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Ron H.J. Mathijssen
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Journal Articles

Randomized Phase II Cabazitaxel Dose Individualization and Neutropenia Prevention Trial in Patients with Metastatic Castration-Resistant Prostate Cancer

Aurelius Omlin, Richard Cathomas, Gunhild von Amsberg, Christoph Reuter, Susan Feyerabend, Wolfgang Loidl, Martin Boegemann, Anja Lorch, Axel Heidenreich, Igor Tsaur, Julian Larcher-Senn, Stefan A.J. Buck, Ron H.J. Mathijssen, Ulrich Jaehde, Silke Gillessen, Markus Joerger
Journal: Clinical Cancer Research
Clin Cancer Res (2023) 29 (10): 1887–1893.
https://doi.org/10.1158/1078-0432.CCR-22-3360
Published: 15 May 2023
View article titled, Randomized Phase II Cabazitaxel Dose Individualization and Neutropenia Prevention Trial in Patients with Metastatic Castration-Resistant Prostate Cancer
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Includes: Supplementary data
Journal Articles

Correction: A Phase I Study of an MPS1 Inhibitor (BAY 1217389) in Combination with Paclitaxel Using a Novel Randomized Continual Reassessment Method for Dose Escalation

Florence Atrafi, Oliver Boix, Vivek Subbiah, Jennifer R. Diamond, Sant P. Chawla, Anthony W. Tolcher, Patricia M. LoRusso, Joseph P. Eder, Martin Gutierrez, Kumar Sankhala, Prabhu Rajagopalan, Isabelle Genvresse, Simon Langer, Ron H.J. Mathijssen, Jaap Verweij, Ingmar Bruns, Martijn P. Lolkema
Journal: Clinical Cancer Research
Clin Cancer Res (2022) 28 (13): 2969.
https://doi.org/10.1158/1078-0432.CCR-22-1792
Published: 01 July 2022
View article titled, Correction: A Phase I Study of an MPS1 Inhibitor (BAY 1217389) in Combination with Paclitaxel Using a Novel Randomized Continual Reassessment Method for Dose Escalation
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Journal Articles

Precision Dosing of Targeted Therapies Is Ready for Prime Time

Stefanie L. Groenland, Remy B. Verheijen, Markus Joerger, Ron H.J. Mathijssen, Alex Sparreboom, Jos H. Beijnen, Jan H. Beumer, Neeltje Steeghs, Alwin D.R. Huitema
Journal: Clinical Cancer Research
Clin Cancer Res (2021) 27 (24): 6644–6652.
https://doi.org/10.1158/1078-0432.CCR-20-4555
Published: 15 December 2021
View article titled, Precision Dosing of Targeted Therapies Is Ready for Prime Time
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Journal Articles

A Phase I Study of an MPS1 Inhibitor (BAY 1217389) in Combination with Paclitaxel Using a Novel Randomized Continual Reassessment Method for Dose Escalation

Florence Atrafi, Oliver Boix, Vivek Subbiah, Jennifer R. Diamond, Sant P. Chawla, Anthony W. Tolcher, Patricia M. LoRusso, Joseph P. Eder, Martin Gutierrez, Kumar Sankhala, Prabhu Rajagopalan, Isabelle Genvresse, Simon Langer, Ron H.J. Mathijssen, Jaap Verweij, Ingmar Bruns, Martijn P. Lolkema
Journal: Clinical Cancer Research
Clin Cancer Res (2021) 27 (23): 6366–6375.
https://doi.org/10.1158/1078-0432.CCR-20-4185
Published: 01 December 2021
View article titled, A Phase I Study of an MPS1 Inhibitor (BAY 1217389) in Combination with Paclitaxel Using a Novel Randomized Continual Reassessment Method for Dose Escalation
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Includes: Supplementary data
Journal Articles

Intratumoral Comparison of Nanoparticle Entrapped Docetaxel (CPC634) with Conventional Docetaxel in Patients with Solid Tumors

Florence Atrafi, Ruben A.G. van Eerden, Marte A.M van Hylckama Vlieg, Esther Oomen-de Hoop, Peter de Bruijn, Martijn P. Lolkema, Adriaan Moelker, Cristianne J. Rijcken, Rob Hanssen, Alex Sparreboom, Ferry A.L.M. Eskens, Ron H.J. Mathijssen, Stijn L.W. Koolen
Journal: Clinical Cancer Research
Clin Cancer Res (2020) 26 (14): 3537–3545.
https://doi.org/10.1158/1078-0432.CCR-20-0008
Published: 15 July 2020
View article titled, Intratumoral Comparison of Nanoparticle Entrapped Docetaxel (CPC634) with Conventional Docetaxel in Patients with Solid Tumors
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Includes: Supplementary data
Journal Articles

