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Journal Articles

Phase I/II Study of the Mesothelin-targeted Immunotoxin LMB-100 with Nab-Paclitaxel for Patients with Advanced Pancreatic Adenocarcinoma

Christine Alewine, Mehwish Ahmad, Cody J. Peer, Zishuo I. Hu, Min-Jung Lee, Akira Yuno, Jessica D. Kindrick, Anish Thomas, Seth M. Steinberg, Jane B. Trepel, William D. Figg, Raffit Hassan, Ira Pastan
Journal: Clinical Cancer Research
Clin Cancer Res (2020) 26 (4): 828–836.
https://doi.org/10.1158/1078-0432.CCR-19-2586
Published: 14 February 2020
View article titled, Phase I/II Study of the Mesothelin-targeted Immunotoxin LMB-100 with Nab-Paclitaxel for Patients with Advanced Pancreatic Adenocarcinoma
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Includes: Supplementary data
Journal Articles

Clinical Response of Live-Attenuated, Listeria monocytogenes Expressing Mesothelin (CRS-207) with Chemotherapy in Patients with Malignant Pleural Mesothelioma

Raffit Hassan, Evan Alley, Hedy Kindler, Scott Antonia, Thierry Jahan, Somayeh Honarmand, Nitya Nair, Chan C. Whiting, Amanda Enstrom, Ed Lemmens, Takahiro Tsujikawa, Sushil Kumar, Gina Choe, Anish Thomas, Katherine McDougall, Aimee L. Murphy, Elizabeth Jaffee, Lisa M. Coussens, Dirk G. Brockstedt
Journal: Clinical Cancer Research
Clin Cancer Res (2019) 25 (19): 5787–5798.
https://doi.org/10.1158/1078-0432.CCR-19-0070
Published: 01 October 2019
View article titled, Clinical Response of Live-Attenuated, <em>Listeria monocytogenes</em> Expressing Mesothelin (CRS-207) with Chemotherapy in Patients with Malignant Pleural Mesothelioma
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Includes: Supplementary data
Journal Articles

Tumor-Derived GM-CSF Promotes Granulocyte Immunosuppression in Mesothelioma Patients

Swati Khanna, Suzanne Graef, Francis Mussai, Anish Thomas, Neha Wali, Bahar Guliz Yenidunya, Constance Yuan, Betsy Morrow, Jingli Zhang, Firouzeh Korangy, Tim F. Greten, Seth M. Steinberg, Maryalice Stetler-Stevenson, Gary Middleton, Carmela De Santo, Raffit Hassan
Journal: Clinical Cancer Research
Clin Cancer Res (2018) 24 (12): 2859–2872.
https://doi.org/10.1158/1078-0432.CCR-17-3757
Published: 14 June 2018
View article titled, Tumor-Derived GM-CSF Promotes Granulocyte Immunosuppression in Mesothelioma Patients
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Includes: Supplementary data
Journal Articles

Efficacy of Anti-mesothelin Immunotoxin RG7787 plus Nab-Paclitaxel against Mesothelioma Patient–Derived Xenografts and Mesothelin as a Biomarker of Tumor Response

Jingli Zhang, Swati Khanna, Qun Jiang, Christine Alewine, Markku Miettinen, Ira Pastan, Raffit Hassan
Journal: Clinical Cancer Research
Clin Cancer Res (2017) 23 (6): 1564–1574.
https://doi.org/10.1158/1078-0432.CCR-16-1667
Published: 14 March 2017
View article titled, Efficacy of Anti-mesothelin Immunotoxin RG7787 plus Nab-Paclitaxel against Mesothelioma Patient–Derived Xenografts and Mesothelin as a Biomarker of Tumor Response
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Includes: Supplementary data
Journal Articles

