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Journal Articles

SNP of Aromatase Predict Long-term Survival and Aromatase Inhibitor Toxicity in Patients with Early Breast Cancer: A Biomarker Analysis of the GIM4 and GIM5 Trials

Benedetta Conte, Luca Boni, Giancarlo Bisagni, Antonio Durando, Giovanni Sanna, Stefania Gori, Ornella Garrone, Stefano Tamberi, Sabino De Placido, Francesco Schettini, Antonio Pazzola, Riccardo Ponzone, Filippo Montemurro, Gianluigi Lunardi, Rosario Notaro, Maria De Angioletti, Anna Turletti, Mauro Mansutti, Fabio Puglisi, Antonio Frassoldati, Mauro Porpiglia, Alessandra Fabi, Daniele Generali, Giovanni Scognamiglio, Maura Rossi, Fara Brasó-Maristany, Aleix Prat, Barbara Cardinali, Patrizia Piccioli, Martina Serra, Sonia Lastraioli, Claudia Bighin, Francesca Poggio, Matteo Lambertini, Lucia Del Mastro
Journal: Clinical Cancer Research
Clin Cancer Res (2023) 29 (24): 5217–5226.
https://doi.org/10.1158/1078-0432.CCR-23-1568
Published: 15 December 2023
View article titled, SNP of Aromatase Predict Long-term Survival and Aromatase Inhibitor Toxicity in Patients with Early Breast Cancer: A Biomarker Analysis of the GIM4 and GIM5 Trials
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Includes: Supplementary data
Journal Articles

Pertuzumab, Trastuzumab, and an Aromatase Inhibitor for HER2-Positive and Hormone Receptor–Positive Metastatic or Locally Advanced Breast Cancer: PERTAIN Final Analysis

Grazia Arpino, Juan de la Haba Rodríguez, Jean-Marc Ferrero, Sabino De Placido, C. Kent Osborne, Dirk Klingbiel, Valentine Revelant, Christine Wohlfarth, Raf Poppe, Mothaffar F. Rimawi, for the PERTAIN Study Group
Journal: Clinical Cancer Research
Clin Cancer Res (2023) 29 (8): 1468–1476.
https://doi.org/10.1158/1078-0432.CCR-22-1092
Published: 14 April 2023
View article titled, Pertuzumab, Trastuzumab, and an Aromatase Inhibitor for HER2-Positive and Hormone Receptor–Positive Metastatic or Locally Advanced Breast Cancer: PERTAIN Final Analysis
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Includes: Supplementary data
Journal Articles

Sphingosine Kinase 1 Overexpression Contributes to Cetuximab Resistance in Human Colorectal Cancer Models

Roberta Rosa, Roberta Marciano, Umberto Malapelle, Luigi Formisano, Lucia Nappi, Claudia D'Amato, Valentina D'Amato, Vincenzo Damiano, Gabriella Marfè, Silvana Del Vecchio, Antonella Zannetti, Adelaide Greco, Alfonso De Stefano, Chiara Carlomagno, Bianca Maria Veneziani, Giancarlo Troncone, Sabino De Placido, Roberto Bianco
Journal: Clinical Cancer Research
Clin Cancer Res (2013) 19 (1): 138–147.
https://doi.org/10.1158/1078-0432.CCR-12-1050
Published: 02 January 2013
View article titled, Sphingosine Kinase 1 Overexpression Contributes to Cetuximab Resistance in Human Colorectal Cancer Models
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Includes: Supplementary data
Journal Articles

Novel Toll-Like Receptor 9 Agonist Induces Epidermal Growth Factor Receptor (EGFR) Inhibition and Synergistic Antitumor Activity with EGFR Inhibitors

Vincenzo Damiano, Rosa Caputo, Roberto Bianco, Francesco P. D'Armiento, Antonio Leonardi, Sabino De Placido, A. Raffaele Bianco, Sudhir Agrawal, Fortunato Ciardiello, Giampaolo Tortora
Journal: Clinical Cancer Research
Clin Cancer Res (2006) 12 (2): 577–583.
https://doi.org/10.1158/1078-0432.CCR-05-1943
Published: 20 January 2006
View article titled, Novel Toll-Like Receptor 9 Agonist Induces Epidermal Growth Factor Receptor (EGFR) Inhibition and Synergistic Antitumor Activity with EGFR Inhibitors
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Journal Articles

