Myeloid Leukemia to NAMPT Inhibition
Open the PDF for Targeting DNA Damage Repair Functions of Two Histone Deacetylases, HDAC8 and SIRT6, Sensitizes Acute Myeloid Leukemia to NAMPT Inhibition in another window
Includes: Supplementary data
Journal Articles

Entospletinib in Combination with Induction Chemotherapy in Previously Untreated Acute Myeloid Leukemia: Response and Predictive Significance of HOXA9 and MEIS1 Expression

Alison R. Walker, John C. Byrd, James S. Blachly, Bhavana Bhatnagar, Alice S. Mims, Shelley Orwick, Tara L. Lin, Howland E. Crosswell, Danjie Zhang, Mark D. Minden, Veerendra Munugalavadla, Lauren Long, Jinfeng Liu, Yang Pan, Thomas Oellerich, Hubert Serve, Arati V. Rao, William G. Blum
Journal: Clinical Cancer Research
Clin Cancer Res (2020) 26 (22): 5852–5859.
https://doi.org/10.1158/1078-0432.CCR-20-1064
Published: 13 November 2020
View article titled, Entospletinib in Combination with Induction Chemotherapy in Previously Untreated Acute Myeloid Leukemia: Response and Predictive Significance of <em>HOXA9</em> and <em>MEIS1</em> Expression
Open the PDF for Entospletinib in Combination with Induction Chemotherapy in Previously Untreated Acute Myeloid Leukemia: Response and Predictive Significance of <em>HOXA9</em> and <em>MEIS1</em> Expression in another window
Includes: Supplementary data
Journal Articles

Genetic Characterization and Prognostic Relevance of Acquired Uniparental Disomies in Cytogenetically Normal Acute Myeloid Leukemia

Christopher J. Walker, Jessica Kohlschmidt, Ann-Kathrin Eisfeld, Krzysztof Mrózek, Sandya Liyanarachchi, Chi Song, Deedra Nicolet, James S. Blachly, Marius Bill, Dimitrios Papaioannou, Christopher C. Oakes, Brian Giacopelli, Luke K. Genutis, Sophia E. Maharry, Shelley Orwick, Kellie J. Archer, Bayard L. Powell, Jonathan E. Kolitz, Geoffrey L. Uy, Eunice S. Wang, Andrew J. Carroll, Richard M. Stone, John C. Byrd, Albert de la Chapelle, Clara D. Bloomfield
Journal: Clinical Cancer Research
Clin Cancer Res (2019) 25 (21): 6524–6531.
https://doi.org/10.1158/1078-0432.CCR-19-0725
Published: 01 November 2019
View article titled, Genetic Characterization and Prognostic Relevance of Acquired Uniparental Disomies in Cytogenetically Normal Acute Myeloid Leukemia
Open the PDF for Genetic Characterization and Prognostic Relevance of Acquired Uniparental Disomies in Cytogenetically Normal Acute Myeloid Leukemia in another window
Includes: Supplementary data
Journal Articles

Emergence of Polyclonal FLT3 Tyrosine Kinase Domain Mutations during Sequential Therapy with Sorafenib and Sunitinib in FLT3-ITD–Positive Acute Myeloid Leukemia

Sharyn D. Baker, Eric I. Zimmerman, Yong-Dong Wang, Shelley Orwick, Douglas S. Zatechka, Jassada Buaboonnam, Geoffrey A. Neale, Scott R. Olsen, Eric J. Enemark, Sheila Shurtleff, Jeffrey E. Rubnitz, Charles G. Mullighan, Hiroto Inaba
Journal: Clinical Cancer Research
Clin Cancer Res (2013) 19 (20): 5758–5768.
https://doi.org/10.1158/1078-0432.CCR-13-1323
Published: 14 October 2013
View article titled, Emergence of Polyclonal FLT3 Tyrosine Kinase Domain Mutations during Sequential Therapy with Sorafenib and Sunitinib in FLT3-ITD–Positive Acute Myeloid Leukemia
Open the PDF for Emergence of Polyclonal FLT3 Tyrosine Kinase Domain Mutations during Sequential Therapy with Sorafenib and Sunitinib in FLT3-ITD–Positive Acute Myeloid Leukemia in another window
Includes: Supplementary data
Journal Articles

Interaction of the Multikinase Inhibitors Sorafenib and Sunitinib with Solute Carriers and ATP-Binding Cassette Transporters

Shuiying Hu, Zhaoyuan Chen, Ryan Franke, Shelley Orwick, Ming Zhao, Michelle A. Rudek, Alex Sparreboom, Sharyn D. Baker
Journal: Clinical Cancer Research
Clin Cancer Res (2009) 15 (19): 6062–6069.
https://doi.org/10.1158/1078-0432.CCR-09-0048
Published: 30 September 2009
View article titled, Interaction of the Multikinase Inhibitors Sorafenib and Sunitinib with Solute Carriers and ATP-Binding Cassette Transporters
Open the PDF for Interaction of the Multikinase Inhibitors Sorafenib and Sunitinib with Solute Carriers and ATP-Binding Cassette Transporters in another window
Includes: Supplementary data