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Samuel Leung
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Journal Articles

Targeted and Shallow Whole-Genome Sequencing Identifies Therapeutic Opportunities in p53abn Endometrial Cancers

Amy Jamieson, Juliana Sobral de Barros, Dawn R. Cochrane, J. Maxwell Douglas, Sameer Shankar, Branden J. Lynch, Samuel Leung, Spencer Martin, Janine Senz, Amy Lum, Yvette Drew, C. Blake Gilks, David G. Huntsman, Jessica N. McAlpine
Journal: Clinical Cancer Research
Clin Cancer Res (2024) 30 (11): 2461–2474.
https://doi.org/10.1158/1078-0432.CCR-23-3689
Published: 03 June 2024
View article titled, Targeted and Shallow Whole-Genome Sequencing Identifies Therapeutic Opportunities in p53abn Endometrial Cancers
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Includes: Supplementary data
Journal Articles

Abstract PR002: Proteomic profiling of endometrial carcinomas

Dawn R. Cochrane, Gian Luca Negri, Jutta Huvila, Juliana Sobral de Barros, Forouh Kalantari, Nissreen Mohammad, David Farnell, Emily Thompson, Amy Lum, Sandra E. Spencer, Amy Jamieson, Samuel Leung, Derek Chiu, Martin Koebel, Stefan Kommoss, Friedrich Kommoss, Blake Gilks, Lien Hoang, David Huntsman, Gregg B. Morin, Jessica N. McAlpine
Journal: Clinical Cancer Research
Clin Cancer Res (2024) 30 (5_Supplement): PR002.
https://doi.org/10.1158/1557-3265.ENDO24-PR002
Published: 01 March 2024
View article titled, Abstract PR002: Proteomic profiling of endometrial carcinomas
Journal Articles

Abstract B012: Application of shallow whole genome sequencing to identify therapeutic opportunities in p53abn endometrial cancers

Amy Jamieson, Juliana Sobral de Barros, Dawn R. Cochrane, Maxwell Douglas, Sameer Shankar, Samuel Leung, Branden Lynch, Janine Senz, Blake Gilks, David G. Huntsman, Jessica N. McAlpine
Journal: Clinical Cancer Research
Clin Cancer Res (2024) 30 (5_Supplement): B012.
https://doi.org/10.1158/1557-3265.ENDO24-B012
Published: 01 March 2024
View article titled, Abstract B012: Application of shallow whole genome sequencing to identify therapeutic opportunities in p53abn endometrial cancers
Journal Articles

Abstract B031: High risk no specific molecular profile (HR-NSMP) endometrial cancer can be stratified into three subgroups based on tumor grade and estrogen receptor status with differing clinicopathologic characteristics and outcomes

Andrea Neilson, Amy Jamieson, Derek Chiu, Samuel Leung, Amy Lum, Jennifer Pors, Stefan Kommoss, Aline Talhouk, David G. Huntsman, Naveena Singh, C. Blake Gilks, Jessica N. McAlpine
Journal: Clinical Cancer Research
Clin Cancer Res (2024) 30 (5_Supplement): B031.
https://doi.org/10.1158/1557-3265.ENDO24-B031
Published: 01 March 2024
View article titled, Abstract B031: High risk no specific molecular profile (HR-NSMP) endometrial cancer can be stratified into three subgroups based on tumor grade and estrogen receptor status with differing clinicopathologic characteristics and outcomes
Journal Articles

Abstract B026: Substratification of mismatch repair deficient (MMRd) endometrial cancers can provide prognostic and predictive refinement

Amy Jamieson, Jennifer Pors, Samuel Leung, Derek Chiu, Stefan Kommoss, Aline Talhouk, David G. Huntsman, Naveena Singh, Blake Gilks, Jessica N. McAlpine
Journal: Clinical Cancer Research
Clin Cancer Res (2024) 30 (5_Supplement): B026.
https://doi.org/10.1158/1557-3265.ENDO24-B026
Published: 01 March 2024
View article titled, Abstract B026: Substratification of mismatch repair deficient (MMRd) endometrial cancers can provide prognostic and predictive refinement
Journal Articles

Triple-Negative PAM50 Non-Basal Breast Cancer Subtype Predicts Benefit from Extended Adjuvant Capecitabine

