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Ravi K. Amaravadi
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Journal Articles

Tumor-Infiltrating Lymphocytes in Necrotic Tumors after Melanoma Neoadjuvant Anti–PD-1 Therapy Correlate with Pathologic Response and Recurrence-Free Survival

Kevin L. Ma, Tara C. Mitchell, Meaghan Dougher, Cimarron E. Sharon, Gabriella N. Tortorello, David E. Elder, Eric E. Morgan, Phyllis A. Gimotty, Alexander C. Huang, Ravi K. Amaravadi, Lynn M. Schuchter, Ahron Flowers, John T. Miura, Giorgos C. Karakousis, Xiaowei Xu
Journal: Clinical Cancer Research
Clin Cancer Res (2024) 30 (21): 4987–4994.
https://doi.org/10.1158/1078-0432.CCR-23-3775
Published: 01 November 2024
View articletitled, Tumor-Infiltrating Lymphocytes in Necrotic Tumors after Melanoma Neoadjuvant Anti–PD-1 Therapy Correlate with Pathologic Response and Recurrence-Free Survival
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Includes: Supplementary data
Journal Articles

FDG PET/CT Imaging 1 Week after a Single Dose of Pembrolizumab Predicts Treatment Response in Patients with Advanced Melanoma

Thomas M. Anderson, Bryan H. Chang, Alexander C. Huang, Xiaowei Xu, Daniel Yoon, Catherine G. Shang, Rosemarie Mick, Erin Schubert, Suzanne McGettigan, Kristin Kreider, Wei Xu, E. John Wherry, Lynn M. Schuchter, Ravi K. Amaravadi, Tara C. Mitchell, Michael D. Farwell
Journal: Clinical Cancer Research
Clin Cancer Res (2024) 30 (9): 1758–1767.
https://doi.org/10.1158/1078-0432.CCR-23-2390
Published: 01 May 2024
View articletitled, FDG PET/CT Imaging 1 Week after a Single Dose of Pembrolizumab Predicts Treatment Response in Patients with Advanced Melanoma
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Includes: Supplementary data
Journal Articles

BAMM (BRAF Autophagy and MEK Inhibition in Melanoma): A Phase I/II Trial of Dabrafenib, Trametinib, and Hydroxychloroquine in Advanced BRAFV600-mutant Melanoma

Janice M. Mehnert, Tara C. Mitchell, Alexander C. Huang, Tomas S. Aleman, Benjamin J. Kim, Lynn M. Schuchter, Gerald P. Linette, Giorgos C. Karakousis, Sheryl Mitnick, Lydia Giles, Mary Carberry, Noelle Frey, Andrew Kossenkov, Roman Groisberg, Leonel F. Hernandez-Aya, George Ansstas, Ann W. Silk, Sunandana Chandra, Jeffrey A. Sosman, Phyllis A. Gimotty, Rosemarie Mick, Ravi K. Amaravadi
Journal: Clinical Cancer Research
Clin Cancer Res (2022) 28 (6): 1098–1106.
https://doi.org/10.1158/1078-0432.CCR-21-3382
Published: 15 March 2022
View articletitled, BAMM (BRAF Autophagy and MEK Inhibition in Melanoma): A Phase I/II Trial of Dabrafenib, Trametinib, and Hydroxychloroquine in Advanced BRAFV600-mutant Melanoma
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Includes: Supplementary data
Journal Articles

A Randomized Phase II Preoperative Study of Autophagy Inhibition with High-Dose Hydroxychloroquine and Gemcitabine/Nab-Paclitaxel in Pancreatic Cancer Patients

Herbert J. Zeh, Nathan Bahary, Brian A. Boone, Aatur D. Singhi, Jennifer Lee Miller-Ocuin, Daniel P. Normolle, Amer H. Zureikat, Melissa E. Hogg, David L. Bartlett, Kenneth K. Lee, Allan Tsung, J. Wallis Marsh, Pranav Murthy, Daolin Tang, Natalie Seiser, Ravi K. Amaravadi, Virginia Espina, Lance Liotta, Michael T. Lotze
Journal: Clinical Cancer Research
Series: Author Choice
Clin Cancer Res (2020) 26 (13): 3126–3134.
https://doi.org/10.1158/1078-0432.CCR-19-4042
Published: 01 July 2020
View articletitled, A Randomized Phase II Preoperative Study of Autophagy Inhibition with High-Dose Hydroxychloroquine and Gemcitabine/Nab-Paclitaxel in Pancreatic Cancer Patients
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Includes: Supplementary data
Journal Articles