Pembrolizumab Exposure–Response Assessments Challenged by Association of Cancer Cachexia and Catabolic Clearance—Letter

Sander Bins, Stijn L.W. Koolen, Ron H.J. Mathijssen
Journal: Clinical Cancer Research
Clin Cancer Res (2019) 25 (10): 3192.
https://doi.org/10.1158/1078-0432.CCR-19-0164
Published: 15 May 2019
View article titled, Pembrolizumab Exposure–Response Assessments Challenged by Association of Cancer Cachexia and Catabolic Clearance—Letter
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Journal Articles

Impact of Concomitant Administration of Gastric Acid–Suppressive Agents and Pazopanib on Outcomes in Soft-Tissue Sarcoma Patients Treated within the EORTC 62043/62072 Trials

Olivier Mir, Nathan Touati, Michela Lia, Saskia Litière, Axel Le Cesne, Stefan Sleijfer, Jean-Yves Blay, Michael Leahy, Robin Young, Ron H.J. Mathijssen, Nielka P. Van Erp, Hans Gelderblom, Winette T. Van der Graaf, Alessandro Gronchi
Journal: Clinical Cancer Research
Series: Author Choice
Clin Cancer Res (2019) 25 (5): 1479–1485.
https://doi.org/10.1158/1078-0432.CCR-18-2748
Published: 01 March 2019
View article titled, Impact of Concomitant Administration of Gastric Acid–Suppressive Agents and Pazopanib on Outcomes in Soft-Tissue Sarcoma Patients Treated within the EORTC 62043/62072 Trials
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Includes: Supplementary data
Journal Articles

Phase I Study of CC-486 Alone and in Combination with Carboplatin or nab-Paclitaxel in Patients with Relapsed or Refractory Solid Tumors

Daniel D. Von Hoff, Drew W. Rasco, Elisabeth I. Heath, Pamela N. Munster, Jan H.M. Schellens, Nicolas Isambert, Christophe Le Tourneau, Bert O'Neil, Ron H.J. Mathijssen, Jose A. Lopez-Martin, W. Jeff Edenfield, Miguel Martin, Patricia M. LoRusso, Gordon L. Bray, Jorge DiMartino, Aaron Nguyen, Kejian Liu, Eric Laille, Johanna C. Bendell
Journal: Clinical Cancer Research
Clin Cancer Res (2018) 24 (17): 4072–4080.
https://doi.org/10.1158/1078-0432.CCR-17-3716
Published: 04 September 2018
View article titled, Phase I Study of CC-486 Alone and in Combination with Carboplatin or nab-Paclitaxel in Patients with Relapsed or Refractory Solid Tumors
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Includes: Supplementary data
Journal Articles

A Genetic Polymorphism in CTLA-4 Is Associated with Overall Survival in Sunitinib-Treated Patients with Clear Cell Metastatic Renal Cell Carcinoma

Xiaoyan Liu, Jesse J. Swen, Meta H.M. Diekstra, Epie Boven, Daniel Castellano, Hans Gelderblom, Ron H.J. Mathijssen, Sita H. Vermeulen, Egbert Oosterwijk, Kerstin Junker, Max Roessler, Kristin Alexiusdottir, Asgerdur Sverrisdottir, Marius T. Radu, Valentin Ambert, Tim Eisen, Anne Warren, Cristina Rodríguez-Antona, Jesus García-Donas, Stefan Böhringer, Karel K.M. Koudijs, Lambertus A.L.M. Kiemeney, Brian I. Rini, Henk-Jan Guchelaar
Journal: Clinical Cancer Research
Clin Cancer Res (2018) 24 (10): 2350–2356.
https://doi.org/10.1158/1078-0432.CCR-17-2815
Published: 14 May 2018
View article titled, A Genetic Polymorphism in <em>CTLA-4</em> Is Associated with Overall Survival in Sunitinib-Treated Patients with Clear Cell Metastatic Renal Cell Carcinoma
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Includes: Supplementary data
Journal Articles

