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Ryon P. Graf
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Journal Articles

Association of Homologous Recombination Repair Alterations with Outcomes in Patients with Metastatic Hormone-Sensitive Prostate Cancer

Open Access
Chadi Hage Chehade, Ryon P. Graf, Zeynep Irem Ozay, Georges Gebrael, Nicolas Sayegh, Gerald Li, Benjamin L. Maughan, Emmanuel S. Antonarakis, Rana R. McKay, Neeraj Agarwal, Umang Swami
Journal: Clinical Cancer Research
Clin Cancer Res OF1–OF9.
https://doi.org/10.1158/1078-0432.CCR-25-1178
Published: 01 July 2025
View article titled, Association of Homologous Recombination Repair Alterations with Outcomes in Patients with Metastatic Hormone-Sensitive Prostate Cancer
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Includes: Supplementary data
Journal Articles

Abstract P2-03-27: Prevalence of actionable genomic alterations (GA) and predictive value of tumor mutational burden (TMB) for immune checkpoint inhibitor (ICI) effectiveness in HR(+)HER2(-) metastatic breast cancer (MBC)

Free
Mariya Rozenblit, Julia C. F. Quintanilha, Jeffrey S. Ross, Mia Levy, Ryon P. Graf
Journal: Clinical Cancer Research
Clin Cancer Res (2025) 31 (12_Supplement): P2-03-27.
https://doi.org/10.1158/1557-3265.SABCS24-P2-03-27
Published: 13 June 2025
View article titled, Abstract P2-03-27: Prevalence of actionable genomic alterations (GA) and predictive value of tumor mutational burden (TMB) for immune checkpoint inhibitor (ICI) effectiveness in HR(+)HER2(-) metastatic breast cancer (MBC)
Journal Articles

Effectiveness of PARP Inhibitor Maintenance Therapy in Ovarian Cancer by BRCA1/2 and a Scar-Based HRD Signature in Real-World Practice

Open Access
Debra L. Richardson, Julia C. F. Quintanilha, Natalie Danziger, Gerald Li, Ethan Sokol, Alexa B. Schrock, Ericka Ebot, Neeru Bhardwaj, Tanesha Norris, Anosheh Afghahi, Anthony Frachioni, Christina Washington, Lauren Dockery, Julia Elvin, Ryon P. Graf, Kathleen N. Moore
Journal: Clinical Cancer Research
Clin Cancer Res (2024) 30 (20): 4644–4653.
https://doi.org/10.1158/1078-0432.CCR-24-1225
Published: 15 October 2024
View article titled, Effectiveness of PARP Inhibitor Maintenance Therapy in Ovarian Cancer by BRCA1/2 and a Scar-Based HRD Signature in Real-World Practice
Open the PDF for Effectiveness of PARP Inhibitor Maintenance Therapy in Ovarian Cancer by BRCA1/2 and a Scar-Based HRD Signature in Real-World Practice in another window
Includes: Supplementary data
Journal Articles

Circulating Tumor DNA Assessment for Treatment Monitoring Adds Value to PSA in Metastatic Castration-Resistant Prostate Cancer

Open Access
Christopher J. Sweeney, Russell Petry, Chang Xu, Merrida Childress, Jie He, David Fabrizio, Ole Gjoerup, Samantha Morley, Timothy Catlett, Zoe J. Assaf, Kobe Yuen, Matthew Wongchenko, Kalpit Shah, Pratyush Gupta, Priti Hegde, Lincoln W. Pasquina, Sanjeev Mariathasan, Ryon P. Graf, Thomas Powles
Journal: Clinical Cancer Research
Clin Cancer Res (2024) 30 (18): 4115–4122.
https://doi.org/10.1158/1078-0432.CCR-24-1096
Published: 13 September 2024
View article titled, Circulating Tumor DNA Assessment for Treatment Monitoring Adds Value to PSA in Metastatic Castration-Resistant Prostate Cancer
Open the PDF for Circulating Tumor DNA Assessment for Treatment Monitoring Adds Value to PSA in Metastatic Castration-Resistant Prostate Cancer in another window
Includes: Supplementary data
Journal Articles

Measurement of ctDNA Tumor Fraction Identifies Informative Negative Liquid Biopsy Results and Informs Value of Tissue Confirmation

Open Access
Christian D. Rolfo, Russell W. Madison, Lincoln W. Pasquina, Derek W. Brown, Yanmei Huang, Jason D. Hughes, Ryon P. Graf, Geoffrey R. Oxnard, Hatim Husain
Journal: Clinical Cancer Research
Clin Cancer Res (2024) 30 (11): 2452–2460.
https://doi.org/10.1158/1078-0432.CCR-23-3321
Published: 03 June 2024
View article titled, Measurement of ctDNA Tumor Fraction Identifies Informative Negative Liquid Biopsy Results and Informs Value of Tissue Confirmation
Open the PDF for Measurement of ctDNA Tumor Fraction Identifies Informative Negative Liquid Biopsy Results and Informs Value of Tissue Confirmation in another window
Includes: Supplementary data
Journal Articles

Circulating Tumor DNA Enables Sensitive Detection of Actionable Gene Fusions and Rearrangements Across Cancer Types

Open Access
Pashtoon M. Kasi, Jessica K. Lee, Lincoln W. Pasquina, Brennan Decker, Pierre Vanden Borre, Dean C. Pavlick, Justin M. Allen, Christine Parachoniak, Julia C. F. Quintanilha, Ryon P. Graf, Alexa B. Schrock, Geoffrey R. Oxnard, Christine M. Lovly, Hanna Tukachinsky, Vivek Subbiah
Journal: Clinical Cancer Research
Clin Cancer Res (2024) 30 (4): 836–848.
https://doi.org/10.1158/1078-0432.CCR-23-2693
Published: 16 February 2024
View article titled, Circulating Tumor DNA Enables Sensitive Detection of Actionable Gene Fusions and Rearrangements Across Cancer Types
Open the PDF for Circulating Tumor DNA Enables Sensitive Detection of Actionable Gene Fusions and Rearrangements Across Cancer Types in another window
Includes: Supplementary data
Journal Articles

