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Ronald D. Alvarez
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Journal Articles

GEN-1 in Combination with Neoadjuvant Chemotherapy for Patients with Advanced Epithelial Ovarian Cancer: A Phase I Dose-escalation Study

Premal H. Thaker, William H. Bradley, Charles A. Leath, III, Camille Gunderson Jackson, Nicholas Borys, Khursheed Anwer, Lauren Musso, Junko Matsuzaki, Wiam Bshara, Kunle Odunsi, Ronald D. Alvarez
Journal: Clinical Cancer Research
Clin Cancer Res (2021) 27 (20): 5536–5545.
https://doi.org/10.1158/1078-0432.CCR-21-0360
Published: 15 October 2021
View article titled, GEN-1 in Combination with Neoadjuvant Chemotherapy for Patients with Advanced Epithelial Ovarian Cancer: A Phase I Dose-escalation Study
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Includes: Supplementary data
Journal Articles

Abstract A58: An ovarian patient-derived xenograft model to identify the chemoresistant population

Zachary C. Dobbin, Ashwini K. Katre, Monjri M. Shah, Britt K. Erickson, Hauping Chen, Ronald D. Alvarez, Michael G. Conner, Dongquan Chen, Charles N. Landen
Journal: Clinical Cancer Research
Clin Cancer Res (2013) 19 (19_Supplement): A58.
https://doi.org/10.1158/1078-0432.OVCA13-A58
Published: 13 May 2014
View article titled, Abstract A58: An ovarian patient-derived xenograft model to identify the chemoresistant population
Journal Articles

Enhanced Cancer Radiotherapy through Immunosuppressive Stromal Cell Destruction in Tumors

Chao-Yi Wu, Li-Hua Yang, Huang-Yu Yang, Jayne Knoff, Shiwen Peng, Yi-Hsin Lin, Chenguang Wang, Ronald D. Alvarez, Sara I. Pai, Richard B.S. Roden, Chien-Fu Hung, T-C Wu
Journal: Clinical Cancer Research
Clin Cancer Res (2014) 20 (3): 644–657.
https://doi.org/10.1158/1078-0432.CCR-13-1334
Published: 02 February 2014
View article titled, Enhanced Cancer Radiotherapy through Immunosuppressive Stromal Cell Destruction in Tumors
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Includes: Supplementary data
Journal Articles

A Phase I Clinical Trial of Ad5.SSTR/TK.RGD, a Novel Infectivity-Enhanced Bicistronic Adenovirus, in Patients with Recurrent Gynecologic Cancer

Kenneth H. Kim, Igor Dmitriev, Janis P. O'Malley, Minghui Wang, Souheil Saddekni, Zhiying You, Meredith A. Preuss, Raymond D. Harris, Rosemarie Aurigemma, Gene P. Siegal, Kurt R. Zinn, David T. Curiel, Ronald D. Alvarez
Journal: Clinical Cancer Research
Clin Cancer Res (2012) 18 (12): 3440–3451.
https://doi.org/10.1158/1078-0432.CCR-11-2852
Published: 14 June 2012
View article titled, A Phase I Clinical Trial of Ad5.SSTR/TK.RGD, a Novel Infectivity-Enhanced Bicistronic Adenovirus, in Patients with Recurrent Gynecologic Cancer
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Includes: Supplementary data
Journal Articles

Stem Cell Pathways Contribute to Clinical Chemoresistance in Ovarian Cancer

Adam D. Steg, Kerri S. Bevis, Ashwini A. Katre, Angela Ziebarth, Zachary C. Dobbin, Ronald D. Alvarez, Kui Zhang, Michael Conner, Charles N. Landen
Journal: Clinical Cancer Research
Clin Cancer Res (2012) 18 (3): 869–881.
https://doi.org/10.1158/1078-0432.CCR-11-2188
Published: 31 January 2012
View article titled, Stem Cell Pathways Contribute to Clinical Chemoresistance in Ovarian Cancer
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Includes: Supplementary data
Journal Articles

