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Ross L. Levine
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Journal Articles

Development of Resistance to Type II JAK2 Inhibitors in MPN Depends on AXL Kinase and Is Targetable

Tamara Codilupi, Jakub Szybinski, Stefanie Arunasalam, Sarah Jungius, Andrew C. Dunbar, Simona Stivala, Sime Brkic, Camille Albrecht, Lenka Vokalova, Julie L. Yang, Katarzyna Buczak, Nilabh Ghosh, Jakob R. Passweg, Alicia Rovo, Anne Angelillo-Scherrer, Dmitry Pankov, Stefan Dirnhofer, Ross L. Levine, Richard Koche, Sara C. Meyer
Journal: Clinical Cancer Research
Clin Cancer Res (2024) 30 (3): 586–599.
https://doi.org/10.1158/1078-0432.CCR-23-0163
Published: 01 February 2024
View article titled, Development of Resistance to Type II JAK2 Inhibitors in MPN Depends on AXL Kinase and Is Targetable
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Includes: Supplementary data
Journal Articles

Crizotinib Has Preclinical Efficacy in Philadelphia-Negative Myeloproliferative Neoplasms

Lindsay M. Gurska, Rachel Okabe, Alexandra Schurer, Meng Maxine Tong, Mark Soto, Daniel Choi, Kristina Ames, Shira Glushakow-Smith, Allison Montoya, Ellen Tein, Linde A. Miles, Haiying Cheng, Pamela Hankey-Giblin, Ross L. Levine, Swati Goel, Balazs Halmos, Kira Gritsman
Journal: Clinical Cancer Research
Clin Cancer Res (2023) 29 (5): 943–956.
https://doi.org/10.1158/1078-0432.CCR-22-1763
Published: 01 March 2023
View article titled, Crizotinib Has Preclinical Efficacy in Philadelphia-Negative Myeloproliferative Neoplasms
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Includes: Supplementary data
Journal Articles

Bone Marrow Surveillance of Pediatric Cancer Survivors Identifies Clones that Predict Therapy-Related Leukemia

Barbara Spitzer, Kayleigh D. Rutherford, Gunes Gundem, Erin M. McGovern, Nathan E. Millard, Juan E. Arango Ossa, Irene Y. Cheung, Teng Gao, Max F. Levine, Yanming Zhang, Juan S. Medina-Martínez, Yi Feng, Ryan N. Ptashkin, Kelly L. Bolton, Noushin Farnoud, Yangyu Zhou, Minal A. Patel, Georgios Asimomitis, Cassidy C. Cobbs, Neeman Mohibullah, Kety H. Huberman, Maria E. Arcilla, Brian H. Kushner, Shakeel Modak, Andrew L. Kung, Ahmet Zehir, Ross L. Levine, Scott A. Armstrong, Nai Kong V. Cheung, Elli Papaemmanuil
Journal: Clinical Cancer Research
Clin Cancer Res (2022) 28 (8): 1614–1627.
https://doi.org/10.1158/1078-0432.CCR-21-2451
Published: 14 April 2022
View article titled, Bone Marrow Surveillance of Pediatric Cancer Survivors Identifies Clones that Predict Therapy-Related Leukemia
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Includes: Supplementary data
Journal Articles

Recurrent Mutations in Cyclin D3 Confer Clinical Resistance to FLT3 Inhibitors in Acute Myeloid Leukemia

Catherine C. Smith, Aaron D. Viny, Evan Massi, Cyriac Kandoth, Nicholas D. Socci, Franck Rapaport, Matthieu Najm, Juan S. Medina-Martinez, Elli Papaemmanuil, Theodore C. Tarver, Henry H. Hsu, Mai H. Le, Brian West, Gideon Bollag, Barry S. Taylor, Ross L. Levine, Neil P. Shah
Journal: Clinical Cancer Research
Clin Cancer Res (2021) 27 (14): 4003–4011.
https://doi.org/10.1158/1078-0432.CCR-20-3458
Published: 15 July 2021
View article titled, Recurrent Mutations in Cyclin D3 Confer Clinical Resistance to FLT3 Inhibitors in Acute Myeloid Leukemia
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Includes: Supplementary data
Journal Articles

Therapeutic Efficacy of Combined JAK1/2, Pan-PIM, and CDK4/6 Inhibition in Myeloproliferative Neoplasms