New Life for Immunotoxin Cancer Therapy

Raffit Hassan, Christine Alewine, Ira Pastan
Journal: Clinical Cancer Research
Clin Cancer Res (2016) 22 (5): 1055–1058.
https://doi.org/10.1158/1078-0432.CCR-15-1623
Published: 29 February 2016
View article titled, New Life for Immunotoxin Cancer Therapy
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Journal Articles

Phase II Clinical Trial of Amatuximab, a Chimeric Antimesothelin Antibody with Pemetrexed and Cisplatin in Advanced Unresectable Pleural Mesothelioma

Raffit Hassan, Hedy L. Kindler, Thierry Jahan, Lyudmila Bazhenova, Martin Reck, Anish Thomas, Ira Pastan, Jeff Parno, Daniel J. O'Shannessy, Penny Fatato, Julia D. Maltzman, Bruce A. Wallin
Journal: Clinical Cancer Research
Clin Cancer Res (2014) 20 (23): 5927–5936.
https://doi.org/10.1158/1078-0432.CCR-14-0804
Published: 30 November 2014
View article titled, Phase II Clinical Trial of Amatuximab, a Chimeric Antimesothelin Antibody with Pemetrexed and Cisplatin in Advanced Unresectable Pleural Mesothelioma
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Includes: Supplementary data
Journal Articles

Mesothelin-fc fusion protein detection using a novel microelectronic acoustic sensor platform

Anthony Dickherber, Christopher Corso, William Hunt, Ira Pastan, Mitchell Ho, Raffit Hassan
Journal: Clinical Cancer Research
Clin Cancer Res (2007) 13 (19_Supplement): A26.
Published: 15 August 2014
View article titled, Mesothelin-fc fusion protein detection using a novel microelectronic acoustic sensor platform
Journal Articles

A Live-Attenuated Listeria Vaccine (ANZ-100) and a Live-Attenuated Listeria Vaccine Expressing Mesothelin (CRS-207) for Advanced Cancers: Phase I Studies of Safety and Immune Induction

Dung T. Le, Dirk G. Brockstedt, Ran Nir-Paz, Johannes Hampl, Shruti Mathur, John Nemunaitis, Daniel H. Sterman, Raffit Hassan, Eric Lutz, Bentley Moyer, Martin Giedlin, Jana-Lynn Louis, Elizabeth A. Sugar, Alice Pons, Andrea L. Cox, Jordana Levine, Aimee Luck Murphy, Peter Illei, Thomas W. Dubensky, Jr, Joseph E. Eiden, Elizabeth M. Jaffee, Daniel A. Laheru
Journal: Clinical Cancer Research
Clin Cancer Res (2012) 18 (3): 858–868.
https://doi.org/10.1158/1078-0432.CCR-11-2121
Published: 31 January 2012
View article titled, A Live-Attenuated Listeria Vaccine (ANZ-100) and a Live-Attenuated Listeria Vaccine Expressing Mesothelin (CRS-207) for Advanced Cancers: Phase I Studies of Safety and Immune Induction
Open the PDF for A Live-Attenuated Listeria Vaccine (ANZ-100) and a Live-Attenuated Listeria Vaccine Expressing Mesothelin (CRS-207) for Advanced Cancers: Phase I Studies of Safety and Immune Induction in another window
Includes: Supplementary data
Journal Articles

Pentostatin Plus Cyclophosphamide Safely and Effectively Prevents Immunotoxin Immunogenicity in Murine Hosts

Miriam E. Mossoba, Masanori Onda, Justin Taylor, Paul R. Massey, Shirin Treadwell, Elad Sharon, Raffit Hassan, Ira Pastan, Daniel H. Fowler
Journal: Clinical Cancer Research
Clin Cancer Res (2011) 17 (11): 3697–3705.
https://doi.org/10.1158/1078-0432.CCR-11-0493
Published: 01 June 2011
View article titled, Pentostatin Plus Cyclophosphamide Safely and Effectively Prevents Immunotoxin Immunogenicity in Murine Hosts
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Journal Articles