Targeting the Notch Ligand Jagged1 in Both Tumor Cells and Stroma in Ovarian Cancer

Adam D. Steg, Ashwini A. Katre, Blake Goodman, Hee-Dong Han, Alpa M. Nick, Rebecca L. Stone, Robert L. Coleman, Ronald D. Alvarez, Gabriel Lopez-Berestein, Anil K. Sood, Charles N. Landen
Journal: Clinical Cancer Research
Clin Cancer Res (2011) 17 (17): 5674–5685.
https://doi.org/10.1158/1078-0432.CCR-11-0432
Published: 01 September 2011
View article titled, Targeting the Notch Ligand Jagged1 in Both Tumor Cells and Stroma in Ovarian Cancer
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Journal Articles

A Phase I Study of a Tropism-Modified Conditionally Replicative Adenovirus for Recurrent Malignant Gynecologic Diseases

Kristopher J. Kimball, Meredith A. Preuss, Mack N. Barnes, Minghui Wang, Gene P. Siegal, Wen Wan, Huichien Kuo, Souheil Saddekni, Cecil R. Stockard, William E. Grizzle, Raymond D. Harris, Rosemarie Aurigemma, David T. Curiel, Ronald D. Alvarez
Journal: Clinical Cancer Research
Clin Cancer Res (2010) 16 (21): 5277–5287.
https://doi.org/10.1158/1078-0432.CCR-10-0791
Published: 31 October 2010
View article titled, A Phase I Study of a Tropism-Modified Conditionally Replicative Adenovirus for Recurrent Malignant Gynecologic Diseases
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Journal Articles

Identifying the Safety Profile of Ad5.SSTR/TK.RGD, a Novel Infectivity-Enhanced Bicistronic Adenovirus, in Anticipation of a Phase I Clinical Trial in Patients with Recurrent Ovarian Cancer

Kellie Matthews, Patricia E. Noker, Baohong Tian, Sheila D. Grimes, Ronna Fulton, Karen Schweikart, Raymond Harris, Rose Aurigemma, Minghui Wang, Mack N. Barnes, Gene P. Siegal, Akseli Hemminki, Kurt Zinn, David T. Curiel, Ronald D. Alvarez
Journal: Clinical Cancer Research
Clin Cancer Res (2009) 15 (12): 4131–4137.
https://doi.org/10.1158/1078-0432.CCR-08-3354
Published: 15 June 2009
View article titled, Identifying the Safety Profile of Ad5.SSTR/TK.RGD, a Novel Infectivity-Enhanced Bicistronic Adenovirus, in Anticipation of a Phase I Clinical Trial in Patients with Recurrent Ovarian Cancer
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Journal Articles

A Fiber-Modified Mesothelin Promoter–Based Conditionally Replicating Adenovirus for Treatment of Ovarian Cancer

Yuko Tsuruta, Larisa Pereboeva, Martina Breidenbach, Daniel T. Rein, Minghui Wang, Ronald D. Alvarez, Gene P. Siegal, Paul Dent, Paul B. Fisher, David T. Curiel
Journal: Clinical Cancer Research
Clin Cancer Res (2008) 14 (11): 3582–3588.
https://doi.org/10.1158/1078-0432.CCR-07-5053
Published: 02 June 2008
View article titled, A Fiber-Modified Mesothelin Promoter–Based Conditionally Replicating Adenovirus for Treatment of Ovarian Cancer
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Journal Articles

Pretreatment with Cisplatin Enhances E7-Specific CD8+ T-Cell–Mediated Antitumor Immunity Induced by DNA Vaccination

Chih-Wen Tseng, Chien-Fu Hung, Ronald D. Alvarez, Cornelia Trimble, Warner K. Huh, Daejin Kim, Chi-Mu Chuang, Cheng-Tao Lin, Ya-Chea Tsai, Liangmei He, Archana Monie, T-C. Wu
Journal: Clinical Cancer Research
Clin Cancer Res (2008) 14 (10): 3185–3192.
https://doi.org/10.1158/1078-0432.CCR-08-0037
Published: 15 May 2008
View article titled, Pretreatment with Cisplatin Enhances E7-Specific CD8<sup>+</sup> T-Cell–Mediated Antitumor Immunity Induced by DNA Vaccination
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Journal Articles

