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Rona Yaeger
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Journal Articles

Tumor-Agnostic Genomic and Clinical Analysis of BRAF Fusions Identifies Actionable Targets

Monica F. Chen, Soo-Ryum Yang, Jessica J. Tao, Antoine Desilets, Eli L. Diamond, Clare Wilhelm, Ezra Rosen, Yixiao Gong, Kerry Mullaney, Jean Torrisi, Robert J. Young, Romel Somwar, Helena A. Yu, Mark G. Kris, Gregory J. Riely, Maria E. Arcila, Marc Ladanyi, Mark T.A. Donoghue, Neal Rosen, Rona Yaeger, Alexander Drilon, Yonina R. Murciano-Goroff, Michael Offin
Journal: Clinical Cancer Research
Clin Cancer Res (2024) 30 (17): 3812–3823.
https://doi.org/10.1158/1078-0432.CCR-23-3981
Published: 03 September 2024
View article titled, Tumor-Agnostic Genomic and Clinical Analysis of <em>BRAF</em> Fusions Identifies Actionable Targets
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Includes: Supplementary data
Journal Articles

Molecular and Clinical Determinants of Acquired Resistance and Treatment Duration for Targeted Therapies in Colorectal Cancer

Emily Harrold, Fergus Keane, Henry Walch, Joanne F. Chou, Jenna Sinopoli, Silvia Palladino, Duaa H. Al-Rawi, Kalyani Chadalavada, Paolo Manca, Sree Chalasani, Jessica Yang, Andrea Cercek, Jinru Shia, Marinela Capanu, Samuel F. Bakhoum, Nikolaus Schultz, Walid K. Chatila, Rona Yaeger
Journal: Clinical Cancer Research
Clin Cancer Res (2024) 30 (12): 2672–2683.
https://doi.org/10.1158/1078-0432.CCR-23-4005
Published: 14 June 2024
View article titled, Molecular and Clinical Determinants of Acquired Resistance and Treatment Duration for Targeted Therapies in Colorectal Cancer
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Includes: Supplementary data
Journal Articles

Negative Hyperselection of Patients with HER2+ and RAS Wild-Type Metastatic Colorectal Cancer Receiving Dual HER2 Blockade: the PRESSING-HER2 Study

Giovanni Randon, Yoshiaki Nakamura, Rona Yaeger, Sara Lonardi, Chiara Cremolini, Elena Elez, Federico Nichetti, Filippo Ghelardi, Vincenzo Nasca, Francesca Bergamo, Veronica Conca, Javier Ros, Hideaki Bando, Giulia Maddalena, Simone Oldani, Michele Prisciandaro, Alessandra Raimondi, Alexa B. Schrock, Luca Agnelli, Henry Walch, Takayuki Yoshino, Filippo Pietrantonio
Journal: Clinical Cancer Research
Clin Cancer Res (2024) 30 (2): 436–443.
https://doi.org/10.1158/1078-0432.CCR-23-1379
Published: 17 January 2024
View article titled, Negative Hyperselection of Patients with HER2<sup>+</sup> and <em>RAS</em> Wild-Type Metastatic Colorectal Cancer Receiving Dual HER2 Blockade: the PRESSING-HER2 Study
Open the PDF for Negative Hyperselection of Patients with HER2<sup>+</sup> and <em>RAS</em> Wild-Type Metastatic Colorectal Cancer Receiving Dual HER2 Blockade: the PRESSING-HER2 Study in another window
Includes: Supplementary data
Journal Articles

Molecular Pathways and Mechanisms of BRAF in Cancer Therapy

Poulikos I. Poulikakos, Ryan J. Sullivan, Rona Yaeger
Journal: Clinical Cancer Research
Clin Cancer Res (2022) 28 (21): 4618–4628.
https://doi.org/10.1158/1078-0432.CCR-21-2138
Published: 01 November 2022
View article titled, Molecular Pathways and Mechanisms of BRAF in Cancer Therapy
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Journal Articles

KRASG12C Mutation Is Associated with Increased Risk of Recurrence in Surgically Resected Lung Adenocarcinoma

