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Rosa Caputo
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Journal Articles

A Novel Toll-Like Receptor 9 Agonist Cooperates with Trastuzumab in Trastuzumab-Resistant Breast Tumors through Multiple Mechanisms of Action

Vincenzo Damiano, Sonia Garofalo, Roberta Rosa, Roberto Bianco, Rosa Caputo, Teresa Gelardi, Gerardina Merola, Luigi Racioppi, Corrado Garbi, Ekambar R. Kandimalla, Sudhir Agrawal, Giampaolo Tortora
Journal: Clinical Cancer Research
Clin Cancer Res (2009) 15 (22): 6921–6930.
https://doi.org/10.1158/1078-0432.CCR-09-1599
Published: 11 November 2009
View article titled, A Novel Toll-Like Receptor 9 Agonist Cooperates with Trastuzumab in Trastuzumab-Resistant Breast Tumors through Multiple Mechanisms of Action
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Journal Articles

Novel Toll-Like Receptor 9 Agonist Induces Epidermal Growth Factor Receptor (EGFR) Inhibition and Synergistic Antitumor Activity with EGFR Inhibitors

Vincenzo Damiano, Rosa Caputo, Roberto Bianco, Francesco P. D'Armiento, Antonio Leonardi, Sabino De Placido, A. Raffaele Bianco, Sudhir Agrawal, Fortunato Ciardiello, Giampaolo Tortora
Journal: Clinical Cancer Research
Clin Cancer Res (2006) 12 (2): 577–583.
https://doi.org/10.1158/1078-0432.CCR-05-1943
Published: 20 January 2006
View article titled, Novel Toll-Like Receptor 9 Agonist Induces Epidermal Growth Factor Receptor (EGFR) Inhibition and Synergistic Antitumor Activity with EGFR Inhibitors
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Journal Articles

Cooperative Antitumor Effect of Multitargeted Kinase Inhibitor ZD6474 and Ionizing Radiation in Glioblastoma

Vincenzo Damiano, Davide Melisi, Cataldo Bianco, David Raben, Rosa Caputo, Gabriella Fontanini, Roberto Bianco, Anderson Ryan, A. Raffaele Bianco, Sabino De Placido, Fortunato Ciardiello, Giampaolo Tortora
Journal: Clinical Cancer Research
Clin Cancer Res (2005) 11 (15): 5639–5644.
https://doi.org/10.1158/1078-0432.CCR-05-0174
Published: 01 August 2005
View article titled, Cooperative Antitumor Effect of Multitargeted Kinase Inhibitor ZD6474 and Ionizing Radiation in Glioblastoma
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Journal Articles

Combined Targeting of Epidermal Growth Factor Receptor and MDM2 by Gefitinib and Antisense MDM2 Cooperatively Inhibit Hormone-Independent Prostate Cancer

Roberto Bianco, Roberta Caputo, Rosa Caputo, Vincenzo Damiano, Sabino De Placido, Corrado Ficorella, Sudhir Agrawal, A. Raffaele Bianco, Fortunato Ciardiello, Giampaolo Tortora
Journal: Clinical Cancer Research
Clin Cancer Res (2004) 10 (14): 4858–4864.
https://doi.org/10.1158/1078-0432.CCR-03-0497
Published: 21 July 2004
View article titled, Combined Targeting of Epidermal Growth Factor Receptor and MDM2 by Gefitinib and Antisense MDM2 Cooperatively Inhibit Hormone-Independent Prostate Cancer
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Journal Articles

Antitumor Activity of ZD6474, a Vascular Endothelial Growth Factor Receptor Tyrosine Kinase Inhibitor, in Human Cancer Cells with Acquired Resistance to Antiepidermal Growth Factor Receptor Therapy

Fortunato Ciardiello, Roberto Bianco, Roberta Caputo, Rosa Caputo, Vincenzo Damiano, Teresa Troiani, Davide Melisi, Ferdinando De Vita, Sabino De Placido, A. Raffaele Bianco, Giampaolo Tortora
Journal: Clinical Cancer Research
Clin Cancer Res (2004) 10 (2): 784–793.
https://doi.org/10.1158/1078-0432.CCR-1100-03
Published: 03 February 2004
View article titled, Antitumor Activity of ZD6474, a Vascular Endothelial Growth Factor Receptor Tyrosine Kinase Inhibitor, in Human Cancer Cells with Acquired Resistance to Antiepidermal Growth Factor Receptor Therapy
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Journal Articles

Helicobacter pylori VacA Toxin Up-Regulates Vascular Endothelial Growth Factor Expression in MKN 28 Gastric Cells through an Epidermal Growth Factor Receptor-, Cyclooxygenase-2-dependent Mechanism

