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Salvatore Siena
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Journal Articles

Circulating Tumor DNA to Drive Treatment in Metastatic Colorectal Cancer

Giorgio Patelli, Gianluca Mauri, Federica Tosi, Alessio Amatu, Katia Bencardino, Erica Bonazzina, Elio Gregory Pizzutilo, Federica Villa, Gabriele Calvanese, Alberto Giuseppe Agostara, Stefano Stabile, Silvia Ghezzi, Giovanni Crisafulli, Federica Di Nicolantonio, Silvia Marsoni, Alberto Bardelli, Salvatore Siena, Andrea Sartore-Bianchi
Journal: Clinical Cancer Research
Clin Cancer Res (2023) 29 (22): 4530–4539.
https://doi.org/10.1158/1078-0432.CCR-23-0079
Published: 14 November 2023
View article titled, Circulating Tumor DNA to Drive Treatment in Metastatic Colorectal Cancer
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Journal Articles

Targeting the DNA Damage Response Pathways and Replication Stress in Colorectal Cancer

Erika Durinikova, Nicole M. Reilly, Kristi Buzo, Elisa Mariella, Rosaria Chilà, Annalisa Lorenzato, João M. L. Dias, Gaia Grasso, Federica Pisati, Simona Lamba, Giorgio Corti, Andrea Degasperi, Carlotta Cancelliere, Gianluca Mauri, Pietro Andrei, Michael Linnebacher, Silvia Marsoni, Salvatore Siena, Andrea Sartore-Bianchi, Serena Nik-Zainal, Federica Di Nicolantonio, Alberto Bardelli, Sabrina Arena
Journal: Clinical Cancer Research
Clin Cancer Res (2022) 28 (17): 3874–3889.
https://doi.org/10.1158/1078-0432.CCR-22-0875
Published: 01 September 2022
View article titled, Targeting the DNA Damage Response Pathways and Replication Stress in Colorectal Cancer
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Includes: Supplementary data
Journal Articles

Correction: Updated Integrated Analysis of the Efficacy and Safety of Entrectinib in Patients with NTRK Fusion–Positive Solid Tumors

George D. Demetri, Filippo De Braud, Alexander Drilon, Salvatore Siena, Manish R. Patel, Byoung Chul Cho, Stephen V. Liu, Myung-Ju Ahn, Chao-Hua Chiu, Jessica J. Lin, Koichi Goto, Jeeyun Lee, Lyudmila Bazhenova, Thomas John, Marwan Fakih, Sant P. Chawla, Rafal Dziadziuszko, Takashi Seto, Sebastian Heinzmann, Bethany Pitcher, David Chen, Timothy R. Wilson, Christian Rolfo
Journal: Clinical Cancer Research
Clin Cancer Res (2022) 28 (10): 2196.
https://doi.org/10.1158/1078-0432.CCR-22-1108
Published: 13 May 2022
View article titled, Correction: Updated Integrated Analysis of the Efficacy and Safety of Entrectinib in Patients with <em>NTRK</em> Fusion–Positive Solid Tumors
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Journal Articles

Updated Integrated Analysis of the Efficacy and Safety of Entrectinib in Patients With NTRK Fusion-Positive Solid Tumors

George D. Demetri, Filippo De Braud, Alexander Drilon, Salvatore Siena, Manish R. Patel, Byoung Chul Cho, Stephen V. Liu, Myung-Ju Ahn, Chao-Hua Chiu, Jessica J. Lin, Koichi Goto, Jeeyun Lee, Lyudmila Bazhenova, Thomas John, Marwan Fakih, Sant P. Chawla, Rafal Dziadziuszko, Takashi Seto, Sebastian Heinzmann, Bethany Pitcher, David Chen, Timothy R. Wilson, Christian Rolfo
Journal: Clinical Cancer Research
Clin Cancer Res (2022) 28 (7): 1302–1312.
https://doi.org/10.1158/1078-0432.CCR-21-3597
Published: 01 April 2022
View article titled, Updated Integrated Analysis of the Efficacy and Safety of Entrectinib in Patients With <em>NTRK</em> Fusion-Positive Solid Tumors
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Includes: Supplementary data
Journal Articles

