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Journal Articles

Development and Validation of the Gene Expression Predictor of High-grade Serous Ovarian Carcinoma Molecular SubTYPE (PrOTYPE)

Aline Talhouk, Joshy George, Chen Wang, Timothy Budden, Tuan Zea Tan, Derek S. Chiu, Stefan Kommoss, Huei San Leong, Stephanie Chen, Maria P. Intermaggio, Blake Gilks, Tayyebeh M. Nazeran, Mila Volchek, Wafaa Elatre, Rex C. Bentley, Janine Senz, Amy Lum, Veronica Chow, Hanwei Sudderuddin, Robertson Mackenzie, Samuel C.Y. Leong, Geyi Liu, Dustin Johnson, Billy Chen, AOCS Group, Jennifer Alsop, Susana N. Banerjee, Sabine Behrens, Clara Bodelon, Alison H. Brand, Louise Brinton, Michael E. Carney, Yoke-Eng Chiew, Kara L. Cushing-Haugen, Cezary Cybulski, Darren Ennis, Sian Fereday, Renée T. Fortner, Jesús García-Donas, Aleksandra Gentry-Maharaj, Rosalind Glasspool, Teodora Goranova, Casey S. Greene, Paul Haluska, Holly R. Harris, Joy Hendley, Brenda Y. Hernandez, Esther Herpel, Mercedes Jimenez-Linan, Chloe Karpinskyj, Scott H. Kaufmann, Gary L. Keeney, Catherine J. Kennedy, Martin Köbel, Jennifer M. Koziak, Melissa C. Larson, Jenny Lester, Liz-Anne Lewsley, Jolanta Lissowska, Jan Lubiński, Hugh Luk, Geoff Macintyre, Sven Mahner, Iain A. McNeish, Janusz Menkiszak, Nikilyn Nevins, Ana Osorio, Oleg Oszurek, José Palacios, Samantha Hinsley, Celeste L. Pearce, Malcolm C. Pike, Anna M. Piskorz, Isabelle Ray-Coquard, Valerie Rhenius, Cristina Rodriguez-Antona, Raghwa Sharma, Mark E. Sherman, Dilrini De Silva, Naveena Singh, Peter Sinn, Dennis Slamon, Honglin Song, Helen Steed, Euan A. Stronach, Pamela J. Thompson, Aleksandra Tołoczko, Britton Trabert, Nadia Traficante, Chiu-Chen Tseng, Martin Widschwendter, Lynne R. Wilkens, Stacey J. Winham, Boris Winterhoff, Alicia Beeghly-Fadiel, Javier Benitez, Andrew Berchuck, James D. Brenton, Robert Brown, Jenny Chang-Claude, Georgia Chenevix-Trench, Anna deFazio, Peter A. Fasching, María J. García, Simon A. Gayther, Marc T. Goodman, Jacek Gronwald, Michelle J. Henderson, Beth Y. Karlan, Linda E. Kelemen, Usha Menon, Sandra Orsulic, Paul D.P. Pharoah, Nicolas Wentzensen, Anna H. Wu, Joellen M. Schildkraut, Mary Anne Rossing, Gottfried E. Konecny, David G. Huntsman, Ruby Yun-Ju Huang, Ellen L. Goode, Susan J. Ramus, Jennifer A. Doherty, David D. Bowtell, Michael S. Anglesio
Journal: Clinical Cancer Research
Clin Cancer Res (2020) 26 (20): 5411–5423.
https://doi.org/10.1158/1078-0432.CCR-20-0103
Published: 15 October 2020
View article titled, Development and Validation of the Gene Expression Predictor of High-grade Serous Ovarian Carcinoma Molecular SubTYPE (PrOTYPE)
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Includes: Supplementary data
Journal Articles

Cytokines Produced by Dendritic Cells Administered Intratumorally Correlate with Clinical Outcome in Patients with Diverse Cancers

Vivek Subbiah, Ravi Murthy, David S. Hong, Robert M. Prins, Chitra Hosing, Kyle Hendricks, Deepthi Kolli, Lori Noffsinger, Robert Brown, Mary McGuire, Siquing Fu, Sarina Piha-Paul, Aung Naing, Anthony P. Conley, Robert S. Benjamin, Indreshpal Kaur, Marnix L. Bosch
Journal: Clinical Cancer Research
Series: Author Choice
Clin Cancer Res (2018) 24 (16): 3845–3856.
https://doi.org/10.1158/1078-0432.CCR-17-2707
Published: 14 August 2018
View article titled, Cytokines Produced by Dendritic Cells Administered Intratumorally Correlate with Clinical Outcome in Patients with Diverse Cancers
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Includes: Supplementary data
Journal Articles