Gregory D. Jones, Raul Caso, Kay See Tan, Brooke Mastrogiacomo, Francisco Sanchez-Vega, Yuan Liu, James G. Connolly, Yonina R. Murciano-Goroff, Matthew J. Bott, Prasad S. Adusumilli, Daniela Molena, Gaetano Rocco, Valerie W. Rusch, Smita Sihag, Sandra Misale, Rona Yaeger, Alexander Drilon, Kathryn C. Arbour, Gregory J. Riely, Neal Rosen, Piro Lito, Haiying Zhang, David C. Lyden, Charles M. Rudin, David R. Jones, Bob T. Li, James M. Isbell
Journal: Clinical Cancer Research
Clin Cancer Res (2021) 27 (9): 2604–2612.
https://doi.org/10.1158/1078-0432.CCR-20-4772
Published: 01 May 2021
View article titled, <em>KRAS</em><sup>G12C</sup> Mutation Is Associated with Increased Risk of Recurrence in Surgically Resected Lung Adenocarcinoma
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Includes: Supplementary data
Journal Articles

Phase II Single-arm Study of Durvalumab and Tremelimumab with Concurrent Radiotherapy in Patients with Mismatch Repair–proficient Metastatic Colorectal Cancer

Neil H. Segal, Andrea Cercek, Geoffrey Ku, Abraham J. Wu, Andreas Rimner, Danny N. Khalil, Diane Reidy-Lagunes, John Cuaron, T. Jonathan Yang, Martin R. Weiser, Paul B. Romesser, Zsofia K. Stadler, Anna M. Varghese, Karuna Ganesh, Rona Yaeger, Louise C. Connell, David Faleck, Ghassan K. Abou-Alfa, Kathleen C. Mcauliffe, Pamela Vaiskauskas, Mark L. Solter, Martinique Ogle, Matthew J. Adamow, Aliya Holland, Pallavi Vedantam, Phillip Wong, Taha Merghoub, Efsevia Vakiani, Travis J. Hollmann, Krishna Juluru, Joanne F. Chou, Marinela Capanu, Joseph Erinjeri, Stephen Solomon, Yoshiya Yamada, Nancy Kemeny, Christopher H. Crane, Leonard B. Saltz
Journal: Clinical Cancer Research
Clin Cancer Res (2021) 27 (8): 2200–2208.
https://doi.org/10.1158/1078-0432.CCR-20-2474
Published: 15 April 2021
View article titled, Phase II Single-arm Study of Durvalumab and Tremelimumab with Concurrent Radiotherapy in Patients with Mismatch Repair–proficient Metastatic Colorectal Cancer
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Includes: Supplementary data
Journal Articles

Characterization and Clinical Outcomes of DNA Mismatch Repair–deficient Small Bowel Adenocarcinoma

Alicia Latham, Jinru Shia, Zalak Patel, Diane L. Reidy-Lagunes, Neil H. Segal, Rona Yaeger, Karuna Ganesh, Louise Connell, Nancy E. Kemeny, David P. Kelsen, Jaclyn F. Hechtman, Garrett M. Nash, Philip B. Paty, Ahmet Zehir, Kaitlin A. Tkachuk, Rania Sheikh, Arnold J. Markowitz, Diana Mandelker, Kenneth Offit, Michael F. Berger, Andrea Cercek, Julio Garcia-Aguilar, Leonard B. Saltz, Martin R. Weiser, Zsofia K. Stadler
Journal: Clinical Cancer Research
Clin Cancer Res (2021) 27 (5): 1429–1437.
https://doi.org/10.1158/1078-0432.CCR-20-2892
Published: 01 March 2021
View article titled, Characterization and Clinical Outcomes of DNA Mismatch Repair–deficient Small Bowel Adenocarcinoma
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Includes: Supplementary data
Journal Articles

Mismatch Repair–Deficient Rectal Cancer and Resistance to Neoadjuvant Chemotherapy

