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Samuel Singer
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Journal Articles

Developing Novel Genomic Risk Stratification Models in Soft Tissue and Uterine Leiomyosarcoma

Josephine K. Dermawan, Sarah Chiang, Samuel Singer, Bhumika Jadeja, Martee L. Hensley, William D. Tap, Sujana Movva, Robert G. Maki, Cristina R. Antonescu
Journal: Clinical Cancer Research
Clin Cancer Res (2024) 30 (10): 2260–2271.
https://doi.org/10.1158/1078-0432.CCR-24-0148
Published: 15 May 2024
View article titled, Developing Novel Genomic Risk Stratification Models in Soft Tissue and Uterine Leiomyosarcoma
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Includes: Supplementary data
Journal Articles

Therapy-Induced Senescence Contributes to the Efficacy of Abemaciclib in Patients with Dedifferentiated Liposarcoma

Caroline E. Gleason, Mark A. Dickson, Mary E. Klein (Dooley), Cristina R. Antonescu, Rodrigo Gularte-Mérida, Marimar Benitez, Juliana I. Delgado, Raghu P. Kataru, Mark Wei Yi Tan, Martina Bradic, Travis E. Adamson, Kenneth Seier, Allison L. Richards, Marta Palafox, Eric Chan, Sandra P. D'Angelo, Mrinal M. Gounder, Mary Louise Keohan, Ciara M. Kelly, Ping Chi, Sujana Movva, Jonathan Landa, Aimee M. Crago, Mark T.A. Donoghue, Li-Xuan Qin, Violetta Serra, Mesruh Turkekul, Afsar Barlas, Daniel M. Firester, Katia Manova-Todorova, Babak J. Mehrara, Marta Kovatcheva, Nguan Soon Tan, Samuel Singer, William D. Tap, Andrew Koff
Journal: Clinical Cancer Research
Clin Cancer Res (2024) 30 (4): 703–718.
https://doi.org/10.1158/1078-0432.CCR-23-2378
Published: 16 February 2024
View article titled, Therapy-Induced Senescence Contributes to the Efficacy of Abemaciclib in Patients with Dedifferentiated Liposarcoma
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Includes: Supplementary data
Journal Articles

PDGFRβ Signaling Cooperates with β-Catenin to Modulate c-Abl and Biologic Behavior of Desmoid-Type Fibromatosis

Jia Hu, Meera R. Hameed, Narasimhan P. Agaram, Karissa A. Whiting, Li-Xuan Qin, Anthony M. Villano, Rachael B. O'Connor, Julian M. Rozenberg, Sonia Cohen, Katherine Prendergast, Sara Kryeziu, Richard L. White, Jr, Mitchell C. Posner, Nicholas D. Socci, Mrinal M. Gounder, Samuel Singer, Aimee M. Crago
Journal: Clinical Cancer Research
Clin Cancer Res (2024) 30 (2): 450–461.
https://doi.org/10.1158/1078-0432.CCR-23-2313
Published: 17 January 2024
View article titled, PDGFRβ Signaling Cooperates with β-Catenin to Modulate c-Abl and Biologic Behavior of Desmoid-Type Fibromatosis
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Includes: Supplementary data
Journal Articles

Novel Genomic Risk Stratification Model for Primary Gastrointestinal Stromal Tumors (GIST) in the Adjuvant Therapy Era

Josephine K. Dermawan, Ciara Kelly, Zhidong Gao, Shaleigh Smith, Bhumika Jadeja, Samuel Singer, William D. Tap, Ping Chi, Cristina R. Antonescu
Journal: Clinical Cancer Research
Clin Cancer Res (2023) 29 (19): 3974–3985.
https://doi.org/10.1158/1078-0432.CCR-23-1184
Published: 02 October 2023
View article titled, Novel Genomic Risk Stratification Model for Primary Gastrointestinal Stromal Tumors (GIST) in the Adjuvant Therapy Era
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Includes: Supplementary data
Journal Articles

A Phase II Study of Epacadostat and Pembrolizumab in Patients with Advanced Sarcoma

Ciara M. Kelly, Li-Xuan Qin, Karissa A. Whiting, Allison L. Richards, Viswatej Avutu, Jason E. Chan, Ping Chi, Mark A. Dickson, Mrinal M. Gounder, Mary Louise Keohan, Sujana Movva, Benjamin A. Nacev, Evan Rosenbaum, Travis Adamson, Samuel Singer, Edmund K. Bartlett, Aimee M. Crago, Sam S. Yoon, Sinchun Hwang, Joseph P. Erinjeri, Cristina R. Antonescu, William D. Tap, Sandra P. D'Angelo
Journal: Clinical Cancer Research
Clin Cancer Res (2023) 29 (11): 2043–2051.
https://doi.org/10.1158/1078-0432.CCR-22-3911
Published: 01 June 2023
View article titled, A Phase II Study of Epacadostat and Pembrolizumab in Patients with Advanced Sarcoma
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Includes: Supplementary data
Journal Articles