Platinum-Based Chemotherapy Induces Methylation Changes in Blood DNA Associated with Overall Survival in Patients with Ovarian Cancer

James M. Flanagan, Angela Wilson, Chail Koo, Nahal Masrour, John Gallon, Erick Loomis, Kirsty Flower, Charlotte Wilhelm-Benartzi, Alexander Hergovich, Paula Cunnea, Hani Gabra, Elena Ioana Braicu, Jalid Sehouli, Silvia Darb-Esfahani, Adriaan Vanderstichele, Ignace Vergote, Caroline Kreuzinger, Dan Cacsire Castillo-Tong, G. Bea A. Wisman, Els MJJ Berns, Nadeem Siddiqui, James Paul, Robert Brown
Journal: Clinical Cancer Research
Clin Cancer Res (2017) 23 (9): 2213–2222.
https://doi.org/10.1158/1078-0432.CCR-16-1754
Published: 30 April 2017
View article titled, Platinum-Based Chemotherapy Induces Methylation Changes in Blood DNA Associated with Overall Survival in Patients with Ovarian Cancer
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Includes: Supplementary data
Journal Articles

Epigenetic Regulation of the Homeobox Gene MSX1 Associates with Platinum-Resistant Disease in High-Grade Serous Epithelial Ovarian Cancer

Nair A. Bonito, Jane Borley, Charlotte S. Wilhelm-Benartzi, Sadaf Ghaem-Maghami, Robert Brown
Journal: Clinical Cancer Research
Clin Cancer Res (2016) 22 (12): 3097–3104.
https://doi.org/10.1158/1078-0432.CCR-15-1669
Published: 14 June 2016
View article titled, Epigenetic Regulation of the Homeobox Gene <em>MSX1</em> Associates with Platinum-Resistant Disease in High-Grade Serous Epithelial Ovarian Cancer
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Includes: Supplementary data
Journal Articles

Suspicion blind epigenome scanning reveals loci that may stratify ovarian cancers by taxane-platinum treatment responsiveness

Muhammad A. Budiman, Jacquiline Hall, Rebecca K. Maloney, Craig A. Tatham, Angel M. Garrido, Robert W. Citek, Joey A. Bedell, Jared M. Ordway, Yulia Korshunova, Jorge Leon, Jeffrey A. Jeddeloh, Robert Brown, John D. McPherson
Journal: Clinical Cancer Research
Clin Cancer Res (2006) 12 (19_Supplement): A97.
Published: 15 August 2014
View article titled, Suspicion blind epigenome scanning reveals loci that may stratify ovarian cancers by taxane-platinum treatment responsiveness
Journal Articles

Genome scale epigenetic profiling identifies numerous novel DNA methylation-based biomarkers capable of identifying cancerous breast tissue samples.

Jared M. Ordway, Jorge Leon, Yulia Korshunova, Muhammad A. Budiman, Jacqueline Hall, Rebecca K. Maloney, Joseph A. Bedell, Robert W. Citek, Jeffrey A. Jeddeloh, Robert Brown, John D. McPherson
Journal: Clinical Cancer Research
Clin Cancer Res (2006) 12 (19_Supplement): A102.
Published: 15 August 2014
View article titled, Genome scale epigenetic profiling identifies numerous novel DNA methylation-based biomarkers capable of identifying cancerous breast tissue samples.
Journal Articles

Development of a cell line based gene classifier to predict therapeutic response of head and neck cancer patients

Seema Gupta, Sana Ghafoor, Craig Wood, Kathryn Masker, Robert Brown, Amy Law, Phillip Pellitteri, Ping Zhang, David Carey, Mansoor Ahmed
Journal: Clinical Cancer Research
Clin Cancer Res (2007) 13 (22_Supplement): C57.
Published: 15 August 2014
View article titled, Development of a cell line based gene classifier to predict therapeutic response of head and neck cancer patients
Journal Articles

Promoter CpG Island Methylation of Genes in Key Cancer Pathways Associates with Clinical Outcome in High-Grade Serous Ovarian Cancer