Brief Overview of Preclinical and Clinical Studies in the Development of Intraperitoneal Radioimmunotherapy for Ovarian Cancer

Ruby F. Meredith, Donald J. Buchsbaum, Ronald D. Alvarez, Albert F. LoBuglio
Journal: Clinical Cancer Research
Clin Cancer Res (2007) 13 (18): 5643s–5645s.
https://doi.org/10.1158/1078-0432.CCR-07-0985
Published: 17 September 2007
View article titled, Brief Overview of Preclinical and Clinical Studies in the Development of Intraperitoneal Radioimmunotherapy for Ovarian Cancer
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Journal Articles

A Mosaic Fiber Adenovirus Serotype 5 Vector Containing Reovirus σ1 and Adenovirus Serotype 3 Knob Fibers Increases Transduction in an Ovarian Cancer Ex vivo System via a Coxsackie and Adenovirus Receptor–Independent Pathway

Yuko Tsuruta, Larisa Pereboeva, Joel N. Glasgow, Daniel T. Rein, Yosuke Kawakami, Ronald D. Alvarez, Rodney P. Rocconi, Gene P. Siegal, Paul Dent, Paul B. Fisher, David T. Curiel
Journal: Clinical Cancer Research
Clin Cancer Res (2007) 13 (9): 2777–2783.
https://doi.org/10.1158/1078-0432.CCR-06-2706
Published: 01 May 2007
View article titled, A Mosaic Fiber Adenovirus Serotype 5 Vector Containing Reovirus σ1 and Adenovirus Serotype 3 Knob Fibers Increases Transduction in an Ovarian Cancer <em>Ex vivo</em> System via a Coxsackie and Adenovirus Receptor–Independent Pathway
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Journal Articles

A Novel Ex vivo Model System for Evaluation of Conditionally Replicative Adenoviruses Therapeutic Efficacy and Toxicity

Tyler O. Kirby, Angel Rivera, Daniel Rein, Minghui Wang, Ilya Ulasov, Martina Breidenbach, Manjula Kataram, Juan L. Contreras, Carlos Krumdieck, Masato Yamamoto, Marianne G. Rots, Hidde J. Haisma, Ronald D. Alvarez, Parameshwar J. Mahasreshti, David T. Curiel
Journal: Clinical Cancer Research
Clin Cancer Res (2004) 10 (24): 8697–8703.
https://doi.org/10.1158/1078-0432.CCR-04-1166
Published: 28 December 2004
View article titled, A Novel <em>Ex vivo</em> Model System for Evaluation of Conditionally Replicative Adenoviruses Therapeutic Efficacy and Toxicity
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Journal Articles

Transcriptional Blocks Limit Adenoviral Replication in Primary Ovarian Tumor

Meredith A. Preuss, John T. Lam, Minghui Wang, Charles A. Leath, III, Manjula Kataram, Parameshwar J. Mahasreshti, Ronald D. Alvarez, David T. Curiel
Journal: Clinical Cancer Research
Clin Cancer Res (2004) 10 (9): 3189–3194.
https://doi.org/10.1158/1078-0432.CCR-03-0802
Published: 06 May 2004
View article titled, Transcriptional Blocks Limit Adenoviral Replication in Primary Ovarian Tumor
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Journal Articles

Intravenous Delivery of Adenovirus-mediated Soluble FLT-1 Results in Liver Toxicity

Parameshwar J. Mahasreshti, Manjula Kataram, Ming H. Wang, Cecil R. Stockard, William E. Grizzle, Delicia Carey, Gene P. Siegal, Hidde J. Haisma, Ronald D. Alvarez, David T. Curiel
Journal: Clinical Cancer Research
Clin Cancer Res (2003) 9 (7): 2701–2710.
Published: 01 July 2003
View article titled, Intravenous Delivery of Adenovirus-mediated Soluble FLT-1 Results in Liver Toxicity
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Journal Articles