Influence of Enzalutamide on Cabazitaxel Pharmacokinetics: a Drug–Drug Interaction Study in Metastatic Castration-resistant Prostate Cancer (mCRPC) Patients

Bodine P.S. Belderbos, Sander Bins, Roelof W.F. van Leeuwen, Esther Oomen-de Hoop, Nelly van der Meer, Peter de Bruijn, Paul Hamberg, Esther N.M. Overkleeft, Wendy M. van der Deure, Martijn P. Lolkema, Ronald de Wit, Ron H.J. Mathijssen
Journal: Clinical Cancer Research
Clin Cancer Res (2018) 24 (3): 541–546.
https://doi.org/10.1158/1078-0432.CCR-17-2336
Published: 31 January 2018
View article titled, Influence of Enzalutamide on Cabazitaxel Pharmacokinetics: a Drug–Drug Interaction Study in Metastatic Castration-resistant Prostate Cancer (mCRPC) Patients
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Journal Articles

Effects of Budesonide on Cabazitaxel Pharmacokinetics and Cabazitaxel-Induced Diarrhea: A Randomized, Open-Label Multicenter Phase II Study

Annemieke J.M. Nieuweboer, Anne-Joy M. de Graan, Paul Hamberg, Sander Bins, Robert J. van Soest, Robbert J. van Alphen, Andries M. Bergman, Aart Beeker, Henk van Halteren, Albert J. ten Tije, Hanneke Zuetenhorst, Nelly van der Meer, Dana Chitu, Ronald de Wit, Ron H.J. Mathijssen
Journal: Clinical Cancer Research
Clin Cancer Res (2017) 23 (7): 1679–1683.
https://doi.org/10.1158/1078-0432.CCR-16-2110
Published: 02 April 2017
View article titled, Effects of Budesonide on Cabazitaxel Pharmacokinetics and Cabazitaxel-Induced Diarrhea: A Randomized, Open-Label Multicenter Phase II Study
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Includes: Supplementary data
Journal Articles

Individualized Tamoxifen Dose Escalation—Letter

Stijn L.W. Koolen, Sander Bins, Ron H.J. Mathijssen
Journal: Clinical Cancer Research
Series: Author Choice
Clin Cancer Res (2016) 22 (24): 6300.
https://doi.org/10.1158/1078-0432.CCR-16-1967
Published: 15 December 2016
View article titled, Individualized Tamoxifen Dose Escalation—Letter
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Journal Articles

Individualized Pazopanib Dosing: A Prospective Feasibility Study in Cancer Patients

Remy B. Verheijen, Sander Bins, Ron H.J. Mathijssen, Martijn P. Lolkema, Leni van Doorn, Jan H.M. Schellens, Jos H. Beijnen, Marlies H.G. Langenberg, Alwin D.R. Huitema, Neeltje Steeghs
Journal: Clinical Cancer Research
Clin Cancer Res (2016) 22 (23): 5738–5746.
https://doi.org/10.1158/1078-0432.CCR-16-1255
Published: 30 November 2016
View article titled, Individualized Pazopanib Dosing: A Prospective Feasibility Study in Cancer Patients
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Journal Articles

Phase I Study of RGB-286638, A Novel, Multitargeted Cyclin-Dependent Kinase Inhibitor in Patients with Solid Tumors

Diane A.J. van der Biessen, Herman Burger, Peter de Bruijn, Cor H.J. Lamers, Nicole Naus, Hannes Loferer, Erik A.C. Wiemer, Ron H.J. Mathijssen, Maja J.A. de Jonge
Journal: Clinical Cancer Research
Clin Cancer Res (2014) 20 (18): 4776–4783.
https://doi.org/10.1158/1078-0432.CCR-14-0325
Published: 14 September 2014
View article titled, Phase I Study of RGB-286638, A Novel, Multitargeted Cyclin-Dependent Kinase Inhibitor in Patients with Solid Tumors
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Includes: Supplementary data
Journal Articles

Abstract A55: Influence of ABCB1 polymorphisms on paclitaxel pharmacokinetics in ovarian cancer patients

