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Sebastien J. Hotte
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Journal Articles

Randomized Phase II Study of Durvalumab with or without Tremelimumab in Patients with Metastatic Castration-Resistant Prostate Cancer

Eric Winquist, Sebastien J. Hotte, Kim Chi, Srikala Sridhar, Susan Ellard, Michael Ong, Nayyer Iqbal, Muhammad Salim, Urban Emmenegger, Joel R. Gingerich, Aly-Khan Lalani, Pierre Major, Christian Kollmannsberger, Steven Yip, Aaron Hansen, Daygen Finch, Christina Canil, James Hutchenreuther, Francisco Vera-Badillo, Martin Smoragiewicz, Michael Cabanero, Ming-Sound Tsao, Elie Ritch, Alexander W. Wyatt, Lesley Seymour
Journal: Clinical Cancer Research
Clin Cancer Res (2025) 31 (1): 45–55.
https://doi.org/10.1158/1078-0432.CCR-24-1612
Published: 06 January 2025
View article titled, Randomized Phase II Study of Durvalumab with or without Tremelimumab in Patients with Metastatic Castration-Resistant Prostate Cancer
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Includes: Supplementary data
Journal Articles

Phase I Dose-Escalation Study of the Safety and Pharmacokinetics of AGS15E Monotherapy in Patients with Metastatic Urothelial Carcinoma

Daniel P. Petrylak, Bernhard J. Eigl, Saby George, Elisabeth I. Heath, Sebastien J. Hotte, David D. Chism, Lisle M. Nabell, Joel Picus, Susanna Y. Cheng, Leonard J. Appleman, Guru P. Sonpavde, Alicia K. Morgans, Pourya Pourhosseini, Ruishan Wu, Laura Standley, Ruslan Croitoru, Evan Y. Yu
Journal: Clinical Cancer Research
Clin Cancer Res (2024) 30 (1): 63–73.
https://doi.org/10.1158/1078-0432.CCR-22-3627
Published: 05 January 2024
View article titled, Phase I Dose-Escalation Study of the Safety and Pharmacokinetics of AGS15E Monotherapy in Patients with Metastatic Urothelial Carcinoma
Open the PDF for Phase I Dose-Escalation Study of the Safety and Pharmacokinetics of AGS15E Monotherapy in Patients with Metastatic Urothelial Carcinoma in another window
Includes: Supplementary data
Journal Articles

Olaparib Efficacy in Patients with Metastatic Castration-resistant Prostate Cancer and BRCA1, BRCA2, or ATM Alterations Identified by Testing Circulating Tumor DNA

Nobuaki Matsubara, Johann de Bono, David Olmos, Giuseppe Procopio, Satoru Kawakami, Yüksel Ürün, Robbert van Alphen, Aude Flechon, Michael A. Carducci, Young Deuk Choi, Sebastien J. Hotte, Ernesto Korbenfeld, Gero Kramer, Neeraj Agarwal, Kim N. Chi, Simon Dearden, Christopher Gresty, Jinyu Kang, Christian Poehlein, Elizabeth A. Harrington, Maha Hussain
Journal: Clinical Cancer Research
Clin Cancer Res (2023) 29 (1): 92–99.
https://doi.org/10.1158/1078-0432.CCR-21-3577
Published: 04 January 2023
View article titled, Olaparib Efficacy in Patients with Metastatic Castration-resistant Prostate Cancer and <em>BRCA1, BRCA2</em>, or <em>ATM</em> Alterations Identified by Testing Circulating Tumor DNA
Open the PDF for Olaparib Efficacy in Patients with Metastatic Castration-resistant Prostate Cancer and <em>BRCA1, BRCA2</em>, or <em>ATM</em> Alterations Identified by Testing Circulating Tumor DNA in another window
Includes: Supplementary data
Journal Articles

Phase I Study of Decitabine in Combination with Vorinostat in Patients with Advanced Solid Tumors and Non-Hodgkin's Lymphomas

Anastasios Stathis, Sebastien J. Hotte, Eric X. Chen, Holger W. Hirte, Amit M. Oza, Patricia Moretto, Sheila Webster, Anne Laughlin, Lee-Anne Stayner, Shauna McGill, Lisa Wang, Wen-jiang Zhang, Igor Espinoza-Delgado, Julianne L. Holleran, Merrill J. Egorin, Lillian L. Siu
Journal: Clinical Cancer Research
Clin Cancer Res (2011) 17 (6): 1582–1590.
https://doi.org/10.1158/1078-0432.CCR-10-1893
Published: 15 March 2011
View article titled, Phase I Study of Decitabine in Combination with Vorinostat in Patients with Advanced Solid Tumors and Non-Hodgkin's Lymphomas
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Includes: Supplementary data
Journal Articles

Vascular Endothelial Growth Factor Concentration as a Predictive Marker: Ready for Primetime?

Peter A. Kavsak, Hal Hirte, Sebastien J. Hotte
Journal: Clinical Cancer Research
Clin Cancer Res (2010) 16 (4): 1341.
https://doi.org/10.1158/1078-0432.CCR-09-1476
Published: 15 February 2010
View article titled, Vascular Endothelial Growth Factor Concentration as a Predictive Marker: Ready for Primetime?
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Journal Articles

A Phase I Study of OGX-011, a 2′-Methoxyethyl Phosphorothioate Antisense to Clusterin, in Combination with Docetaxel in Patients with Advanced Cancer

Kim N. Chi, Lillian L. Siu, Hal Hirte, Sebastien J. Hotte, Jennifer Knox, Christian Kollmansberger, Martin Gleave, Emma Guns, Jean Powers, Wendy Walsh, Dongsheng Tu, Elizabeth Eisenhauer
Journal: Clinical Cancer Research
Clin Cancer Res (2008) 14 (3): 833–839.
https://doi.org/10.1158/1078-0432.CCR-07-1310
Published: 01 February 2008
View article titled, A Phase I Study of OGX-011, a 2′-Methoxyethyl Phosphorothioate Antisense to Clusterin, in Combination with Docetaxel in Patients with Advanced Cancer
Open the PDF for A Phase I Study of OGX-011, a 2′-Methoxyethyl Phosphorothioate Antisense to Clusterin, in Combination with Docetaxel in Patients with Advanced Cancer in another window