Optimized EGFR Blockade Strategies in EGFR Addicted Gastroesophageal Adenocarcinomas

Simona Corso, Filippo Pietrantonio, Maria Apicella, Cristina Migliore, Daniela Conticelli, Annalisa Petrelli, Laura D'Errico, Stefania Durando, Daniel Moya-Rull, Sara E. Bellomo, Stefano Ughetto, Maurizio Degiuli, Rossella Reddavid, Uberto Fumagalli, Stefano De Pascale, Giovanni Sgroi, Emanuele Rausa, Gian Luca Baiocchi, Sarah Molfino, Giovanni De Manzoni, Maria Bencivenga, Salvatore Siena, Andrea Sartore-Bianchi, Federica Morano, Salvatore Corallo, Michele Prisciandaro, Maria Di Bartolomeo, Annunziata Gloghini, Silvia Marsoni, Antonino Sottile, Anna Sapino, Caterina Marchiò, Asa Dahle-Smith, Zosia Miedzybrodzka, Jessica Lee, Siraj M. Ali, Jeffrey S. Ross, Brian M. Alexander, Vincent A. Miller, Russell Petty, Alexa B. Schrock, Silvia Giordano
Journal: Clinical Cancer Research
Clin Cancer Res (2021) 27 (11): 3126–3140.
https://doi.org/10.1158/1078-0432.CCR-20-0121
Published: 01 June 2021
View article titled, Optimized EGFR Blockade Strategies in <em>EGFR</em> Addicted Gastroesophageal Adenocarcinomas
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Includes: Supplementary data
Journal Articles

A Phase Ib/II Study of the BRAF Inhibitor Encorafenib Plus the MEK Inhibitor Binimetinib in Patients with BRAFV600E/K-mutant Solid Tumors

Ryan J. Sullivan, Jeffrey Weber, Sapna Patel, Reinhard Dummer, Matteo S. Carlino, Daniel S.W. Tan, Celeste Lebbé, Salvatore Siena, Elena Elez, Lance Wollenberg, Michael D. Pickard, Victor Sandor, Paolo A. Ascierto
Journal: Clinical Cancer Research
Series: Author Choice
Clin Cancer Res (2020) 26 (19): 5102–5112.
https://doi.org/10.1158/1078-0432.CCR-19-3550
Published: 01 October 2020
View article titled, A Phase Ib/II Study of the BRAF Inhibitor Encorafenib Plus the MEK Inhibitor Binimetinib in Patients with <em>BRAF<sup>V600E/K</sup></em>-mutant Solid Tumors
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Includes: Supplementary data
Journal Articles

Abstract B11: Whole-exome sequencing analysis of urine transrenal tumor DNA in metastatic colorectal cancer patients

Giovanni Crisafulli, Benedetta Mussolin, Andrea Cassingena, Monica Montone, Alice Bartolini, Ludovic Barault, Antonio Martinetti, Federica Morano, Filippo Pietrantonio, Andrea Sartore-Bianchi, Salvatore Siena, Federica Di Nicolatonio, Silvia Marsoni, Alberto Bardelli, Giulia Siravegna
Journal: Clinical Cancer Research
Clin Cancer Res (2020) 26 (11_Supplement): B11.
https://doi.org/10.1158/1557-3265.LiqBiop20-B11
Published: 01 June 2020
View article titled, Abstract B11: Whole-exome sequencing analysis of urine transrenal tumor DNA in metastatic colorectal cancer patients
Journal Articles

BRAF-Mutant Transcriptional Subtypes Predict Outcome of Combined BRAF, MEK, and EGFR Blockade with Dabrafenib, Trametinib, and Panitumumab in Patients with Colorectal Cancer