Bo Gao, Annemieke J.M. Nieuweboer, Hongmei Xu, Jonathan Beesley, Inge M. Ghobadi Moghaddam-Helmantel, Anne-Joy M. de Graan, Peter de Bruijn, Howard Gurney, Sharon E. Johnatty, Philip Beale, Georgia Chenevix-Trench, Rosemary L. Balleine, Ron H.J. Ron H.J. Mathijssen, Paul R. Harnett
Journal: Clinical Cancer Research
Clin Cancer Res (2013) 19 (19_Supplement): A55.
https://doi.org/10.1158/1078-0432.OVCA13-A55
Published: 13 May 2014
View article titled, Abstract A55: Influence of ABCB1 polymorphisms on paclitaxel pharmacokinetics in ovarian cancer patients
Journal Articles

A Pharmacogenetic Predictive Model for Paclitaxel Clearance Based on the DMET Platform

Anne-Joy M. de Graan, Laure Elens, Marcel Smid, John W. Martens, Alex Sparreboom, Annemieke J.M. Nieuweboer, Lena E. Friberg, Samira Elbouazzaoui, Erik A.C. Wiemer, Bronno van der Holt, Jaap Verweij, Ron H.N. van Schaik, Ron H.J. Mathijssen
Journal: Clinical Cancer Research
Clin Cancer Res (2013) 19 (18): 5210–5217.
https://doi.org/10.1158/1078-0432.CCR-13-0487
Published: 16 September 2013
View article titled, A Pharmacogenetic Predictive Model for Paclitaxel Clearance Based on the DMET Platform
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Journal Articles

Toward Prediction of Efficacy of Chemotherapy: A Proof of Concept Study in Lung Cancer Patients Using [11C]docetaxel and Positron Emission Tomography

Astrid A.M. van der Veldt, Mark Lubberink, Ron H.J. Mathijssen, Walter J. Loos, Gerarda J.M. Herder, Henri N. Greuter, Emile F.I. Comans, Hugo B. Rutten, Jonas Eriksson, Albert D. Windhorst, N. Harry Hendrikse, Pieter E. Postmus, Egbert F. Smit, Adriaan A. Lammertsma
Journal: Clinical Cancer Research
Clin Cancer Res (2013) 19 (15): 4163–4173.
https://doi.org/10.1158/1078-0432.CCR-12-3779
Published: 31 July 2013
View article titled, Toward Prediction of Efficacy of Chemotherapy: A Proof of Concept Study in Lung Cancer Patients Using [<sup>11</sup>C]docetaxel and Positron Emission Tomography
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Includes: Supplementary data
Journal Articles

CYP3A4*22 Genotype and Systemic Exposure Affect Paclitaxel-Induced Neurotoxicity

Anne-Joy M. de Graan, Laure Elens, Jason A. Sprowl, Alex Sparreboom, Lena E. Friberg, Bronno van der Holt, Pleun J. de Raaf, Peter de Bruijn, Frederike K. Engels, Ferry A.L.M. Eskens, Erik A.C. Wiemer, Jaap Verweij, Ron H.J. Mathijssen, Ron H.N. van Schaik
Journal: Clinical Cancer Research
Clin Cancer Res (2013) 19 (12): 3316–3324.
https://doi.org/10.1158/1078-0432.CCR-12-3786
Published: 13 June 2013
View article titled, <em>CYP3A4*22</em> Genotype and Systemic Exposure Affect Paclitaxel-Induced Neurotoxicity
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Includes: Supplementary data
Journal Articles

Long-term Prospective Population PK Study in GIST Patients—Response

Ron H.J. Mathijssen, Peter de Bruijn, Karel Eechoute, Alex Sparreboom
Journal: Clinical Cancer Research
Clin Cancer Res (2013) 19 (4): 950.
https://doi.org/10.1158/1078-0432.CCR-12-3807
Published: 14 February 2013
View article titled, Long-term Prospective Population PK Study in GIST Patients—Response
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Journal Articles

A Long-term Prospective Population Pharmacokinetic Study on Imatinib Plasma Concentrations in GIST Patients

Karel Eechoute, Martin N. Fransson, An K. Reyners, Floris A. de Jong, Alex Sparreboom, Winette T.A. van der Graaf, Lena E. Friberg, Gaia Schiavon, Erik A.C. Wiemer, Jaap Verweij, Walter J. Loos, Ron H.J. Mathijssen, Ugo De Giorgi
Journal: Clinical Cancer Research
Clin Cancer Res (2012) 18 (20): 5780–5787.
https://doi.org/10.1158/1078-0432.CCR-12-0490
Published: 14 October 2012
View article titled, A Long-term Prospective Population Pharmacokinetic Study on Imatinib Plasma Concentrations in GIST Patients
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Includes: Supplementary data