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Scott H. Kaufmann
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Journal Articles

Concurrent RB1 Loss and BRCA Deficiency Predicts Enhanced Immunologic Response and Long-term Survival in Tubo-ovarian High-grade Serous Carcinoma

Open Access
Flurina A.M. Saner, Kazuaki Takahashi, Timothy Budden, Ahwan Pandey, Dinuka Ariyaratne, Tibor A. Zwimpfer, Nicola S. Meagher, Sian Fereday, Laura Twomey, Kathleen I. Pishas, Therese Hoang, Adelyn Bolithon, Nadia Traficante, for the Australian Ovarian Cancer Study Group, Kathryn Alsop, Elizabeth L. Christie, Eun-Young Kang, Gregg S. Nelson, Prafull Ghatage, Cheng-Han Lee, Marjorie J. Riggan, Jennifer Alsop, Matthias W. Beckmann, Jessica Boros, Alison H. Brand, Angela Brooks-Wilson, Michael E. Carney, Penny Coulson, Madeleine Courtney-Brooks, Kara L. Cushing-Haugen, Cezary Cybulski, Mona A. El-Bahrawy, Esther Elishaev, Ramona Erber, Simon A. Gayther, Aleksandra Gentry-Maharaj, C. Blake Gilks, Paul R. Harnett, Holly R. Harris, Arndt Hartmann, Alexander Hein, Joy Hendley, Brenda Y. Hernandez, Anna Jakubowska, Mercedes Jimenez-Linan, Michael E. Jones, Scott H. Kaufmann, Catherine J. Kennedy, Tomasz Kluz, Jennifer M. Koziak, Björg Kristjansdottir, Nhu D. Le, Marcin Lener, Jenny Lester, Jan Lubiński, Constantina Mateoiu, Sandra Orsulic, Matthias Ruebner, Minouk J. Schoemaker, Mitul Shah, Raghwa Sharma, Mark E. Sherman, Yurii B. Shvetsov, T. Rinda Soong, Helen Steed, Paniti Sukumvanich, Aline Talhouk, Sarah E. Taylor, Robert A. Vierkant, Chen Wang, Martin Widschwendter, Lynne R. Wilkens, Stacey J. Winham, Michael S. Anglesio, Andrew Berchuck, James D. Brenton, Ian Campbell, Linda S. Cook, Jennifer A. Doherty, Peter A. Fasching, Renée T. Fortner, Marc T. Goodman, Jacek Gronwald, David G. Huntsman, Beth Y. Karlan, Linda E. Kelemen, Usha Menon, Francesmary Modugno, Paul D.P. Pharoah, Joellen M. Schildkraut, Karin Sundfeldt, Anthony J. Swerdlow, Ellen L. Goode, Anna DeFazio, Martin Köbel, Susan J. Ramus, David D.L. Bowtell, Dale W. Garsed
Journal: Clinical Cancer Research
Clin Cancer Res (2024) 30 (16): 3481–3498.
https://doi.org/10.1158/1078-0432.CCR-23-3552
Published: 15 August 2024
View articletitled, Concurrent RB1 Loss and BRCA Deficiency Predicts Enhanced Immunologic Response and Long-term Survival in Tubo-ovarian High-grade Serous Carcinoma
Open the PDF for Concurrent RB1 Loss and BRCA Deficiency Predicts Enhanced Immunologic Response and Long-term Survival in Tubo-ovarian High-grade Serous Carcinoma in another window
Includes: Supplementary data
Journal Articles

Development and Validation of the Gene Expression Predictor of High-grade Serous Ovarian Carcinoma Molecular SubTYPE (PrOTYPE)

