1-9 of 9
Richard W.J. Groen
Close
Save search
Follow your search
Access your saved searches in your account
Would you like to receive an alert when new items match your search?
Close Modal
Sort by
Journal Articles

Specific Targeting of Multiple Myeloma by Dual Split-signaling Chimeric Antigen Receptor T cells Directed against CD38 and CD138

Jort J. van der Schans, Ziyu Wang, Jennemiek van Arkel, Thijs van Schaik, Afroditi Katsarou, Ruud Ruiter, Thomas Baardemans, Huipin Yuan, Joost de Bruijn, Sonja Zweegman, Niels W.C.J. van de Donk, Richard W.J. Groen, Maria Themeli, Tuna Mutis
Journal: Clinical Cancer Research
Clin Cancer Res (2023) 29 (20): 4219–4229.
https://doi.org/10.1158/1078-0432.CCR-23-0132
Published: 13 October 2023
View article titled, Specific Targeting of Multiple Myeloma by Dual Split-signaling Chimeric Antigen Receptor T cells Directed against CD38 and CD138
Open the PDF for Specific Targeting of Multiple Myeloma by Dual Split-signaling Chimeric Antigen Receptor T cells Directed against CD38 and CD138 in another window
Includes: Supplementary data
Journal Articles

Bone Marrow Mesenchymal Stromal Cells Can Render Multiple Myeloma Cells Resistant to Cytotoxic Machinery of CAR T Cells through Inhibition of Apoptosis

Lisa C. Holthof, Jort J. van der Schans, Afroditi Katsarou, Renée Poels, Anne T. Gelderloos, Esther Drent, Susan E. van Hal-van Veen, Fengzhi Li, Sonja Zweegman, Niels W.C.J. van de Donk, Maria Themeli, Richard W.J. Groen, Tuna Mutis
Journal: Clinical Cancer Research
Clin Cancer Res (2021) 27 (13): 3793–3803.
https://doi.org/10.1158/1078-0432.CCR-20-2188
Published: 01 July 2021
View article titled, Bone Marrow Mesenchymal Stromal Cells Can Render Multiple Myeloma Cells Resistant to Cytotoxic Machinery of CAR T Cells through Inhibition of Apoptosis
Open the PDF for Bone Marrow Mesenchymal Stromal Cells Can Render Multiple Myeloma Cells Resistant to Cytotoxic Machinery of CAR T Cells through Inhibition of Apoptosis in another window
Includes: Supplementary data
Journal Articles

Combined CD28 and 4-1BB Costimulation Potentiates Affinity-tuned Chimeric Antigen Receptor–engineered T Cells

Esther Drent, Renée Poels, Ruud Ruiter, Niels W.C.J. van de Donk, Sonja Zweegman, Huipin Yuan, Joost de Bruijn, Michel Sadelain, Henk M. Lokhorst, Richard W.J. Groen, Tuna Mutis, Maria Themeli
Journal: Clinical Cancer Research
Clin Cancer Res (2019) 25 (13): 4014–4025.
https://doi.org/10.1158/1078-0432.CCR-18-2559
Published: 01 July 2019
View article titled, Combined CD28 and 4-1BB Costimulation Potentiates Affinity-tuned Chimeric Antigen Receptor–engineered T Cells
Open the PDF for Combined CD28 and 4-1BB Costimulation Potentiates Affinity-tuned Chimeric Antigen Receptor–engineered T Cells in another window
Includes: Supplementary data
Journal Articles

Monocytes and Granulocytes Reduce CD38 Expression Levels on Myeloma Cells in Patients Treated with Daratumumab

Jakub Krejcik, Kris A. Frerichs, Inger S. Nijhof, Berris van Kessel, Jeroen F. van Velzen, Andries C. Bloem, Marloes E.C. Broekmans, Sonja Zweegman, Johan van Meerloo, René J.P. Musters, Pino J. Poddighe, Richard W.J. Groen, Christopher Chiu, Torben Plesner, Henk M. Lokhorst, A. Kate Sasser, Tuna Mutis, Niels W.C.J. van de Donk
Journal: Clinical Cancer Research
Clin Cancer Res (2017) 23 (24): 7498–7511.
https://doi.org/10.1158/1078-0432.CCR-17-2027
Published: 14 December 2017
View article titled, Monocytes and Granulocytes Reduce CD38 Expression Levels on Myeloma Cells in Patients Treated with Daratumumab
Open the PDF for Monocytes and Granulocytes Reduce CD38 Expression Levels on Myeloma Cells in Patients Treated with Daratumumab in another window
Includes: Supplementary data
Journal Articles

Preclinical Evidence for the Therapeutic Potential of CD38-Targeted Immuno-Chemotherapy in Multiple Myeloma Patients Refractory to Lenalidomide and Bortezomib