Rosa Caputo, Concetta Tuccillo, Barbara A. Manzo, Raffaele Zarrilli, Giampaolo Tortora, Camillo Del Vecchio Blanco, Vittorio Ricci, Fortunato Ciardiello, Marco Romano
Journal: Clinical Cancer Research
Clin Cancer Res (2003) 9 (6): 2015–2021.
Published: 01 June 2003
View article titled, <em>Helicobacter pylori</em> VacA Toxin Up-Regulates Vascular Endothelial Growth Factor Expression in MKN 28 Gastric Cells through an Epidermal Growth Factor Receptor-, Cyclooxygenase-2-dependent Mechanism
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Journal Articles

Combination of a Selective Cyclooxygenase-2 Inhibitor with Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor ZD1839 and Protein Kinase A Antisense Causes Cooperative Antitumor and Antiangiogenic Effect

Giampaolo Tortora, Rosa Caputo, Vincenzo Damiano, Davide Melisi, Roberto Bianco, Gabriella Fontanini, Bianca Maria Veneziani, Sabino De Placido, A. Raffaele Bianco, Fortunato Ciardiello
Journal: Clinical Cancer Research
Clin Cancer Res (2003) 9 (4): 1566–1572.
Published: 01 April 2003
View article titled, Combination of a Selective Cyclooxygenase-2 Inhibitor with Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor ZD1839 and Protein Kinase A Antisense Causes Cooperative Antitumor and Antiangiogenic Effect
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Journal Articles

Antitumor Effects of ZD6474, a Small Molecule Vascular Endothelial Growth Factor Receptor Tyrosine Kinase Inhibitor, with Additional Activity against Epidermal Growth Factor Receptor Tyrosine Kinase

Fortunato Ciardiello, Rosa Caputo, Vincenzo Damiano, Roberta Caputo, Teresa Troiani, Donatella Vitagliano, Francesca Carlomagno, Bianca Maria Veneziani, Gabriella Fontanini, A. Raffaele Bianco, Giampaolo Tortora
Journal: Clinical Cancer Research
Clin Cancer Res (2003) 9 (4): 1546–1556.
Published: 01 April 2003
View article titled, Antitumor Effects of ZD6474, a Small Molecule Vascular Endothelial Growth Factor Receptor Tyrosine Kinase Inhibitor, with Additional Activity against Epidermal Growth Factor Receptor Tyrosine Kinase
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Journal Articles

Combined Targeted Inhibition of bcl -2, bcl -XL, Epidermal Growth Factor Receptor, and Protein Kinase A Type I Causes Potent Antitumor, Apoptotic, and Antiangiogenic Activity

Giampaolo Tortora, Rosa Caputo, Vincenzo Damiano, Roberta Caputo, Teresa Troiani, Bianca Maria Veneziani, Sabino De Placido, Angelo Raffaele Bianco, Uwe Zangemeister-Wittke, Fortunato Ciardiello
Journal: Clinical Cancer Research
Clin Cancer Res (2003) 9 (2): 866–871.
Published: 01 February 2003
View article titled, Combined Targeted Inhibition of <em>bcl</em> -2, <em>bcl</em> -XL, Epidermal Growth Factor Receptor, and Protein Kinase A Type I Causes Potent Antitumor, Apoptotic, and Antiangiogenic Activity
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Journal Articles

Enhancement of Antitumor Activity of Ionizing Radiation by Combined Treatment with the Selective Epidermal Growth Factor Receptor-Tyrosine Kinase Inhibitor ZD1839 (Iressa)

Cataldo Bianco, Giampaolo Tortora, Roberto Bianco, Roberta Caputo, Bianca Maria Veneziani, Rosa Caputo, Vincenzo Damiano, Teresa Troiani, Gabriella Fontanini, David Raben, Stefano Pepe, A. Raffaele Bianco, Fortunato Ciardiello
Journal: Clinical Cancer Research
Clin Cancer Res (2002) 8 (10): 3250–3258.
Published: 01 October 2002
View article titled, Enhancement of Antitumor Activity of Ionizing Radiation by Combined Treatment with the Selective Epidermal Growth Factor Receptor-Tyrosine Kinase Inhibitor ZD1839 (Iressa)
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Journal Articles

Oral Administration of a Novel Taxane, an Antisense Oligonucleotide Targeting Protein Kinase A, and the Epidermal Growth Factor Receptor Inhibitor Iressa Causes Cooperative Antitumor and Antiangiogenic Activity