Wei Dai, Constanze Zeller, Nahal Masrour, Nadeem Siddiqui, James Paul, Robert Brown
Journal: Clinical Cancer Research
Clin Cancer Res (2013) 19 (20): 5788–5797.
https://doi.org/10.1158/1078-0432.CCR-13-1217
Published: 14 October 2013
View article titled, Promoter CpG Island Methylation of Genes in Key Cancer Pathways Associates with Clinical Outcome in High-Grade Serous Ovarian Cancer
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Includes: Supplementary data
Journal Articles

Cumulative Genetic Risk Predicts Platinum/Taxane-Induced Neurotoxicity

Sarah McWhinney-Glass, Stacey J. Winham, Daniel L. Hertz, Jane Yen Revollo, Jim Paul, Yijing He, Robert Brown, Alison A. Motsinger-Reif, Howard L. McLeod, For the Scottish Gynaecological Clinical Trials Group
Journal: Clinical Cancer Research
Clin Cancer Res (2013) 19 (20): 5769–5776.
https://doi.org/10.1158/1078-0432.CCR-13-0774
Published: 14 October 2013
View article titled, Cumulative Genetic Risk Predicts Platinum/Taxane-Induced Neurotoxicity
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Includes: Supplementary data
Journal Articles

Platinum Sensitivity–Related Germline Polymorphism Discovered via a Cell-Based Approach and Analysis of Its Association with Outcome in Ovarian Cancer Patients

R. Stephanie Huang, Sharon E. Johnatty, Eric R. Gamazon, Hae Kyung Im, Dana Ziliak, Shiwei Duan, Wei Zhang, Emily O. Kistner, Peixian Chen, Jonathan Beesley, Shuangli Mi, Peter H. O'Donnell, Yarden S. Fraiman, Soma Das, Nancy J. Cox, Yi Lu, Stuart MacGregor, Ellen L. Goode, Robert A. Vierkant, Brooke L. Fridley, Estrid Hogdall, Susanne K. Kjaer, Allan Jensen, Kirsten B. Moysich, Matthew Grasela, Kunle Odunsi, Robert Brown, Jim Paul, Diether Lambrechts, Evelyn Despierre, Ignace Vergote, Jenny Gross, Beth Y. Karlan, Anna deFazio, Georgia Chenevix-Trench, M. Eileen Dolan
Journal: Clinical Cancer Research
Clin Cancer Res (2011) 17 (16): 5490–5500.
https://doi.org/10.1158/1078-0432.CCR-11-0724
Published: 14 August 2011
View article titled, Platinum Sensitivity–Related Germline Polymorphism Discovered via a Cell-Based Approach and Analysis of Its Association with Outcome in Ovarian Cancer Patients
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Includes: Supplementary data
Journal Articles

Systematic CpG Islands Methylation Profiling of Genes in the Wnt Pathway in Epithelial Ovarian Cancer Identifies Biomarkers of Progression-Free Survival

Wei Dai, Jens M. Teodoridis, Constanze Zeller, Janet Graham, Jenny Hersey, James M. Flanagan, Euan Stronach, David W. Millan, Nadeem Siddiqui, Jim Paul, Robert Brown
Journal: Clinical Cancer Research
Clin Cancer Res (2011) 17 (12): 4052–4062.
https://doi.org/10.1158/1078-0432.CCR-10-3021
Published: 15 June 2011
View article titled, Systematic CpG Islands Methylation Profiling of Genes in the Wnt Pathway in Epithelial Ovarian Cancer Identifies Biomarkers of Progression-Free Survival
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Includes: Supplementary data
Journal Articles

The Role of KRAS rs61764370 in Invasive Epithelial Ovarian Cancer: Implications for Clinical Testing

