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Robert C. Bast
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Journal Articles

A Blood-Based Metabolite Panel for Distinguishing Ovarian Cancer from Benign Pelvic Masses

Ehsan Irajizad, Chae Y. Han, Joseph Celestino, Ranran Wu, Eunice Murage, Rachelle Spencer, Jennifer B. Dennison, Jody Vykoukal, James P. Long, Kim Anh Do, Charles Drescher, Karen Lu, Zhen Lu, Robert C. Bast, Sam Hanash, Johannes F. Fahrmann
Journal: Clinical Cancer Research
Clin Cancer Res (2022) 28 (21): 4669–4676.
https://doi.org/10.1158/1078-0432.CCR-22-1113
Published: 01 November 2022
View article titled, A Blood-Based Metabolite Panel for Distinguishing Ovarian Cancer from Benign Pelvic Masses
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Includes: Supplementary data
Journal Articles

Correction: Paclitaxel Sensitivity of Ovarian Cancer Can be Enhanced by Knocking Down Pairs of Kinases that Regulate MAP4 Phosphorylation and Microtubule Stability

Hailing Yang, Weiqun Mao, Cristian Rodriguez-Aguayo, Lingegowda S. Mangala, Geoffrey Bartholomeusz, Lakesla R. Iles, Nicholas B. Jennings, Ahmed Ashour Ahmed, Anil K. Sood, Gabriel Lopez-Berestein, Zhen Lu, Robert C. Bast, Jr
Journal: Clinical Cancer Research
Clin Cancer Res (2020) 26 (18): 5050.
https://doi.org/10.1158/1078-0432.CCR-20-3198
Published: 15 September 2020
View article titled, Correction: Paclitaxel Sensitivity of Ovarian Cancer Can be Enhanced by Knocking Down Pairs of Kinases that Regulate MAP4 Phosphorylation and Microtubule Stability
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Journal Articles

Abstract B43: A serum protein biomarker signature for the detection of early stages of ovarian cancer

Amy P. Skubitz, Kristin L. Boylan, Timothy K. Starr, Xuan Pu, Qing Cao, Kate Geschwind, Robert C. Bast, Jr., Karen H. Lu, Joseph Celestino, Ashley J. Petersen
Journal: Clinical Cancer Research
Clin Cancer Res (2020) 26 (13_Supplement): B43.
https://doi.org/10.1158/1557-3265.OVCA19-B43
Published: 01 July 2020
View article titled, Abstract B43: A serum protein biomarker signature for the detection of early stages of ovarian cancer
Journal Articles

Abstract AP08: DEVELOPMENT OF A MULTI-PROTEIN CLASSIFIER FOR OVARIAN CANCER DETECTION BY SIMULTANEOUS MEASUREMENT OF 92 SERUM PROTEINS ON PROSEEK MULTIPLEX ONCOLOGY II PLATES

Amy P.N. Skubitz, Kristin L.M. Boylan, Kate Geschwind, Qing Cao, Timothy K. Starr, Melissa A. Geller, Joseph Celestino, Robert C. Bast, Jr., Karen H. Lu, Joseph S. Koopmeiners
Journal: Clinical Cancer Research
Clin Cancer Res (2019) 25 (22_Supplement): AP08.
https://doi.org/10.1158/1557-3265.OVCASYMP18-AP08
Published: 15 November 2019
View article titled, Abstract AP08: DEVELOPMENT OF A MULTI-PROTEIN CLASSIFIER FOR OVARIAN CANCER DETECTION BY SIMULTANEOUS MEASUREMENT OF 92 SERUM PROTEINS ON PROSEEK MULTIPLEX ONCOLOGY II PLATES
Journal Articles

6-Phosphofructo-2-Kinase/Fructose-2,6-Biphosphatase-2 Regulates TP53-Dependent Paclitaxel Sensitivity in Ovarian and Breast Cancers