Karama Asleh, Ana Lluch, Angela Goytain, Carlos Barrios, Xue Q. Wang, Laura Torrecillas, Dongxia Gao, Manuel Ruiz-Borrego, Samuel Leung, José Bines, Ángel Guerrero-Zotano, Jose Ángel García-Sáenz, Juan Miguel Cejalvo, Jesus Herranz, Roberto Torres, Juan de la Haba-Rodriguez, Francisco Ayala, Henry Gómez, Federico Rojo, Torsten O. Nielsen, Miguel Martin
Journal: Clinical Cancer Research
Clin Cancer Res (2023) 29 (2): 389–400.
https://doi.org/10.1158/1078-0432.CCR-22-2191
Published: 17 January 2023
View article titled, Triple-Negative PAM50 Non-Basal Breast Cancer Subtype Predicts Benefit from Extended Adjuvant Capecitabine
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Includes: Supplementary data
Journal Articles

Abstract PR002: Global proteomic profiling of endometrial carcinomas identify prognostic markers

Dawn R. Cochrane, Gian Negri, Jutta Huvila, David A. Farnell, Emily Thompson, Winnie Yang, Genny Trigo-Gonzales, Amy Lum, Sandra Spencer, Ryan Riley, Samuel Leung, Christine Chow, Jamie Lim, Martin Koebel, Stefan Kommoss, Friedrich Kommoss, Lien Hoang, David G. Huntsman, Gregg Morin, Jessica N. McAlpine
Journal: Clinical Cancer Research
Clin Cancer Res (2021) 27 (3_Supplement): PR002.
https://doi.org/10.1158/1557-3265.ENDOMET20-PR002
Published: 01 February 2021
View article titled, Abstract PR002: Global proteomic profiling of endometrial carcinomas identify prognostic markers
Journal Articles

Endometrial Cancer Molecular Risk Stratification is Equally Prognostic for Endometrioid Ovarian Carcinoma

Pauline Krämer, Aline Talhouk, Mary Anne Brett, Derek S. Chiu, Evan S. Cairns, Daniëlla A. Scheunhage, Rory F.L. Hammond, David Farnell, Tayyebeh M. Nazeran, Marcel Grube, Zhouchunyang Xia, Janine Senz, Samuel Leung, Lukas Feil, Jana Pasternak, Katherine Dixon, Andreas Hartkopf, Bernhard Krämer, Sara Brucker, Florian Heitz, Andreas du Bois, Philipp Harter, Felix K.F. Kommoss, Hans-Peter Sinn, Sabine Heublein, Friedrich Kommoss, Hans-Walter Vollert, Ranjit Manchanda, Cornelis D. de Kroon, Hans W. Nijman, Marco de Bruyn, Emily F. Thompson, Ali Bashashati, Jessica N. McAlpine, Naveena Singh, Anna V. Tinker, Annette Staebler, Tjalling Bosse, Stefan Kommoss, Martin Köbel, Michael S. Anglesio
Journal: Clinical Cancer Research
Clin Cancer Res (2020) 26 (20): 5400–5410.
https://doi.org/10.1158/1078-0432.CCR-20-1268
Published: 15 October 2020
View article titled, Endometrial Cancer Molecular Risk Stratification is Equally Prognostic for Endometrioid Ovarian Carcinoma
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Includes: Supplementary data
Journal Articles

Arginine Depletion Therapy with ADI-PEG20 Limits Tumor Growth in Argininosuccinate Synthase–Deficient Ovarian Cancer, Including Small-Cell Carcinoma of the Ovary, Hypercalcemic Type

Jennifer X. Ji, Dawn R. Cochrane, Basile Tessier-Cloutier, Shary Yutin Chen, Germain Ho, Khyatiben V. Pathak, Isabel N. Alcazar, David Farnell, Samuel Leung, Angela Cheng, Christine Chow, Shane Colborne, Gian Luca Negri, Friedrich Kommoss, Anthony Karnezis, Gregg B. Morin, Jessica N. McAlpine, C. Blake Gilks, Bernard E. Weissman, Jeffrey M. Trent, Lynn Hoang, Patrick Pirrotte, Yemin Wang, David G. Huntsman
Journal: Clinical Cancer Research
Clin Cancer Res (2020) 26 (16): 4402–4413.
https://doi.org/10.1158/1078-0432.CCR-19-1905
Published: 14 August 2020
View article titled, Arginine Depletion Therapy with ADI-PEG20 Limits Tumor Growth in Argininosuccinate Synthase–Deficient Ovarian Cancer, Including Small-Cell Carcinoma of the Ovary, Hypercalcemic Type
Open the PDF for Arginine Depletion Therapy with ADI-PEG20 Limits Tumor Growth in Argininosuccinate Synthase–Deficient Ovarian Cancer, Including Small-Cell Carcinoma of the Ovary, Hypercalcemic Type in another window
Includes: Supplementary data
Journal Articles