Gary Middleton, Yiqun Yang, Catarina D. Campbell, Thierry André, Chloe E. Atreya, Jan H.M. Schellens, Takayuki Yoshino, Johanna C. Bendell, Antoine Hollebecque, Autumn J. McRee, Salvatore Siena, Michael S. Gordon, Josep Tabernero, Rona Yaeger, Peter J. O'Dwyer, Filip De Vos, Eric Van Cutsem, John M. Millholland, Jan C. Brase, Fatima Rangwala, Eduard Gasal, Ryan B. Corcoran
Journal: Clinical Cancer Research
Series: Author Choice
Clin Cancer Res (2020) 26 (11): 2466–2476.
https://doi.org/10.1158/1078-0432.CCR-19-3579
Published: 01 June 2020
View article titled, <em>BRAF</em>-Mutant Transcriptional Subtypes Predict Outcome of Combined BRAF, MEK, and EGFR Blockade with Dabrafenib, Trametinib, and Panitumumab in Patients with Colorectal Cancer
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Includes: Supplementary data
Journal Articles

A Subset of Colorectal Cancers with Cross-Sensitivity to Olaparib and Oxaliplatin

Sabrina Arena, Giorgio Corti, Erika Durinikova, Monica Montone, Nicole M. Reilly, Mariangela Russo, Annalisa Lorenzato, Pamela Arcella, Luca Lazzari, Giuseppe Rospo, Massimiliano Pagani, Carlotta Cancelliere, Carola Negrino, Claudio Isella, Alice Bartolini, Andrea Cassingena, Alessio Amatu, Gianluca Mauri, Andrea Sartore-Bianchi, Gloria Mittica, Enzo Medico, Silvia Marsoni, Michael Linnebacher, Sergio Abrignani, Salvatore Siena, Federica Di Nicolantonio, Alberto Bardelli
Journal: Clinical Cancer Research
Clin Cancer Res (2020) 26 (6): 1372–1384.
https://doi.org/10.1158/1078-0432.CCR-19-2409
Published: 13 March 2020
View article titled, A Subset of Colorectal Cancers with Cross-Sensitivity to Olaparib and Oxaliplatin
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Includes: Supplementary data
Journal Articles

Patient-Derived Xenografts and Matched Cell Lines Identify Pharmacogenomic Vulnerabilities in Colorectal Cancer

Luca Lazzari, Giorgio Corti, Gabriele Picco, Claudio Isella, Monica Montone, Pamela Arcella, Erika Durinikova, Eugenia R. Zanella, Luca Novara, Fabiane Barbosa, Andrea Cassingena, Carlotta Cancelliere, Enzo Medico, Andrea Sartore-Bianchi, Salvatore Siena, Mathew J. Garnett, Andrea Bertotti, Livio Trusolino, Federica Di Nicolantonio, Michael Linnebacher, Alberto Bardelli, Sabrina Arena
Journal: Clinical Cancer Research
Clin Cancer Res (2019) 25 (20): 6243–6259.
https://doi.org/10.1158/1078-0432.CCR-18-3440
Published: 15 October 2019
View article titled, Patient-Derived Xenografts and Matched Cell Lines Identify Pharmacogenomic Vulnerabilities in Colorectal Cancer
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Includes: Supplementary data
Journal Articles

Plasma HER2 (ERBB2) Copy Number Predicts Response to HER2-targeted Therapy in Metastatic Colorectal Cancer

Giulia Siravegna, Andrea Sartore-Bianchi, Rebecca J. Nagy, Kanwal Raghav, Justin I. Odegaard, Richard B. Lanman, Livio Trusolino, Silvia Marsoni, Salvatore Siena, Alberto Bardelli
Journal: Clinical Cancer Research
Clin Cancer Res (2019) 25 (10): 3046–3053.
https://doi.org/10.1158/1078-0432.CCR-18-3389
Published: 15 May 2019
View article titled, Plasma HER2 (<em>ERBB2</em>) Copy Number Predicts Response to HER2-targeted Therapy in Metastatic Colorectal Cancer
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Includes: Supplementary data
Journal Articles

A Multicenter Phase II Study of AMG 337 in Patients with MET-Amplified Gastric/Gastroesophageal Junction/Esophageal Adenocarcinoma and Other MET-Amplified Solid Tumors