Andrea Cercek, Gustavo Dos Santos Fernandes, Campbell S. Roxburgh, Karuna Ganesh, Shu Ng, Francisco Sanchez-Vega, Rona Yaeger, Neil H. Segal, Diane L. Reidy-Lagunes, Anna M. Varghese, Arnold Markowitz, Chao Wu, Bryan Szeglin, Charles-Etienne Gabriel Sauvé, Erin Salo-Mullen, Christina Tran, Zalak Patel, Asha Krishnan, Kaitlyn Tkachuk, Garrett M. Nash, Jose Guillem, Philip B. Paty, Jinru Shia, Nikolaus Schultz, Julio Garcia-Aguilar, Luis A. Diaz, Karyn Goodman, Leonard B. Saltz, Martin R. Weiser, J. Joshua Smith, Zsofia K. Stadler
Journal: Clinical Cancer Research
Clin Cancer Res (2020) 26 (13): 3271–3279.
https://doi.org/10.1158/1078-0432.CCR-19-3728
Published: 01 July 2020
View article titled, Mismatch Repair–Deficient Rectal Cancer and Resistance to Neoadjuvant Chemotherapy
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Includes: Supplementary data
Journal Articles

BRAF-Mutant Transcriptional Subtypes Predict Outcome of Combined BRAF, MEK, and EGFR Blockade with Dabrafenib, Trametinib, and Panitumumab in Patients with Colorectal Cancer

Gary Middleton, Yiqun Yang, Catarina D. Campbell, Thierry André, Chloe E. Atreya, Jan H.M. Schellens, Takayuki Yoshino, Johanna C. Bendell, Antoine Hollebecque, Autumn J. McRee, Salvatore Siena, Michael S. Gordon, Josep Tabernero, Rona Yaeger, Peter J. O'Dwyer, Filip De Vos, Eric Van Cutsem, John M. Millholland, Jan C. Brase, Fatima Rangwala, Eduard Gasal, Ryan B. Corcoran
Journal: Clinical Cancer Research
Series: Author Choice
Clin Cancer Res (2020) 26 (11): 2466–2476.
https://doi.org/10.1158/1078-0432.CCR-19-3579
Published: 01 June 2020
View article titled, <em>BRAF</em>-Mutant Transcriptional Subtypes Predict Outcome of Combined BRAF, MEK, and EGFR Blockade with Dabrafenib, Trametinib, and Panitumumab in Patients with Colorectal Cancer
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Includes: Supplementary data
Journal Articles

Overcoming Adaptive Resistance to KRAS Inhibitors Through Vertical Pathway Targeting

Rona Yaeger, David B. Solit
Journal: Clinical Cancer Research
Clin Cancer Res (2020) 26 (7): 1538–1540.
https://doi.org/10.1158/1078-0432.CCR-19-4060
Published: 01 April 2020
View article titled, Overcoming Adaptive Resistance to KRAS Inhibitors Through Vertical Pathway Targeting
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Journal Articles

Coaltered Ras/B-raf and TP53 Is Associated with Extremes of Survivorship and Distinct Patterns of Metastasis in Patients with Metastatic Colorectal Cancer

Jashodeep Datta, J. Joshua Smith, Walid K. Chatila, John C. McAuliffe, Cyriac Kandoth, Efsevia Vakiani, Timothy L. Frankel, Karuna Ganesh, Isaac Wasserman, Marla Lipsyc-Sharf, Jose Guillem, Garrett M. Nash, Philip B. Paty, Martin R. Weiser, Leonard B. Saltz, Michael F. Berger, William R. Jarnagin, Vinod Balachandran, T. Peter Kingham, Nancy E. Kemeny, Andrea Cercek, Julio Garcia-Aguilar, Barry S. Taylor, Agnes Viale, Rona Yaeger, David B. Solit, Nikolaus Schultz, Michael I. D'Angelica
Journal: Clinical Cancer Research
Clin Cancer Res (2020) 26 (5): 1077–1085.
https://doi.org/10.1158/1078-0432.CCR-19-2390
Published: 02 March 2020
View article titled, Coaltered <em>Ras/B-raf</em> and <em>TP53</em> Is Associated with Extremes of Survivorship and Distinct Patterns of Metastasis in Patients with Metastatic Colorectal Cancer
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Includes: Supplementary data
Journal Articles

Response to Anti-EGFR Therapy in Patients with BRAF non-V600–Mutant Metastatic Colorectal Cancer