Paul D. P. Pharoah, Rachel T. Palmieri, Susan J. Ramus, Simon A. Gayther, Irene L. Andrulis, Hoda Anton-Culver, Natalia Antonenkova, Antonis C. Antoniou, David Goldgar, Mary S. Beattie, Matthias W. Beckmann, Michael J. Birrer, Natalia Bogdanova, Kelly L. Bolton, Wendy Brewster, Angela Brooks-Wilson, Robert Brown, Ralf Butzow, Trinidad Caldes, Maria Adelaide Caligo, Ian Campbell, Jenny Chang-Claude, Y. Ann Chen, Linda S. Cook, Fergus J. Couch, Daniel W. Cramer, Julie M. Cunningham, Evelyn Despierre, Jennifer A. Doherty, Thilo Dörk, Matthias Dürst, Diana M. Eccles, Arif B. Ekici, Douglas Easton, Peter A. Fasching, Anna de Fazio, David A. Fenstermacher, James M. Flanagan, Brooke L. Fridley, Eitan Friedman, Bo Gao, Olga Sinilnikova, Aleksandra Gentry-Maharaj, Andrew K. Godwin, Ellen L. Goode, Marc T. Goodman, Jenny Gross, Thomas V. O. Hansen, Paul Harnett, Matti Rookus, Tuomas Heikkinen, Rebecca Hein, Claus Høgdall, Estrid Høgdall, Edwin S. Iversen, Anna Jakubowska, Sharon E. Johnatty, Beth Y. Karlan, Noah D. Kauff, Stanley B. Kaye, Georgia Chenevix-Trench, Linda E. Kelemen, Lambertus A. Kiemeney, Susanne Krüger Kjaer, Diether Lambrechts, James P. LaPolla, Conxi Lázaro, Nhu D. Le, Arto Leminen, Karin Leunen, Douglas A. Levine, Yi Lu, Lene Lundvall, Stuart Macgregor, Tamara Marees, Leon F. Massuger, John R. McLaughlin, Usha Menon, Marco Montagna, Kirsten B. Moysich, Steven A. Narod, Katherine L. Nathanson, Lotte Nedergaard, Roberta B. Ness, Heli Nevanlinna, Stefan Nickels, Ana Osorio, Jim Paul, Celeste Leigh Pearce, Catherine M. Phelan, Malcolm C. Pike, Paolo Radice, Mary Anne Rossing, Joellen M. Schildkraut, Thomas A. Sellers, Christian F. Singer, Honglin Song, Daniel O. Stram, Rebecca Sutphen, Annika Lindblom, Kathryn L. Terry, Ya-Yu Tsai, Anne M. van Altena, Ignace Vergote, Robert A. Vierkant, Allison F. Vitonis, Christine Walsh, Shan Wang-Gohrke, Barbara Wappenschmidt, Anna H. Wu, Argyrios Ziogas, Andrew Berchuck, Harvey A. Risch
Journal: Clinical Cancer Research
Clin Cancer Res (2011) 17 (11): 3742–3750.
https://doi.org/10.1158/1078-0432.CCR-10-3405
Published: 01 June 2011
View article titled, The Role of <em>KRAS</em> rs61764370 in Invasive Epithelial Ovarian Cancer: Implications for Clinical Testing
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Journal Articles

ABCB1 (MDR 1) Polymorphisms and Progression-Free Survival among Women with Ovarian Cancer following Paclitaxel/Carboplatin Chemotherapy

Sharon E. Johnatty, Jonathan Beesley, Jim Paul, Sian Fereday, Amanda B. Spurdle, Penelope M. Webb, Karen Byth, Sharon Marsh, Howard McLeod, AOCS Study Group, Paul R. Harnett, Robert Brown, Anna deFazio, Georgia Chenevix-Trench
Journal: Clinical Cancer Research
Clin Cancer Res (2008) 14 (17): 5594–5601.
https://doi.org/10.1158/1078-0432.CCR-08-0606
Published: 02 September 2008
View article titled, <em>ABCB1</em> (<em>MDR 1</em>) Polymorphisms and Progression-Free Survival among Women with Ovarian Cancer following Paclitaxel/Carboplatin Chemotherapy
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Journal Articles

Novel Molecular Subtypes of Serous and Endometrioid Ovarian Cancer Linked to Clinical Outcome

Richard W. Tothill, Anna V. Tinker, Joshy George, Robert Brown, Stephen B. Fox, Stephen Lade, Daryl S. Johnson, Melanie K. Trivett, Dariush Etemadmoghadam, Bianca Locandro, Nadia Traficante, Sian Fereday, Jillian A. Hung, Yoke-Eng Chiew, Izhak Haviv, Australian Ovarian Cancer Study Group, Dorota Gertig, Anna deFazio, David D.L. Bowtell
Journal: Clinical Cancer Research
Clin Cancer Res (2008) 14 (16): 5198–5208.
https://doi.org/10.1158/1078-0432.CCR-08-0196
Published: 12 August 2008
View article titled, Novel Molecular Subtypes of Serous and Endometrioid Ovarian Cancer Linked to Clinical Outcome
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Includes: Supplementary data
Journal Articles

The Use of Magnetic Resonance Imaging to Noninvasively Detect Genetic Signatures in Oligodendroglioma

