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Journal Articles

Antitumor Efficacy of the Novel KIT Inhibitor IDRX-42 (Formerly M4205) in Patient- and Cell Line–Derived Xenograft Models of Gastrointestinal Stromal Tumor (GIST)

Luna De Sutter, Agnieszka Wozniak, Jasper Verreet, Ulla Vanleeuw, Lore De Cock, Nina Linde, Christine Drechsler, Christina Esdar, Raf Sciot, Patrick Schöffski
Journal: Clinical Cancer Research
Clin Cancer Res (2023) 29 (15): 2859–2868.
https://doi.org/10.1158/1078-0432.CCR-22-3822
Published: 01 August 2023
View article titled, Antitumor Efficacy of the Novel KIT Inhibitor IDRX-42 (Formerly M4205) in Patient- and Cell Line–Derived Xenograft Models of Gastrointestinal Stromal Tumor (GIST)
Open the PDF for Antitumor Efficacy of the Novel KIT Inhibitor IDRX-42 (Formerly M4205) in Patient- and Cell Line–Derived Xenograft Models of Gastrointestinal Stromal Tumor (GIST) in another window
Includes: Supplementary data
Journal Articles

Comprehensive Molecular Analysis of Inflammatory Myofibroblastic Tumors Reveals Diverse Genomic Landscape and Potential Predictive Markers for Response to Crizotinib

Che-Jui Lee, Patrick Schöffski, Elodie Modave, Tom van Wezel, Bram Boeckx, Jozef Sufliarsky, Hans Gelderblom, Jean-Yves Blay, Maria Debiec-Rychter, Raf Sciot, Judith V.M.G. Bovée, Diether Lambrechts, Agnieszka Wozniak
Journal: Clinical Cancer Research
Clin Cancer Res (2021) 27 (24): 6737–6748.
https://doi.org/10.1158/1078-0432.CCR-21-1165
Published: 15 December 2021
View article titled, Comprehensive Molecular Analysis of Inflammatory Myofibroblastic Tumors Reveals Diverse Genomic Landscape and Potential Predictive Markers for Response to Crizotinib
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Includes: Supplementary data
Journal Articles

Robust Activity of Avapritinib, Potent and Highly Selective Inhibitor of Mutated KIT, in Patient-derived Xenograft Models of Gastrointestinal Stromal Tumors

Yemarshet K. Gebreyohannes, Agnieszka Wozniak, Madalina-Elena Zhai, Jasmien Wellens, Jasmien Cornillie, Ulla Vanleeuw, Erica Evans, Alexandra K. Gardino, Christoph Lengauer, Maria Debiec-Rychter, Raf Sciot, Patrick Schöffski
Journal: Clinical Cancer Research
Clin Cancer Res (2019) 25 (2): 609–618.
https://doi.org/10.1158/1078-0432.CCR-18-1858
Published: 15 January 2019
View article titled, Robust Activity of Avapritinib, Potent and Highly Selective Inhibitor of Mutated KIT, in Patient-derived Xenograft Models of Gastrointestinal Stromal Tumors
Open the PDF for Robust Activity of Avapritinib, Potent and Highly Selective Inhibitor of Mutated KIT, in Patient-derived Xenograft Models of Gastrointestinal Stromal Tumors in another window
Includes: Supplementary data
Journal Articles

In-depth Genetic Analysis of Sclerosing Epithelioid Fibrosarcoma Reveals Recurrent Genomic Alterations and Potential Treatment Targets

Elsa Arbajian, Florian Puls, Cristina R. Antonescu, Fernanda Amary, Raf Sciot, Maria Debiec-Rychter, Vaiyapuri P. Sumathi, Marcus Järås, Linda Magnusson, Jenny Nilsson, Jakob Hofvander, Fredrik Mertens
Journal: Clinical Cancer Research
Clin Cancer Res (2017) 23 (23): 7426–7434.
https://doi.org/10.1158/1078-0432.CCR-17-1856
Published: 30 November 2017
View article titled, In-depth Genetic Analysis of Sclerosing Epithelioid Fibrosarcoma Reveals Recurrent Genomic Alterations and Potential Treatment Targets
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Includes: Supplementary data
Journal Articles