Phase I Clinical Trial of the Chimeric Anti-Mesothelin Monoclonal Antibody MORAb-009 in Patients with Mesothelin-Expressing Cancers

Raffit Hassan, Steven J. Cohen, Martin Phillips, Ira Pastan, Elad Sharon, Ronan J. Kelly, Charles Schweizer, Susan Weil, Daniel Laheru
Journal: Clinical Cancer Research
Clin Cancer Res (2010) 16 (24): 6132–6138.
https://doi.org/10.1158/1078-0432.CCR-10-2275
Published: 16 December 2010
View article titled, Phase I Clinical Trial of the Chimeric Anti-Mesothelin Monoclonal Antibody MORAb-009 in Patients with Mesothelin-Expressing Cancers
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Journal Articles

Phase I Trial of Continuous Infusion Anti-Mesothelin Recombinant Immunotoxin SS1P

Robert J. Kreitman, Raffit Hassan, David J. FitzGerald, Ira Pastan
Journal: Clinical Cancer Research
Clin Cancer Res (2009) 15 (16): 5274–5279.
https://doi.org/10.1158/1078-0432.CCR-09-0062
Published: 12 August 2009
View article titled, Phase I Trial of Continuous Infusion Anti-Mesothelin Recombinant Immunotoxin SS1P
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Journal Articles

Anti–Mesothelin Immunotoxin SS1P in Combination with Gemcitabine Results in Increased Activity against Mesothelin-Expressing Tumor Xenografts

Raffit Hassan, V. Courtney Broaddus, Shannon Wilson, David J. Liewehr, Jingli Zhang
Journal: Clinical Cancer Research
Clin Cancer Res (2007) 13 (23): 7166–7171.
https://doi.org/10.1158/1078-0432.CCR-07-1592
Published: 03 December 2007
View article titled, Anti–Mesothelin Immunotoxin SS1P in Combination with Gemcitabine Results in Increased Activity against Mesothelin-Expressing Tumor Xenografts
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Journal Articles

Phase I Study of SS1P, a Recombinant Anti-Mesothelin Immunotoxin Given as a Bolus I.V. Infusion to Patients with Mesothelin-Expressing Mesothelioma, Ovarian, and Pancreatic Cancers

Raffit Hassan, Susie Bullock, Ahalya Premkumar, Robert J. Kreitman, Hedy Kindler, Mark C. Willingham, Ira Pastan
Journal: Clinical Cancer Research
Clin Cancer Res (2007) 13 (17): 5144–5149.
https://doi.org/10.1158/1078-0432.CCR-07-0869
Published: 04 September 2007
View article titled, Phase I Study of SS1P, a Recombinant Anti-Mesothelin Immunotoxin Given as a Bolus I.V. Infusion to Patients with Mesothelin-Expressing Mesothelioma, Ovarian, and Pancreatic Cancers
Open the PDF for Phase I Study of SS1P, a Recombinant Anti-Mesothelin Immunotoxin Given as a Bolus I.V. Infusion to Patients with Mesothelin-Expressing Mesothelioma, Ovarian, and Pancreatic Cancers in another window
Journal Articles

Mesothelin Expression in Human Lung Cancer

Mitchell Ho, Tapan K. Bera, Mark C. Willingham, Masanori Onda, Raffit Hassan, David FitzGerald, Ira Pastan
Journal: Clinical Cancer Research
Clin Cancer Res (2007) 13 (5): 1571–1575.
https://doi.org/10.1158/1078-0432.CCR-06-2161
Published: 01 March 2007
View article titled, Mesothelin Expression in Human Lung Cancer
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Journal Articles

Tumor-Directed Radiation and the Immunotoxin SS1P in the Treatment of Mesothelin-Expressing Tumor Xenografts

