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Sami N. Malek
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Journal Articles

Follicular Lymphoma–associated BTK Mutations are Inactivating Resulting in Augmented AKT Activation

Nan Hu, Fangyang Wang, Tianyu Sun, Zhengfan Xu, Jing Zhang, Denzil Bernard, Shilin Xu, Shaomeng Wang, Mark Kaminski, Suma Devata, Tycel Phillips, Sami N. Malek
Journal: Clinical Cancer Research
Clin Cancer Res (2021) 27 (8): 2301–2313.
https://doi.org/10.1158/1078-0432.CCR-20-3741
Published: 15 April 2021
View article titled, Follicular Lymphoma–associated BTK Mutations are Inactivating Resulting in Augmented AKT Activation
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Includes: Supplementary data
Journal Articles

Abstract 10: Precision medicine strategy to elucidate and target Bcl-2 prosurvival proteins in a wide spectrum of cancers

Karson J. Kump, Matthew Lieberman, Rita A. Avelar, Charles Foucar, Malathi Kandarpa, Antonio Di Cristofano, Russell J. Ryan, Sami N. Malek, Ryan A. Wilcox, Dale L. Bixby, Tycel J. Phillips, Moshe Talpaz, Analisa DiFeo, Zaneta Nikolovska-Coleska
Journal: Clinical Cancer Research
Clin Cancer Res (2020) 26 (12_Supplement_1): 10.
https://doi.org/10.1158/1557-3265.ADVPRECMED20-10
Published: 15 June 2020
View article titled, Abstract 10: Precision medicine strategy to elucidate and target Bcl-2 prosurvival proteins in a wide spectrum of cancers
Journal Articles

Cell-Intrinsic Determinants of Ibrutinib-Induced Apoptosis in Chronic Lymphocytic Leukemia

Nisar A. Amin, Sriram Balasubramanian, Kamlai Saiya-Cork, Kerby Shedden, Nan Hu, Sami N. Malek
Journal: Clinical Cancer Research
Clin Cancer Res (2017) 23 (4): 1049–1059.
https://doi.org/10.1158/1078-0432.CCR-15-2921
Published: 14 February 2017
View article titled, Cell-Intrinsic Determinants of Ibrutinib-Induced Apoptosis in Chronic Lymphocytic Leukemia
Open the PDF for Cell-Intrinsic Determinants of Ibrutinib-Induced Apoptosis in Chronic Lymphocytic Leukemia in another window
Includes: Supplementary data
Journal Articles

Recurrent Mutations in the MTOR Regulator RRAGC in Follicular Lymphoma

Zhang Xiao Ying, Meiyan Jin, Luke F. Peterson, Denzil Bernard, Kamlai Saiya-Cork, Mehmet Yildiz, Shaomeng Wang, Mark S. Kaminski, Alfred E. Chang, Daniel J. Klionsky, Sami N. Malek
Journal: Clinical Cancer Research
Clin Cancer Res (2016) 22 (21): 5383–5393.
https://doi.org/10.1158/1078-0432.CCR-16-0609
Published: 31 October 2016
View article titled, Recurrent Mutations in the MTOR Regulator RRAGC in Follicular Lymphoma
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Includes: Supplementary data
Journal Articles

A Quantitative Analysis of Subclonal and Clonal Gene Mutations before and after Therapy in Chronic Lymphocytic Leukemia

Nisar A. Amin, Erlene Seymour, Kamlai Saiya-Cork, Brian Parkin, Kerby Shedden, Sami N. Malek
Journal: Clinical Cancer Research
Clin Cancer Res (2016) 22 (17): 4525–4535.
https://doi.org/10.1158/1078-0432.CCR-15-3103
Published: 31 August 2016
View article titled, A Quantitative Analysis of Subclonal and Clonal Gene Mutations before and after Therapy in Chronic Lymphocytic Leukemia
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Includes: Supplementary data
Journal Articles

Integrated Genomic Profiling, Therapy Response, and Survival in Adult Acute Myelogenous Leukemia

Brian Parkin, Peter Ouillette, Mehmet Yildiz, Kamlai Saiya-Cork, Kerby Shedden, Sami N. Malek
Journal: Clinical Cancer Research
Clin Cancer Res (2015) 21 (9): 2045–2056.
https://doi.org/10.1158/1078-0432.CCR-14-0921
Published: 30 April 2015
View article titled, Integrated Genomic Profiling, Therapy Response, and Survival in Adult Acute Myelogenous Leukemia
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Includes: Supplementary data
Journal Articles