Raajit K. Rampal, Maria Pinzon-Ortiz, Amritha Varshini Hanasoge Somasundara, Benjamin Durham, Richard Koche, Barbara Spitzer, Shoron Mowla, Aishwarya Krishnan, Bing Li, Wenbin An, Andriy Derkach, Sean Devlin, Xianhui Rong, Tyler Longmire, Shira Esther Eisman, Keith Cordner, Justin T. Whitfield, Gary Vanasse, Zhu A. Cao, Ross L. Levine
Journal: Clinical Cancer Research
Clin Cancer Res (2021) 27 (12): 3456–3468.
https://doi.org/10.1158/1078-0432.CCR-20-4898
Published: 15 June 2021
View article titled, Therapeutic Efficacy of Combined JAK1/2, Pan-PIM, and CDK4/6 Inhibition in Myeloproliferative Neoplasms
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Includes: Supplementary data
Journal Articles

Activation of JAK/STAT Signaling in Megakaryocytes Sustains Myeloproliferation In Vivo

Brittany Woods, Wei Chen, Sophia Chiu, Christian Marinaccio, Chunling Fu, Lilly Gu, Marinka Bulic, Qiong Yang, Anouar Zouak, Shengxian Jia, Praveen Kumar Suraneni, Kailin Xu, Ross L. Levine, John D. Crispino, Qiang Jeremy Wen
Journal: Clinical Cancer Research
Clin Cancer Res (2019) 25 (19): 5901–5912.
https://doi.org/10.1158/1078-0432.CCR-18-4089
Published: 01 October 2019
View article titled, Activation of JAK/STAT Signaling in Megakaryocytes Sustains Myeloproliferation <em>In Vivo</em>
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Includes: Supplementary data
Journal Articles

Unfolding the Role of Calreticulin in Myeloproliferative Neoplasm Pathogenesis

Tiffany R. Merlinsky, Ross L. Levine, Elodie Pronier
Journal: Clinical Cancer Research
Clin Cancer Res (2019) 25 (10): 2956–2962.
https://doi.org/10.1158/1078-0432.CCR-18-3777
Published: 15 May 2019
View article titled, Unfolding the Role of Calreticulin in Myeloproliferative Neoplasm Pathogenesis
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Journal Articles

Identification of Clonal Hematopoiesis Mutations in Solid Tumor Patients Undergoing Unpaired Next-Generation Sequencing Assays

Catherine C. Coombs, Nancy K. Gillis, Xianming Tan, Jonathan S. Berg, Markus Ball, Maria E. Balasis, Nathan D. Montgomery, Kelly L. Bolton, Joel S. Parker, Tania E. Mesa, Sean J. Yoder, Michele C. Hayward, Nirali M. Patel, Kristy L. Richards, Christine M. Walko, Todd C. Knepper, John T. Soper, Jared Weiss, Juneko E. Grilley-Olson, William Y. Kim, H. Shelton Earp, III, Ross L. Levine, Elli Papaemmanuil, Ahmet Zehir, D. Neil Hayes, Eric Padron
Journal: Clinical Cancer Research
Clin Cancer Res (2018) 24 (23): 5918–5924.
https://doi.org/10.1158/1078-0432.CCR-18-1201
Published: 03 December 2018
View article titled, Identification of Clonal Hematopoiesis Mutations in Solid Tumor Patients Undergoing Unpaired Next-Generation Sequencing Assays
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Includes: Supplementary data
Journal Articles

Abstract IA41: Role of JAK-STAT pathway activation in MPN pathogenesis and therapeutic response.

Sara Meyer, Maria Kleppe, Neha Bhagwat, Priya Koppikar, Minsuk Kwak, Thomas Radimerski, Rong Fan, Ross L. Levine
Journal: Clinical Cancer Research
Clin Cancer Res (2015) 21 (17_Supplement): IA41.
https://doi.org/10.1158/1557-3265.HEMMAL14-IA41
Published: 19 August 2015
View article titled, Abstract IA41: Role of JAK-STAT pathway activation in MPN pathogenesis and therapeutic response.
Journal Articles

Molecular Pathways: Molecular Basis for Sensitivity and Resistance to JAK Kinase Inhibitors

Sara C. Meyer, Ross L. Levine
Journal: Clinical Cancer Research
Clin Cancer Res (2014) 20 (8): 2051–2059.
https://doi.org/10.1158/1078-0432.CCR-13-0279
Published: 15 April 2014
View article titled, Molecular Pathways: Molecular Basis for Sensitivity and Resistance to JAK Kinase Inhibitors
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