Phosphoinositide 3-Kinase Inhibitors Combined with Imatinib in Patient-Derived Xenograft Models of Gastrointestinal Stromal Tumors: Rationale and Efficacy

Thomas Van Looy, Agnieszka Wozniak, Giuseppe Floris, Raf Sciot, Haifu Li, Jasmien Wellens, Ulla Vanleeuw, Jonathan A. Fletcher, Paul W. Manley, Maria Debiec-Rychter, Patrick Schöffski
Journal: Clinical Cancer Research
Clin Cancer Res (2014) 20 (23): 6071–6082.
https://doi.org/10.1158/1078-0432.CCR-14-1823
Published: 30 November 2014
View article titled, Phosphoinositide 3-Kinase Inhibitors Combined with Imatinib in Patient-Derived Xenograft Models of Gastrointestinal Stromal Tumors: Rationale and Efficacy
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Includes: Supplementary data
Journal Articles

Tumor Genotype Is an Independent Prognostic Factor in Primary Gastrointestinal Stromal Tumors of Gastric Origin: A European Multicenter Analysis Based on ConticaGIST

Agnieszka Wozniak, Piotr Rutkowski, Patrick Schöffski, Isabelle Ray-Coquard, Isabelle Hostein, Hans-Ulrich Schildhaus, Axel Le Cesne, Elzbieta Bylina, Janusz Limon, Jean-Yves Blay, Janusz A. Siedlecki, Eva Wardelmann, Raf Sciot, Jean-Michel Coindre, Maria Debiec-Rychter
Journal: Clinical Cancer Research
Series: Author Choice
Clin Cancer Res (2014) 20 (23): 6105–6116.
https://doi.org/10.1158/1078-0432.CCR-14-1677
Published: 30 November 2014
View article titled, Tumor Genotype Is an Independent Prognostic Factor in Primary Gastrointestinal Stromal Tumors of Gastric Origin: A European Multicenter Analysis Based on ConticaGIST
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Includes: Supplementary data
Journal Articles

Evaluation of MDM2 and CDK4 gene amplification and expression as potential tools for the diagnosis of atypical lipomatous tumors/well-differentiated liposarcomas in paraffin-embedded material

Els Meulemans, Ernst-Jan Speel, Andrea Rüland, Maria Debiec-Rychter, Raf Sciot, Patrick Pauwels
Journal: Clinical Cancer Research
Clin Cancer Res (2006) 12 (19_Supplement): A38.
Published: 15 August 2014
View article titled, Evaluation of <em>MDM2</em> and <em>CDK4</em> gene amplification and expression as potential tools for the diagnosis of atypical lipomatous tumors/well-differentiated liposarcomas in paraffin-embedded material
Journal Articles

A Potent Combination of the Novel PI3K Inhibitor, GDC-0941, with Imatinib in Gastrointestinal Stromal Tumor Xenografts: Long-Lasting Responses after Treatment Withdrawal

Giuseppe Floris, Agnieszka Wozniak, Raf Sciot, Haifu Li, Lori Friedman, Thomas Van Looy, Jasmien Wellens, Peter Vermaelen, Christophe M. Deroose, Jonathan A. Fletcher, Maria Debiec-Rychter, Patrick Schöffski
Journal: Clinical Cancer Research
Clin Cancer Res (2013) 19 (3): 620–630.
https://doi.org/10.1158/1078-0432.CCR-12-2853
Published: 31 January 2013
View article titled, A Potent Combination of the Novel PI3K Inhibitor, GDC-0941, with Imatinib in Gastrointestinal Stromal Tumor Xenografts: Long-Lasting Responses after Treatment Withdrawal
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Includes: Supplementary data
Journal Articles