Autophagy Inhibition to Augment mTOR Inhibition: a Phase I/II Trial of Everolimus and Hydroxychloroquine in Patients with Previously Treated Renal Cell Carcinoma

Naomi B. Haas, Leonard J. Appleman, Mark Stein, Maryann Redlinger, Melissa Wilks, Xiaowei Xu, Angelique Onorati, Anusha Kalavacharla, Taehyong Kim, Chao Jie Zhen, Sabah Kadri, Jeremy P. Segal, Phyllis A. Gimotty, Lisa E. Davis, Ravi K. Amaravadi
Journal: Clinical Cancer Research
Clin Cancer Res (2019) 25 (7): 2080–2087.
https://doi.org/10.1158/1078-0432.CCR-18-2204
Published: 01 April 2019
View articletitled, Autophagy Inhibition to Augment mTOR Inhibition: a Phase I/II Trial of Everolimus and Hydroxychloroquine in Patients with Previously Treated Renal Cell Carcinoma
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Includes: Supplementary data
Journal Articles

Age Correlates with Response to Anti-PD1, Reflecting Age-Related Differences in Intratumoral Effector and Regulatory T-Cell Populations

Curtis H. Kugel, III, Stephen M. Douglass, Marie R. Webster, Amanpreet Kaur, Qin Liu, Xiangfan Yin, Sarah A. Weiss, Farbod Darvishian, Rami N. Al-Rohil, Abibatou Ndoye, Reeti Behera, Gretchen M. Alicea, Brett L. Ecker, Mitchell Fane, Michael J. Allegrezza, Nikolaos Svoronos, Vinit Kumar, Daniel Y. Wang, Rajasekharan Somasundaram, Siwen Hu-Lieskovan, Alpaslan Ozgun, Meenhard Herlyn, Jose R. Conejo-Garcia, Dmitry Gabrilovich, Erica L. Stone, Theodore S. Nowicki, Jeffrey Sosman, Rajat Rai, Matteo S. Carlino, Georgina V. Long, Richard Marais, Antoni Ribas, Zeynep Eroglu, Michael A. Davies, Bastian Schilling, Dirk Schadendorf, Wei Xu, Ravi K. Amaravadi, Alexander M. Menzies, Jennifer L. McQuade, Douglas B. Johnson, Iman Osman, Ashani T. Weeraratna
Journal: Clinical Cancer Research
Clin Cancer Res (2018) 24 (21): 5347–5356.
https://doi.org/10.1158/1078-0432.CCR-18-1116
Published: 01 November 2018
View articletitled, Age Correlates with Response to Anti-PD1, Reflecting Age-Related Differences in Intratumoral Effector and Regulatory T-Cell Populations
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Includes: Supplementary data
Journal Articles

Induction of Telomere Dysfunction Prolongs Disease Control of Therapy-Resistant Melanoma

Gao Zhang, Lawrence W. Wu, Ilgen Mender, Michal Barzily-Rokni, Marc R. Hammond, Omotayo Ope, Chaoran Cheng, Themistoklis Vasilopoulos, Sergio Randell, Norah Sadek, Aurelie Beroard, Min Xiao, Tian Tian, Jiufeng Tan, Umar Saeed, Eric Sugarman, Clemens Krepler, Patricia Brafford, Katrin Sproesser, Sengottuvelan Murugan, Rajasekharan Somasundaram, Bradley Garman, Bradley Wubbenhorst, Jonathan Woo, Xiangfan Yin, Qin Liu, Dennie T. Frederick, Benchun Miao, Wei Xu, Giorgos C. Karakousis, Xiaowei Xu, Lynn M. Schuchter, Tara C. Mitchell, Lawrence N. Kwong, Ravi K. Amaravadi, Yiling Lu, Genevieve M. Boland, Zhi Wei, Katherine Nathanson, Utz Herbig, Gordon B. Mills, Keith T. Flaherty, Meenhard Herlyn, Jerry W. Shay
Journal: Clinical Cancer Research
Clin Cancer Res (2018) 24 (19): 4771–4784.
https://doi.org/10.1158/1078-0432.CCR-17-2773
Published: 01 October 2018
View articletitled, Induction of Telomere Dysfunction Prolongs Disease Control of Therapy-Resistant Melanoma
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Includes: Multimedia, Supplementary data
Journal Articles