Rona Yaeger, Daisuke Kotani, Sebastián Mondaca, Aparna R. Parikh, Hideaki Bando, Emily E. Van Seventer, Hiroya Taniguchi, HuiYong Zhao, Claire N. Thant, Elisa de Stanchina, Neal Rosen, Ryan B. Corcoran, Takayuki Yoshino, Zhan Yao, Hiromichi Ebi
Journal: Clinical Cancer Research
Clin Cancer Res (2019) 25 (23): 7089–7097.
https://doi.org/10.1158/1078-0432.CCR-19-2004
Published: 02 December 2019
View article titled, Response to Anti-EGFR Therapy in Patients with BRAF non-V600–Mutant Metastatic Colorectal Cancer
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Includes: Supplementary data
Journal Articles

SMAD4 Loss in Colorectal Cancer Patients Correlates with Recurrence, Loss of Immune Infiltrate, and Chemoresistance

Isaac Wasserman, Lik Hang Lee, Shuji Ogino, Michael R. Marco, Chao Wu, Xi Chen, Jashodeep Datta, Eran Sadot, Bryan Szeglin, Jose G. Guillem, Philip B. Paty, Martin R. Weiser, Garrett M. Nash, Leonard Saltz, Afsar Barlas, Katia Manova-Todorova, Srijaya Prakash Babu Uppada, Arthur E. Elghouayel, Peter Ntiamoah, Jonathan N. Glickman, Tsuyoshi Hamada, Keisuke Kosumi, Kentaro Inamura, Andrew T. Chan, Reiko Nishihara, Andrea Cercek, Karuna Ganesh, Nancy E. Kemeny, Punita Dhawan, Rona Yaeger, Charles L. Sawyers, Julio Garcia-Aguilar, Marios Giannakis, Jinru Shia, J. Joshua Smith
Journal: Clinical Cancer Research
Clin Cancer Res (2019) 25 (6): 1948–1956.
https://doi.org/10.1158/1078-0432.CCR-18-1726
Published: 15 March 2019
View article titled, SMAD4 Loss in Colorectal Cancer Patients Correlates with Recurrence, Loss of Immune Infiltrate, and Chemoresistance
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Includes: Supplementary data
Journal Articles

Clinical Features and Outcomes of Patients with Colorectal Cancers Harboring NRAS Mutations

Andrea Cercek, Maria Ignez Braghiroli, Joanne F. Chou, Jaclyn F. Hechtman, Nancy Kemeny, Leonard Saltz, Marinela Capanu, Rona Yaeger
Journal: Clinical Cancer Research
Series: Author Choice
Clin Cancer Res (2017) 23 (16): 4753–4760.
https://doi.org/10.1158/1078-0432.CCR-17-0400
Published: 14 August 2017
View article titled, Clinical Features and Outcomes of Patients with Colorectal Cancers Harboring NRAS Mutations
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Includes: Supplementary data
Journal Articles

RAF plus EGFR Inhibition for BRAF-Mutant Metastatic Colorectal Cancer—Response

Rona Yaeger, Leonard B. Saltz
Journal: Clinical Cancer Research
Clin Cancer Res (2015) 21 (9): 2188.
https://doi.org/10.1158/1078-0432.CCR-15-0412
Published: 30 April 2015
View article titled, RAF plus EGFR Inhibition for BRAF-Mutant Metastatic Colorectal Cancer—Response
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Journal Articles

Pilot Trial of Combined BRAF and EGFR Inhibition in BRAF-Mutant Metastatic Colorectal Cancer Patients

Rona Yaeger, Andrea Cercek, Eileen M. O'Reilly, Diane L. Reidy, Nancy Kemeny, Tamar Wolinsky, Marinela Capanu, Marc J. Gollub, Neal Rosen, Michael F. Berger, Mario E. Lacouture, Efsevia Vakiani, Leonard B. Saltz
Journal: Clinical Cancer Research
Clin Cancer Res (2015) 21 (6): 1313–1320.
https://doi.org/10.1158/1078-0432.CCR-14-2779
Published: 12 March 2015
View article titled, Pilot Trial of Combined BRAF and EGFR Inhibition in <em>BRAF</em>-Mutant Metastatic Colorectal Cancer Patients
Open the PDF for Pilot Trial of Combined BRAF and EGFR Inhibition in <em>BRAF</em>-Mutant Metastatic Colorectal Cancer Patients in another window
Includes: Supplementary data