Giampaolo Tortora, Rosa Caputo, Vincenzo Damiano, Gabriella Fontanini, Davide Melisi, Bianca Maria Veneziani, Franco Zunino, A. Raffaele Bianco, Fortunato Ciardiello
Journal: Clinical Cancer Research
Clin Cancer Res (2001) 7 (12): 4156–4163.
Published: 01 December 2001
View article titled, Oral Administration of a Novel Taxane, an Antisense Oligonucleotide Targeting Protein Kinase A, and the Epidermal Growth Factor Receptor Inhibitor Iressa Causes Cooperative Antitumor and Antiangiogenic Activity
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Journal Articles

Combined Blockade of Protein Kinase A and Bcl-2 by Antisense Strategy Induces Apoptosis and Inhibits Tumor Growth and Angiogenesis

Giampaolo Tortora, Rosa Caputo, Vincenzo Damiano, Roberto Bianco, Gabriella Fontanini, Sabina Cuccato, Sabino De Placido, A. Raffaele Bianco, Fortunato Ciardiello
Journal: Clinical Cancer Research
Clin Cancer Res (2001) 7 (8): 2537–2544.
Published: 01 August 2001
View article titled, Combined Blockade of Protein Kinase A and Bcl-2 by Antisense Strategy Induces Apoptosis and Inhibits Tumor Growth and Angiogenesis
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Journal Articles

Inhibition of Growth Factor Production and Angiogenesis in Human Cancer Cells by ZD1839 (Iressa), a Selective Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor

Fortunato Ciardiello, Rosa Caputo, Roberto Bianco, Vincenzo Damiano, Gabriella Fontanini, Sabina Cuccato, Sabino De Placido, A. Raffaele Bianco, Giampaolo Tortora
Journal: Clinical Cancer Research
Clin Cancer Res (2001) 7 (5): 1459–1465.
Published: 01 May 2001
View article titled, Inhibition of Growth Factor Production and Angiogenesis in Human Cancer Cells by ZD1839 (Iressa), a Selective Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor
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Journal Articles

Antiangiogenic and Antitumor Activity of Anti-Epidermal Growth Factor Receptor C225 Monoclonal Antibody in Combination with Vascular Endothelial Growth Factor Antisense Oligonucleotide in Human GEO Colon Cancer Cells

Fortunato Ciardiello, Roberto Bianco, Vincenzo Damiano, Gabriella Fontanini, Rosa Caputo, Grazia Pomatico, Sabino De Placido, A. Raffaele Bianco, John Mendelsohn, Giampaolo Tortora
Journal: Clinical Cancer Research
Clin Cancer Res (2000) 6 (9): 3739–3747.
Published: 01 September 2000
View article titled, Antiangiogenic and Antitumor Activity of Anti-Epidermal Growth Factor Receptor C225 Monoclonal Antibody in Combination with Vascular Endothelial Growth Factor Antisense Oligonucleotide in Human GEO Colon Cancer Cells
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Journal Articles

Antitumor Effect and Potentiation of Cytotoxic Drugs Activity in Human Cancer Cells by ZD-1839 (Iressa), an Epidermal Growth Factor Receptor-selective Tyrosine Kinase Inhibitor

Fortunato Ciardiello, Rosa Caputo, Roberto Bianco, Vincenzo Damiano, Grazia Pomatico, Sabino De Placido, A. Raffaele Bianco, Giampaolo Tortora
Journal: Clinical Cancer Research
Clin Cancer Res (2000) 6 (5): 2053–2063.
Published: 01 May 2000
View article titled, Antitumor Effect and Potentiation of Cytotoxic Drugs Activity in Human Cancer Cells by ZD-1839 (Iressa), an Epidermal Growth Factor Receptor-selective Tyrosine Kinase Inhibitor
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Journal Articles

Cooperative Inhibitory Effect of Novel Mixed Backbone Oligonucleotide Targeting Protein Kinase A in Combination with Docetaxel and Anti-Epidermal Growth Factor-Receptor Antibody on Human Breast Cancer Cell Growth

Giampaolo Tortora, Rosa Caputo, Grazia Pomatico, Stefano Pepe, A. Raffaele Bianco, Sudhir Agrawal, John Mendelsohn, Fortunato Ciardiello
Journal: Clinical Cancer Research
Clin Cancer Res (1999) 5 (4): 875–881.
Published: 01 April 1999
View article titled, Cooperative Inhibitory Effect of Novel Mixed Backbone Oligonucleotide Targeting Protein Kinase A in Combination with Docetaxel and Anti-Epidermal Growth Factor-Receptor Antibody on Human Breast Cancer Cell Growth
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