Clonal Evolution, Genomic Drivers, and Effects of Therapy in Chronic Lymphocytic Leukemia

Peter Ouillette, Kamlai Saiya-Cork, Erlene Seymour, Cheng Li, Kerby Shedden, Sami N. Malek
Journal: Clinical Cancer Research
Clin Cancer Res (2013) 19 (11): 2893–2904.
https://doi.org/10.1158/1078-0432.CCR-13-0138
Published: 30 May 2013
View article titled, Clonal Evolution, Genomic Drivers, and Effects of Therapy in Chronic Lymphocytic Leukemia
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Includes: Supplementary data
Journal Articles

The Prognostic Significance of Various 13q14 Deletions in Chronic Lymphocytic Leukemia

Peter Ouillette, Roxane Collins, Sajid Shakhan, Jinghui Li, Cheng Li, Kerby Shedden, Sami N. Malek
Journal: Clinical Cancer Research
Clin Cancer Res (2011) 17 (21): 6778–6790.
https://doi.org/10.1158/1078-0432.CCR-11-0785
Published: 31 October 2011
View article titled, The Prognostic Significance of Various 13q14 Deletions in Chronic Lymphocytic Leukemia
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Includes: Supplementary data
Journal Articles

A Pathobiological Role of the Insulin Receptor in Chronic Lymphocytic Leukemia

Kamlai Saiya-Cork, Roxane Collins, Brian Parkin, Peter Ouillette, Erlene Kuizon, Lisa Kujawski, Harry Erba, Erica Campagnaro, Kerby Shedden, Mark Kaminski, Sami N. Malek
Journal: Clinical Cancer Research
Clin Cancer Res (2011) 17 (9): 2679–2692.
https://doi.org/10.1158/1078-0432.CCR-10-2058
Published: 01 May 2011
View article titled, A Pathobiological Role of the Insulin Receptor in Chronic Lymphocytic Leukemia
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Includes: Supplementary data
Journal Articles

NF1 Inactivation in Adult Acute Myelogenous Leukemia

Brian Parkin, Peter Ouillette, Yin Wang, Yan Liu, Whitney Wright, Diane Roulston, Anjali Purkayastha, Amanda Dressel, Judith Karp, Paula Bockenstedt, Ammar Al-Zoubi, Moshe Talpaz, Lisa Kujawski, Yang Liu, Kerby Shedden, Sajid Shakhan, Cheng Li, Harry Erba, Sami N. Malek
Journal: Clinical Cancer Research
Clin Cancer Res (2010) 16 (16): 4135–4147.
https://doi.org/10.1158/1078-0432.CCR-09-2639
Published: 11 August 2010
View article titled, NF1 Inactivation in Adult Acute Myelogenous Leukemia
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Includes: Supplementary data
Journal Articles

Aggressive Chronic Lymphocytic Leukemia with Elevated Genomic Complexity Is Associated with Multiple Gene Defects in the Response to DNA Double-Strand Breaks

Peter Ouillette, Samuel Fossum, Brian Parkin, Li Ding, Paula Bockenstedt, Ammar Al-Zoubi, Kerby Shedden, Sami N. Malek
Journal: Clinical Cancer Research
Clin Cancer Res (2010) 16 (3): 835–847.
https://doi.org/10.1158/1078-0432.CCR-09-2534
Published: 01 February 2010
View article titled, Aggressive Chronic Lymphocytic Leukemia with Elevated Genomic Complexity Is Associated with Multiple Gene Defects in the Response to DNA Double-Strand Breaks
Open the PDF for Aggressive Chronic Lymphocytic Leukemia with Elevated Genomic Complexity Is Associated with Multiple Gene Defects in the Response to DNA Double-Strand Breaks in another window
Includes: Supplementary data
Journal Articles

Comprehensive Analysis of Copy Number and Allele Status Identifies Multiple Chromosome Defects Underlying Follicular Lymphoma Pathogenesis

Charles W. Ross, Peter D. Ouillette, Chris M. Saddler, Kerby A. Shedden, Sami N. Malek
Journal: Clinical Cancer Research
Clin Cancer Res (2007) 13 (16): 4777–4785.
https://doi.org/10.1158/1078-0432.CCR-07-0456
Published: 15 August 2007
View article titled, Comprehensive Analysis of Copy Number and Allele Status Identifies Multiple Chromosome Defects Underlying Follicular Lymphoma Pathogenesis
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