Biology and Targetability of the Extended Spectrum of PIK3CA Mutations Detected in Breast Carcinoma

Open Access
Hope S. Rugo, Kira Raskina, Alexa B. Schrock, Russell W. Madison, Ryon P. Graf, Ethan S. Sokol, Smruthy Sivakumar, Jessica K. Lee, Virginia Fisher, Geoffrey R. Oxnard, Hanna Tukachinsky
Journal: Clinical Cancer Research
Clin Cancer Res (2023) 29 (6): 1056–1067.
https://doi.org/10.1158/1078-0432.CCR-22-2115
Published: 14 March 2023
View article titled, Biology and Targetability of the Extended Spectrum of PIK3CA Mutations Detected in Breast Carcinoma
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Includes: Supplementary data
Journal Articles

SPOP Mutations as a Predictive Biomarker for Androgen Receptor Axis–Targeted Therapy in De Novo Metastatic Castration-Sensitive Prostate Cancer

Available to Purchase
Umang Swami, Ryon P. Graf, Roberto H. Nussenzveig, Virginia Fisher, Hanna Tukachinsky, Alexa B. Schrock, Gerald Li, Jeffrey S. Ross, Nicolas Sayegh, Nishita Tripathi, Vinay Mathew Thomas, Geoffrey R. Oxnard, Emmanuel S. Antonarakis, Neeraj Agarwal
Journal: Clinical Cancer Research
Clin Cancer Res (2022) 28 (22): 4917–4925.
https://doi.org/10.1158/1078-0432.CCR-22-2228
Published: 14 November 2022
View article titled, SPOP Mutations as a Predictive Biomarker for Androgen Receptor Axis–Targeted Therapy in De Novo Metastatic Castration-Sensitive Prostate Cancer
Open the PDF for SPOP Mutations as a Predictive Biomarker for Androgen Receptor Axis–Targeted Therapy in De Novo Metastatic Castration-Sensitive Prostate Cancer in another window
Includes: Supplementary data
Journal Articles

Genomic Analysis of Circulating Tumor DNA in 3,334 Patients with Advanced Prostate Cancer Identifies Targetable BRCA Alterations and AR Resistance Mechanisms

Free
Hanna Tukachinsky, Russell W. Madison, Jon H. Chung, Ole V. Gjoerup, Eric A. Severson, Lucas Dennis, Bernard J. Fendler, Samantha Morley, Lei Zhong, Ryon P. Graf, Jeffrey S. Ross, Brian M. Alexander, Wassim Abida, Simon Chowdhury, Charles J. Ryan, Karim Fizazi, Tony Golsorkhi, Simon P. Watkins, Andrew Simmons, Andrea Loehr, Jeffrey M. Venstrom, Geoffrey R. Oxnard
Journal: Clinical Cancer Research
Series: Author Choice
Clin Cancer Res (2021) 27 (11): 3094–3105.
https://doi.org/10.1158/1078-0432.CCR-20-4805
Published: 01 June 2021
View article titled, Genomic Analysis of Circulating Tumor DNA in 3,334 Patients with Advanced Prostate Cancer Identifies Targetable BRCA Alterations and AR Resistance Mechanisms
Open the PDF for Genomic Analysis of Circulating Tumor DNA in 3,334 Patients with Advanced Prostate Cancer Identifies Targetable BRCA Alterations and AR Resistance Mechanisms in another window
Includes: Supplementary data
Journal Articles

Single-Cell Circulating Tumor Cell Analysis Reveals Genomic Instability as a Distinctive Feature of Aggressive Prostate Cancer

Available to Purchase
Paymaneh D. Malihi, Ryon P. Graf, Angel Rodriguez, Naveen Ramesh, Jerry Lee, Ramsay Sutton, Rhett Jiles, Carmen Ruiz Velasco, Emi Sei, Anand Kolatkar, Christopher Logothetis, Nicholas E. Navin, Paul Corn, Ana M. Aparicio, Ryan Dittamore, James Hicks, Peter Kuhn, Amado J. Zurita
Journal: Clinical Cancer Research
Clin Cancer Res (2020) 26 (15): 4143–4153.
https://doi.org/10.1158/1078-0432.CCR-19-4100
Published: 03 August 2020
View article titled, Single-Cell Circulating Tumor Cell Analysis Reveals Genomic Instability as a Distinctive Feature of Aggressive Prostate Cancer
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Includes: Supplementary data
Journal Articles

The Initial Detection and Partial Characterization of Circulating Tumor Cells in Neuroendocrine Prostate Cancer

Free
Himisha Beltran, Adam Jendrisak, Mark Landers, Juan Miguel Mosquera, Myriam Kossai, Jessica Louw, Rachel Krupa, Ryon P. Graf, Nicole A. Schreiber, David M. Nanus, Scott T. Tagawa, Dena Marrinucci, Ryan Dittamore, Howard I. Scher
Journal: Clinical Cancer Research
Clin Cancer Res (2016) 22 (6): 1510–1519.
https://doi.org/10.1158/1078-0432.CCR-15-0137
Published: 14 March 2016
View article titled, The Initial Detection and Partial Characterization of Circulating Tumor Cells in Neuroendocrine Prostate Cancer
Open the PDF for The Initial Detection and Partial Characterization of Circulating Tumor Cells in Neuroendocrine Prostate Cancer in another window
Includes: Supplementary data