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Journal Articles

Impact of Biomarker-Matched Therapies on Outcomes in Patients with Sarcoma Enrolled in Early-Phase Clinical Trials (SAMBA 101)

Open Access
Roberto Carmagnani Pestana, Justin T. Moyers, Jason Roszik, Shiraj Sen, David S. Hong, Aung Naing, Cynthia E. Herzog, Siqing Fu, Sarina A. Piha-Paul, Jordi Rodon, Timothy A. Yap, Daniel D. Karp, Apostolia M. Tsimberidou, Shubham Pant, Maria A. Zarzour, Ravin Ratan, Vinod Ravi, Robert S. Benjamin, Alexander J. Lazar, Wei-Lien Wang, Najat Daw, Jonathan B. Gill, Douglas J. Harrison, Valerae O. Lewis, Christina L. Roland, Shreyaskumar R. Patel, J. Andrew Livingston, Neeta Somaiah, Joseph A. Ludwig, Anthony P. Conley, Nelson Hamerschlak, Richard Gorlick, Funda Meric-Bernstam, Vivek Subbiah
Journal: Clinical Cancer Research
Clin Cancer Res (2023) 29 (9): 1708–1718.
https://doi.org/10.1158/1078-0432.CCR-22-3629
Published: 01 May 2023
View articletitled, Impact of Biomarker-Matched Therapies on Outcomes in Patients with Sarcoma Enrolled in Early-Phase Clinical Trials (SAMBA 101)
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Includes: Supplementary data
Journal Articles

Examining Stripes on a Herd of Zebras: Impact of Genomic Matching for Ultrarare Sarcomas in Phase 1 Clinical Trials (SAMBA 102)

Open Access
Justin T. Moyers, Roberto Carmagnani Pestana, Jason Roszik, David S. Hong, Aung Naing, Siqing Fu, Sarina Piha-Paul, Timothy A. Yap, Daniel Karp, Jordi Rodon, Andy Livingston, Maria Alejandra Zarzour, Vinod Ravi, Shreyaskumar Patel, Robert S. Benjamin, Joseph Ludwig, Cynthia Herzog, Ravin Ratan, Neeta Somaiah, Anthony Conley, Richard Gorlick, Funda Meric-Bernstam, Vivek Subbiah
Journal: Clinical Cancer Research
Clin Cancer Res (2023) 29 (2): 401–409.
https://doi.org/10.1158/1078-0432.CCR-22-2509
Published: 17 January 2023
View articletitled, Examining Stripes on a Herd of Zebras: Impact of Genomic Matching for Ultrarare Sarcomas in Phase 1 Clinical Trials (SAMBA 102)
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Includes: Supplementary data
Journal Articles

Membrane-Anchored and Tumor-Targeted IL12 (attIL12)-PBMC Therapy for Osteosarcoma

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Qing Yang, Jiemiao Hu, Zhiliang Jia, Qi Wang, Jing Wang, Long Hoang Dao, Wendong Zhang, Sheng Zhang, Xueqing Xia, Richard Gorlick, Shulin Li
Journal: Clinical Cancer Research
Clin Cancer Res (2022) 28 (17): 3862–3873.
https://doi.org/10.1158/1078-0432.CCR-22-0721
Published: 01 September 2022
View articletitled, Membrane-Anchored and Tumor-Targeted IL12 (attIL12)-PBMC Therapy for Osteosarcoma
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Includes: Supplementary data
Journal Articles

The B7-H3–Targeting Antibody–Drug Conjugate m276-SL-PBD Is Potently Effective Against Pediatric Cancer Preclinical Solid Tumor Models

Available to Purchase
Nathan M. Kendsersky, Jarrett Lindsay, E. Anders Kolb, Malcolm A. Smith, Beverly A. Teicher, Stephen W. Erickson, Eric J. Earley, Yael P. Mosse, Daniel Martinez, Jennifer Pogoriler, Kateryna Krytska, Khushbu Patel, David Groff, Matthew Tsang, Samson Ghilu, Yifei Wang, Steven Seaman, Yang Feng, Brad St. Croix, Richard Gorlick, Raushan Kurmasheva, Peter J. Houghton, John M. Maris
Journal: Clinical Cancer Research
Clin Cancer Res (2021) 27 (10): 2938–2946.
https://doi.org/10.1158/1078-0432.CCR-20-4221
Published: 15 May 2021
View articletitled, The B7-H3–Targeting Antibody–Drug Conjugate m276-SL-PBD Is Potently Effective Against Pediatric Cancer Preclinical Solid Tumor Models
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Includes: Supplementary data
Journal Articles