Cooperative Antitumor Effect of Multitargeted Kinase Inhibitor ZD6474 and Ionizing Radiation in Glioblastoma

Vincenzo Damiano, Davide Melisi, Cataldo Bianco, David Raben, Rosa Caputo, Gabriella Fontanini, Roberto Bianco, Anderson Ryan, A. Raffaele Bianco, Sabino De Placido, Fortunato Ciardiello, Giampaolo Tortora
Journal: Clinical Cancer Research
Clin Cancer Res (2005) 11 (15): 5639–5644.
https://doi.org/10.1158/1078-0432.CCR-05-0174
Published: 01 August 2005
View article titled, Cooperative Antitumor Effect of Multitargeted Kinase Inhibitor ZD6474 and Ionizing Radiation in Glioblastoma
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Journal Articles

A Meta-Analysis on the Interaction between HER-2 Expression and Response to Endocrine Treatment in Advanced Breast Cancer

Michele De Laurentiis, Grazia Arpino, Erminia Massarelli, Angela Ruggiero, Chiara Carlomagno, Fortunato Ciardiello, Giampaolo Tortora, Diego D'Agostino, Francesca Caputo, Giuseppe Cancello, Emilia Montagna, Luca Malorni, Luigia Zinno, Rossella Lauria, Angelo Raffaele Bianco, Sabino De Placido
Journal: Clinical Cancer Research
Clin Cancer Res (2005) 11 (13): 4741–4748.
https://doi.org/10.1158/1078-0432.CCR-04-2569
Published: 06 July 2005
View article titled, A Meta-Analysis on the Interaction between HER-2 Expression and Response to Endocrine Treatment in Advanced Breast Cancer
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Journal Articles

Combined Targeting of Epidermal Growth Factor Receptor and MDM2 by Gefitinib and Antisense MDM2 Cooperatively Inhibit Hormone-Independent Prostate Cancer

Roberto Bianco, Roberta Caputo, Rosa Caputo, Vincenzo Damiano, Sabino De Placido, Corrado Ficorella, Sudhir Agrawal, A. Raffaele Bianco, Fortunato Ciardiello, Giampaolo Tortora
Journal: Clinical Cancer Research
Clin Cancer Res (2004) 10 (14): 4858–4864.
https://doi.org/10.1158/1078-0432.CCR-03-0497
Published: 21 July 2004
View article titled, Combined Targeting of Epidermal Growth Factor Receptor and MDM2 by Gefitinib and Antisense MDM2 Cooperatively Inhibit Hormone-Independent Prostate Cancer
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Journal Articles

Antitumor Activity of ZD6474, a Vascular Endothelial Growth Factor Receptor Tyrosine Kinase Inhibitor, in Human Cancer Cells with Acquired Resistance to Antiepidermal Growth Factor Receptor Therapy

Fortunato Ciardiello, Roberto Bianco, Roberta Caputo, Rosa Caputo, Vincenzo Damiano, Teresa Troiani, Davide Melisi, Ferdinando De Vita, Sabino De Placido, A. Raffaele Bianco, Giampaolo Tortora
Journal: Clinical Cancer Research
Clin Cancer Res (2004) 10 (2): 784–793.
https://doi.org/10.1158/1078-0432.CCR-1100-03
Published: 03 February 2004
View article titled, Antitumor Activity of ZD6474, a Vascular Endothelial Growth Factor Receptor Tyrosine Kinase Inhibitor, in Human Cancer Cells with Acquired Resistance to Antiepidermal Growth Factor Receptor Therapy
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Journal Articles

Combination of a Selective Cyclooxygenase-2 Inhibitor with Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor ZD1839 and Protein Kinase A Antisense Causes Cooperative Antitumor and Antiangiogenic Effect

Giampaolo Tortora, Rosa Caputo, Vincenzo Damiano, Davide Melisi, Roberto Bianco, Gabriella Fontanini, Bianca Maria Veneziani, Sabino De Placido, A. Raffaele Bianco, Fortunato Ciardiello
Journal: Clinical Cancer Research
Clin Cancer Res (2003) 9 (4): 1566–1572.
Published: 01 April 2003
View article titled, Combination of a Selective Cyclooxygenase-2 Inhibitor with Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor ZD1839 and Protein Kinase A Antisense Causes Cooperative Antitumor and Antiangiogenic Effect
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Journal Articles