Mitotic Checkpoints and Chromosome Instability Are Strong Predictors of Clinical Outcome in Gastrointestinal Stromal Tumors

Pauline Lagarde, Gaëlle Pérot, Audrey Kauffmann, Céline Brulard, Valérie Dapremont, Isabelle Hostein, Agnès Neuville, Agnieszka Wozniak, Raf Sciot, Patrick Schöffski, Alain Aurias, Jean-Michel Coindre, Maria Debiec-Rychter, Frédéric Chibon
Journal: Clinical Cancer Research
Clin Cancer Res (2012) 18 (3): 826–838.
https://doi.org/10.1158/1078-0432.CCR-11-1610
Published: 31 January 2012
View article titled, Mitotic Checkpoints and Chromosome Instability Are Strong Predictors of Clinical Outcome in Gastrointestinal Stromal Tumors
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Includes: Supplementary data
Journal Articles

The Novel HSP90 Inhibitor, IPI-493, Is Highly Effective in Human Gastrostrointestinal Stromal Tumor Xenografts Carrying Heterogeneous KIT Mutations

Giuseppe Floris, Raf Sciot, Agnieszka Wozniak, Thomas Van Looy, Jasmien Wellens, Gavino Faa, Emmanuel Normant, Maria Debiec-Rychter, Patrick Schöffski
Journal: Clinical Cancer Research
Clin Cancer Res (2011) 17 (17): 5604–5614.
https://doi.org/10.1158/1078-0432.CCR-11-0562
Published: 01 September 2011
View article titled, The Novel HSP90 Inhibitor, IPI-493, Is Highly Effective in Human Gastrostrointestinal Stromal Tumor Xenografts Carrying Heterogeneous <em>KIT</em> Mutations
Open the PDF for The Novel HSP90 Inhibitor, IPI-493, Is Highly Effective in Human Gastrostrointestinal Stromal Tumor Xenografts Carrying Heterogeneous <em>KIT</em> Mutations in another window
Includes: Supplementary data
Journal Articles

High Efficacy of Panobinostat Towards Human Gastrointestinal Stromal Tumors in a Xenograft Mouse Model

Giuseppe Floris, Maria Debiec-Rychter, Raf Sciot, Cristiana Stefan, Steffen Fieuws, Kathleen Machiels, Peter Atadja, Agnieszka Wozniak, Gavino Faa, Patrick Schöffski
Journal: Clinical Cancer Research
Clin Cancer Res (2009) 15 (12): 4066–4076.
https://doi.org/10.1158/1078-0432.CCR-08-2588
Published: 15 June 2009
View article titled, High Efficacy of Panobinostat Towards Human Gastrointestinal Stromal Tumors in a Xenograft Mouse Model
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Includes: Supplementary data
Journal Articles

Cell Cycle/Apoptosis Molecule Expression Correlates with Imatinib Response in Patients with Advanced Gastrointestinal Stromal Tumors

Salvatore Romeo, Maria Debiec-Rychter, Martine Van Glabbeke, Heidi Van Paassen, Paola Comite, Ronald Van Eijk, Jan Oosting, Jaap Verweij, Philippe Terrier, Ulrike Schneider, Raf Sciot, Jean Yves Blay, Pancras C.W. Hogendoorn, on behalf of the European Organization for Research and Treatment of Cancer Soft Tissue and Bone Sarcoma Group
Journal: Clinical Cancer Research
Clin Cancer Res (2009) 15 (12): 4191–4198.
https://doi.org/10.1158/1078-0432.CCR-08-3297
Published: 15 June 2009
View article titled, Cell Cycle/Apoptosis Molecule Expression Correlates with Imatinib Response in Patients with Advanced Gastrointestinal Stromal Tumors
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Includes: Supplementary data
Journal Articles