Abstract PR012: Targeted sequencing of 2,138 bone and soft tissue sarcomas reveals commonly altered pathways, subtype-independent genetic clusters, and potential therapeutic targets

Benjamin A. Nacev, Francisco Sanchez-Vega, Shaleigh Smith, Cristina Antonescu, Evan Rosenbaum, Hongyu Shi, Cerise Tang, Nicholas Socci, Satshil Rana, Rodrigo Gularte-Merida, Ahmet Zehir, Mrinal Gounder, Timothy Bowler, Anisha Luthra, Bhumika Jadeja, Azusa Okada, Jonathan Strong, Jake Stoller, Jason Chan, Ping Chi, Sandra D'Angelo, Mark Dickson, Ciara Kelly, Mary Louise Keohan, Sujana Movva, Katherine Thornton, Paul Meyers, Leonard Wexler, Emily Slotkin, Julia Glade Bender, Neerav Shukla, Martee Hensley, John Healey, Michael La Quaglia, Kaled Alektiar, Aimee Crago, Sam Yoon, Brian Untch, Sarah Chiang, Narasimhan Agaram, Meera Hameed, Michael Berger, David Solit, Nikolaus Schultz, Marc Ladanyi, Samuel Singer, William Tap
Journal: Clinical Cancer Research
Clin Cancer Res (2022) 28 (18_Supplement): PR012.
https://doi.org/10.1158/1557-3265.SARCOMAS22-PR012
Published: 15 September 2022
View article titled, Abstract PR012: Targeted sequencing of 2,138 bone and soft tissue sarcomas reveals commonly altered pathways, subtype-independent genetic clusters, and potential therapeutic targets
Journal Articles

Abstract A028: Growth factor signaling and kinase inhibitors regulate oncogenesis in desmoid fibromatosis by modulating activity of the beta-catenin transcription target ABL1

Jia Hu, Anthony Villano, Rachael O'Connor, Yuliy Rozenberg, Alankrta Venkatesh, Mrinal Gounder, Nicholas Socci, Samuel Singer, Meera Hameed, Aimee M. Crago
Journal: Clinical Cancer Research
Clin Cancer Res (2022) 28 (18_Supplement): A028.
https://doi.org/10.1158/1557-3265.SARCOMAS22-A028
Published: 15 September 2022
View article titled, Abstract A028: Growth factor signaling and kinase inhibitors regulate oncogenesis in desmoid fibromatosis by modulating activity of the beta-catenin transcription target ABL1
Journal Articles

Phase Ib Trial of the Combination of Imatinib and Binimetinib in Patients with Advanced Gastrointestinal Stromal Tumors

Ping Chi, Li-Xuan Qin, Niedzica Camacho, Ciara M. Kelly, Sandra P. D'Angelo, Mark A. Dickson, Mrinal M. Gounder, Mary L. Keohan, Sujana Movva, Benjamin A. Nacev, Evan Rosenbaum, Katherine A. Thornton, Aimee M. Crago, Jasmine H. Francis, Moriah Martindale, Haley T. Phelan, Matthew D. Biniakewitz, Cindy J. Lee, Samuel Singer, Sinchun Hwang, Michael F. Berger, Yu Chen, Cristina R. Antonescu, William D. Tap
Journal: Clinical Cancer Research
Clin Cancer Res (2022) 28 (8): 1507–1517.
https://doi.org/10.1158/1078-0432.CCR-21-3909
Published: 14 April 2022
View article titled, Phase Ib Trial of the Combination of Imatinib and Binimetinib in Patients with Advanced Gastrointestinal Stromal Tumors
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Includes: Supplementary data
Journal Articles

Long-term Follow-up and Patterns of Response, Progression, and Hyperprogression in Patients after PD-1 Blockade in Advanced Sarcoma

