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Richard G. Vile
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Journal Articles

APOBEC and Cancer Viroimmunotherapy: Thinking the Unthinkable

Richard G. Vile, Alan Melcher, Hardev Pandha, Kevin J. Harrington, Jose S. Pulido
Journal: Clinical Cancer Research
Clin Cancer Res (2021) 27 (12): 3280–3290.
https://doi.org/10.1158/1078-0432.CCR-20-1888
Published: 15 June 2021
View articletitled, APOBEC and Cancer Viroimmunotherapy: Thinking the Unthinkable
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Journal Articles

Ad5NULL-A20: A Tropism-Modified, αvβ6 Integrin-Selective Oncolytic Adenovirus for Epithelial Ovarian Cancer Therapies

Hanni Uusi-Kerttula, James A. Davies, Jill M. Thompson, Phonphimon Wongthida, Laura Evgin, Kevin G. Shim, Angela Bradshaw, Alexander T. Baker, Pierre J. Rizkallah, Rachel Jones, Louise Hanna, Emma Hudson, Richard G. Vile, John D. Chester, Alan L. Parker
Journal: Clinical Cancer Research
Clin Cancer Res (2018) 24 (17): 4215–4224.
https://doi.org/10.1158/1078-0432.CCR-18-1089
Published: 04 September 2018
View articletitled, Ad5NULL-A20: A Tropism-Modified, αvβ6 Integrin-Selective Oncolytic Adenovirus for Epithelial Ovarian Cancer Therapies
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Includes: Supplementary data
Journal Articles

Phase I/II Trial of Carboplatin and Paclitaxel Chemotherapy in Combination with Intravenous Oncolytic Reovirus in Patients with Advanced Malignancies

Eleni M. Karapanagiotou, Victoria Roulstone, Katie Twigger, Mercel Ball, MaryAnne Tanay, Chris Nutting, Kate Newbold, Martin E. Gore, James Larkin, Konstantinos N. Syrigos, Matt Coffey, Brad Thompson, Karl Mettinger, Richard G. Vile, Hardev S. Pandha, Geoff D. Hall, Alan A. Melcher, John Chester, Kevin J. Harrington
Journal: Clinical Cancer Research
Clin Cancer Res (2012) 18 (7): 2080–2089.
https://doi.org/10.1158/1078-0432.CCR-11-2181
Published: 01 April 2012
View articletitled, Phase I/II Trial of Carboplatin and Paclitaxel Chemotherapy in Combination with Intravenous Oncolytic Reovirus in Patients with Advanced Malignancies
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Includes: Supplementary data
Journal Articles

Immune Recruitment and Therapeutic Synergy: Keys to Optimizing Oncolytic Viral Therapy?

Jay D. Naik, Christopher J. Twelves, Peter J. Selby, Richard G. Vile, John D. Chester
Journal: Clinical Cancer Research
Clin Cancer Res (2011) 17 (13): 4214–4224.
https://doi.org/10.1158/1078-0432.CCR-10-2848
Published: 05 July 2011
View articletitled, Immune Recruitment and Therapeutic Synergy: Keys to Optimizing Oncolytic Viral Therapy?
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Journal Articles

Internalization of Oncolytic Reovirus by Human Dendritic Cell Carriers Protects the Virus from Neutralization

Elizabeth J. Ilett, Montserrat Bárcena, Fiona Errington-Mais, Stephen Griffin, Kevin J. Harrington, Hardev S. Pandha, Matthew Coffey, Peter J. Selby, Ronald W.A.L. Limpens, Mieke Mommaas, Rob C. Hoeben, Richard G. Vile, Alan A. Melcher
Journal: Clinical Cancer Research
Clin Cancer Res (2011) 17 (9): 2767–2776.
https://doi.org/10.1158/1078-0432.CCR-10-3266
Published: 01 May 2011
View articletitled, Internalization of Oncolytic Reovirus by Human Dendritic Cell Carriers Protects the Virus from Neutralization
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Journal Articles

Two-Stage Phase I Dose-Escalation Study of Intratumoral Reovirus Type 3 Dearing and Palliative Radiotherapy in Patients with Advanced Cancers

Kevin J. Harrington, Eleni M. Karapanagiotou, Victoria Roulstone, Katie R. Twigger, Christine L. White, Laura Vidal, Debbie Beirne, Robin Prestwich, Kate Newbold, Merina Ahmed, Khin Thway, Christopher M. Nutting, Matt Coffey, Dean Harris, Richard G. Vile, Hardev S. Pandha, Johann S. DeBono, Alan A. Melcher
Journal: Clinical Cancer Research
Clin Cancer Res (2010) 16 (11): 3067–3077.
https://doi.org/10.1158/1078-0432.CCR-10-0054
Published: 31 May 2010
View articletitled, Two-Stage Phase I Dose-Escalation Study of Intratumoral Reovirus Type 3 Dearing and Palliative Radiotherapy in Patients with Advanced Cancers
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Includes: Supplementary data
Journal Articles

Immune-Mediated Antitumor Activity of Reovirus Is Required for Therapy and Is Independent of Direct Viral Oncolysis and Replication

Robin J. Prestwich, Elizabeth J. Ilett, Fiona Errington, Rosa M. Diaz, Lynette P. Steele, Tim Kottke, Jill Thompson, Feorillo Galivo, Kevin J. Harrington, Hardev S. Pandha, Peter J. Selby, Richard G. Vile, Alan A. Melcher
Journal: Clinical Cancer Research
Clin Cancer Res (2009) 15 (13): 4374–4381.
https://doi.org/10.1158/1078-0432.CCR-09-0334
Published: 01 July 2009
View articletitled, Immune-Mediated Antitumor Activity of Reovirus Is Required for Therapy and Is Independent of Direct Viral Oncolysis and Replication
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Journal Articles