Eric Van Cutsem, Boguslawa Karaszewska, Yoon-Koo Kang, Hyun Cheol Chung, Veena Shankaran, Salvatore Siena, Ning F. Go, Hui Yang, Marco Schupp, David Cunningham
Journal: Clinical Cancer Research
Clin Cancer Res (2019) 25 (8): 2414–2423.
https://doi.org/10.1158/1078-0432.CCR-18-1337
Published: 15 April 2019
View article titled, A Multicenter Phase II Study of AMG 337 in Patients with <em>MET</em>-Amplified Gastric/Gastroesophageal Junction/Esophageal Adenocarcinoma and Other <em>MET</em>-Amplified Solid Tumors
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Journal Articles

Mutation-Enrichment Next-Generation Sequencing for Quantitative Detection of KRAS Mutations in Urine Cell-Free DNA from Patients with Advanced Cancers

Takeo Fujii, Afsaneh Barzi, Andrea Sartore-Bianchi, Andrea Cassingena, Giulia Siravegna, Daniel D. Karp, Sarina A. Piha-Paul, Vivek Subbiah, Apostolia M. Tsimberidou, Helen J. Huang, Silvio Veronese, Federica Di Nicolantonio, Sandeep Pingle, Cecile Rose T. Vibat, Saege Hancock, David Berz, Vladislava O. Melnikova, Mark G. Erlander, Rajyalakshmi Luthra, E. Scott Kopetz, Funda Meric-Bernstam, Salvatore Siena, Heinz-Josef Lenz, Alberto Bardelli, Filip Janku
Journal: Clinical Cancer Research
Clin Cancer Res (2017) 23 (14): 3657–3666.
https://doi.org/10.1158/1078-0432.CCR-16-2592
Published: 13 July 2017
View article titled, Mutation-Enrichment Next-Generation Sequencing for Quantitative Detection of <em>KRAS</em> Mutations in Urine Cell-Free DNA from Patients with Advanced Cancers
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Includes: Supplementary data
Journal Articles

Promoter CpG Island Hypermethylation of the DNA Repair Enzyme MGMT Predicts Clinical Response to Dacarbazine in a Phase II Study for Metastatic Colorectal Cancer

Alessio Amatu, Andrea Sartore-Bianchi, Catia Moutinho, Alessandro Belotti, Katia Bencardino, Giuseppe Chirico, Andrea Cassingena, Francesca Rusconi, Anna Esposito, Michele Nichelatti, Manel Esteller, Salvatore Siena
Journal: Clinical Cancer Research
Clin Cancer Res (2013) 19 (8): 2265–2272.
https://doi.org/10.1158/1078-0432.CCR-12-3518
Published: 15 April 2013
View article titled, Promoter CpG Island Hypermethylation of the DNA Repair Enzyme MGMT Predicts Clinical Response to Dacarbazine in a Phase II Study for Metastatic Colorectal Cancer
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Includes: Supplementary data
Journal Articles

Massively Parallel Tumor Multigene Sequencing to Evaluate Response to Panitumumab in a Randomized Phase III Study of Metastatic Colorectal Cancer

Marc Peeters, Kelly S. Oliner, Alex Parker, Salvatore Siena, Eric Van Cutsem, Jing Huang, Yves Humblet, Jean-Luc Van Laethem, Thierry André, Jeffrey Wiezorek, David Reese, Scott D. Patterson
Journal: Clinical Cancer Research
Clin Cancer Res (2013) 19 (7): 1902–1912.
https://doi.org/10.1158/1078-0432.CCR-12-1913
Published: 02 April 2013
View article titled, Massively Parallel Tumor Multigene Sequencing to Evaluate Response to Panitumumab in a Randomized Phase III Study of Metastatic Colorectal Cancer
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Includes: Supplementary data
Journal Articles

Epidermal Growth Factor Receptor Expression and Activation in Nonseminomatous Germ Cell Tumors

Mauro Moroni, Silvio Veronese, Roberta Schiavo, Ornella Carminati, Boe S. Sorensen, Marcello Gambacorta, Salvatore Siena
Journal: Clinical Cancer Research
Clin Cancer Res (2001) 7 (9): 2770–2775.
Published: 01 September 2001
View article titled, Epidermal Growth Factor Receptor Expression and Activation in Nonseminomatous Germ Cell Tumors
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