Twenty-year Results of the Naples GUN Randomized Trial: Predictive Factors of Adjuvant Tamoxifen Efficacy in Early Breast Cancer

Sabino De Placido, Michelino De Laurentiis, Chiara Carlomagno, Ciro Gallo, Franco Perrone, Stefano Pepe, Angela Ruggiero, Alfredo Marinelli, Clorindo Pagliarulo, Luigi Panico, Guido Pettinato, Giuseppe Petrella, Angelo Raffaele Bianco
Journal: Clinical Cancer Research
Clin Cancer Res (2003) 9 (3): 1039–1046.
Published: 01 March 2003
View article titled, Twenty-year Results of the Naples GUN Randomized Trial: <subtitle>Predictive Factors of Adjuvant Tamoxifen Efficacy in Early Breast Cancer</subtitle>
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Journal Articles

Combined Targeted Inhibition of bcl -2, bcl -XL, Epidermal Growth Factor Receptor, and Protein Kinase A Type I Causes Potent Antitumor, Apoptotic, and Antiangiogenic Activity

Giampaolo Tortora, Rosa Caputo, Vincenzo Damiano, Roberta Caputo, Teresa Troiani, Bianca Maria Veneziani, Sabino De Placido, Angelo Raffaele Bianco, Uwe Zangemeister-Wittke, Fortunato Ciardiello
Journal: Clinical Cancer Research
Clin Cancer Res (2003) 9 (2): 866–871.
Published: 01 February 2003
View article titled, Combined Targeted Inhibition of <em>bcl</em> -2, <em>bcl</em> -XL, Epidermal Growth Factor Receptor, and Protein Kinase A Type I Causes Potent Antitumor, Apoptotic, and Antiangiogenic Activity
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Journal Articles

Expression of Epidermal Growth Factor Receptor Correlates with Disease Relapse and Progression to Androgen-independence in Human Prostate Cancer

Giuseppe Di Lorenzo, Giampaolo Tortora, Francesco P. D’Armiento, Gaetano De Rosa, Stefania Staibano, Riccardo Autorino, Massimo D’Armiento, Michele De Laurentiis, Sabino De Placido, Giuseppe Catalano, A. Raffaele Bianco, Fortunato Ciardiello
Journal: Clinical Cancer Research
Clin Cancer Res (2002) 8 (11): 3438–3444.
Published: 01 November 2002
View article titled, Expression of Epidermal Growth Factor Receptor Correlates with Disease Relapse and Progression to Androgen-independence in Human Prostate Cancer
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Journal Articles

Combined Blockade of Protein Kinase A and Bcl-2 by Antisense Strategy Induces Apoptosis and Inhibits Tumor Growth and Angiogenesis

Giampaolo Tortora, Rosa Caputo, Vincenzo Damiano, Roberto Bianco, Gabriella Fontanini, Sabina Cuccato, Sabino De Placido, A. Raffaele Bianco, Fortunato Ciardiello
Journal: Clinical Cancer Research
Clin Cancer Res (2001) 7 (8): 2537–2544.
Published: 01 August 2001
View article titled, Combined Blockade of Protein Kinase A and Bcl-2 by Antisense Strategy Induces Apoptosis and Inhibits Tumor Growth and Angiogenesis
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Journal Articles

Inhibition of Growth Factor Production and Angiogenesis in Human Cancer Cells by ZD1839 (Iressa), a Selective Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor

Fortunato Ciardiello, Rosa Caputo, Roberto Bianco, Vincenzo Damiano, Gabriella Fontanini, Sabina Cuccato, Sabino De Placido, A. Raffaele Bianco, Giampaolo Tortora
Journal: Clinical Cancer Research
Clin Cancer Res (2001) 7 (5): 1459–1465.
Published: 01 May 2001
View article titled, Inhibition of Growth Factor Production and Angiogenesis in Human Cancer Cells by ZD1839 (Iressa), a Selective Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor
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Journal Articles

Antitumor Activity of Combined Treatment of Human Cancer Cells with Ionizing Radiation and Anti-Epidermal Growth Factor Receptor Monoclonal Antibody C225 plus Type I Protein Kinase A Antisense Oligonucleotide