Free
Aline Talhouk, Joshy George, Chen Wang, Timothy Budden, Tuan Zea Tan, Derek S. Chiu, Stefan Kommoss, Huei San Leong, Stephanie Chen, Maria P. Intermaggio, Blake Gilks, Tayyebeh M. Nazeran, Mila Volchek, Wafaa Elatre, Rex C. Bentley, Janine Senz, Amy Lum, Veronica Chow, Hanwei Sudderuddin, Robertson Mackenzie, Samuel C.Y. Leong, Geyi Liu, Dustin Johnson, Billy Chen, AOCS Group, Jennifer Alsop, Susana N. Banerjee, Sabine Behrens, Clara Bodelon, Alison H. Brand, Louise Brinton, Michael E. Carney, Yoke-Eng Chiew, Kara L. Cushing-Haugen, Cezary Cybulski, Darren Ennis, Sian Fereday, Renée T. Fortner, Jesús García-Donas, Aleksandra Gentry-Maharaj, Rosalind Glasspool, Teodora Goranova, Casey S. Greene, Paul Haluska, Holly R. Harris, Joy Hendley, Brenda Y. Hernandez, Esther Herpel, Mercedes Jimenez-Linan, Chloe Karpinskyj, Scott H. Kaufmann, Gary L. Keeney, Catherine J. Kennedy, Martin Köbel, Jennifer M. Koziak, Melissa C. Larson, Jenny Lester, Liz-Anne Lewsley, Jolanta Lissowska, Jan Lubiński, Hugh Luk, Geoff Macintyre, Sven Mahner, Iain A. McNeish, Janusz Menkiszak, Nikilyn Nevins, Ana Osorio, Oleg Oszurek, José Palacios, Samantha Hinsley, Celeste L. Pearce, Malcolm C. Pike, Anna M. Piskorz, Isabelle Ray-Coquard, Valerie Rhenius, Cristina Rodriguez-Antona, Raghwa Sharma, Mark E. Sherman, Dilrini De Silva, Naveena Singh, Peter Sinn, Dennis Slamon, Honglin Song, Helen Steed, Euan A. Stronach, Pamela J. Thompson, Aleksandra Tołoczko, Britton Trabert, Nadia Traficante, Chiu-Chen Tseng, Martin Widschwendter, Lynne R. Wilkens, Stacey J. Winham, Boris Winterhoff, Alicia Beeghly-Fadiel, Javier Benitez, Andrew Berchuck, James D. Brenton, Robert Brown, Jenny Chang-Claude, Georgia Chenevix-Trench, Anna deFazio, Peter A. Fasching, María J. García, Simon A. Gayther, Marc T. Goodman, Jacek Gronwald, Michelle J. Henderson, Beth Y. Karlan, Linda E. Kelemen, Usha Menon, Sandra Orsulic, Paul D.P. Pharoah, Nicolas Wentzensen, Anna H. Wu, Joellen M. Schildkraut, Mary Anne Rossing, Gottfried E. Konecny, David G. Huntsman, Ruby Yun-Ju Huang, Ellen L. Goode, Susan J. Ramus, Jennifer A. Doherty, David D. Bowtell, Michael S. Anglesio
Journal: Clinical Cancer Research
Clin Cancer Res (2020) 26 (20): 5411–5423.
https://doi.org/10.1158/1078-0432.CCR-20-0103
Published: 15 October 2020
View articletitled, Development and Validation of the Gene Expression Predictor of High-grade Serous Ovarian Carcinoma Molecular SubTYPE (PrOTYPE)
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Includes: Supplementary data
Journal Articles

Abstract IA02: DNA repair gene promoter methylation patterns adapt and influence PARP inhibitor response

Free
Kasenija Nesic, Rachel M Hurley, Cordelia McGehee, Olga Kondrashova, Maria I. Harrell, Giada V. Zapparoli, Ashan Musafer, Ming E. Wong, John Weroha, Xiaonan Hou, Hu Li, Vivian Negron, Kevin Peterson, Paula Schneider, Elizabeth M. Swisher, Melissa Southey, Alexander Dobrovic, Matthew Wakefield, Scott H. Kaufmann, Clare L. Scott
Journal: Clinical Cancer Research
Clin Cancer Res (2020) 26 (13_Supplement): IA02.
https://doi.org/10.1158/1557-3265.OVCA19-IA02
Published: 01 July 2020
View articletitled, Abstract IA02: DNA repair gene promoter methylation patterns adapt and influence PARP inhibitor response
Journal Articles

Abstract A33: Loss of ZC3H18 disrupts homologous recombination repair and sensitizes ovarian cancer cells to PARP inhibitors and DNA cross-linking agents

