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Robert H. Vonderheide
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Journal Articles

Neoadjuvant Selicrelumab, an Agonist CD40 Antibody, Induces Changes in the Tumor Microenvironment in Patients with Resectable Pancreatic Cancer

Katelyn T. Byrne, Courtney B. Betts, Rosemarie Mick, Shamilene Sivagnanam, David L. Bajor, Daniel A. Laheru, E. Gabriela Chiorean, Mark H. O'Hara, Shannon M. Liudahl, Craig Newcomb, Cécile Alanio, Ana P. Ferreira, Byung S. Park, Takuya Ohtani, Austin P. Huffman, Sara A. Väyrynen, Andressa Dias Costa, Judith C. Kaiser, Andreanne M. Lacroix, Colleen Redlinger, Martin Stern, Jonathan A. Nowak, E. John Wherry, Martin A. Cheever, Brian M. Wolpin, Emma E. Furth, Elizabeth M. Jaffee, Lisa M. Coussens, Robert H. Vonderheide
Journal: Clinical Cancer Research
Clin Cancer Res (2021) 27 (16): 4574–4586.
https://doi.org/10.1158/1078-0432.CCR-21-1047
Published: 15 August 2021
View article titled, Neoadjuvant Selicrelumab, an Agonist CD40 Antibody, Induces Changes in the Tumor Microenvironment in Patients with Resectable Pancreatic Cancer
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Includes: Supplementary data
Journal Articles

Alternatives to Perpetual Chemotherapy for Metastatic Pancreatic Cancer

Kim A. Reiss, Robert H. Vonderheide
Journal: Clinical Cancer Research
Clin Cancer Res (2021) 27 (13): 3540–3542.
https://doi.org/10.1158/1078-0432.CCR-21-0612
Published: 01 July 2021
View article titled, Alternatives to Perpetual Chemotherapy for Metastatic Pancreatic Cancer
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Journal Articles

Evaluation of Cyclophosphamide/GVAX Pancreas Followed by Listeria-Mesothelin (CRS-207) with or without Nivolumab in Patients with Pancreatic Cancer

Takahiro Tsujikawa, Todd Crocenzi, Jennifer N. Durham, Elizabeth A. Sugar, Annie A. Wu, Beth Onners, Julie M. Nauroth, Robert A. Anders, Elana J. Fertig, Daniel A. Laheru, Kim Reiss, Robert H. Vonderheide, Andrew H. Ko, Margaret A. Tempero, George A. Fisher, Michael Considine, Ludmila Danilova, Dirk G. Brockstedt, Lisa M. Coussens, Elizabeth M. Jaffee, Dung T. Le
Journal: Clinical Cancer Research
Clin Cancer Res (2020) 26 (14): 3578–3588.
https://doi.org/10.1158/1078-0432.CCR-19-3978
Published: 15 July 2020
View article titled, Evaluation of Cyclophosphamide/GVAX Pancreas Followed by Listeria-Mesothelin (CRS-207) with or without Nivolumab in Patients with Pancreatic Cancer
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Includes: Supplementary data
Journal Articles

Genomic Signatures Predict the Immunogenicity of BRCA-Deficient Breast Cancer

Adam A. Kraya, Kara N. Maxwell, Bradley Wubbenhorst, Brandon M. Wenz, John Pluta, Andrew J. Rech, Liza M. Dorfman, Nicole Lunceford, Amanda Barrett, Nandita Mitra, Jennifer J.D. Morrissette, Michael Feldman, Anupma Nayak, Susan M. Domchek, Robert H. Vonderheide, Katherine L. Nathanson
Journal: Clinical Cancer Research
Clin Cancer Res (2019) 25 (14): 4363–4374.
https://doi.org/10.1158/1078-0432.CCR-18-0468
Published: 15 July 2019
View article titled, Genomic Signatures Predict the Immunogenicity of BRCA-Deficient Breast Cancer
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Includes: Supplementary data
Journal Articles

Immune Cytolytic Activity Stratifies Molecular Subsets of Human Pancreatic Cancer

David Balli, Andrew J. Rech, Ben Z. Stanger, Robert H. Vonderheide
Journal: Clinical Cancer Research
Clin Cancer Res (2017) 23 (12): 3129–3138.
https://doi.org/10.1158/1078-0432.CCR-16-2128
Published: 14 June 2017
View article titled, Immune Cytolytic Activity Stratifies Molecular Subsets of Human Pancreatic Cancer
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Includes: Supplementary data
Journal Articles

Immunotherapy for Breast Cancer: What Are We Missing?