A Multicenter Phase I Study Evaluating Dual PI3K and BRAF Inhibition with PX-866 and Vemurafenib in Patients with Advanced BRAF V600–Mutant Solid Tumors

Clinton Yam, Xiaowei Xu, Michael A. Davies, Phyllis A. Gimotty, Jennifer J.D. Morrissette, Michael T. Tetzlaff, Khalida M. Wani, Shujing Liu, Wanleng Deng, Meghan Buckley, Jianhua Zhao, Ravi K. Amaravadi, Naomi B. Haas, Ragini R. Kudchadkar, Anna C. Pavlick, Jeffrey A. Sosman, Hussein Tawbi, Luke Walker, Lynn M. Schuchter, Giorgos C. Karakousis, Tara C. Gangadhar
Journal: Clinical Cancer Research
Clin Cancer Res (2018) 24 (1): 22–32.
https://doi.org/10.1158/1078-0432.CCR-17-1807
Published: 02 January 2018
View articletitled, A Multicenter Phase I Study Evaluating Dual PI3K and BRAF Inhibition with PX-866 and Vemurafenib in Patients with Advanced BRAF V600–Mutant Solid Tumors
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Includes: Supplementary data
Journal Articles

Multiple Gastrointestinal Polyps in Patients Treated with BRAF Inhibitors

Ravi K. Amaravadi, Kathryn E. Hamilton, Xiaohong Ma, Shengfu Piao, Armando Del Portillo, Katherine L. Nathanson, Matteo S. Carlino, Georgina V. Long, Igor Puzanov, Xiaowei Xu, Jennifer J.D. Morrissette, Kenneth Y. Tsai, Keith T. Flaherty, Jeffrey A. Sosman, Grant R. Goodman, Grant A. McArthur, Anil K. Rustgi, David C. Metz, Lynn M. Schuchter, Paul B. Chapman, Antonia R. Sepulveda
Journal: Clinical Cancer Research
Clin Cancer Res (2015) 21 (23): 5215–5221.
https://doi.org/10.1158/1078-0432.CCR-15-0469
Published: 30 November 2015
View articletitled, Multiple Gastrointestinal Polyps in Patients Treated with BRAF Inhibitors
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Includes: Supplementary data
Journal Articles

BRAF Inhibition Stimulates Melanoma-Associated Macrophages to Drive Tumor Growth

Tao Wang, Min Xiao, Yingbin Ge, Clemens Krepler, Eric Belser, Alfonso Lopez-Coral, Xiaowei Xu, Gao Zhang, Rikka Azuma, Qin Liu, Rui Liu, Ling Li, Ravi K. Amaravadi, Wei Xu, Giorgos Karakousis, Tara C. Gangadhar, Lynn M. Schuchter, Melissa Lieu, Sanika Khare, Molly B. Halloran, Meenhard Herlyn, Russel E. Kaufman
Journal: Clinical Cancer Research
Clin Cancer Res (2015) 21 (7): 1652–1664.
https://doi.org/10.1158/1078-0432.CCR-14-1554
Published: 31 March 2015
View articletitled, BRAF Inhibition Stimulates Melanoma-Associated Macrophages to Drive Tumor Growth
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Includes: Supplementary data
Journal Articles

Autophagy Inhibition Sensitizes Colon Cancer Cells to Antiangiogenic and Cytotoxic Therapy

Muthu Selvakumaran, Ravi K. Amaravadi, Irina A. Vasilevskaya, Peter J. O'Dwyer
Journal: Clinical Cancer Research
Clin Cancer Res (2013) 19 (11): 2995–3007.
https://doi.org/10.1158/1078-0432.CCR-12-1542
Published: 30 May 2013
View articletitled, Autophagy Inhibition Sensitizes Colon Cancer Cells to Antiangiogenic and Cytotoxic Therapy
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Includes: Supplementary data
Journal Articles

The Novel SMAC Mimetic Birinapant Exhibits Potent Activity against Human Melanoma Cells

