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Ryan B. Corcoran
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Journal Articles

Minimal Residual Disease using a Plasma-Only Circulating Tumor DNA Assay to Predict Recurrence of Metastatic Colorectal Cancer Following Curative Intent Treatment

Aparna R. Parikh, Bryant H. Chee, Jill Tsai, Thereasa A. Rich, Kristin S. Price, Sonia A. Patel, Li Zhang, Faaiz Ibrahim, Mikaela Esquivel, Emily E. Van Seventer, Joy X. Jarnagin, Victoria M. Raymond, Carlos U. Corvera, Kenzo Hirose, Eric K. Nakakura, Ryan B. Corcoran, Katherine Van Loon, Chloe E. Atreya
Journal: Clinical Cancer Research
Clin Cancer Res (2024) 30 (14): 2964–2973.
https://doi.org/10.1158/1078-0432.CCR-23-3660
Published: 15 July 2024
View article titled, Minimal Residual Disease using a Plasma-Only Circulating Tumor DNA Assay to Predict Recurrence of Metastatic Colorectal Cancer Following Curative Intent Treatment
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Includes: Supplementary data
Journal Articles

The Irreversible FGFR Inhibitor KIN-3248 Overcomes FGFR2 Kinase Domain Mutations

Eranga R. Balasooriya, Qibiao Wu, Haley Ellis, Yuanli Zhen, Bryanna L. Norden, Ryan B. Corcoran, Adithi Mohan, Eric Martin, Aleksandra Franovic, John Tyhonas, Matthew Lardy, Kathryn B. Grandinetti, Robert Pelham, Liliana Soroceanu, Vanessa S. Silveira, Nabeel Bardeesy
Journal: Clinical Cancer Research
Clin Cancer Res (2024) 30 (10): 2181–2192.
https://doi.org/10.1158/1078-0432.CCR-23-3588
Published: 15 May 2024
View article titled, The Irreversible FGFR Inhibitor KIN-3248 Overcomes FGFR2 Kinase Domain Mutations
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Includes: Supplementary data
Journal Articles

Phase I/II Study of Combined BCL-xL and MEK Inhibition with Navitoclax and Trametinib in KRAS or NRAS Mutant Advanced Solid Tumors

Ryan B. Corcoran, Khanh T. Do, Jeong E. Kim, James M. Cleary, Aparna R. Parikh, Oladapo O. Yeku, Niya Xiong, Colin D. Weekes, Jennifer Veneris, Leanne G. Ahronian, Gianluca Mauri, Jun Tian, Bryanna L. Norden, Alexa G. Michel, Emily E. Van Seventer, Giulia Siravegna, Kyle Camphausen, Gary Chi, Isobel J. Fetter, Joan S. Brugge, Helen Chen, Naoko Takebe, Richard T. Penson, Dejan Juric, Keith T. Flaherty, Ryan J. Sullivan, Jeffrey W. Clark, Rebecca S. Heist, Ursula A. Matulonis, Joyce F. Liu, Geoffrey I. Shapiro
Journal: Clinical Cancer Research
Clin Cancer Res (2024) 30 (9): 1739–1749.
https://doi.org/10.1158/1078-0432.CCR-23-3135
Published: 01 May 2024
View article titled, Phase I/II Study of Combined BCL-xL and MEK Inhibition with Navitoclax and Trametinib in KRAS or NRAS Mutant Advanced Solid Tumors
Open the PDF for Phase I/II Study of Combined BCL-xL and MEK Inhibition with Navitoclax and Trametinib in KRAS or NRAS Mutant Advanced Solid Tumors in another window
Includes: Supplementary data
Journal Articles

Landscape of Clinical Resistance Mechanisms to FGFR Inhibitors in FGFR2-Altered Cholangiocarcinoma

Qibiao Wu, Haley Ellis, Giulia Siravegna, Alexa G. Michel, Bryanna L. Norden, Ferran Fece de la Cruz, Eranga Roshan Balasooriya, Yuanli Zhen, Vanessa S. Silveira, Jianwe Che, Ryan B. Corcoran, Nabeel Bardeesy
Journal: Clinical Cancer Research
Clin Cancer Res (2024) 30 (1): 198–208.
https://doi.org/10.1158/1078-0432.CCR-23-1317
Published: 05 January 2024
View article titled, Landscape of Clinical Resistance Mechanisms to FGFR Inhibitors in FGFR2-Altered Cholangiocarcinoma
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Includes: Supplementary data
Journal Articles

