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Roberto Bianco
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Journal Articles

CCNE1 and PLK1 Mediate Resistance to Palbociclib in HR+/HER2− Metastatic Breast Cancer

Ángel Guerrero-Zotano, Stefania Belli, Christoph Zielinski, Miguel Gil-Gil, Antonio Fernandez-Serra, Manuel Ruiz-Borrego, Eva Maria Ciruelos Gil, Javier Pascual, Montserrat Muñoz-Mateu, Begoña Bermejo, Mireia Margeli Vila, Antonio Antón, Laura Murillo, Bella Nissenbaum, Yuan Liu, Jesús Herranz, Daniel Fernández-García, Rosalía Caballero, José Antonio López-Guerrero, Roberto Bianco, Luigi Formisano, Nicholas Turner, Miguel Martín
Journal: Clinical Cancer Research
Clin Cancer Res (2023) 29 (8): 1557–1568.
https://doi.org/10.1158/1078-0432.CCR-22-2206
Published: 14 April 2023
View article titled, <em>CCNE1</em> and <em>PLK1</em> Mediate Resistance to Palbociclib in HR+/HER2− Metastatic Breast Cancer
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Includes: Supplementary data
Journal Articles

Nuclear FGFR1 Regulates Gene Transcription and Promotes Antiestrogen Resistance in ER+ Breast Cancer

Alberto Servetto, Rahul Kollipara, Luigi Formisano, Chang-Ching Lin, Kyung-Min Lee, Dhivya R. Sudhan, Paula I. Gonzalez-Ericsson, Sumanta Chatterjee, Angel Guerrero-Zotano, Saurabh Mendiratta, Hiroaki Akamatsu, Nicholas James, Roberto Bianco, Ariella B. Hanker, Ralf Kittler, Carlos L. Arteaga
Journal: Clinical Cancer Research
Clin Cancer Res (2021) 27 (15): 4379–4396.
https://doi.org/10.1158/1078-0432.CCR-20-3905
Published: 01 August 2021
View article titled, Nuclear FGFR1 Regulates Gene Transcription and Promotes Antiestrogen Resistance in ER<sup>+</sup> Breast Cancer
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Includes: Supplementary data
Journal Articles

Correction: Association of FGFR1 with ERα Maintains Ligand-Independent ER Transcription and Mediates Resistance to Estrogen Deprivation in ER+ Breast Cancer

Luigi Formisano, Kimberly M. Stauffer, Christian D. Young, Neil E. Bhola, Angel L. Guerrero-Zotano, Valerie M. Jansen, Mónica M. Estrada, Katherine E. Hutchinson, Jennifer M. Giltnane, Luis J. Schwarz, Yao Lu, Justin M. Balko, Olivier Deas, Stefano Cairo, Jean-Gabriel Judde, Ingrid A. Mayer, Melinda Sanders, Teresa C. Dugger, Roberto Bianco, Thomas Stricker, Carlos L. Arteaga
Journal: Clinical Cancer Research
Clin Cancer Res (2019) 25 (4): 1433.
https://doi.org/10.1158/1078-0432.CCR-18-4268
Published: 15 February 2019
View article titled, Correction: Association of FGFR1 with ERα Maintains Ligand-Independent ER Transcription and Mediates Resistance to Estrogen Deprivation in ER<sup>+</sup> Breast Cancer
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Journal Articles

Association of FGFR1 with ERα Maintains Ligand-Independent ER Transcription and Mediates Resistance to Estrogen Deprivation in ER+ Breast Cancer

Luigi Formisano, Kimberly M. Stauffer, Christian D. Young, Neil E. Bhola, Angel L. Guerrero-Zotano, Valerie M. Jansen, Mónica M. Estrada, Katherine E. Hutchinson, Jennifer M. Giltnane, Luis J. Schwarz, Yao Lu, Justin M. Balko, Olivier Deas, Stefano Cairo, Jean-Gabriel Judde, Ingrid A. Mayer, Melinda Sanders, Teresa C. Dugger, Roberto Bianco, Thomas Stricker, Carlos L. Arteaga
Journal: Clinical Cancer Research
Clin Cancer Res (2017) 23 (20): 6138–6150.
https://doi.org/10.1158/1078-0432.CCR-17-1232
Published: 12 October 2017
View article titled, Association of FGFR1 with ERα Maintains Ligand-Independent ER Transcription and Mediates Resistance to Estrogen Deprivation in ER<sup>+</sup> Breast Cancer
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Includes: Supplementary data
Journal Articles

SMO Gene Amplification and Activation of the Hedgehog Pathway as Novel Mechanisms of Resistance to Anti-Epidermal Growth Factor Receptor Drugs in Human Lung Cancer