Hailing Yang, Zhang Shu, Yongying Jiang, Weiqun Mao, Lan Pang, Abena Redwood, Sabrina L. Jeter-Jones, Nicholas B. Jennings, Argentina Ornelas, Jinhua Zhou, Cristian Rodriguez-Aguayo, Geoffrey Bartholomeusz, LaKesla R. Iles, Niki M. Zacharias, Steven W. Millward, Gabriel Lopez-Berestein, Xiao-Feng Le, Ahmed A. Ahmed, Helen Piwnica-Worms, Anil K. Sood, Robert C. Bast, Zhen Lu
Journal: Clinical Cancer Research
Clin Cancer Res (2019) 25 (18): 5702–5716.
https://doi.org/10.1158/1078-0432.CCR-18-3448
Published: 13 September 2019
View article titled, 6-Phosphofructo-2-Kinase/Fructose-2,6-Biphosphatase-2 Regulates TP53-Dependent Paclitaxel Sensitivity in Ovarian and Breast Cancers
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Includes: Supplementary data
Journal Articles

Paclitaxel Sensitivity of Ovarian Cancer Can be Enhanced by Knocking Down Pairs of Kinases that Regulate MAP4 Phosphorylation and Microtubule Stability

Hailing Yang, Weiqun Mao, Cristian Rodriguez-Aguayo, Lingegowda S. Mangala, Geoffrey Bartholomeusz, Lakesla R. Iles, Nicholas B. Jennings, Ahmed Ashour Ahmed, Anil K. Sood, Gabriel Lopez-Berestein, Zhen Lu, Robert C. Bast, Jr.
Journal: Clinical Cancer Research
Clin Cancer Res (2018) 24 (20): 5072–5084.
https://doi.org/10.1158/1078-0432.CCR-18-0504
Published: 15 October 2018
View article titled, Paclitaxel Sensitivity of Ovarian Cancer Can be Enhanced by Knocking Down Pairs of Kinases that Regulate MAP4 Phosphorylation and Microtubule Stability
Open the PDF for Paclitaxel Sensitivity of Ovarian Cancer Can be Enhanced by Knocking Down Pairs of Kinases that Regulate MAP4 Phosphorylation and Microtubule Stability in another window
Includes: Supplementary data
Journal Articles

Abstract IA15: Early detection of ovarian cancer: An update

Robert C. Bast, Jr.
Journal: Clinical Cancer Research
Clin Cancer Res (2018) 24 (15_Supplement): IA15.
https://doi.org/10.1158/1557-3265.OVCA17-IA15
Published: 01 August 2018
View article titled, Abstract IA15: Early detection of ovarian cancer: An update
Journal Articles

Abstract B20: Simultaneous measurement of 92 serum protein biomarkers for the development of a multiprotein classifier for ovarian cancer detection

Amy P.N. Skubitz, Kristin L.M. Boylan, Kate Geschwind, Qing Cao, Timothy K. Starr, Melissa A. Geller, Robert C. Bast, Jr., Karen H. Lu, Joseph S. Koopmeiners
Journal: Clinical Cancer Research
Clin Cancer Res (2018) 24 (15_Supplement): B20.
https://doi.org/10.1158/1557-3265.OVCA17-B20
Published: 01 August 2018
View article titled, Abstract B20: Simultaneous measurement of 92 serum protein biomarkers for the development of a multiprotein classifier for ovarian cancer detection
Journal Articles

Elevation of TP53 Autoantibody Before CA125 in Preclinical Invasive Epithelial Ovarian Cancer

Wei-Lei Yang, Aleksandra Gentry-Maharaj, Archana Simmons, Andy Ryan, Evangelia Ourania Fourkala, Zhen Lu, Keith A. Baggerly, Yang Zhao, Karen H. Lu, David Bowtell, Ian Jacobs, Steven J. Skates, Wei-Wu He, Usha Menon, Robert C. Bast, Jr
Journal: Clinical Cancer Research
Clin Cancer Res (2017) 23 (19): 5912–5922.
https://doi.org/10.1158/1078-0432.CCR-17-0284
Published: 01 October 2017
View article titled, Elevation of TP53 Autoantibody Before CA125 in Preclinical Invasive Epithelial Ovarian Cancer
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Includes: Supplementary data
Journal Articles

A Novel Compound ARN-3236 Inhibits Salt-Inducible Kinase 2 and Sensitizes Ovarian Cancer Cell Lines and Xenografts to Paclitaxel