Cell-Free HPV DNA Provides an Accurate and Rapid Diagnosis of HPV-Associated Head and Neck Cancer

Giulia Siravegna, Connor J. O'Boyle, Shohreh Varmeh, Natalia Queenan, Alexa Michel, Jarrod Stein, Julia Thierauf, Peter M. Sadow, William C. Faquin, Simon K. Perry, Adam Z. Bard, Wei Wang, Daniel G. Deschler, Kevin S. Emerick, Mark A. Varvares, Jong C. Park, John R. Clark, Annie W. Chan, Vanessa Carlota Andreu Arasa, Osamu Sakai, Jochen Lennerz, Ryan B. Corcoran, Lori J. Wirth, Derrick T. Lin, A. John Iafrate, Jeremy D. Richmon, Daniel L. Faden
Journal: Clinical Cancer Research
Clin Cancer Res (2022) 28 (4): 719–727.
https://doi.org/10.1158/1078-0432.CCR-21-3151
Published: 15 February 2022
View article titled, Cell-Free HPV DNA Provides an Accurate and Rapid Diagnosis of HPV-Associated Head and Neck Cancer
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Includes: Supplementary data
Journal Articles

Plasma-only ctDNA-Guided MRD Detection in Patients with CRC—Response

Aparna R. Parikh, Ryan B. Corcoran
Journal: Clinical Cancer Research
Clin Cancer Res (2021) 27 (23): 6614–6615.
https://doi.org/10.1158/1078-0432.CCR-21-3306
Published: 01 December 2021
View article titled, Plasma-only ctDNA-Guided MRD Detection in Patients with CRC—Response
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Journal Articles

Results and Molecular Correlates from a Pilot Study of Neoadjuvant Induction FOLFIRINOX Followed by Chemoradiation and Surgery for Gastroesophageal Adenocarcinomas

Jennifer Y. Wo, Jeffrey W. Clark, Christine E. Eyler, Mari Mino-Kenudson, Samuel J. Klempner, Jill N. Allen, Florence K. Keane, Aparna R. Parikh, Eric Roeland, Lorraine C. Drapek, David P. Ryan, Ryan B. Corcoran, Emily Van Seventer, Isobel J. Fetter, Heather A. Shahzade, Melin J. Khandekar, Michael Lanuti, Christopher R. Morse, Rebecca S. Heist, Christine A. Ulysse, Benjamin Christopher, Christian Baglini, Beow Y. Yeap, John T. Mullen, Theodore S. Hong
Journal: Clinical Cancer Research
Clin Cancer Res (2021) 27 (23): 6343–6353.
https://doi.org/10.1158/1078-0432.CCR-21-0331
Published: 01 December 2021
View article titled, Results and Molecular Correlates from a Pilot Study of Neoadjuvant Induction FOLFIRINOX Followed by Chemoradiation and Surgery for Gastroesophageal Adenocarcinomas
Open the PDF for Results and Molecular Correlates from a Pilot Study of Neoadjuvant Induction FOLFIRINOX Followed by Chemoradiation and Surgery for Gastroesophageal Adenocarcinomas in another window
Includes: Supplementary data
Journal Articles

Minimal Residual Disease Detection using a Plasma-only Circulating Tumor DNA Assay in Patients with Colorectal Cancer

Aparna R. Parikh, Emily E. Van Seventer, Giulia Siravegna, Anna V. Hartwig, Ariel Jaimovich, Yupeng He, Katie Kanter, Madeleine G. Fish, Kathryn D. Fosbenner, Benchun Miao, Susannah Phillips, John H. Carmichael, Nihaarika Sharma, Joy Jarnagin, Islam Baiev, Yojan S. Shah, Isobel J. Fetter, Heather A. Shahzade, Jill N. Allen, Lawrence S. Blaszkowsky, Jeffrey W. Clark, Jon S. Dubois, Joseph W. Franses, Bruce J. Giantonio, Lipika Goyal, Samuel J. Klempner, Ryan D. Nipp, Eric J. Roeland, David P. Ryan, Colin D. Weekes, Jennifer Y. Wo, Theodore S. Hong, Liliana Bordeianou, Cristina R. Ferrone, Motaz Qadan, Hiroko Kunitake, David Berger, Rocco Ricciardi, James C. Cusack, Victoria M. Raymond, AmirAli Talasaz, Genevieve M. Boland, Ryan B. Corcoran
Journal: Clinical Cancer Research
Series: Author Choice
Clin Cancer Res (2021) 27 (20): 5586–5594.
https://doi.org/10.1158/1078-0432.CCR-21-0410
Published: 15 October 2021
View article titled, Minimal Residual Disease Detection using a Plasma-only Circulating Tumor DNA Assay in Patients with Colorectal Cancer
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Includes: Supplementary data
Journal Articles