Broad Spectrum Activity of the Checkpoint Kinase 1 Inhibitor Prexasertib as a Single Agent or Chemopotentiator Across a Range of Preclinical Pediatric Tumor Models

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Caitlin D. Lowery, Michele Dowless, Matthew Renschler, Wayne Blosser, Alle B. VanWye, Jennifer R. Stephens, Philip W. Iversen, Aimee Bence Lin, Richard P. Beckmann, Kateryna Krytska, Kristina A. Cole, John M. Maris, Douglas S. Hawkins, Brian P. Rubin, Raushan T. Kurmasheva, Peter J. Houghton, Richard Gorlick, E. Anders Kolb, Min H. Kang, C. Patrick Reynolds, Stephen W. Erickson, Beverly A. Teicher, Malcolm A. Smith, Louis F. Stancato
Journal: Clinical Cancer Research
Clin Cancer Res (2019) 25 (7): 2278–2289.
https://doi.org/10.1158/1078-0432.CCR-18-2728
Published: 01 April 2019
View articletitled, Broad Spectrum Activity of the Checkpoint Kinase 1 Inhibitor Prexasertib as a Single Agent or Chemopotentiator Across a Range of Preclinical Pediatric Tumor Models
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Includes: Supplementary data
Journal Articles

Abstract PR01: A DNA methylation-based classifier for accurate molecular diagnosis of bone sarcomas

Free
Shengyang Wu, Benjamin Cooper, Fang Bu, Christopher Bowman, Jonathan K. Killian, Shiyang Wang, Twana Jackson, Daniel Gorovets, Richard Gorlick, Kristen Thomas, Matthias Karajannis, Matija Snuderl
Journal: Clinical Cancer Research
Clin Cancer Res (2018) 24 (2_Supplement): PR01.
https://doi.org/10.1158/1557-3265.SARCOMAS17-PR01
Published: 15 January 2018
View articletitled, Abstract PR01: A DNA methylation-based classifier for accurate molecular diagnosis of bone sarcomas
Journal Articles

To B(MP-2) or Not To B(MP-2): Cytokines and Tumor Surgery—Letter

Available to Purchase
David S. Geller, Jonathan Gill, Michael Roth, Richard Gorlick
Journal: Clinical Cancer Research
Clin Cancer Res (2015) 21 (17): 4022.
https://doi.org/10.1158/1078-0432.CCR-15-0470
Published: 31 August 2015
View articletitled, To B(MP-2) or Not To B(MP-2): Cytokines and Tumor Surgery—Letter
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Journal Articles

Development of a Model System to Evaluate Local Recurrence in Osteosarcoma and Assessment of the Effects of Bone Morphogenetic Protein-2

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David S. Geller, Michael Y. Singh, Wendong Zhang, Jonathan Gill, Michael E. Roth, Mimi Y. Kim, Xianhong Xie, Christopher K. Singh, Howard D. Dorfman, Esperanza Villanueva-Siles, Amy Park, Sajida Piperdi, Richard Gorlick
Journal: Clinical Cancer Research
Clin Cancer Res (2015) 21 (13): 3003–3012.
https://doi.org/10.1158/1078-0432.CCR-14-0986
Published: 30 June 2015
View articletitled, Development of a Model System to Evaluate Local Recurrence in Osteosarcoma and Assessment of the Effects of Bone Morphogenetic Protein-2
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Includes: Supplementary data
Journal Articles

Synergistic Activity of PARP Inhibition by Talazoparib (BMN 673) with Temozolomide in Pediatric Cancer Models in the Pediatric Preclinical Testing Program

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Malcolm A. Smith, C. Patrick Reynolds, Min H. Kang, E. Anders Kolb, Richard Gorlick, Hernan Carol, Richard B. Lock, Stephen T. Keir, John M. Maris, Catherine A. Billups, Dmitry Lyalin, Raushan T. Kurmasheva, Peter J. Houghton
Journal: Clinical Cancer Research
Clin Cancer Res (2015) 21 (4): 819–832.
https://doi.org/10.1158/1078-0432.CCR-14-2572
Published: 16 February 2015
View articletitled, Synergistic Activity of PARP Inhibition by Talazoparib (BMN 673) with Temozolomide in Pediatric Cancer Models in the Pediatric Preclinical Testing Program
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Includes: Supplementary data
Journal Articles