Carminia Maria Della Corte, Claudio Bellevicine, Giovanni Vicidomini, Donata Vitagliano, Umberto Malapelle, Marina Accardo, Alessio Fabozzi, Alfonso Fiorelli, Morena Fasano, Federica Papaccio, Erika Martinelli, Teresa Troiani, Giancarlo Troncone, Mario Santini, Roberto Bianco, Fortunato Ciardiello, Floriana Morgillo
Journal: Clinical Cancer Research
Series: Author Choice
Clin Cancer Res (2015) 21 (20): 4686–4697.
https://doi.org/10.1158/1078-0432.CCR-14-3319
Published: 14 October 2015
View article titled, SMO Gene Amplification and Activation of the Hedgehog Pathway as Novel Mechanisms of Resistance to Anti-Epidermal Growth Factor Receptor Drugs in Human Lung Cancer
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Includes: Supplementary data
Journal Articles

Maintenance Treatment with Cetuximab and BAY86-9766 Increases Antitumor Efficacy of Irinotecan plus Cetuximab in Human Colorectal Cancer Xenograft Models

Teresa Troiani, Stefania Napolitano, Giulia Martini, Erika Martinelli, Claudia Cardone, Nicola Normanno, Donata Vitagliano, Floriana Morgillo, Francesca Fenizia, Matilde Lambiase, Luigi Formisano, Roberto Bianco, Davide Ciardiello, Fortunato Ciardiello
Journal: Clinical Cancer Research
Clin Cancer Res (2015) 21 (18): 4153–4164.
https://doi.org/10.1158/1078-0432.CCR-15-0211
Published: 14 September 2015
View article titled, Maintenance Treatment with Cetuximab and BAY86-9766 Increases Antitumor Efficacy of Irinotecan plus Cetuximab in Human Colorectal Cancer Xenograft Models
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Journal Articles

Increased TGF-α as a Mechanism of Acquired Resistance to the Anti-EGFR Inhibitor Cetuximab through EGFR–MET Interaction and Activation of MET Signaling in Colon Cancer Cells

Teresa Troiani, Erika Martinelli, Stefania Napolitano, Donata Vitagliano, Loreta Pia Ciuffreda, Sara Costantino, Floriana Morgillo, Anna Capasso, Vincenzo Sforza, Anna Nappi, Raffaele De Palma, Elena D'Aiuto, Liberato Berrino, Roberto Bianco, Fortunato Ciardiello
Journal: Clinical Cancer Research
Clin Cancer Res (2013) 19 (24): 6751–6765.
https://doi.org/10.1158/1078-0432.CCR-13-0423
Published: 16 December 2013
View article titled, Increased TGF-α as a Mechanism of Acquired Resistance to the Anti-EGFR Inhibitor Cetuximab through EGFR–MET Interaction and Activation of MET Signaling in Colon Cancer Cells
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Includes: Supplementary data
Journal Articles

Sphingosine Kinase 1 Overexpression Contributes to Cetuximab Resistance in Human Colorectal Cancer Models

Roberta Rosa, Roberta Marciano, Umberto Malapelle, Luigi Formisano, Lucia Nappi, Claudia D'Amato, Valentina D'Amato, Vincenzo Damiano, Gabriella Marfè, Silvana Del Vecchio, Antonella Zannetti, Adelaide Greco, Alfonso De Stefano, Chiara Carlomagno, Bianca Maria Veneziani, Giancarlo Troncone, Sabino De Placido, Roberto Bianco
Journal: Clinical Cancer Research
Clin Cancer Res (2013) 19 (1): 138–147.
https://doi.org/10.1158/1078-0432.CCR-12-1050
Published: 02 January 2013
View article titled, Sphingosine Kinase 1 Overexpression Contributes to Cetuximab Resistance in Human Colorectal Cancer Models
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Includes: Supplementary data
Journal Articles

Toll-like Receptor 9 Agonist IMO Cooperates with Cetuximab in K-Ras Mutant Colorectal and Pancreatic Cancers

Roberta Rosa, Davide Melisi, Vincenzo Damiano, Roberto Bianco, Sonia Garofalo, Teresa Gelardi, Sudhir Agrawal, Federica Di Nicolantonio, Aldo Scarpa, Alberto Bardelli, Giampaolo Tortora
Journal: Clinical Cancer Research
Clin Cancer Res (2011) 17 (20): 6531–6541.
https://doi.org/10.1158/1078-0432.CCR-10-3376
Published: 14 October 2011
View article titled, Toll-like Receptor 9 Agonist IMO Cooperates with Cetuximab in <em>K</em>-<em>Ras</em> Mutant Colorectal and Pancreatic Cancers
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Includes: Supplementary data
Journal Articles

A Novel Toll-Like Receptor 9 Agonist Cooperates with Trastuzumab in Trastuzumab-Resistant Breast Tumors through Multiple Mechanisms of Action