Abstract B09: Single-cell RNA sequencing of normal endometrial organoids uncovers novel cell-type markers for prognostication of primary tumor samples

Dawn R. Cochrane, Kieran R. Campbell, Kendall Greening, Germain C. Ho, James Hopkins, Minh Bui, Vassilena Sharlandjieva, Daniel Lai, Maya DeGrood, Evan W. Gibbard, Samuel Leung, Angela S. Cheng, Jamie L.P. Lim, Samantha Neilson, David Farnell, Friedrich Kommoss, Jessica N. McAlpine, Sohrab P. Shah, David G. Huntsman
Journal: Clinical Cancer Research
Clin Cancer Res (2020) 26 (13_Supplement): B09.
https://doi.org/10.1158/1557-3265.OVCA19-B09
Published: 01 July 2020
View article titled, Abstract B09: Single-cell RNA sequencing of normal endometrial organoids uncovers novel cell-type markers for prognostication of primary tumor samples
Journal Articles

Molecular Subtype Not Immune Response Drives Outcomes in Endometrial Carcinoma

Aline Talhouk, Heather Derocher, Pascal Schmidt, Samuel Leung, Katy Milne, C. Blake Gilks, Michael S. Anglesio, Brad H. Nelson, Jessica N. McAlpine
Journal: Clinical Cancer Research
Clin Cancer Res (2019) 25 (8): 2537–2548.
https://doi.org/10.1158/1078-0432.CCR-18-3241
Published: 15 April 2019
View article titled, Molecular Subtype Not Immune Response Drives Outcomes in Endometrial Carcinoma
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Includes: Supplementary data
Journal Articles

The Magnitude of Androgen Receptor Positivity in Breast Cancer Is Critical for Reliable Prediction of Disease Outcome

Carmela Ricciardelli, Tina Bianco-Miotto, Shalini Jindal, Lisa M. Butler, Samuel Leung, Catriona M. McNeil, Sandra A. O'Toole, Esmaeil Ebrahimie, Ewan K.A. Millar, Andrew J. Sakko, Alexandra I. Ruiz, Sarah L. Vowler, David G. Huntsman, Stephen N. Birrell, Robert L. Sutherland, Carlo Palmieri, Theresa E. Hickey, Wayne D. Tilley
Journal: Clinical Cancer Research
Series: Author Choice
Clin Cancer Res (2018) 24 (10): 2328–2341.
https://doi.org/10.1158/1078-0432.CCR-17-1199
Published: 14 May 2018
View article titled, The Magnitude of Androgen Receptor Positivity in Breast Cancer Is Critical for Reliable Prediction of Disease Outcome
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Includes: Supplementary data
Journal Articles

Endometrial Carcinomas with POLE Exonuclease Domain Mutations Have a Favorable Prognosis

Melissa K. McConechy, Aline Talhouk, Samuel Leung, Derek Chiu, Winnie Yang, Janine Senz, Linda J. Reha-Krantz, Cheng-Han Lee, David G. Huntsman, C. Blake Gilks, Jessica N. McAlpine
Journal: Clinical Cancer Research
Clin Cancer Res (2016) 22 (12): 2865–2873.
https://doi.org/10.1158/1078-0432.CCR-15-2233
Published: 14 June 2016
View article titled, Endometrial Carcinomas with <em>POLE</em> Exonuclease Domain Mutations Have a Favorable Prognosis
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Includes: Supplementary data
Journal Articles

Preclinical Efficacy and Safety Assessment of an Antibody–Drug Conjugate Targeting the c-RET Proto-Oncogene for Breast Carcinoma

Minh Nguyen, Shuichi Miyakawa, Junichi Kato, Toshiyuki Mori, Toshimitsu Arai, Mark Armanini, Karen Gelmon, Rinat Yerushalmi, Samuel Leung, Dongxia Gao, Gregory Landes, Mary Haak-Frendscho, Kathleen Elias, Andrew D. Simmons
Journal: Clinical Cancer Research
Clin Cancer Res (2015) 21 (24): 5552–5562.
https://doi.org/10.1158/1078-0432.CCR-15-0468
Published: 14 December 2015
View article titled, Preclinical Efficacy and Safety Assessment of an Antibody–Drug Conjugate Targeting the c-RET Proto-Oncogene for Breast Carcinoma
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Includes: Supplementary data
Journal Articles