BRAF-Mutant Transcriptional Subtypes Predict Outcome of Combined BRAF, MEK, and EGFR Blockade with Dabrafenib, Trametinib, and Panitumumab in Patients with Colorectal Cancer

Gary Middleton, Yiqun Yang, Catarina D. Campbell, Thierry André, Chloe E. Atreya, Jan H.M. Schellens, Takayuki Yoshino, Johanna C. Bendell, Antoine Hollebecque, Autumn J. McRee, Salvatore Siena, Michael S. Gordon, Josep Tabernero, Rona Yaeger, Peter J. O'Dwyer, Filip De Vos, Eric Van Cutsem, John M. Millholland, Jan C. Brase, Fatima Rangwala, Eduard Gasal, Ryan B. Corcoran
Journal: Clinical Cancer Research
Series: Author Choice
Clin Cancer Res (2020) 26 (11): 2466–2476.
https://doi.org/10.1158/1078-0432.CCR-19-3579
Published: 01 June 2020
View article titled, <em>BRAF</em>-Mutant Transcriptional Subtypes Predict Outcome of Combined BRAF, MEK, and EGFR Blockade with Dabrafenib, Trametinib, and Panitumumab in Patients with Colorectal Cancer
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Includes: Supplementary data
Journal Articles

Serial ctDNA Monitoring to Predict Response to Systemic Therapy in Metastatic Gastrointestinal Cancers

Aparna R. Parikh, Amikasra Mojtahed, Jaime L. Schneider, Katie Kanter, Emily E. Van Seventer, Isobel J. Fetter, Ashraf Thabet, Madeleine G. Fish, Bezaye Teshome, Kathryn Fosbenner, Brandon Nadres, Heather A. Shahzade, Jill N. Allen, Lawrence S. Blaszkowsky, David P. Ryan, Bruce Giantonio, Lipika Goyal, Ryan D. Nipp, Eric Roeland, Colin D. Weekes, Jennifer Y. Wo, Andrew X. Zhu, Dora Dias-Santagata, A. John Iafrate, Jochen K. Lennerz, Theodore S. Hong, Giulia Siravegna, Nora Horick, Jeffrey W. Clark, Ryan B. Corcoran
Journal: Clinical Cancer Research
Series: Author Choice
Clin Cancer Res (2020) 26 (8): 1877–1885.
https://doi.org/10.1158/1078-0432.CCR-19-3467
Published: 15 April 2020
View article titled, Serial ctDNA Monitoring to Predict Response to Systemic Therapy in Metastatic Gastrointestinal Cancers
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Includes: Supplementary data
Journal Articles

Vertical Pathway Inhibition Overcomes Adaptive Feedback Resistance to KRASG12C Inhibition

Meagan B. Ryan, Ferran Fece de la Cruz, Sarah Phat, David T. Myers, Edmond Wong, Heather A. Shahzade, Catriona B. Hong, Ryan B. Corcoran
Journal: Clinical Cancer Research
Series: Author Choice
Clin Cancer Res (2020) 26 (7): 1633–1643.
https://doi.org/10.1158/1078-0432.CCR-19-3523
Published: 01 April 2020
View article titled, Vertical Pathway Inhibition Overcomes Adaptive Feedback Resistance to KRAS<sup>G12C</sup> Inhibition
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Includes: Supplementary data
Journal Articles

Co-occurring Alterations in the RAS–MAPK Pathway Limit Response to MET Inhibitor Treatment in MET Exon 14 Skipping Mutation-Positive Lung Cancer

Julia K. Rotow, Philippe Gui, Wei Wu, Victoria M. Raymond, Richard B. Lanman, Frederic J. Kaye, Nir Peled, Ferran Fece de la Cruz, Brandon Nadres, Ryan B. Corcoran, Iwei Yeh, Boris C. Bastian, Petr Starostik, Kimberly Newsom, Victor R. Olivas, Alexander M. Wolff, James S. Fraser, Eric A. Collisson, Caroline E. McCoach, D. Ross Camidge, Jose Pacheco, Lyudmila Bazhenova, Tianhong Li, Trever G. Bivona, Collin M. Blakely
Journal: Clinical Cancer Research
Clin Cancer Res (2020) 26 (2): 439–449.
https://doi.org/10.1158/1078-0432.CCR-19-1667
Published: 15 January 2020
View article titled, Co-occurring Alterations in the RAS–MAPK Pathway Limit Response to MET Inhibitor Treatment in MET Exon 14 Skipping Mutation-Positive Lung Cancer
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Includes: Supplementary data
Journal Articles

