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Sharyn D. Baker
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Journal Articles

Preclinical and Pilot Study of Type I FLT3 Tyrosine Kinase Inhibitor, Crenolanib, with Sorafenib in Acute Myeloid Leukemia and FLT3-Internal Tandem Duplication

Hiroto Inaba, Jolieke G. van Oosterwijk, John C. Panetta, Lie Li, Daelynn R. Buelow, James S. Blachly, Sheila Shurtleff, Ching-Hon Pui, Raul C. Ribeiro, Jeffrey E. Rubnitz, Stanley Pounds, Sharyn D. Baker
Journal: Clinical Cancer Research
Clin Cancer Res (2022) 28 (12): 2536–2546.
https://doi.org/10.1158/1078-0432.CCR-21-4450
Published: 13 June 2022
View article titled, Preclinical and Pilot Study of Type I FLT3 Tyrosine Kinase Inhibitor, Crenolanib, with Sorafenib in Acute Myeloid Leukemia and <em>FLT3</em>-Internal Tandem Duplication
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Includes: Supplementary data
Journal Articles

Sorafenib Population Pharmacokinetics and Skin Toxicities in Children and Adolescents with Refractory/Relapsed Leukemia or Solid Tumor Malignancies

Hiroto Inaba, John C. Panetta, Stanley B. Pounds, Lei Wang, Lie Li, Fariba Navid, Sara M. Federico, Eric D. Eisenmann, Aksana Vasilyeva, Yong-Dong Wang, Sheila Shurtleff, Ching-Hon Pui, Tanja A. Gruber, Raul C. Ribeiro, Jeffrey E. Rubnitz, Sharyn D. Baker
Journal: Clinical Cancer Research
Clin Cancer Res (2019) 25 (24): 7320–7330.
https://doi.org/10.1158/1078-0432.CCR-19-0470
Published: 13 December 2019
View article titled, Sorafenib Population Pharmacokinetics and Skin Toxicities in Children and Adolescents with Refractory/Relapsed Leukemia or Solid Tumor Malignancies
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Includes: Supplementary data
Journal Articles

Cellular Uptake of Imatinib into Leukemic Cells Is Independent of Human Organic Cation Transporter 1 (OCT1)

Anne T. Nies, Elke Schaeffeler, Heiko van der Kuip, Ingolf Cascorbi, Oliver Bruhn, Michael Kneba, Christiane Pott, Ute Hofmann, Christopher Volk, Shuiying Hu, Sharyn D. Baker, Alex Sparreboom, Peter Ruth, Hermann Koepsell, Matthias Schwab
Journal: Clinical Cancer Research
Clin Cancer Res (2014) 20 (4): 985–994.
https://doi.org/10.1158/1078-0432.CCR-13-1999
Published: 16 February 2014
View article titled, Cellular Uptake of Imatinib into Leukemic Cells Is Independent of Human Organic Cation Transporter 1 (OCT1)
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Includes: Supplementary data
Journal Articles

Emergence of Polyclonal FLT3 Tyrosine Kinase Domain Mutations during Sequential Therapy with Sorafenib and Sunitinib in FLT3-ITD–Positive Acute Myeloid Leukemia

Sharyn D. Baker, Eric I. Zimmerman, Yong-Dong Wang, Shelley Orwick, Douglas S. Zatechka, Jassada Buaboonnam, Geoffrey A. Neale, Scott R. Olsen, Eric J. Enemark, Sheila Shurtleff, Jeffrey E. Rubnitz, Charles G. Mullighan, Hiroto Inaba
Journal: Clinical Cancer Research
Clin Cancer Res (2013) 19 (20): 5758–5768.
https://doi.org/10.1158/1078-0432.CCR-13-1323
Published: 14 October 2013
View article titled, Emergence of Polyclonal FLT3 Tyrosine Kinase Domain Mutations during Sequential Therapy with Sorafenib and Sunitinib in FLT3-ITD–Positive Acute Myeloid Leukemia
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Includes: Supplementary data
Journal Articles