Raffit Hassan, Juanita Williams-Gould, Seth M. Steinberg, David J. Liewehr, Junko Yokokawa, Kwong Y. Tsang, Robert J. Surawski, Tamalee Scott, Kevin Camphausen
Journal: Clinical Cancer Research
Clin Cancer Res (2006) 12 (16): 4983–4988.
https://doi.org/10.1158/1078-0432.CCR-06-0441
Published: 16 August 2006
View article titled, Tumor-Directed Radiation and the Immunotoxin SS1P in the Treatment of Mesothelin-Expressing Tumor Xenografts
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Journal Articles

Synergistic Antitumor Activity of Taxol and Immunotoxin SS1P in Tumor-Bearing Mice

YuJian Zhang, Laiman Xiang, Raffit Hassan, Chang H. Paik, Jorge A. Carrasquillo, Beom-su Jang, Nhat Le, Mitchell Ho, Ira Pastan
Journal: Clinical Cancer Research
Clin Cancer Res (2006) 12 (15): 4695–4701.
https://doi.org/10.1158/1078-0432.CCR-06-0346
Published: 09 August 2006
View article titled, Synergistic Antitumor Activity of Taxol and Immunotoxin SS1P in Tumor-Bearing Mice
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Journal Articles

Megakaryocyte Potentiation Factor Cleaved from Mesothelin Precursor Is a Useful Tumor Marker in the Serum of Patients with Mesothelioma

Masanori Onda, Satoshi Nagata, Mitchell Ho, Tapan K. Bera, Raffit Hassan, Richard H. Alexander, Ira Pastan
Journal: Clinical Cancer Research
Clin Cancer Res (2006) 12 (14): 4225–4231.
https://doi.org/10.1158/1078-0432.CCR-06-0472
Published: 20 July 2006
View article titled, Megakaryocyte Potentiation Factor Cleaved from Mesothelin Precursor Is a Useful Tumor Marker in the Serum of Patients with Mesothelioma
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Journal Articles

Detection and Quantitation of Serum Mesothelin, a Tumor Marker for Patients with Mesothelioma and Ovarian Cancer

Raffit Hassan, Alan T. Remaley, Maureen L. Sampson, Jingli Zhang, Derrick D. Cox, James Pingpank, Richard Alexander, Mark Willingham, Ira Pastan, Masanori Onda
Journal: Clinical Cancer Research
Clin Cancer Res (2006) 12 (2): 447–453.
https://doi.org/10.1158/1078-0432.CCR-05-1477
Published: 20 January 2006
View article titled, Detection and Quantitation of Serum Mesothelin, a Tumor Marker for Patients with Mesothelioma and Ovarian Cancer
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Journal Articles

Identification of Novel Human CTL Epitopes and Their Agonist Epitopes of Mesothelin

Junko Yokokawa, Claudia Palena, Philip Arlen, Raffit Hassan, Mitchell Ho, Ira Pastan, Jeffrey Schlom, Kwong Y. Tsang
Journal: Clinical Cancer Research
Clin Cancer Res (2005) 11 (17): 6342–6351.
https://doi.org/10.1158/1078-0432.CCR-05-0596
Published: 06 September 2005
View article titled, Identification of Novel Human CTL Epitopes and Their Agonist Epitopes of Mesothelin
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Journal Articles

New Monoclonal Antibodies to Mesothelin Useful for Immunohistochemistry, Fluorescence-Activated Cell Sorting, Western Blotting, and ELISA

Masanori Onda, Mark Willingham, Satoshi Nagata, Tapan K. Bera, Richard Beers, Mitchell Ho, Raffit Hassan, Robert J. Kreitman, Ira Pastan
Journal: Clinical Cancer Research
Clin Cancer Res (2005) 11 (16): 5840–5846.
https://doi.org/10.1158/1078-0432.CCR-05-0578
Published: 22 August 2005
View article titled, New Monoclonal Antibodies to Mesothelin Useful for Immunohistochemistry, Fluorescence-Activated Cell Sorting, Western Blotting, and ELISA
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