Robert Brown, Magdalena Zlatescu, Angelique Sijben, Gloria Roldan, Jay Easaw, Peter Forsyth, Ian Parney, Robert Sevick, Elizabeth Yan, Douglas Demetrick, David Schiff, Gregory Cairncross, Ross Mitchell
Journal: Clinical Cancer Research
Clin Cancer Res (2008) 14 (8): 2357–2362.
https://doi.org/10.1158/1078-0432.CCR-07-1964
Published: 15 April 2008
View article titled, The Use of Magnetic Resonance Imaging to Noninvasively Detect Genetic Signatures in Oligodendroglioma
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Journal Articles

A Phase 1 Pharmacokinetic and Pharmacodynamic Study of the Histone Deacetylase Inhibitor Belinostat in Patients with Advanced Solid Tumors

Nicola L. Steele, Jane A. Plumb, Laura Vidal, Jette Tjørnelund, Poul Knoblauch, Annie Rasmussen, Chean Eng Ooi, Peter Buhl-Jensen, Robert Brown, T.R. Jeffry Evans, Johann S. DeBono
Journal: Clinical Cancer Research
Clin Cancer Res (2008) 14 (3): 804–810.
https://doi.org/10.1158/1078-0432.CCR-07-1786
Published: 01 February 2008
View article titled, A Phase 1 Pharmacokinetic and Pharmacodynamic Study of the Histone Deacetylase Inhibitor Belinostat in Patients with Advanced Solid Tumors
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Journal Articles

Inactivation of HOXA Genes by Hypermethylation in Myeloid and Lymphoid Malignancy is Frequent and Associated with Poor Prognosis

Gordon Strathdee, Tessa L. Holyoake, Alyson Sim, Anton Parker, David G. Oscier, Junia V. Melo, Stefan Meyer, Tim Eden, Anne M. Dickinson, Joanne C. Mountford, Heather G. Jorgensen, Richard Soutar, Robert Brown
Journal: Clinical Cancer Research
Clin Cancer Res (2007) 13 (17): 5048–5055.
https://doi.org/10.1158/1078-0432.CCR-07-0919
Published: 04 September 2007
View article titled, Inactivation of <em>HOXA</em> Genes by Hypermethylation in Myeloid and Lymphoid Malignancy is Frequent and Associated with Poor Prognosis
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Includes: Supplementary data
Journal Articles

ABCB1 2677G>T/A Genotype and Paclitaxel Pharmacogenetics in Ovarian Cancer

Sharon Marsh, Cristi R. King, Howard L. McLeod, Jim Paul, Gillian Gifford, Robert Brown
Journal: Clinical Cancer Research
Clin Cancer Res (2006) 12 (13): 4127–4129.
https://doi.org/10.1158/1078-0432.CCR-06-0461
Published: 03 July 2006
View article titled, ABCB1 2677G&gt;T/A Genotype and Paclitaxel Pharmacogenetics in Ovarian Cancer
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Journal Articles

Prognostic DNA Methylation Biomarkers in Ovarian Cancer

Susan H. Wei, Curtis Balch, Henry H. Paik, Yoo-Sung Kim, Rae Lynn Baldwin, Sandya Liyanarachchi, Lang Li, Zailong Wang, Joseph C. Wan, Ramana V. Davuluri, Beth Y. Karlan, Gillian Gifford, Robert Brown, Sun Kim, Tim H-M. Huang, Kenneth P. Nephew
Journal: Clinical Cancer Research
Clin Cancer Res (2006) 12 (9): 2788–2794.
https://doi.org/10.1158/1078-0432.CCR-05-1551
Published: 04 May 2006
View article titled, Prognostic DNA Methylation Biomarkers in Ovarian Cancer
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Includes: Supplementary data
Journal Articles

Hypermethylation of 18S and 28S Ribosomal DNAs Predicts Progression-Free Survival in Patients with Ovarian Cancer

Michael W.Y. Chan, Susan H. Wei, Ping Wen, Zailong Wang, Daniela E. Matei, Joseph C. Liu, Sandya Liyanarachchi, Robert Brown, Kenneth P. Nephew, Pearlly S. Yan, Tim H-M. Huang
Journal: Clinical Cancer Research
Clin Cancer Res (2005) 11 (20): 7376–7383.
https://doi.org/10.1158/1078-0432.CCR-05-1100
Published: 20 October 2005
View article titled, Hypermethylation of 18S and 28S Ribosomal DNAs Predicts Progression-Free Survival in Patients with Ovarian Cancer
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