Improved Systemic Delivery of Oncolytic Reovirus to Established Tumors Using Preconditioning with Cyclophosphamide-Mediated Treg Modulation and Interleukin-2

Timothy Kottke, Jill Thompson, Rosa Maria Diaz, Jose Pulido, Candice Willmon, Matt Coffey, Peter Selby, Alan Melcher, Kevin Harrington, Richard G. Vile
Journal: Clinical Cancer Research
Clin Cancer Res (2009) 15 (2): 561–569.
https://doi.org/10.1158/1078-0432.CCR-08-1688
Published: 15 January 2009
View articletitled, Improved Systemic Delivery of Oncolytic Reovirus to Established Tumors Using Preconditioning with Cyclophosphamide-Mediated Treg Modulation and Interleukin-2
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Journal Articles

Tumor Infection by Oncolytic Reovirus Primes Adaptive Antitumor Immunity

Robin J. Prestwich, Fiona Errington, Elizabeth J. Ilett, Ruth S.M. Morgan, Karen J. Scott, Timothy Kottke, Jill Thompson, Ewan E. Morrison, Kevin J. Harrington, Hardev S. Pandha, Peter J. Selby, Richard G. Vile, Alan A. Melcher
Journal: Clinical Cancer Research
Clin Cancer Res (2008) 14 (22): 7358–7366.
https://doi.org/10.1158/1078-0432.CCR-08-0831
Published: 14 November 2008
View articletitled, Tumor Infection by Oncolytic Reovirus Primes Adaptive Antitumor Immunity
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Journal Articles

A Phase I Study of Intravenous Oncolytic Reovirus Type 3 Dearing in Patients with Advanced Cancer

Laura Vidal, Hardev S. Pandha, Timothy A. Yap, Christine L. White, Katie Twigger, Richard G. Vile, Alan Melcher, Matt Coffey, Kevin J. Harrington, Johann S. DeBono
Journal: Clinical Cancer Research
Clin Cancer Res (2008) 14 (21): 7127–7137.
https://doi.org/10.1158/1078-0432.CCR-08-0524
Published: 03 November 2008
View articletitled, A Phase I Study of Intravenous Oncolytic Reovirus Type 3 Dearing in Patients with Advanced Cancer
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Journal Articles

Radiation-Mediated Up-Regulation of Gene Expression from Replication-Defective Adenoviral Vectors: Implications for Sodium Iodide Symporter Gene Therapy

Mohan Hingorani, Christine L. White, Shane Zaidi, Andrew Merron, Inge Peerlinck, Martin E. Gore, Christopher M. Nutting, Hardev S. Pandha, Alan A. Melcher, Richard G. Vile, Georges Vassaux, Kevin J. Harrington
Journal: Clinical Cancer Research
Clin Cancer Res (2008) 14 (15): 4915–4924.
https://doi.org/10.1158/1078-0432.CCR-07-4049
Published: 01 August 2008
View articletitled, Radiation-Mediated Up-Regulation of Gene Expression from Replication-Defective Adenoviral Vectors: Implications for Sodium Iodide Symporter Gene Therapy
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Includes: Supplementary data
Journal Articles

Enhanced In vitro and In vivo Cytotoxicity of Combined Reovirus and Radiotherapy

Katie Twigger, Laura Vidal, Christine L. White, Johann S. De Bono, Shreerang Bhide, Matt Coffey, Brad Thompson, Richard G. Vile, Lucy Heinemann, Hardev S. Pandha, Fiona Errington, Alan A. Melcher, Kevin J. Harrington
Journal: Clinical Cancer Research
Clin Cancer Res (2008) 14 (3): 912–923.
https://doi.org/10.1158/1078-0432.CCR-07-1400
Published: 01 February 2008
View articletitled, Enhanced In vitro and In vivo Cytotoxicity of Combined Reovirus and Radiotherapy
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Includes: Supplementary data
Journal Articles

Effective Targeting of Solid Tumors in Patients With Locally Advanced Cancers by Radiolabeled Pegylated Liposomes

Kevin J. Harrington, Sima Mohammadtaghi, Paul S. Uster, Daphne Glass, A. Michael Peters, Richard G. Vile, J. Simon W. Stewart
Journal: Clinical Cancer Research
Clin Cancer Res (2001) 7 (2): 243–254.
Published: 01 February 2001
View articletitled, Effective Targeting of Solid Tumors in Patients With Locally Advanced Cancers by Radiolabeled Pegylated Liposomes
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Journal Articles

Pegylated Liposome-encapsulated Doxorubicin and Cisplatin Enhance the Effect of Radiotherapy in a Tumor Xenograft Model

Kevin J. Harrington, Gail Rowlinson-Busza, Konstantinos N. Syrigos, Richard G. Vile, Paul S. Uster, A. Michael Peters, J. Simon W. Stewart
Journal: Clinical Cancer Research
Clin Cancer Res (2000) 6 (12): 4939–4949.
Published: 01 December 2000
View articletitled, Pegylated Liposome-encapsulated Doxorubicin and Cisplatin Enhance the Effect of Radiotherapy in a Tumor Xenograft Model
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Journal Articles

Pegylated Liposomes Have Potential as Vehicles for Intratumoral and Subcutaneous Drug Delivery

Kevin J. Harrington, Gail Rowlinson-Busza, Konstantinos N. Syrigos, Paul S. Uster, Richard G. Vile, J. Simon W. Stewart
Journal: Clinical Cancer Research
Clin Cancer Res (2000) 6 (6): 2528–2537.
Published: 01 June 2000
View articletitled, Pegylated Liposomes Have Potential as Vehicles for Intratumoral and Subcutaneous Drug Delivery
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