Contribution of Abcc4-Mediated Gastric Transport to the Absorption and Efficacy of Dasatinib

Brian D. Furmanski, Shuiying Hu, Ken-ichi Fujita, Lie Li, Alice A. Gibson, Laura J. Janke, Richard T. Williams, John D. Schuetz, Alex Sparreboom, Sharyn D. Baker
Journal: Clinical Cancer Research
Clin Cancer Res (2013) 19 (16): 4359–4370.
https://doi.org/10.1158/1078-0432.CCR-13-0980
Published: 13 August 2013
View article titled, Contribution of Abcc4-Mediated Gastric Transport to the Absorption and Efficacy of Dasatinib
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Includes: Supplementary data
Journal Articles

Phase I Trial, Pharmacokinetics, and Pharmacodynamics of Vandetanib and Dasatinib in Children with Newly Diagnosed Diffuse Intrinsic Pontine Glioma

Alberto Broniscer, Sharyn D. Baker, Cynthia Wetmore, Atmaram S. Pai Panandiker, Jie Huang, Andrew M. Davidoff, Arzu Onar-Thomas, John C. Panetta, Thomas K. Chin, Thomas E. Merchant, Justin N. Baker, Sue C. Kaste, Amar Gajjar, Clinton F. Stewart
Journal: Clinical Cancer Research
Clin Cancer Res (2013) 19 (11): 3050–3058.
https://doi.org/10.1158/1078-0432.CCR-13-0306
Published: 30 May 2013
View article titled, Phase I Trial, Pharmacokinetics, and Pharmacodynamics of Vandetanib and Dasatinib in Children with Newly Diagnosed Diffuse Intrinsic Pontine Glioma
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Includes: Supplementary data
Journal Articles

Contribution of OATP1B1 and OATP1B3 to the Disposition of Sorafenib and Sorafenib-Glucuronide

Eric I. Zimmerman, Shuiying Hu, Justin L. Roberts, Alice A. Gibson, Shelley J. Orwick, Lie Li, Alex Sparreboom, Sharyn D. Baker
Journal: Clinical Cancer Research
Clin Cancer Res (2013) 19 (6): 1458–1466.
https://doi.org/10.1158/1078-0432.CCR-12-3306
Published: 14 March 2013
View article titled, Contribution of OATP1B1 and OATP1B3 to the Disposition of Sorafenib and Sorafenib-Glucuronide
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Includes: Supplementary data
Journal Articles

Phase I and Clinical Pharmacology Study of Bevacizumab, Sorafenib, and Low-Dose Cyclophosphamide in Children and Young Adults with Refractory/Recurrent Solid Tumors

Fariba Navid, Sharyn D. Baker, M. Beth McCarville, Clinton F. Stewart, Catherine A. Billups, Jianrong Wu, Andrew M. Davidoff, Sheri L. Spunt, Wayne L. Furman, Lisa M. McGregor, Shuiying Hu, John C. Panetta, David Turner, Demba Fofana, Wilburn E. Reddick, Wing Leung, Victor M. Santana
Journal: Clinical Cancer Research
Clin Cancer Res (2013) 19 (1): 236–246.
https://doi.org/10.1158/1078-0432.CCR-12-1897
Published: 02 January 2013
View article titled, Phase I and Clinical Pharmacology Study of Bevacizumab, Sorafenib, and Low-Dose Cyclophosphamide in Children and Young Adults with Refractory/Recurrent Solid Tumors
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Journal Articles

Ontogeny and Sorafenib Metabolism

Eric I. Zimmerman, Justin L. Roberts, Lie Li, David Finkelstein, Alice Gibson, Amarjit S. Chaudhry, Erin G. Schuetz, Jeffrey E. Rubnitz, Hiroto Inaba, Sharyn D. Baker
Journal: Clinical Cancer Research
Clin Cancer Res (2012) 18 (20): 5788–5795.
https://doi.org/10.1158/1078-0432.CCR-12-1967
Published: 14 October 2012
View article titled, Ontogeny and Sorafenib Metabolism
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Includes: Supplementary data
Journal Articles