Robert H. Vonderheide, Susan M. Domchek, Amy S. Clark
Journal: Clinical Cancer Research
Clin Cancer Res (2017) 23 (11): 2640–2646.
https://doi.org/10.1158/1078-0432.CCR-16-2569
Published: 31 May 2017
View article titled, Immunotherapy for Breast Cancer: What Are We Missing?
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Journal Articles

A Phase I Study of an Agonist CD40 Monoclonal Antibody (CP-870,893) in Combination with Gemcitabine in Patients with Advanced Pancreatic Ductal Adenocarcinoma

Gregory L. Beatty, Drew A. Torigian, E. Gabriela Chiorean, Babak Saboury, Alex Brothers, Abass Alavi, Andrea B. Troxel, Weijing Sun, Ursina R. Teitelbaum, Robert H. Vonderheide, Peter J. O'Dwyer
Journal: Clinical Cancer Research
Clin Cancer Res (2013) 19 (22): 6286–6295.
https://doi.org/10.1158/1078-0432.CCR-13-1320
Published: 14 November 2013
View article titled, A Phase I Study of an Agonist CD40 Monoclonal Antibody (CP-870,893) in Combination with Gemcitabine in Patients with Advanced Pancreatic Ductal Adenocarcinoma
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Includes: Supplementary data
Journal Articles

Agonistic CD40 Antibodies and Cancer Therapy

Robert H. Vonderheide, Martin J. Glennie
Journal: Clinical Cancer Research
Clin Cancer Res (2013) 19 (5): 1035–1043.
https://doi.org/10.1158/1078-0432.CCR-12-2064
Published: 03 March 2013
View article titled, Agonistic CD40 Antibodies and Cancer Therapy
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Journal Articles

Rehabilitation for Oncogene Addiction: Role of Immunity in Cellular Sobriety

David L. Bajor, Robert H. Vonderheide
Journal: Clinical Cancer Research
Clin Cancer Res (2012) 18 (5): 1192–1194.
https://doi.org/10.1158/1078-0432.CCR-11-3322
Published: 01 March 2012
View article titled, Rehabilitation for Oncogene Addiction: Role of Immunity in Cellular Sobriety
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Includes: Supplementary data
Journal Articles

Tremelimumab in Combination with Exemestane in Patients with Advanced Breast Cancer and Treatment-Associated Modulation of Inducible Costimulator Expression on Patient T Cells

Robert H. Vonderheide, Patricia M. LoRusso, Magi Khalil, Elaina M. Gartner, Divis Khaira, Denis Soulieres, Prudence Dorazio, Jennifer A. Trosko, Jens Rüter, Gabriella L. Mariani, Tiziana Usari, Susan M. Domchek
Journal: Clinical Cancer Research
Clin Cancer Res (2010) 16 (13): 3485–3494.
https://doi.org/10.1158/1078-0432.CCR-10-0505
Published: 30 June 2010
View article titled, Tremelimumab in Combination with Exemestane in Patients with Advanced Breast Cancer and Treatment-Associated Modulation of Inducible Costimulator Expression on Patient T Cells
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Includes: Supplementary data
Journal Articles

Interferon-γ–Dependent Infiltration of Human T Cells into Neuroblastoma Tumors In vivo

Gregor S.D. Reid, Xiaochuan Shan, Christina M. Coughlin, Wiem Lassoued, Bruce R. Pawel, Leonard H. Wexler, Carol J. Thiele, Maria Tsokos, Jack L. Pinkus, Geraldine S. Pinkus, Stephan A. Grupp, Robert H. Vonderheide
Journal: Clinical Cancer Research
Clin Cancer Res (2009) 15 (21): 6602–6608.
https://doi.org/10.1158/1078-0432.CCR-09-0829
Published: 02 November 2009
View article titled, Interferon-γ–Dependent Infiltration of Human T Cells into Neuroblastoma Tumors <em>In vivo</em>
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Journal Articles

Functional Unresponsiveness and Replicative Senescence of Myeloid Leukemia Antigen–specific CD8+ T Cells After Allogeneic Stem Cell Transplantation

Gregory L. Beatty, Jasmine S. Smith, Ran Reshef, Kunal P. Patel, Theresa A. Colligon, Barbara A. Vance, Noelle V. Frey, F. Brad Johnson, David L. Porter, Robert H. Vonderheide
Journal: Clinical Cancer Research
Clin Cancer Res (2009) 15 (15): 4944–4953.
https://doi.org/10.1158/1078-0432.CCR-08-3332
Published: 29 July 2009
View article titled, Functional Unresponsiveness and Replicative Senescence of Myeloid Leukemia Antigen–specific CD8<sup>+</sup> T Cells After Allogeneic Stem Cell Transplantation
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Includes: Supplementary data
Journal Articles

Rapid Immune Recovery and Graft-versus-Host Disease–like Engraftment Syndrome following Adoptive Transfer of Costimulated Autologous T Cells