Nicholas D. Klemen, Sinchun Hwang, Martina Bradic, Evan Rosenbaum, Mark A. Dickson, Mrinal M. Gounder, Ciara M. Kelly, Mary L. Keohan, Sujana Movva, Katherine A. Thornton, Ping Chi, Benjamin A. Nacev, Jason E. Chan, Edmund K. Bartlett, Allison L. Richards, Samuel Singer, Mark T.A. Donoghue, William D. Tap, Sandra P. D'Angelo
Journal: Clinical Cancer Research
Clin Cancer Res (2022) 28 (5): 939–947.
https://doi.org/10.1158/1078-0432.CCR-21-3445
Published: 01 March 2022
View article titled, Long-term Follow-up and Patterns of Response, Progression, and Hyperprogression in Patients after PD-1 Blockade in Advanced Sarcoma
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Includes: Supplementary data
Journal Articles

A High-Content Screen for C/EBPα Expression Identifies Novel Therapeutic Agents in Dedifferentiated Liposarcoma

Christina V. Angeles, Ana Velez, Jordan Rios, Bernadette Laxa, David Shum, Penelope D. Ruiz, Yawei Shen, Irina Ostrovnaya, Rodrigo Gularte-Mérida, Benjamin A. Nacev, Mark A. Dickson, Hakim Djaballah, Tomoyo Okada, Samuel Singer
Journal: Clinical Cancer Research
Clin Cancer Res (2022) 28 (1): 175–186.
https://doi.org/10.1158/1078-0432.CCR-19-2486
Published: 05 January 2022
View article titled, A High-Content Screen for C/EBPα Expression Identifies Novel Therapeutic Agents in Dedifferentiated Liposarcoma
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Includes: Supplementary data
Journal Articles

Abstract IA18: Integrin-α10 drives metastasis and sarcomagenesis in mxyofibrosarcoma and undifferentiated pleomorphic sarcoma

Samuel Singer
Journal: Clinical Cancer Research
Clin Cancer Res (2018) 24 (2_Supplement): IA18.
https://doi.org/10.1158/1557-3265.SARCOMAS17-IA18
Published: 15 January 2018
View article titled, Abstract IA18: Integrin-α10 drives metastasis and sarcomagenesis in mxyofibrosarcoma and undifferentiated pleomorphic sarcoma
Journal Articles

Abstract B11: An empirical evaluation of array normalization for Agilent microRNA expression arrays

Li-Xuan Qin, Jaya Satagopan, Samuel Singer
Journal: Clinical Cancer Research
Clin Cancer Res (2010) 16 (14_Supplement): B11.
https://doi.org/10.1158/1078-0432.TCMUSA10-B11
Published: 02 February 2016
View article titled, Abstract B11: An empirical evaluation of array normalization for Agilent microRNA expression arrays
Journal Articles

The Cyclin-Dependent Kinase Inhibitor Flavopiridol Potentiates Doxorubicin Efficacy in Advanced Sarcomas: Preclinical Investigations and Results of a Phase I Dose-Escalation Clinical Trial

Jason J. Luke, David R. D'Adamo, Mark A. Dickson, Mary Louise Keohan, Richard D. Carvajal, Robert G. Maki, Elisa de Stanchina, Elgilda Musi, Samuel Singer, Gary K. Schwartz
Journal: Clinical Cancer Research
Clin Cancer Res (2012) 18 (9): 2638–2647.
https://doi.org/10.1158/1078-0432.CCR-11-3203
Published: 30 April 2012
View article titled, The Cyclin-Dependent Kinase Inhibitor Flavopiridol Potentiates Doxorubicin Efficacy in Advanced Sarcomas: Preclinical Investigations and Results of a Phase I Dose-Escalation Clinical Trial
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Includes: Supplementary data
Journal Articles

Copy Number Losses Define Subgroups of Dedifferentiated Liposarcoma with Poor Prognosis and Genomic Instability

Aimee M. Crago, Nicholas D. Socci, Penelope DeCarolis, Rachael O'Connor, Barry S. Taylor, Li-Xuan Qin, Cristina R. Antonescu, Samuel Singer
Journal: Clinical Cancer Research
Clin Cancer Res (2012) 18 (5): 1334–1340.
https://doi.org/10.1158/1078-0432.CCR-11-2820
Published: 01 March 2012
View article titled, Copy Number Losses Define Subgroups of Dedifferentiated Liposarcoma with Poor Prognosis and Genomic Instability
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Includes: Supplementary data
Journal Articles

Activity of Sorafenib against Desmoid Tumor/Deep Fibromatosis

Mrinal M. Gounder, Robert A. Lefkowitz, Mary Louise Keohan, David R. D'Adamo, Meera Hameed, Cristina R. Antonescu, Samuel Singer, Katherine Stout, Linda Ahn, Robert G. Maki
Journal: Clinical Cancer Research
Clin Cancer Res (2011) 17 (12): 4082–4090.
https://doi.org/10.1158/1078-0432.CCR-10-3322
Published: 15 June 2011
View article titled, Activity of Sorafenib against Desmoid Tumor/Deep Fibromatosis
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Journal Articles