Influence of Smoking on the Pharmacokinetics and Toxicity Profiles of Taxane Therapy

Anne-Joy M. de Graan, Walter J. Loos, Lena E. Friberg, Sharyn D. Baker, Jessica M. van der Bol, Leni van Doorn, Erik A.C. Wiemer, Bronno van der Holt, Jaap Verweij, Ron H.J. Mathijssen
Journal: Clinical Cancer Research
Clin Cancer Res (2012) 18 (16): 4425–4432.
https://doi.org/10.1158/1078-0432.CCR-12-0728
Published: 14 August 2012
View article titled, Influence of Smoking on the Pharmacokinetics and Toxicity Profiles of Taxane Therapy
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Includes: Supplementary data
Journal Articles

Influence of Polymorphic OATP1B-Type Carriers on the Disposition of Docetaxel

Anne-Joy M. de Graan, Cynthia S. Lancaster, Amanda Obaidat, Bruno Hagenbuch, Laure Elens, Lena E. Friberg, Peter de Bruijn, Shuiying Hu, Alice A. Gibson, Gitte H. Bruun, Thomas J. Corydon, Torben S. Mikkelsen, Aisha L. Walker, Guoqing Du, Walter J. Loos, Ron H. N. van Schaik, Sharyn D. Baker, Ron H. J. Mathijssen, Alex Sparreboom
Journal: Clinical Cancer Research
Clin Cancer Res (2012) 18 (16): 4433–4440.
https://doi.org/10.1158/1078-0432.CCR-12-0761
Published: 14 August 2012
View article titled, Influence of Polymorphic OATP1B-Type Carriers on the Disposition of Docetaxel
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Includes: Supplementary data
Journal Articles

Interaction of the Multikinase Inhibitors Sorafenib and Sunitinib with Solute Carriers and ATP-Binding Cassette Transporters

Shuiying Hu, Zhaoyuan Chen, Ryan Franke, Shelley Orwick, Ming Zhao, Michelle A. Rudek, Alex Sparreboom, Sharyn D. Baker
Journal: Clinical Cancer Research
Clin Cancer Res (2009) 15 (19): 6062–6069.
https://doi.org/10.1158/1078-0432.CCR-09-0048
Published: 30 September 2009
View article titled, Interaction of the Multikinase Inhibitors Sorafenib and Sunitinib with Solute Carriers and ATP-Binding Cassette Transporters
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Includes: Supplementary data
Journal Articles

A Phase I Dose-Finding Study of 5-Azacytidine in Combination with Sodium Phenylbutyrate in Patients with Refractory Solid Tumors

Jianqing Lin, Jill Gilbert, Michelle A. Rudek, James A. Zwiebel, Steve Gore, Anchalee Jiemjit, Ming Zhao, Sharyn D. Baker, Richard F. Ambinder, James G. Herman, Ross C. Donehower, Michael A. Carducci
Journal: Clinical Cancer Research
Clin Cancer Res (2009) 15 (19): 6241–6249.
https://doi.org/10.1158/1078-0432.CCR-09-0567
Published: 30 September 2009
View article titled, A Phase I Dose-Finding Study of 5-Azacytidine in Combination with Sodium Phenylbutyrate in Patients with Refractory Solid Tumors
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Includes: Supplementary data
Journal Articles

Interaction of Imatinib with Human Organic Ion Carriers

Shuiying Hu, Ryan M. Franke, Kelly K. Filipski, Chaoxin Hu, Shelley J. Orwick, Ernst A. de Bruijn, Herman Burger, Sharyn D. Baker, Alex Sparreboom
Journal: Clinical Cancer Research
Clin Cancer Res (2008) 14 (10): 3141–3148.
https://doi.org/10.1158/1078-0432.CCR-07-4913
Published: 15 May 2008
View article titled, Interaction of Imatinib with Human Organic Ion Carriers
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Journal Articles