Toward a Drug Development Path That Targets Metastatic Progression in Osteosarcoma

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Chand Khanna, Timothy M. Fan, Richard Gorlick, Lee J. Helman, Eugenie S. Kleinerman, Peter C. Adamson, Peter J. Houghton, William D. Tap, Danny R. Welch, Patricia S. Steeg, Glenn Merlino, Poul H.B. Sorensen, Paul Meltzer, David G. Kirsch, Katherine A. Janeway, Brenda Weigel, Lor Randall, Stephen J Withrow, Melissa Paoloni, Rosandra Kaplan, Beverly A. Teicher, Nita L. Seibel, Malcolm Smith, Aykut Üren, Shreyaskumar R. Patel, Jeffrey Trent, Sharon A. Savage, Lisa Mirabello, Denise Reinke, Donald A. Barkaukas, Mark Krailo, Mark Bernstein
Journal: Clinical Cancer Research
Clin Cancer Res (2014) 20 (16): 4200–4209.
https://doi.org/10.1158/1078-0432.CCR-13-2574
Published: 13 August 2014
View articletitled, Toward a Drug Development Path That Targets Metastatic Progression in Osteosarcoma
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Journal Articles

Inhibition of Src Phosphorylation Alters Metastatic Potential of Osteosarcoma In vitro but not In vivo

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Pooja Hingorani, Wendong Zhang, Richard Gorlick, E. Anders Kolb
Journal: Clinical Cancer Research
Clin Cancer Res (2009) 15 (10): 3416–3422.
https://doi.org/10.1158/1078-0432.CCR-08-1657
Published: 18 May 2009
View articletitled, Inhibition of Src Phosphorylation Alters Metastatic Potential of Osteosarcoma In vitro but not In vivo
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Journal Articles

Activation of the RAF/Mitogen-Activated Protein/Extracellular Signal-Regulated Kinase Kinase/Extracellular Signal-Regulated Kinase Pathway Mediates Apoptosis Induced by Chelerythrine in Osteosarcoma

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Rui Yang, Sajida Piperdi, Richard Gorlick
Journal: Clinical Cancer Research
Clin Cancer Res (2008) 14 (20): 6396–6404.
https://doi.org/10.1158/1078-0432.CCR-07-5113
Published: 16 October 2008
View articletitled, Activation of the RAF/Mitogen-Activated Protein/Extracellular Signal-Regulated Kinase Kinase/Extracellular Signal-Regulated Kinase Pathway Mediates Apoptosis Induced by Chelerythrine in Osteosarcoma
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Includes: Supplementary data
Journal Articles

Molecular Characterization of the Pediatric Preclinical Testing Panel

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Geoffrey Neale, Xiaoping Su, Christopher L. Morton, Doris Phelps, Richard Gorlick, Richard B. Lock, C. Patrick Reynolds, John M. Maris, Henry S. Friedman, Jeffrey Dome, Joseph Khoury, Timothy J. Triche, Robert C. Seeger, Richard Gilbertson, Javed Khan, Malcolm A. Smith, Peter J. Houghton
Journal: Clinical Cancer Research
Clin Cancer Res (2008) 14 (14): 4572–4583.
https://doi.org/10.1158/1078-0432.CCR-07-5090
Published: 15 July 2008
View articletitled, Molecular Characterization of the Pediatric Preclinical Testing Panel
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Includes: Supplementary data
Journal Articles

The Folate Receptor α Is Frequently Overexpressed in Osteosarcoma Samples and Plays a Role in the Uptake of the Physiologic Substrate 5-Methyltetrahydrofolate

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Rui Yang, E. Anders Kolb, Jing Qin, Alexander Chou, Rebecca Sowers, Bang Hoang, John H. Healey, Andrew G. Huvos, Paul A. Meyers, Richard Gorlick
Journal: Clinical Cancer Research
Clin Cancer Res (2007) 13 (9): 2557–2567.
https://doi.org/10.1158/1078-0432.CCR-06-1343
Published: 01 May 2007
View articletitled, The Folate Receptor α Is Frequently Overexpressed in Osteosarcoma Samples and Plays a Role in the Uptake of the Physiologic Substrate 5-Methyltetrahydrofolate
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Journal Articles

CXCR4 Expression in Osteosarcoma Cell Lines and Tumor Samples: Evidence for Expression by Tumor Cells