Abstract A17: FBxW7 duality in ovarian cancer: Novel insight into ovarian cancer pathogenesis

Elizabeth Louise Dickson, Lihua Li, Samuel Leung, Christine Chow, Rachel Isaksson Vogel, David Huntsman, C. Blake Gilks, Subbaya Subramanian
Journal: Clinical Cancer Research
Clin Cancer Res (2013) 19 (19_Supplement): A17.
https://doi.org/10.1158/1078-0432.OVCA13-A17
Published: 13 May 2014
View article titled, Abstract A17: FBxW7 duality in ovarian cancer: Novel insight into ovarian cancer pathogenesis
Journal Articles

A 50-Gene Intrinsic Subtype Classifier for Prognosis and Prediction of Benefit from Adjuvant Tamoxifen

Stephen K. Chia, Vivien H. Bramwell, Dongsheng Tu, Lois E. Shepherd, Shan Jiang, Tammi Vickery, Elaine Mardis, Samuel Leung, Karen Ung, Kathleen I. Pritchard, Joel S. Parker, Philip S. Bernard, Charles M. Perou, Matthew J. Ellis, Torsten O. Nielsen
Journal: Clinical Cancer Research
Clin Cancer Res (2012) 18 (16): 4465–4472.
https://doi.org/10.1158/1078-0432.CCR-12-0286
Published: 14 August 2012
View article titled, A 50-Gene Intrinsic Subtype Classifier for Prognosis and Prediction of Benefit from Adjuvant Tamoxifen
Open the PDF for A 50-Gene Intrinsic Subtype Classifier for Prognosis and Prediction of Benefit from Adjuvant Tamoxifen in another window
Includes: Supplementary data
Journal Articles

Responsiveness of Intrinsic Subtypes to Adjuvant Anthracycline Substitution in the NCIC.CTG MA.5 Randomized Trial

Maggie C.U. Cheang, K. David Voduc, Dongsheng Tu, Shan Jiang, Samuel Leung, Stephen K. Chia, Lois E. Shepherd, Mark N. Levine, Kathleen I. Pritchard, Sherri Davies, Inge J. Stijleman, Carole Davis, Mark T.W. Ebbert, Joel S. Parker, Matthew J. Ellis, Philip S. Bernard, Charles M. Perou, Torsten O. Nielsen
Journal: Clinical Cancer Research
Clin Cancer Res (2012) 18 (8): 2402–2412.
https://doi.org/10.1158/1078-0432.CCR-11-2956
Published: 16 April 2012
View article titled, Responsiveness of Intrinsic Subtypes to Adjuvant Anthracycline Substitution in the NCIC.CTG MA.5 Randomized Trial
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Includes: Supplementary data
Journal Articles

A Comparison of PAM50 Intrinsic Subtyping with Immunohistochemistry and Clinical Prognostic Factors in Tamoxifen-Treated Estrogen Receptor–Positive Breast Cancer

Torsten O. Nielsen, Joel S. Parker, Samuel Leung, David Voduc, Mark Ebbert, Tammi Vickery, Sherri R. Davies, Jacqueline Snider, Inge J. Stijleman, Jerry Reed, Maggie C.U. Cheang, Elaine R. Mardis, Charles M. Perou, Philip S. Bernard, Matthew J. Ellis
Journal: Clinical Cancer Research
Clin Cancer Res (2010) 16 (21): 5222–5232.
https://doi.org/10.1158/1078-0432.CCR-10-1282
Published: 31 October 2010
View article titled, A Comparison of PAM50 Intrinsic Subtyping with Immunohistochemistry and Clinical Prognostic Factors in Tamoxifen-Treated Estrogen Receptor–Positive Breast Cancer
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Includes: Supplementary data
Journal Articles

Basal-Like Breast Cancer Defined by Five Biomarkers Has Superior Prognostic Value than Triple-Negative Phenotype

Maggie C.U. Cheang, David Voduc, Chris Bajdik, Samuel Leung, Steven McKinney, Stephen K. Chia, Charles M. Perou, Torsten O. Nielsen
Journal: Clinical Cancer Research
Clin Cancer Res (2008) 14 (5): 1368–1376.
https://doi.org/10.1158/1078-0432.CCR-07-1658
Published: 03 March 2008
View article titled, Basal-Like Breast Cancer Defined by Five Biomarkers Has Superior Prognostic Value than Triple-Negative Phenotype
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