Jinhua Zhou, Albandri Alfraidi, Shu Zhang, Janice M. Santiago-O'Farrill, Venkata Krishna Yerramreddy Reddy, Abdulkhaliq Alsaadi, Ahmed A. Ahmed, Hailing Yang, Jinsong Liu, Weiqun Mao, Yan Wang, Hiroshi Takemori, Hariprasad Vankayalapati, Zhen Lu, Robert C. Bast, Jr
Journal: Clinical Cancer Research
Clin Cancer Res (2017) 23 (8): 1945–1954.
https://doi.org/10.1158/1078-0432.CCR-16-1562
Published: 13 April 2017
View article titled, A Novel Compound ARN-3236 Inhibits Salt-Inducible Kinase 2 and Sensitizes Ovarian Cancer Cell Lines and Xenografts to Paclitaxel
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Includes: Supplementary data
Journal Articles

Abstract A43: DIRAS1 and DIRAS2 are tumor suppressor candidates that inhibit cell growth, motility, and proliferation while regulating autophagy in ovarian cancer.

Margie N. Sutton, Zhen Lu, Robert C. Bast, Jr
Journal: Clinical Cancer Research
Clin Cancer Res (2016) 22 (2_Supplement): A43.
https://doi.org/10.1158/1557-3265.OVCA15-A43
Published: 15 January 2016
View article titled, Abstract A43: DIRAS1 and DIRAS2 are tumor suppressor candidates that inhibit cell growth, motility, and proliferation while regulating autophagy in ovarian cancer.
Journal Articles

Abstract PR18: Survival of ARHI-induced dormant autophagic cell death in vivo requires permissive levels of VEGF, IL-8, and IGF-1 in the tumor microenvironment.

Zhen Lu, Aaron F. Orozco, Hailing Yang, Margie N. Sutton, Yan Wang, Weiqun Mao, Douglas A. Levine, Robert C. Bast, Jr, Robert C. Bast, Jr
Journal: Clinical Cancer Research
Clin Cancer Res (2016) 22 (2_Supplement): PR18.
https://doi.org/10.1158/1557-3265.OVCA15-PR18
Published: 15 January 2016
View article titled, Abstract PR18: Survival of ARHI-induced dormant autophagic cell death in vivo requires permissive levels of VEGF, IL-8, and IGF-1 in the tumor microenvironment.
Journal Articles

Activating and Propagating Polyclonal Gamma Delta T Cells with Broad Specificity for Malignancies

Drew C. Deniger, Sourindra N. Maiti, Tiejuan Mi, Kirsten C. Switzer, Vijaya Ramachandran, Lenka V. Hurton, Sonny Ang, Simon Olivares, Brian A. Rabinovich, M. Helen Huls, Dean A. Lee, Robert C. Bast, Jr, Richard E. Champlin, Laurence J.N. Cooper
Journal: Clinical Cancer Research
Clin Cancer Res (2014) 20 (22): 5708–5719.
https://doi.org/10.1158/1078-0432.CCR-13-3451
Published: 13 November 2014
View article titled, Activating and Propagating Polyclonal Gamma Delta T Cells with Broad Specificity for Malignancies
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Includes: Supplementary data
Journal Articles

Transcriptional and Posttranscriptional Down-Regulation of the Imprinted Tumor Suppressor Gene ARHI (DRAS3) in Ovarian Cancer

Zhen Lu, Robert Z. Luo, Hongqi Peng, Daniel G. Rosen, E. Neely Atkinson, Carla Warneke, Maosheng Huang, Arata Nishmoto, Jinsong Liu, Warren S-L. Liao, Yinhua Yu, Robert C. Bast, Jr.
Journal: Clinical Cancer Research
Clin Cancer Res (2006) 12 (8): 2404–2413.
https://doi.org/10.1158/1078-0432.CCR-05-1036
Published: 25 April 2006
View article titled, Transcriptional and Posttranscriptional Down-Regulation of the Imprinted Tumor Suppressor Gene <em>ARHI</em> (<em>DRAS3</em>) in Ovarian Cancer
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Journal Articles

Patterns of Gene Expression in Different Histotypes of Epithelial Ovarian Cancer Correlate with Those in Normal Fallopian Tube, Endometrium, and Colon