Free
Arun Kanakkanthara, Catherine J. Huntoon, Xiaonan Hou, Minzhi Zhang, Ethan P Heinzen, Ann L. Oberg, John S. Weroha, Scott H. Kaufmann, Larry M. Karnitz
Journal: Clinical Cancer Research
Clin Cancer Res (2020) 26 (13_Supplement): A33.
https://doi.org/10.1158/1557-3265.OVCA19-A33
Published: 01 July 2020
View articletitled, Abstract A33: Loss of ZC3H18 disrupts homologous recombination repair and sensitizes ovarian cancer cells to PARP inhibitors and DNA cross-linking agents
Journal Articles

Abstract PR02: Proteogenomic approach to identify mechanisms of platinum refractoriness in high-grade serous ovarian cancers

Free
Jacob J. Kennedy, Shrabanti Chowdhury, Sara R. Savage, Xiaonan Hou, Catherine J. Huntoon, Richard G. Ivey, Qing Yu, Chenwei Lin, Dongqing Huang, Lei Zhao, Uliana J. Voytovich, Regine M. Schoenherr, Zahra Shire, Steven J. Skates, Jeffrey R. Whiteaker, Andrew N. Hoofnagle, Samuel C. Mok, Bing Zhang, Larry M. Karnitz, S. John Weroha, Steven P. Gygi, Scott H. Kaufmann, Pei Wang, Michael J. Birrer, Amanda G. Paulovich
Journal: Clinical Cancer Research
Clin Cancer Res (2020) 26 (13_Supplement): PR02.
https://doi.org/10.1158/1557-3265.OVCA19-PR02
Published: 01 July 2020
View articletitled, Abstract PR02: Proteogenomic approach to identify mechanisms of platinum refractoriness in high-grade serous ovarian cancers
Journal Articles

The DNA Cytosine Deaminase APOBEC3B is a Molecular Determinant of Platinum Responsiveness in Clear Cell Ovarian Cancer

Available to Purchase
Artur A. Serebrenik, Prokopios P. Argyris, Matthew C. Jarvis, William L. Brown, Martina Bazzaro, Rachel I. Vogel, Britt K. Erickson, Sun-Hee Lee, Krista M. Goergen, Matthew J. Maurer, Ethan P. Heinzen, Ann L. Oberg, Yajue Huang, Xiaonan Hou, S. John Weroha, Scott H. Kaufmann, Reuben S. Harris
Journal: Clinical Cancer Research
Clin Cancer Res (2020) 26 (13): 3397–3407.
https://doi.org/10.1158/1078-0432.CCR-19-2786
Published: 01 July 2020
View articletitled, The DNA Cytosine Deaminase APOBEC3B is a Molecular Determinant of Platinum Responsiveness in Clear Cell Ovarian Cancer
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Includes: Supplementary data
Journal Articles

Anastrozole has an Association between Degree of Estrogen Suppression and Outcomes in Early Breast Cancer and is a Ligand for Estrogen Receptor α

Free
James N. Ingle, Junmei Cairns, Vera J. Suman, Lois E. Shepherd, Peter A. Fasching, Tanya L. Hoskin, Ravinder J. Singh, Zeruesenay Desta, Krishna R. Kalari, Matthew J. Ellis, Paul E. Goss, Bingshu E. Chen, Bernhard Volz, Poulami Barman, Erin E. Carlson, Tufia Haddad, Matthew P. Goetz, Barbara Goodnature, Matthew E. Cuellar, Michael A. Walters, Cristina Correia, Scott H. Kaufmann, Richard M. Weinshilboum, Liewei Wang
Journal: Clinical Cancer Research
Series: Author Choice
Clin Cancer Res (2020) 26 (12): 2986–2996.
https://doi.org/10.1158/1078-0432.CCR-19-3091
Published: 15 June 2020
View articletitled, Anastrozole has an Association between Degree of Estrogen Suppression and Outcomes in Early Breast Cancer and is a Ligand for Estrogen Receptor α
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Includes: Supplementary data
Journal Articles

A Phase I Clinical Trial of the Poly(ADP-ribose) Polymerase Inhibitor Veliparib and Weekly Topotecan in Patients with Solid Tumors