Population Pharmacokinetic-Pharmacodynamic Model of the Vascular-Disrupting Agent 5,6-Dimethylxanthenone-4-Acetic Acid in Cancer Patients

Jing Li, Michael B. Jameson, Bruce C. Baguley, Roberto Pili, Sharyn D. Baker
Journal: Clinical Cancer Research
Clin Cancer Res (2008) 14 (7): 2102–2110.
https://doi.org/10.1158/1078-0432.CCR-07-1475
Published: 01 April 2008
View article titled, Population Pharmacokinetic-Pharmacodynamic Model of the Vascular-Disrupting Agent 5,6-Dimethylxanthenone-4-Acetic Acid in Cancer Patients
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Journal Articles

Influence of CYP3A4 Inhibition on the Steady-State Pharmacokinetics of Imatinib

Nielka P. van Erp, Hans Gelderblom, Mats O. Karlsson, Jing Li, Ming Zhao, Jan Ouwerkerk, Johan W. Nortier, Henk-Jan Guchelaar, Sharyn D. Baker, Alex Sparreboom
Journal: Clinical Cancer Research
Clin Cancer Res (2007) 13 (24): 7394–7400.
https://doi.org/10.1158/1078-0432.CCR-07-0346
Published: 19 December 2007
View article titled, Influence of CYP3A4 Inhibition on the Steady-State Pharmacokinetics of Imatinib
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Journal Articles

Differential Metabolism of Gefitinib and Erlotinib by Human Cytochrome P450 Enzymes

Jing Li, Ming Zhao, Ping He, Manuel Hidalgo, Sharyn D. Baker
Journal: Clinical Cancer Research
Clin Cancer Res (2007) 13 (12): 3731–3737.
https://doi.org/10.1158/1078-0432.CCR-07-0088
Published: 15 June 2007
View article titled, Differential Metabolism of Gefitinib and Erlotinib by Human Cytochrome P450 Enzymes
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Journal Articles

Activated Pregnenolone X-Receptor Is a Target for Ketoconazole and Its Analogs

Hongwei Wang, Haiyan Huang, Hao Li, Denise G. Teotico, Michael Sinz, Sharyn D. Baker, Jeffrey Staudinger, Ganjam Kalpana, Matthew R. Redinbo, Sridhar Mani
Journal: Clinical Cancer Research
Clin Cancer Res (2007) 13 (8): 2488–2495.
https://doi.org/10.1158/1078-0432.CCR-06-1592
Published: 16 April 2007
View article titled, Activated Pregnenolone X-Receptor Is a Target for Ketoconazole and Its Analogs
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Journal Articles

Pharmacokinetics and Toxicity of Weekly Docetaxel in Older Patients

Arti Hurria, Mark T. Fleming, Sharyn D. Baker, Wm. Kevin Kelly, Katie Cutchall, Katherine Panageas, James Caravelli, Henry Yeung, Mark G. Kris, Jorge Gomez, Vincent A. Miller, Gabriella D'Andrea, Howard I. Scher, Larry Norton, Clifford Hudis
Journal: Clinical Cancer Research
Clin Cancer Res (2006) 12 (20): 6100–6105.
https://doi.org/10.1158/1078-0432.CCR-06-0200
Published: 24 October 2006
View article titled, Pharmacokinetics and Toxicity of Weekly Docetaxel in Older Patients
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Journal Articles

Population Pharmacokinetics of Troxacitabine, a Novel Dioxolane Nucleoside Analogue

Carlton K. K. Lee, Eric K. Rowinsky, Jing Li, Francis Giles, Malcolm J. Moore, Manuel Hidalgo, Edmund Capparelli, Jacques Jolivet, Sharyn D. Baker
Journal: Clinical Cancer Research
Clin Cancer Res (2006) 12 (7): 2158–2165.
https://doi.org/10.1158/1078-0432.CCR-05-2249
Published: 11 April 2006
View article titled, Population Pharmacokinetics of Troxacitabine, a Novel Dioxolane Nucleoside Analogue
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