Vincenzo Damiano, Sonia Garofalo, Roberta Rosa, Roberto Bianco, Rosa Caputo, Teresa Gelardi, Gerardina Merola, Luigi Racioppi, Corrado Garbi, Ekambar R. Kandimalla, Sudhir Agrawal, Giampaolo Tortora
Journal: Clinical Cancer Research
Clin Cancer Res (2009) 15 (22): 6921–6930.
https://doi.org/10.1158/1078-0432.CCR-09-1599
Published: 11 November 2009
View article titled, A Novel Toll-Like Receptor 9 Agonist Cooperates with Trastuzumab in Trastuzumab-Resistant Breast Tumors through Multiple Mechanisms of Action
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Journal Articles

Vascular Endothelial Growth Factor Receptor-1 Contributes to Resistance to Anti–Epidermal Growth Factor Receptor Drugs in Human Cancer Cells

Roberto Bianco, Roberta Rosa, Vincenzo Damiano, Gennaro Daniele, Teresa Gelardi, Sonia Garofalo, Valeria Tarallo, Sandro De Falco, Davide Melisi, Roberto Benelli, Adriana Albini, Anderson Ryan, Fortunato Ciardiello, Giampaolo Tortora
Journal: Clinical Cancer Research
Clin Cancer Res (2008) 14 (16): 5069–5080.
https://doi.org/10.1158/1078-0432.CCR-07-4905
Published: 12 August 2008
View article titled, Vascular Endothelial Growth Factor Receptor-1 Contributes to Resistance to Anti–Epidermal Growth Factor Receptor Drugs in Human Cancer Cells
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Includes: Supplementary data
Journal Articles

Gefitinib Induction of In vivo Detectable Signals by Bcl-2/Bcl-xL Modulation of Inositol Trisphosphate Receptor Type 3

Antonella Zannetti, Francesca Iommelli, Rosa Fonti, Angela Papaccioli, Jvana Sommella, Anna Lettieri, Giuseppe Pirozzi, Roberto Bianco, Giampaolo Tortora, Marco Salvatore, Silvana Del Vecchio
Journal: Clinical Cancer Research
Clin Cancer Res (2008) 14 (16): 5209–5219.
https://doi.org/10.1158/1078-0432.CCR-08-0374
Published: 12 August 2008
View article titled, Gefitinib Induction of <em>In vivo</em> Detectable Signals by Bcl-2/Bcl-x<sub>L</sub> Modulation of Inositol Trisphosphate Receptor Type 3
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Journal Articles

Novel Toll-Like Receptor 9 Agonist Induces Epidermal Growth Factor Receptor (EGFR) Inhibition and Synergistic Antitumor Activity with EGFR Inhibitors

Vincenzo Damiano, Rosa Caputo, Roberto Bianco, Francesco P. D'Armiento, Antonio Leonardi, Sabino De Placido, A. Raffaele Bianco, Sudhir Agrawal, Fortunato Ciardiello, Giampaolo Tortora
Journal: Clinical Cancer Research
Clin Cancer Res (2006) 12 (2): 577–583.
https://doi.org/10.1158/1078-0432.CCR-05-1943
Published: 20 January 2006
View article titled, Novel Toll-Like Receptor 9 Agonist Induces Epidermal Growth Factor Receptor (EGFR) Inhibition and Synergistic Antitumor Activity with EGFR Inhibitors
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Journal Articles

Cooperative Antitumor Effect of Multitargeted Kinase Inhibitor ZD6474 and Ionizing Radiation in Glioblastoma

Vincenzo Damiano, Davide Melisi, Cataldo Bianco, David Raben, Rosa Caputo, Gabriella Fontanini, Roberto Bianco, Anderson Ryan, A. Raffaele Bianco, Sabino De Placido, Fortunato Ciardiello, Giampaolo Tortora
Journal: Clinical Cancer Research
Clin Cancer Res (2005) 11 (15): 5639–5644.
https://doi.org/10.1158/1078-0432.CCR-05-0174
Published: 01 August 2005
View article titled, Cooperative Antitumor Effect of Multitargeted Kinase Inhibitor ZD6474 and Ionizing Radiation in Glioblastoma
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Journal Articles

Antitumor Activity of ZD6474, a Vascular Endothelial Growth Factor-2 and Epidermal Growth Factor Receptor Small Molecule Tyrosine Kinase Inhibitor, in Combination with SC-236, a Cyclooxygenase-2 Inhibitor

Concetta Tuccillo, Marco Romano, Teresa Troiani, Erika Martinelli, Floriana Morgillo, Ferdinando De Vita, Roberto Bianco, Gabriella Fontanini, Raffaele A. Bianco, Giampaolo Tortora, Fortunato Ciardiello
Journal: Clinical Cancer Research
Clin Cancer Res (2005) 11 (3): 1268–1276.
https://doi.org/10.1158/1078-0432.1268.11.3
Published: 11 February 2005
View article titled, Antitumor Activity of ZD6474, a Vascular Endothelial Growth Factor-2 and Epidermal Growth Factor Receptor Small Molecule Tyrosine Kinase Inhibitor, in Combination with SC-236, a Cyclooxygenase-2 Inhibitor
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Journal Articles