Cataldo Bianco, Roberto Bianco, Giampaolo Tortora, Vincenzo Damiano, Patrizia Guerrieri, Paolo Montemaggi, John Mendelsohn, Sabino De Placido, A. Raffaele Bianco, Fortunato Ciardiello
Journal: Clinical Cancer Research
Clin Cancer Res (2000) 6 (11): 4343–4350.
Published: 01 November 2000
View article titled, Antitumor Activity of Combined Treatment of Human Cancer Cells with Ionizing Radiation and Anti-Epidermal Growth Factor Receptor Monoclonal Antibody C225 plus Type I Protein Kinase A Antisense Oligonucleotide
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Journal Articles

Antiangiogenic and Antitumor Activity of Anti-Epidermal Growth Factor Receptor C225 Monoclonal Antibody in Combination with Vascular Endothelial Growth Factor Antisense Oligonucleotide in Human GEO Colon Cancer Cells

Fortunato Ciardiello, Roberto Bianco, Vincenzo Damiano, Gabriella Fontanini, Rosa Caputo, Grazia Pomatico, Sabino De Placido, A. Raffaele Bianco, John Mendelsohn, Giampaolo Tortora
Journal: Clinical Cancer Research
Clin Cancer Res (2000) 6 (9): 3739–3747.
Published: 01 September 2000
View article titled, Antiangiogenic and Antitumor Activity of Anti-Epidermal Growth Factor Receptor C225 Monoclonal Antibody in Combination with Vascular Endothelial Growth Factor Antisense Oligonucleotide in Human GEO Colon Cancer Cells
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Journal Articles

Oral Antisense that Targets Protein Kinase A Cooperates with Taxol and Inhibits Tumor Growth, Angiogenesis, and Growth Factor Production

Giampaolo Tortora, Roberto Bianco, Vincenzo Damiano, Gabriella Fontanini, Sabino De Placido, A. Raffaele Bianco, Fortunato Ciardiello
Journal: Clinical Cancer Research
Clin Cancer Res (2000) 6 (6): 2506–2512.
Published: 01 June 2000
View article titled, Oral Antisense that Targets Protein Kinase A Cooperates with Taxol and Inhibits Tumor Growth, Angiogenesis, and Growth Factor Production
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Journal Articles

Antitumor Effect and Potentiation of Cytotoxic Drugs Activity in Human Cancer Cells by ZD-1839 (Iressa), an Epidermal Growth Factor Receptor-selective Tyrosine Kinase Inhibitor

Fortunato Ciardiello, Rosa Caputo, Roberto Bianco, Vincenzo Damiano, Grazia Pomatico, Sabino De Placido, A. Raffaele Bianco, Giampaolo Tortora
Journal: Clinical Cancer Research
Clin Cancer Res (2000) 6 (5): 2053–2063.
Published: 01 May 2000
View article titled, Antitumor Effect and Potentiation of Cytotoxic Drugs Activity in Human Cancer Cells by ZD-1839 (Iressa), an Epidermal Growth Factor Receptor-selective Tyrosine Kinase Inhibitor
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Journal Articles

A Prognostic Model That Makes Quantitative Estimates of Probability of Relapse for Breast Cancer Patients

Michelino De Laurentiis, Sabino De Placido, Angelo R. Bianco, Gary M. Clark, Peter M. Ravdin
Journal: Clinical Cancer Research
Clin Cancer Res (1999) 5 (12): 4133–4139.
Published: 01 December 1999
View article titled, A Prognostic Model That Makes Quantitative Estimates of Probability of Relapse for Breast Cancer Patients
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Journal Articles

Measurement of Neovascularization Is an Independent Prognosticator of Survival in Node-negative Breast Cancer Patients with Long-Term Follow-Up

Sabino De Placido, Chiara Carlomagno, Fortunato Ciardiello, Michelino De Laurentiis, Stefano Pepe, Angela Ruggiero, Giampaolo Tortora, Luigi Panico, Antonio D’Antonio, Guido Pettinato, Giuseppe Petrella, A. Raffaele Bianco
Journal: Clinical Cancer Research
Clin Cancer Res (1999) 5 (10): 2854–2859.
Published: 01 October 1999
View article titled, Measurement of Neovascularization Is an Independent Prognosticator of Survival in Node-negative Breast Cancer Patients with Long-Term Follow-Up
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