Available to Purchase
Andrea E. Wahner Hendrickson, Michael E. Menefee, Lynn C. Hartmann, Harry J. Long, Donald W. Northfelt, Joel M. Reid, Felix Boakye-Agyeman, Olumide Kayode, Karen S. Flatten, Maria I. Harrell, Elizabeth M. Swisher, Guy G. Poirier, Daniel Satele, Jake Allred, Janet L. Lensing, Alice Chen, Jiuping Ji, Yiping Zang, Charles Erlichman, Paul Haluska, Scott H. Kaufmann
Journal: Clinical Cancer Research
Clin Cancer Res (2018) 24 (4): 744–752.
https://doi.org/10.1158/1078-0432.CCR-17-1590
Published: 01 February 2018
View articletitled, A Phase I Clinical Trial of the Poly(ADP-ribose) Polymerase Inhibitor Veliparib and Weekly Topotecan in Patients with Solid Tumors
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Includes: Supplementary data
Journal Articles

Pooled Clustering of High-Grade Serous Ovarian Cancer Gene Expression Leads to Novel Consensus Subtypes Associated with Survival and Surgical Outcomes

Available to Purchase
Chen Wang, Sebastian M. Armasu, Kimberly R. Kalli, Matthew J. Maurer, Ethan P. Heinzen, Gary L. Keeney, William A. Cliby, Ann L. Oberg, Scott H. Kaufmann, Ellen L. Goode
Journal: Clinical Cancer Research
Clin Cancer Res (2017) 23 (15): 4077–4085.
https://doi.org/10.1158/1078-0432.CCR-17-0246
Published: 01 August 2017
View articletitled, Pooled Clustering of High-Grade Serous Ovarian Cancer Gene Expression Leads to Novel Consensus Subtypes Associated with Survival and Surgical Outcomes
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Includes: Supplementary data
Journal Articles

Abstract AP28: BRCA1 and RAD51C Promoter Hypermethylation Confer Sensitivity to PARP Inhibitors in Patients with Platinum Sensitive Ovarian Carcinoma

Free
Elizabeth Swisher, Maria Harrell, Kevin K. Lin, Clare Scott, Sandra Goble, Amit Oza, Robert L. Coleman, Gottfried Konecny, Anna V. Tinker, David M. O'Malley, Rebecca Kristeleit, Ling Ma, James Brenton, Katherine Bell-McGuinn, Ana Oaknin, Alexandra Leary, Elaina Mann, Heidi Giordano, Mitch Rapon, Iain McNeish, Scott H. Kaufmann
Journal: Clinical Cancer Research
Clin Cancer Res (2017) 23 (11_Supplement): AP28.
https://doi.org/10.1158/1557-3265.OVCASYMP16-AP28
Published: 31 May 2017
View articletitled, Abstract AP28: BRCA1 and RAD51C Promoter Hypermethylation Confer Sensitivity to PARP Inhibitors in Patients with Platinum Sensitive Ovarian Carcinoma
Journal Articles

Abstract IS04: PARP INHIBITOR COMBINATIONS FOR THE TREATMENT OF OVARIAN CANCER

Free
Scott H. Kaufmann, Andrea E. Wahner Hendrickson, Maria I Harrell, Michael E. Menefee, Edward J. Tanner, David G Mutch, Elizabeth M. Swisher, Larry M. Karnitz
Journal: Clinical Cancer Research
Clin Cancer Res (2017) 23 (11_Supplement): IS04.
https://doi.org/10.1158/1557-3265.OVCASYMP16-IS04
Published: 31 May 2017
View articletitled, Abstract IS04: PARP INHIBITOR COMBINATIONS FOR THE TREATMENT OF OVARIAN CANCER
Journal Articles

A Phase I Study of Topotecan, Carboplatin and the PARP Inhibitor Veliparib in Acute Leukemias, Aggressive Myeloproliferative Neoplasms, and Chronic Myelomonocytic Leukemia