Rebecca T. Marquez, Keith A. Baggerly, Andrea P. Patterson, Jinsong Liu, Russell Broaddus, Michael Frumovitz, Edward N. Atkinson, David I. Smith, Lynn Hartmann, David Fishman, Andrew Berchuck, Regina Whitaker, David M. Gershenson, Gordon B. Mills, Robert C. Bast, Jr., Karen H. Lu
Journal: Clinical Cancer Research
Clin Cancer Res (2005) 11 (17): 6116–6126.
https://doi.org/10.1158/1078-0432.CCR-04-2509
Published: 06 September 2005
View article titled, Patterns of Gene Expression in Different Histotypes of Epithelial Ovarian Cancer Correlate with Those in Normal Fallopian Tube, Endometrium, and Colon
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Journal Articles

Translational Crossroads for Biomarkers

Robert C. Bast, Jr., Hans Lilja, Nicole Urban, David L. Rimm, Herbert Fritsche, Joe Gray, Robert Veltri, George Klee, Andrew Allen, Nam Kim, Steven Gutman, Mark A. Rubin, Andrew Hruszkewycz
Journal: Clinical Cancer Research
Clin Cancer Res (2005) 11 (17): 6103–6108.
https://doi.org/10.1158/1078-0432.CCR-04-2213
Published: 06 September 2005
View article titled, Translational Crossroads for Biomarkers
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Journal Articles

Gene Expression Profiles Predict Early Relapse in Ovarian Cancer after Platinum-Paclitaxel Chemotherapy

Lynn C. Hartmann, Karen H. Lu, Gerald P. Linette, William A. Cliby, Kimberly R. Kalli, David Gershenson, Robert C. Bast, James Stec, Natalia Iartchouk, David I. Smith, Jeffrey S. Ross, Sebastian Hoersch, Viji Shridhar, James Lillie, Scott H. Kaufmann, Edwin A. Clark, Andrew I. Damokosh
Journal: Clinical Cancer Research
Clin Cancer Res (2005) 11 (6): 2149–2155.
https://doi.org/10.1158/1078-0432.CCR-04-1673
Published: 23 March 2005
View article titled, Gene Expression Profiles Predict Early Relapse in Ovarian Cancer after Platinum-Paclitaxel Chemotherapy
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Journal Articles

Subcellular Localization of p27kip1 Expression Predicts Poor Prognosis in Human Ovarian Cancer

Daniel G. Rosen, Gong Yang, Kathy Qi Cai, Robert C. Bast, Jr., David M. Gershenson, Elvio G. Silva, Jinsong Liu
Journal: Clinical Cancer Research
Clin Cancer Res (2005) 11 (2): 632–637.
https://doi.org/10.1158/1078-0432.632.11.2
Published: 08 February 2005
View article titled, Subcellular Localization of p27<sup>kip1</sup> Expression Predicts Poor Prognosis in Human Ovarian Cancer
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Journal Articles

Expression of the Tumor Suppressor Gene ARHI in Epithelial Ovarian Cancer Is Associated with Increased Expression of p21WAF1/CIP1 and Prolonged Progression-Free Survival

Daniel G. Rosen, Lin Wang, Ajay N. Jain, Karen H. Lu, Robert Z. Luo, Yinhua Yu, Jinsong Liu, Robert C. Bast, Jr.
Journal: Clinical Cancer Research
Clin Cancer Res (2004) 10 (19): 6559–6566.
https://doi.org/10.1158/1078-0432.CCR-04-0698
Published: 08 October 2004
View article titled, Expression of the Tumor Suppressor Gene ARHI in Epithelial Ovarian Cancer Is Associated with Increased Expression of p21<sup>WAF1/CIP1</sup> and Prolonged Progression-Free Survival
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Journal Articles

Use of CA-125 in Clinical Trial Evaluation of New Therapeutic Drugs for Ovarian Cancer

Gordon J. S. Rustin, Robert C. Bast, Jr., Gary J. Kelloff, J. Carl Barrett, Stephen K. Carter, Perry D. Nisen, Caroline C. Sigman, David R. Parkinson, Raymond W. Ruddon
Journal: Clinical Cancer Research
Clin Cancer Res (2004) 10 (11): 3919–3926.
https://doi.org/10.1158/1078-0432.CCR-03-0787
Published: 01 June 2004
View article titled, Use of CA-125 in Clinical Trial Evaluation of New Therapeutic Drugs for Ovarian Cancer
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