Response to Anti-EGFR Therapy in Patients with BRAF non-V600–Mutant Metastatic Colorectal Cancer

Rona Yaeger, Daisuke Kotani, Sebastián Mondaca, Aparna R. Parikh, Hideaki Bando, Emily E. Van Seventer, Hiroya Taniguchi, HuiYong Zhao, Claire N. Thant, Elisa de Stanchina, Neal Rosen, Ryan B. Corcoran, Takayuki Yoshino, Zhan Yao, Hiromichi Ebi
Journal: Clinical Cancer Research
Clin Cancer Res (2019) 25 (23): 7089–7097.
https://doi.org/10.1158/1078-0432.CCR-19-2004
Published: 02 December 2019
View article titled, Response to Anti-EGFR Therapy in Patients with BRAF non-V600–Mutant Metastatic Colorectal Cancer
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Includes: Supplementary data
Journal Articles

Integrative Molecular Characterization of Resistance to Neoadjuvant Chemoradiation in Rectal Cancer

Sophia C. Kamran, Jochen K. Lennerz, Claire A. Margolis, David Liu, Brendan Reardon, Stephanie A. Wankowicz, Emily E. Van Seventer, Adam Tracy, Jennifer Y. Wo, Scott L. Carter, Henning Willers, Ryan B. Corcoran, Theodore S. Hong, Eliezer M. Van Allen
Journal: Clinical Cancer Research
Clin Cancer Res (2019) 25 (18): 5561–5571.
https://doi.org/10.1158/1078-0432.CCR-19-0908
Published: 13 September 2019
View article titled, Integrative Molecular Characterization of Resistance to Neoadjuvant Chemoradiation in Rectal Cancer
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Includes: Supplementary data
Journal Articles

Abstract IA15: Overcoming drug resistance and tumor heterogeneity in gastrointestinal cancers

Ryan B. Corcoran
Journal: Clinical Cancer Research
Clin Cancer Res (2018) 24 (1_Supplement): IA15.
https://doi.org/10.1158/1557-3265.TCM17-IA15
Published: 02 January 2018
View article titled, Abstract IA15: Overcoming drug resistance and tumor heterogeneity in gastrointestinal cancers
Journal Articles

Combined MEK and PI3K Inhibition in a Mouse Model of Pancreatic Cancer

Brinda Alagesan, Gianmarco Contino, Alexander R. Guimaraes, Ryan B. Corcoran, Vikram Deshpande, Gregory R. Wojtkiewicz, Aram F. Hezel, Kwok-Kin Wong, Massimo Loda, Ralph Weissleder, Cyril Benes, Jeffrey A. Engelman, Nabeel Bardeesy
Journal: Clinical Cancer Research
Clin Cancer Res (2015) 21 (2): 396–404.
https://doi.org/10.1158/1078-0432.CCR-14-1591
Published: 14 January 2015
View article titled, Combined MEK and PI3K Inhibition in a Mouse Model of Pancreatic Cancer
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Includes: Supplementary data
Journal Articles

Abstract PR8: Insensitivity to RAF inhibition by vemurafenib in BRAF mutant colorectal cancer by EGFR-mediated reactivation of MAPK signaling

Ryan B. Corcoran, Kenneth E. Hung, Keith T. Flaherty, Adriano Piris, Jennifer A. Wargo, Jeffrey Settleman, Mari Mino-Kenudson, Jeffrey A. Engelman, Hiromichi Ebi, Alexa B. Turke, Erin M. Coffee, Michiya Nishino, Alexandria P. Cogdill, Ronald D. Brown, Patricia Della Pelle, Dora Dias-Santagata
Journal: Clinical Cancer Research
Clin Cancer Res (2012) 18 (10_Supplement): PR8.
https://doi.org/10.1158/1078-0432.MECHRES-PR8
Published: 04 March 2013
View article titled, Abstract PR8: Insensitivity to RAF inhibition by vemurafenib in BRAF mutant colorectal cancer by EGFR-mediated reactivation of MAPK signaling
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