Mechanisms of Sunitinib Resistance in Gastrointestinal Stromal Tumors Harboring KITAY502-3ins Mutation: An In vitro Mutagenesis Screen for Drug Resistance

Tianhua Guo, Mihai Hajdu, Narasimhan P. Agaram, Hiroko Shinoda, Darren Veach, Bayard D. Clarkson, Robert G. Maki, Samuel Singer, Ronald P. DeMatteo, Peter Besmer, Cristina R. Antonescu
Journal: Clinical Cancer Research
Clin Cancer Res (2009) 15 (22): 6862–6870.
https://doi.org/10.1158/1078-0432.CCR-09-1315
Published: 11 November 2009
View article titled, Mechanisms of Sunitinib Resistance in Gastrointestinal Stromal Tumors Harboring <em>KIT</em><sup>AY502-3ins</sup> Mutation: An <em>In vitro</em> Mutagenesis Screen for Drug Resistance
Open the PDF for Mechanisms of Sunitinib Resistance in Gastrointestinal Stromal Tumors Harboring <em>KIT</em><sup>AY502-3ins</sup> Mutation: An <em>In vitro</em> Mutagenesis Screen for Drug Resistance in another window
Journal Articles

A Synovial Sarcoma-Specific Preoperative Nomogram Supports a Survival Benefit to Ifosfamide-Based Chemotherapy and Improves Risk Stratification for Patients

Robert J. Canter, Li-Xuan Qin, Robert G. Maki, Murray F. Brennan, Marc Ladanyi, Samuel Singer
Journal: Clinical Cancer Research
Clin Cancer Res (2008) 14 (24): 8191–8197.
https://doi.org/10.1158/1078-0432.CCR-08-0843
Published: 15 December 2008
View article titled, A Synovial Sarcoma-Specific Preoperative Nomogram Supports a Survival Benefit to Ifosfamide-Based Chemotherapy and Improves Risk Stratification for Patients
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Journal Articles

Sorafenib Inhibits the Imatinib-Resistant KITT670I Gatekeeper Mutation in Gastrointestinal Stromal Tumor

Tianhua Guo, Narasimhan P. Agaram, Grace C. Wong, Glory Hom, David D'Adamo, Robert G. Maki, Gary K. Schwartz, Darren Veach, Bayard D. Clarkson, Samuel Singer, Ronald P. DeMatteo, Peter Besmer, Cristina R. Antonescu
Journal: Clinical Cancer Research
Clin Cancer Res (2007) 13 (16): 4874–4881.
https://doi.org/10.1158/1078-0432.CCR-07-0484
Published: 15 August 2007
View article titled, Sorafenib Inhibits the Imatinib-Resistant <em>KIT</em><sup><em>T670I</em></sup> Gatekeeper Mutation in Gastrointestinal Stromal Tumor
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Journal Articles

Pathologic and Molecular Heterogeneity in Imatinib-Stable or Imatinib-Responsive Gastrointestinal Stromal Tumors

Narasimhan P. Agaram, Peter Besmer, Grace C. Wong, Tianhua Guo, Nicholas D. Socci, Robert G. Maki, Diann DeSantis, Murray F. Brennan, Samuel Singer, Ronald P. DeMatteo, Cristina R. Antonescu
Journal: Clinical Cancer Research
Clin Cancer Res (2007) 13 (1): 170–181.
https://doi.org/10.1158/1078-0432.CCR-06-1508
Published: 02 January 2007
View article titled, Pathologic and Molecular Heterogeneity in Imatinib-Stable or Imatinib-Responsive Gastrointestinal Stromal Tumors
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Journal Articles

Acquired Resistance to Imatinib in Gastrointestinal Stromal Tumor Occurs Through Secondary Gene Mutation

Cristina R. Antonescu, Peter Besmer, Tianhua Guo, Knarik Arkun, Glory Hom, Beata Koryotowski, Margaret A. Leversha, Philip D. Jeffrey, Diann Desantis, Samuel Singer, Murray F. Brennan, Robert G. Maki, Ronald P. DeMatteo
Journal: Clinical Cancer Research
Clin Cancer Res (2005) 11 (11): 4182–4190.
https://doi.org/10.1158/1078-0432.CCR-04-2245
Published: 01 June 2005
View article titled, Acquired Resistance to Imatinib in Gastrointestinal Stromal Tumor Occurs Through Secondary Gene Mutation
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