Aaron P. Rapoport, Edward A. Stadtmauer, Nicole Aqui, Dan Vogl, Anne Chew, Hong-Bin Fang, Stephen Janofsky, Kelly Yager, Elizabeth Veloso, Zhaohui Zheng, Todd Milliron, Sandra Westphal, Julio Cotte, Hong Huynh, Andrea Cannon, Saul Yanovich, Gorgun Akpek, Ming Tan, Kristen Virts, Kathleen Ruehle, Carolynn Harris, Sunita Philip, Robert H. Vonderheide, Bruce L. Levine, Carl H. June
Journal: Clinical Cancer Research
Clin Cancer Res (2009) 15 (13): 4499–4507.
https://doi.org/10.1158/1078-0432.CCR-09-0418
Published: 01 July 2009
View article titled, Rapid Immune Recovery and Graft-versus-Host Disease–like Engraftment Syndrome following Adoptive Transfer of Costimulated Autologous T Cells
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Includes: Supplementary data
Journal Articles

Collapse of the CD27+ B-Cell Compartment Associated with Systemic Plasmacytosis in Patients with Advanced Melanoma and Other Cancers

Erica L. Carpenter, Rosemarie Mick, Andrew J. Rech, Gregory L. Beatty, Theresa A. Colligon, Myrna R. Rosenfeld, David E. Kaplan, Kyong-Mi Chang, Susan M. Domchek, Peter A. Kanetsky, Leslie A. Fecher, Keith T. Flaherty, Lynn M. Schuchter, Robert H. Vonderheide
Journal: Clinical Cancer Research
Clin Cancer Res (2009) 15 (13): 4277–4287.
https://doi.org/10.1158/1078-0432.CCR-09-0537
Published: 01 July 2009
View article titled, Collapse of the CD27+ B-Cell Compartment Associated with Systemic Plasmacytosis in Patients with Advanced Melanoma and Other Cancers
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Journal Articles

A Phase I Clinical Trial of Single-Dose Intrapleural IFN-β Gene Transfer for Malignant Pleural Mesothelioma and Metastatic Pleural Effusions: High Rate of Antitumor Immune Responses

Daniel H. Sterman, Adri Recio, Richard G. Carroll, Colin T. Gillespie, Andrew Haas, Anil Vachani, Veena Kapoor, Jing Sun, Richard Hodinka, Jennifer L. Brown, Michael J. Corbley, Michael Parr, Mitchell Ho, Ira Pastan, Michael Machuzak, William Benedict, Xin-qiao Zhang, Elaina M. Lord, Leslie A. Litzky, Daniel F. Heitjan, Carl H. June, Larry R. Kaiser, Robert H. Vonderheide, Steven M. Albelda
Journal: Clinical Cancer Research
Clin Cancer Res (2007) 13 (15): 4456–4466.
https://doi.org/10.1158/1078-0432.CCR-07-0403
Published: 01 August 2007
View article titled, A Phase I Clinical Trial of Single-Dose Intrapleural IFN-β Gene Transfer for Malignant Pleural Mesothelioma and Metastatic Pleural Effusions: High Rate of Antitumor Immune Responses
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Journal Articles

Prospect of Targeting the CD40 Pathway for Cancer Therapy

Robert H. Vonderheide
Journal: Clinical Cancer Research
Clin Cancer Res (2007) 13 (4): 1083–1088.
https://doi.org/10.1158/1078-0432.CCR-06-1893
Published: 22 February 2007
View article titled, Prospect of Targeting the CD40 Pathway for Cancer Therapy
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Journal Articles

Getting to the Surface: A Link Between Tumor Antigen Discovery and Natural Presentation of Peptide-MHC Complexes

Carolyn E. Clark, Robert H. Vonderheide
Journal: Clinical Cancer Research
Clin Cancer Res (2005) 11 (15): 5333–5336.
https://doi.org/10.1158/1078-0432.CCR-05-1057
Published: 01 August 2005
View article titled, Getting to the Surface: A Link Between Tumor Antigen Discovery and Natural Presentation of Peptide-MHC Complexes
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Journal Articles

Vaccination of Cancer Patients Against Telomerase Induces Functional Antitumor CD8+ T Lymphocytes

Robert H. Vonderheide, Susan M. Domchek, Joachim L. Schultze, Daniel J. George, Kara M. Hoar, Dih-Yih Chen, Katherine F. Stephans, Kenkichi Masutomi, Massimo Loda, Zhinan Xia, Karen S. Anderson, William C. Hahn, Lee M. Nadler
Journal: Clinical Cancer Research
Clin Cancer Res (2004) 10 (3): 828–839.
https://doi.org/10.1158/1078-0432.CCR-0620-3
Published: 10 February 2004
View article titled, Vaccination of Cancer Patients Against Telomerase Induces Functional Antitumor CD8+ T Lymphocytes
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Journal Articles

Characterization of HLA-A3-restricted Cytotoxic T Lymphocytes Reactive against the Widely Expressed Tumor Antigen Telomerase

Robert H. Vonderheide, Karen S. Anderson, William C. Hahn, Mark O. Butler, Joachim L. Schultze, Lee M. Nadler
Journal: Clinical Cancer Research
Clin Cancer Res (2001) 7 (11): 3343–3348.
Published: 01 November 2001
View article titled, Characterization of HLA-A3-restricted Cytotoxic T Lymphocytes Reactive against the Widely Expressed Tumor Antigen Telomerase
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