Combined Targeting of Epidermal Growth Factor Receptor and MDM2 by Gefitinib and Antisense MDM2 Cooperatively Inhibit Hormone-Independent Prostate Cancer

Roberto Bianco, Roberta Caputo, Rosa Caputo, Vincenzo Damiano, Sabino De Placido, Corrado Ficorella, Sudhir Agrawal, A. Raffaele Bianco, Fortunato Ciardiello, Giampaolo Tortora
Journal: Clinical Cancer Research
Clin Cancer Res (2004) 10 (14): 4858–4864.
https://doi.org/10.1158/1078-0432.CCR-03-0497
Published: 21 July 2004
View article titled, Combined Targeting of Epidermal Growth Factor Receptor and MDM2 by Gefitinib and Antisense MDM2 Cooperatively Inhibit Hormone-Independent Prostate Cancer
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Journal Articles

Antitumor Activity of ZD6474, a Vascular Endothelial Growth Factor Receptor Tyrosine Kinase Inhibitor, in Human Cancer Cells with Acquired Resistance to Antiepidermal Growth Factor Receptor Therapy

Fortunato Ciardiello, Roberto Bianco, Roberta Caputo, Rosa Caputo, Vincenzo Damiano, Teresa Troiani, Davide Melisi, Ferdinando De Vita, Sabino De Placido, A. Raffaele Bianco, Giampaolo Tortora
Journal: Clinical Cancer Research
Clin Cancer Res (2004) 10 (2): 784–793.
https://doi.org/10.1158/1078-0432.CCR-1100-03
Published: 03 February 2004
View article titled, Antitumor Activity of ZD6474, a Vascular Endothelial Growth Factor Receptor Tyrosine Kinase Inhibitor, in Human Cancer Cells with Acquired Resistance to Antiepidermal Growth Factor Receptor Therapy
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Journal Articles

Combination of a Selective Cyclooxygenase-2 Inhibitor with Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor ZD1839 and Protein Kinase A Antisense Causes Cooperative Antitumor and Antiangiogenic Effect

Giampaolo Tortora, Rosa Caputo, Vincenzo Damiano, Davide Melisi, Roberto Bianco, Gabriella Fontanini, Bianca Maria Veneziani, Sabino De Placido, A. Raffaele Bianco, Fortunato Ciardiello
Journal: Clinical Cancer Research
Clin Cancer Res (2003) 9 (4): 1566–1572.
Published: 01 April 2003
View article titled, Combination of a Selective Cyclooxygenase-2 Inhibitor with Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor ZD1839 and Protein Kinase A Antisense Causes Cooperative Antitumor and Antiangiogenic Effect
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Journal Articles

Enhancement of Antitumor Activity of Ionizing Radiation by Combined Treatment with the Selective Epidermal Growth Factor Receptor-Tyrosine Kinase Inhibitor ZD1839 (Iressa)

Cataldo Bianco, Giampaolo Tortora, Roberto Bianco, Roberta Caputo, Bianca Maria Veneziani, Rosa Caputo, Vincenzo Damiano, Teresa Troiani, Gabriella Fontanini, David Raben, Stefano Pepe, A. Raffaele Bianco, Fortunato Ciardiello
Journal: Clinical Cancer Research
Clin Cancer Res (2002) 8 (10): 3250–3258.
Published: 01 October 2002
View article titled, Enhancement of Antitumor Activity of Ionizing Radiation by Combined Treatment with the Selective Epidermal Growth Factor Receptor-Tyrosine Kinase Inhibitor ZD1839 (Iressa)
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Journal Articles

Combined Blockade of Protein Kinase A and Bcl-2 by Antisense Strategy Induces Apoptosis and Inhibits Tumor Growth and Angiogenesis

Giampaolo Tortora, Rosa Caputo, Vincenzo Damiano, Roberto Bianco, Gabriella Fontanini, Sabina Cuccato, Sabino De Placido, A. Raffaele Bianco, Fortunato Ciardiello
Journal: Clinical Cancer Research
Clin Cancer Res (2001) 7 (8): 2537–2544.
Published: 01 August 2001
View article titled, Combined Blockade of Protein Kinase A and Bcl-2 by Antisense Strategy Induces Apoptosis and Inhibits Tumor Growth and Angiogenesis
Open the PDF for Combined Blockade of Protein Kinase A and Bcl-2 by Antisense Strategy Induces Apoptosis and Inhibits Tumor Growth and Angiogenesis in another window