Available to Purchase
Keith W. Pratz, Michelle A. Rudek, Ivana Gojo, Mark R. Litzow, Michael A. McDevitt, Jiuping Ji, Larry M. Karnitz, James G. Herman, Robert J. Kinders, B. Douglas Smith, Steven D. Gore, Hetty E. Carraway, Margaret M. Showel, Douglas E. Gladstone, Mark J. Levis, Hua-Ling Tsai, Gary Rosner, Alice Chen, Scott H. Kaufmann, Judith E. Karp
Journal: Clinical Cancer Research
Clin Cancer Res (2017) 23 (4): 899–907.
https://doi.org/10.1158/1078-0432.CCR-16-1274
Published: 14 February 2017
View articletitled, A Phase I Study of Topotecan, Carboplatin and the PARP Inhibitor Veliparib in Acute Leukemias, Aggressive Myeloproliferative Neoplasms, and Chronic Myelomonocytic Leukemia
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Includes: Supplementary data
Journal Articles

A Phase 1 Study of the PARP Inhibitor Veliparib in Combination with Temozolomide in Acute Myeloid Leukemia

Available to Purchase
Ivana Gojo, Jan H. Beumer, Keith W. Pratz, Michael A. McDevitt, Maria R. Baer, Amanda L. Blackford, B. Douglas Smith, Steven D. Gore, Hetty E. Carraway, Margaret M. Showel, Mark J. Levis, Amy E. Dezern, Douglas E. Gladstone, Jiuping Jay Ji, Lihua Wang, Robert J. Kinders, Marie Pouquet, Ismail Ali-Walbi, Michelle A. Rudek, Weijie Poh, James G. Herman, Larry M. Karnitz, Scott H. Kaufmann, Alice Chen, Judith E. Karp
Journal: Clinical Cancer Research
Clin Cancer Res (2017) 23 (3): 697–706.
https://doi.org/10.1158/1078-0432.CCR-16-0984
Published: 31 January 2017
View articletitled, A Phase 1 Study of the PARP Inhibitor Veliparib in Combination with Temozolomide in Acute Myeloid Leukemia
Open the PDF for A Phase 1 Study of the PARP Inhibitor Veliparib in Combination with Temozolomide in Acute Myeloid Leukemia in another window
Includes: Supplementary data
Journal Articles

APOBEC3G Expression Correlates with T-Cell Infiltration and Improved Clinical Outcomes in High-grade Serous Ovarian Carcinoma

Free
Brandon Leonard, Gabriel J. Starrett, Matthew J. Maurer, Ann L. Oberg, Mieke Van Bockstal, Jo Van Dorpe, Olivier De Wever, Jozien Helleman, Anieta M. Sieuwerts, Els M.J.J. Berns, John W.M. Martens, Brett D. Anderson, William L. Brown, Kimberly R. Kalli, Scott H. Kaufmann, Reuben S. Harris
Journal: Clinical Cancer Research
Clin Cancer Res (2016) 22 (18): 4746–4755.
https://doi.org/10.1158/1078-0432.CCR-15-2910
Published: 15 September 2016
View articletitled, APOBEC3G Expression Correlates with T-Cell Infiltration and Improved Clinical Outcomes in High-grade Serous Ovarian Carcinoma
Open the PDF for APOBEC3G Expression Correlates with T-Cell Infiltration and Improved Clinical Outcomes in High-grade Serous Ovarian Carcinoma in another window
Includes: Supplementary data
Journal Articles

Poly (ADP-Ribose) Polymerase Inhibitor Hypersensitivity in Aggressive Myeloproliferative Neoplasms

Available to Purchase
Keith W. Pratz, Brian D. Koh, Anand G. Patel, Karen S. Flatten, Weijie Poh, James G. Herman, Robert Dilley, Maria I. Harrell, B. Douglas Smith, Judith E. Karp, Elizabeth M. Swisher, Michael A. McDevitt, Scott H. Kaufmann
Journal: Clinical Cancer Research
Clin Cancer Res (2016) 22 (15): 3894–3902.
https://doi.org/10.1158/1078-0432.CCR-15-2351
Published: 31 July 2016
View articletitled, Poly (ADP-Ribose) Polymerase Inhibitor Hypersensitivity in Aggressive Myeloproliferative Neoplasms
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Includes: Supplementary data
Journal Articles

Abstract A41: Somatic mutations in human cancer cell lines predict sorafenib response

Free
Daniel R. Rhodes, Scott H. Kaufmann, Xue Wei Meng, Peter Wyngaard, Gary Daubresse, Judith S. Leopold
Journal: Clinical Cancer Research
Clin Cancer Res (2010) 16 (7_Supplement): A41.
https://doi.org/10.1158/1078-0432.TCME10-A41
Published: 02 February 2016
View articletitled, Abstract A41: Somatic mutations in human cancer cell lines predict sorafenib response
Journal Articles

Abstract B50: Antineoplastic activity of Top I inhibitor etirinotecan pegol (NKTR-102) and PARP inhibitor rucaparib (CO-388) in platinum-resistant high-grade serous BRCA WT ovarian cancer PDX models.