A Phase I Study of Combined Modality 90Yttrium-CC49 Intraperitoneal Radioimmunotherapy for Ovarian Cancer

Ronald D. Alvarez, Warner K. Huh, M. B. Khazaeli, Ruby F. Meredith, Edward E. Partridge, Larry C. Kilgore, William E. Grizzle, Sui Shen, J. Max Austin, Mack N. Barnes, Delicia Carey, Jeffrey Schlom, Albert F. LoBuglio
Journal: Clinical Cancer Research
Clin Cancer Res (2002) 8 (9): 2806–2811.
Published: 01 September 2002
View article titled, A Phase I Study of Combined Modality <sup>90</sup>Yttrium-CC49 Intraperitoneal Radioimmunotherapy for Ovarian Cancer
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Journal Articles

Targeting Adenovirus to the Serotype 3 Receptor Increases Gene Transfer Efficiency to Ovarian Cancer Cells

Anna Kanerva, Galina V. Mikheeva, Victor Krasnykh, Candace J. Coolidge, John T. Lam, Parameshwar J. Mahasreshti, Shannon D. Barker, Michael Straughn, Mack N. Barnes, Ronald D. Alvarez, Akseli Hemminki, David T. Curiel
Journal: Clinical Cancer Research
Clin Cancer Res (2002) 8 (1): 275–280.
Published: 01 January 2002
View article titled, Targeting Adenovirus to the Serotype 3 Receptor Increases Gene Transfer Efficiency to Ovarian Cancer Cells
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Journal Articles

Strategies to Accomplish Targeted Expression of Transgenes in Ovarian Cancer for Molecular Therapeutic Applications

Enrique Casado, Jesus Gomez-Navarro, Masato Yamamoto, Yasuo Adachi, Candace J. Coolidge, Waleed O. Arafat, Shannon D. Barker, Minghui H. Wang, Parameshwar J. Mahasreshti, Akseli Hemminki, Manuel Gonzalez-Baron, Mack N. Barnes, Terri B. Pustilnik, Gene P. Siegal, Ronald D. Alvarez, David T. Curiel
Journal: Clinical Cancer Research
Clin Cancer Res (2001) 7 (8): 2496–2504.
Published: 01 August 2001
View article titled, Strategies to Accomplish Targeted Expression of Transgenes in Ovarian Cancer for Molecular Therapeutic Applications
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Journal Articles

Adenovirus-mediated Soluble FLT-1 Gene Therapy for Ovarian Carcinoma

Parameshwar J. Mahasreshti, Jesus G. Navarro, Manjula Kataram, Ming H. Wang, Delicia Carey, Gene P. Siegal, Mack N. Barnes, Dirk M. Nettelbeck, Ronald D. Alvarez, Akseli Hemminki, David T. Curiel
Journal: Clinical Cancer Research
Clin Cancer Res (2001) 7 (7): 2057–2066.
Published: 01 July 2001
View article titled, Adenovirus-mediated Soluble FLT-1 Gene Therapy for Ovarian Carcinoma
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Journal Articles

Selectivity of TAG-72-targeted Adenovirus Gene Transfer to Primary Ovarian Carcinoma Cells versus Autologous Mesothelial Cells in Vitro

F. Joseph Kelly, C. Ryan Miller, Donald J. Buchsbaum, Jesus Gomez-Navarro, Mack N. Barnes, Ronald D. Alvarez, David T. Curiel
Journal: Clinical Cancer Research
Clin Cancer Res (2000) 6 (11): 4323–4333.
Published: 01 November 2000
View article titled, Selectivity of TAG-72-targeted Adenovirus Gene Transfer to Primary Ovarian Carcinoma Cells <em>versus</em> Autologous Mesothelial Cells <em>in Vitro</em>
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