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Caroline Laverdière, Richard Gorlick
Journal: Clinical Cancer Research
Clin Cancer Res (2006) 12 (17): 5254.
https://doi.org/10.1158/1078-0432.CCR-06-1527
Published: 01 September 2006
View articletitled, CXCR4 Expression in Osteosarcoma Cell Lines and Tumor Samples: Evidence for Expression by Tumor Cells
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Journal Articles

Messenger RNA Expression Levels of CXCR4 Correlate with Metastatic Behavior and Outcome in Patients with Osteosarcoma

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Caroline Laverdiere, Bang H. Hoang, Rui Yang, Rebecca Sowers, Jing Qin, Paul A. Meyers, Andrew G. Huvos, John H. Healey, Richard Gorlick
Journal: Clinical Cancer Research
Clin Cancer Res (2005) 11 (7): 2561–2567.
https://doi.org/10.1158/1078-0432.CCR-04-1089
Published: 06 April 2005
View articletitled, Messenger RNA Expression Levels of CXCR4 Correlate with Metastatic Behavior and Outcome in Patients with Osteosarcoma
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Journal Articles

Elevated Physiologic Tumor Pressure Promotes Proliferation and Chemosensitivity in Human Osteosarcoma

Available to Purchase
Saminathan S. Nathan, Gene R. DiResta, Jorge E. Casas-Ganem, Bang H. Hoang, Rebecca Sowers, Rui Yang, Andrew G. Huvos, Richard Gorlick, John H. Healey
Journal: Clinical Cancer Research
Clin Cancer Res (2005) 11 (6): 2389–2397.
https://doi.org/10.1158/1078-0432.CCR-04-2048
Published: 23 March 2005
View articletitled, Elevated Physiologic Tumor Pressure Promotes Proliferation and Chemosensitivity in Human Osteosarcoma
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Journal Articles

An 19F Magnetic Resonance–Based In Vivo Assay of Solid Tumor Methotrexate Resistance: Proof of Principle

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William M. Spees, Terence P.F. Gade, Guangli Yang, William P. Tong, William G. Bornmann, Richard Gorlick, Jason A. Koutcher
Journal: Clinical Cancer Research
Clin Cancer Res (2005) 11 (4): 1454–1461.
https://doi.org/10.1158/1078-0432.CCR-04-1439
Published: 02 March 2005
View articletitled, An 19F Magnetic Resonance–Based In Vivo Assay of Solid Tumor Methotrexate Resistance: Proof of Principle
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Journal Articles

Biology of Childhood Osteogenic Sarcoma and Potential Targets for Therapeutic Development: Meeting Summary

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Richard Gorlick, Peter Anderson, Irene Andrulis, Carola Arndt, G. Peter Beardsley, Mark Bernstein, Julia Bridge, Nai-Kong Cheung, Jeffrey S. Dome, David Ebb, Thomas Gardner, Mark Gebhardt, Holcombe Grier, Marc Hansen, John Healey, Lee Helman, Janet Hock, Janet Houghton, Peter Houghton, Andrew Huvos, Chand Khanna, Mark Kieran, Eugenie Kleinerman, Marc Ladanyi, Ching Lau, David Malkin, Neyssa Marina, Paul Meltzer, Paul Meyers, Deborah Schofield, Cindy Schwartz, Malcolm A. Smith, Jeffrey Toretsky, Maria Tsokos, Leonard Wexler, Jon Wigginton, Stephen Withrow, Mason Schoenfeldt, Barry Anderson
Journal: Clinical Cancer Research
Clin Cancer Res (2003) 9 (15): 5442–5453.
Published: 03 December 2003
View articletitled, Biology of Childhood Osteogenic Sarcoma and Potential Targets for Therapeutic Development: Meeting Summary
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Journal Articles

Sequence Alterations in the Reduced Folate Carrier Are Observed in Osteosarcoma Tumor Samples

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Rui Yang, Rebecca Sowers, BethAnne Mazza, John H. Healey, Andrew Huvos, Holcombe Grier, Mark Bernstein, G. Peter Beardsley, Mark D. Krailo, Meenakshi Devidas, Joseph R. Bertino, Paul A. Meyers, Richard Gorlick
Journal: Clinical Cancer Research
Clin Cancer Res (2003) 9 (2): 837–844.
Published: 01 February 2003
View articletitled, Sequence Alterations in the Reduced Folate Carrier Are Observed in Osteosarcoma Tumor Samples
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