Free
Caroline C. Nitschmann, Rachel M. Hurley, Marc A. Becker, Xiaonan Hou, Ute Hoch, Thomas C. Harding, Deborah H. Charych, Scott H. Kaufmann, Paul Haluska, Saravut J. Weroha
Journal: Clinical Cancer Research
Clin Cancer Res (2016) 22 (2_Supplement): B50.
https://doi.org/10.1158/1557-3265.OVCA15-B50
Published: 15 January 2016
View articletitled, Abstract B50: Antineoplastic activity of Top I inhibitor etirinotecan pegol (NKTR-102) and PARP inhibitor rucaparib (CO-388) in platinum-resistant high-grade serous BRCA WT ovarian cancer PDX models.
Journal Articles

Abstract A07: Homologous recombination mutations and overall survival in high-grade serous, endometrioid, and clear cell ovarian carcinomas.

Free
Maria I. Harrell, Matthew J. Maurer, Ethan P. Heinzen, Ming K. Lee, Kimberly R. Kalli, Kathy J. Agnew, Ann L. Oberg, Tom Walsh, Barbara M. Norquist, Lynn C. Hartmann, Scott H. Kaufmann, Elizabeth M. Swisher
Journal: Clinical Cancer Research
Clin Cancer Res (2016) 22 (2_Supplement): A07.
https://doi.org/10.1158/1557-3265.OVCA15-A07
Published: 15 January 2016
View articletitled, Abstract A07: Homologous recombination mutations and overall survival in high-grade serous, endometrioid, and clear cell ovarian carcinomas.
Journal Articles

Abstract B71: Old age and chemotherapy contribute to the selection of PPM1D somatic mosaic mutations in ovarian cancer.

Free
Maria I. Harrell, Barbara M. Norquist, Tom Walsh, Mark F. Brady, Ming K. Lee, Robert Hershberg, Kimberly R. Kalli, Heather Lankes, Eric Q. Konnick, Colin C. Pritchard, Bradley J. Monk, John K. Chan, Robert Burger, Scott H. Kaufmann, Michael J. Birrer, Elizabeth M. Swisher
Journal: Clinical Cancer Research
Clin Cancer Res (2016) 22 (2_Supplement): B71.
https://doi.org/10.1158/1557-3265.OVCA15-B71
Published: 15 January 2016
View articletitled, Abstract B71: Old age and chemotherapy contribute to the selection of PPM1D somatic mosaic mutations in ovarian cancer.
Journal Articles

Tumorgrafts as In Vivo Surrogates for Women with Ovarian Cancer

Free
S. John Weroha, Marc A. Becker, Sergio Enderica-Gonzalez, Sean C. Harrington, Ann L. Oberg, Matthew J. Maurer, Sarah E. Perkins, Mariam AlHilli, Kristina A. Butler, Sarah McKinstry, Stephanie Fink, Robert B. Jenkins, Xiaonan Hou, Kimberly R. Kalli, Karin M. Goodman, Jann N. Sarkaria, Beth Y. Karlan, Amanika Kumar, Scott H. Kaufmann, Lynn C. Hartmann, Paul Haluska
Journal: Clinical Cancer Research
Series: Author Choice
Clin Cancer Res (2014) 20 (5): 1288–1297.
https://doi.org/10.1158/1078-0432.CCR-13-2611
Published: 02 March 2014
View articletitled, Tumorgrafts as In Vivo Surrogates for Women with Ovarian Cancer
Open the PDF for Tumorgrafts as In Vivo Surrogates for Women with Ovarian Cancer in another window
Includes: Supplementary data