Inger S. Nijhof, Richard W.J. Groen, Willy A. Noort, Berris van Kessel, Regina de Jong-Korlaar, Joost Bakker, Jeroen J.L. van Bueren, Paul W.H.I. Parren, Henk M. Lokhorst, Niels W.C.J. van de Donk, Anton C.M. Martens, Tuna Mutis
Journal: Clinical Cancer Research
Clin Cancer Res (2015) 21 (12): 2802–2810.
https://doi.org/10.1158/1078-0432.CCR-14-1813
Published: 14 June 2015
View article titled, Preclinical Evidence for the Therapeutic Potential of CD38-Targeted Immuno-Chemotherapy in Multiple Myeloma Patients Refractory to Lenalidomide and Bortezomib
Open the PDF for Preclinical Evidence for the Therapeutic Potential of CD38-Targeted Immuno-Chemotherapy in Multiple Myeloma Patients Refractory to Lenalidomide and Bortezomib in another window
Journal Articles

Preclinical Activity of the Oral Proteasome Inhibitor MLN9708 in Myeloma Bone Disease

Antonio Garcia-Gomez, Dalia Quwaider, Miriam Canavese, Enrique M. Ocio, Ze Tian, Juan F. Blanco, Allison J. Berger, Carlos Ortiz-de-Solorzano, Teresa Hernández-Iglesias, Anton C.M. Martens, Richard W.J. Groen, Joaquín Mateo-Urdiales, Susana Fraile, Miguel Galarraga, Dharminder Chauhan, Jesús F. San Miguel, Noopur Raje, Mercedes Garayoa
Journal: Clinical Cancer Research
Clin Cancer Res (2014) 20 (6): 1542–1554.
https://doi.org/10.1158/1078-0432.CCR-13-1657
Published: 13 March 2014
View article titled, Preclinical Activity of the Oral Proteasome Inhibitor MLN9708 in Myeloma Bone Disease
Open the PDF for Preclinical Activity of the Oral Proteasome Inhibitor MLN9708 in Myeloma Bone Disease in another window
Journal Articles

Accessory Cells of the Microenvironment Protect Multiple Myeloma from T-Cell Cytotoxicity through Cell Adhesion-Mediated Immune Resistance

Sanne J. de Haart, Niels W.C.J. van de Donk, Monique C. Minnema, Julie H. Huang, Tineke Aarts-Riemens, Niels Bovenschen, Huipin Yuan, Richard W.J. Groen, Douglas W. McMillin, Jana Jakubikova, Henk M. Lokhorst, Anton C. Martens, Constantine S. Mitsiades, Tuna Mutis
Journal: Clinical Cancer Research
Clin Cancer Res (2013) 19 (20): 5591–5601.
https://doi.org/10.1158/1078-0432.CCR-12-3676
Published: 14 October 2013
View article titled, Accessory Cells of the Microenvironment Protect Multiple Myeloma from T-Cell Cytotoxicity through Cell Adhesion-Mediated Immune Resistance
Open the PDF for Accessory Cells of the Microenvironment Protect Multiple Myeloma from T-Cell Cytotoxicity through Cell Adhesion-Mediated Immune Resistance in another window
Includes: Supplementary data
Journal Articles

Human Regulatory T Cells Do Not Suppress the Antitumor Immunity in the Bone Marrow: A Role for Bone Marrow Stromal Cells in Neutralizing Regulatory T Cells

Teun Guichelaar, Maarten E. Emmelot, Henk Rozemuller, Bianka Martini, Richard W.J. Groen, Gert Storm, Henk M. Lokhorst, Anton C. Martens, Tuna Mutis
Journal: Clinical Cancer Research
Clin Cancer Res (2013) 19 (6): 1467–1475.
https://doi.org/10.1158/1078-0432.CCR-12-2177
Published: 14 March 2013
View article titled, Human Regulatory T Cells Do Not Suppress the Antitumor Immunity in the Bone Marrow: A Role for Bone Marrow Stromal Cells in Neutralizing Regulatory T Cells
Open the PDF for Human Regulatory T Cells Do Not Suppress the Antitumor Immunity in the Bone Marrow: A Role for Bone Marrow Stromal Cells in Neutralizing Regulatory T Cells in another window
Includes: Supplementary data
Journal Articles

Eradication of Medullary Multiple Myeloma by CD4+ Cytotoxic Human T Lymphocytes Directed at a Single Minor Histocompatibility Antigen

Robbert M. Spaapen, Richard W.J. Groen, Kelly van den Oudenalder, Teun Guichelaar, Maureen van Elk, Tineke Aarts-Riemens, Andries C. Bloem, Gert Storm, Anton C. Martens, Henk M. Lokhorst, Tuna Mutis
Journal: Clinical Cancer Research
Clin Cancer Res (2010) 16 (22): 5481–5488.
https://doi.org/10.1158/1078-0432.CCR-10-1340
Published: 14 November 2010
View article titled, Eradication of Medullary Multiple Myeloma by CD4<sup>+</sup> Cytotoxic Human T Lymphocytes Directed at a Single Minor Histocompatibility Antigen
Open the PDF for Eradication of Medullary Multiple Myeloma by CD4<sup>+</sup> Cytotoxic Human T Lymphocytes Directed at a Single Minor Histocompatibility Antigen in another window