Clemens Krepler, Srinivas K. Chunduru, Molly B. Halloran, Xu He, Min Xiao, Adina Vultur, Jessie Villanueva, Yasuhiro Mitsuuchi, Eric M. Neiman, Christopher Benetatos, Katherine L. Nathanson, Ravi K. Amaravadi, Hubert Pehamberger, Mark McKinlay, Meenhard Herlyn
Journal: Clinical Cancer Research
Clin Cancer Res (2013) 19 (7): 1784–1794.
https://doi.org/10.1158/1078-0432.CCR-12-2518
Published: 02 April 2013
View articletitled, The Novel SMAC Mimetic Birinapant Exhibits Potent Activity against Human Melanoma Cells
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Includes: Supplementary data
Journal Articles

Punctate LC3B Expression Is a Common Feature of Solid Tumors and Associated with Proliferation, Metastasis, and Poor Outcome

Rossitza Lazova, Robert L. Camp, Vincent Klump, Summar F. Siddiqui, Ravi K. Amaravadi, John M. Pawelek
Journal: Clinical Cancer Research
Clin Cancer Res (2012) 18 (2): 370–379.
https://doi.org/10.1158/1078-0432.CCR-11-1282
Published: 16 January 2012
View articletitled, Punctate LC3B Expression Is a Common Feature of Solid Tumors and Associated with Proliferation, Metastasis, and Poor Outcome
Open the PDF for Punctate LC3B Expression Is a Common Feature of Solid Tumors and Associated with Proliferation, Metastasis, and Poor Outcome in another window
Includes: Supplementary data
Journal Articles

Measurements of Tumor Cell Autophagy Predict Invasiveness, Resistance to Chemotherapy, and Survival in Melanoma

Xiao-Hong Ma, Shengfu Piao, Dan Wang, Quentin W. Mcafee, Katherine L. Nathanson, Julian J. Lum, Lin Z. Li, Ravi K. Amaravadi
Journal: Clinical Cancer Research
Clin Cancer Res (2011) 17 (10): 3478–3489.
https://doi.org/10.1158/1078-0432.CCR-10-2372
Published: 15 May 2011
View articletitled, Measurements of Tumor Cell Autophagy Predict Invasiveness, Resistance to Chemotherapy, and Survival in Melanoma
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Includes: Supplementary data
Journal Articles

Principles and Current Strategies for Targeting Autophagy for Cancer Treatment

Ravi K. Amaravadi, Jennifer Lippincott-Schwartz, Xiao-Ming Yin, William A. Weiss, Naoko Takebe, William Timmer, Robert S. DiPaola, Michael T. Lotze, Eileen White
Journal: Clinical Cancer Research
Clin Cancer Res (2011) 17 (4): 654–666.
https://doi.org/10.1158/1078-0432.CCR-10-2634
Published: 15 February 2011
View articletitled, Principles and Current Strategies for Targeting Autophagy for Cancer Treatment
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Journal Articles

Phase II Trial of Temozolomide and Sorafenib in Advanced Melanoma Patients with or without Brain Metastases

Ravi K. Amaravadi, Lynn M. Schuchter, David F. McDermott, Amy Kramer, Lydia Giles, Kristi Gramlich, Mary Carberry, Andrea B. Troxel, Richard Letrero, Katherine L. Nathanson, Michael B. Atkins, Peter J. O'Dwyer, Keith T. Flaherty
Journal: Clinical Cancer Research
Clin Cancer Res (2009) 15 (24): 7711–7718.
https://doi.org/10.1158/1078-0432.CCR-09-2074
Published: 14 December 2009
View articletitled, Phase II Trial of Temozolomide and Sorafenib in Advanced Melanoma Patients with or without Brain Metastases
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Journal Articles

The Roles of Therapy-Induced Autophagy and Necrosis in Cancer Treatment

Ravi K. Amaravadi, Craig B. Thompson
Journal: Clinical Cancer Research
Clin Cancer Res (2007) 13 (24): 7271–7279.
https://doi.org/10.1158/1078-0432.CCR-07-1595
Published: 19 December 2007
View articletitled, The Roles of Therapy-Induced Autophagy and Necrosis in Cancer Treatment
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Journal Articles

Targeting the Cell Death-Survival Equation

Edward J. Benz, Jr., David G. Nathan, Ravi K. Amaravadi, Nika N. Danial
Journal: Clinical Cancer Research
Clin Cancer Res (2007) 13 (24): 7250–7253.
https://doi.org/10.1158/1078-0432.CCR-07-2221
Published: 19 December 2007
View articletitled, Targeting the Cell Death-Survival Equation
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