Activity of Dasatinib, a Dual SRC/ABL Kinase Inhibitor, and IPI-504, a Heat Shock Protein 90 Inhibitor, against Gastrointestinal Stromal Tumor–Associated PDGFRAD842V Mutation

Barbara Dewaele, Bartosz Wasag, Jan Cools, Raf Sciot, Hans Prenen, Peter Vandenberghe, Agnieszka Wozniak, Patrick Schöffski, Peter Marynen, Maria Debiec-Rychter
Journal: Clinical Cancer Research
Clin Cancer Res (2008) 14 (18): 5749–5758.
https://doi.org/10.1158/1078-0432.CCR-08-0533
Published: 14 September 2008
View article titled, Activity of Dasatinib, a Dual SRC/ABL Kinase Inhibitor, and IPI-504, a Heat Shock Protein 90 Inhibitor, against Gastrointestinal Stromal Tumor–Associated PDGFRA<sup>D842V</sup> Mutation
Open the PDF for Activity of Dasatinib, a Dual SRC/ABL Kinase Inhibitor, and IPI-504, a Heat Shock Protein 90 Inhibitor, against Gastrointestinal Stromal Tumor–Associated PDGFRA<sup>D842V</sup> Mutation in another window
Journal Articles

Multiple Primary Sporadic Gastrointestinal Stromal Tumors in the Adult: An Underestimated Entity

Daniela Gasparotto, Sabrina Rossi, Italo Bearzi, Claudio Doglioni, Alessandra Marzotto, Jason L. Hornick, Alessandra Grizzo, Chiara Sartor, Alessandra Mandolesi, Raf Sciot, Maria Debiec-Rychter, Angelo Paolo Dei Tos, Roberta Maestro
Journal: Clinical Cancer Research
Clin Cancer Res (2008) 14 (18): 5715–5721.
https://doi.org/10.1158/1078-0432.CCR-08-0622
Published: 14 September 2008
View article titled, Multiple Primary Sporadic Gastrointestinal Stromal Tumors in the Adult: An Underestimated Entity
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Journal Articles

Postoperative Adjuvant Dendritic Cell–Based Immunotherapy in Patients with Relapsed Glioblastoma Multiforme

Steven De Vleeschouwer, Steffen Fieuws, Stefan Rutkowski, Frank Van Calenbergh, Johannes Van Loon, Jan Goffin, Raf Sciot, Guido Wilms, Philippe Demaerel, Monika Warmuth-Metz, Niels Soerensen, Johannes E.A. Wolff, Sabine Wagner, Eckhart Kaempgen, Stefaan W. Van Gool
Journal: Clinical Cancer Research
Clin Cancer Res (2008) 14 (10): 3098–3104.
https://doi.org/10.1158/1078-0432.CCR-07-4875
Published: 15 May 2008
View article titled, Postoperative Adjuvant Dendritic Cell–Based Immunotherapy in Patients with Relapsed Glioblastoma Multiforme
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Journal Articles

EWSR1-CREB1 and EWSR1-ATF1 Fusion Genes in Angiomatoid Fibrous Histiocytoma

Sabrina Rossi, Kàroly Szuhai, Marije Ijszenga, Hans J. Tanke, Lucia Zanatta, Raf Sciot, Christopher D.M. Fletcher, Angelo P. Dei Tos, Pancras C.W. Hogendoorn
Journal: Clinical Cancer Research
Clin Cancer Res (2007) 13 (24): 7322–7328.
https://doi.org/10.1158/1078-0432.CCR-07-1744
Published: 19 December 2007
View article titled, <em>EWSR1-CREB1</em> and <em>EWSR1-ATF1</em> Fusion Genes in Angiomatoid Fibrous Histiocytoma
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Journal Articles

Efficacy of the Kinase Inhibitor SU11248 against Gastrointestinal Stromal Tumor Mutants Refractory to Imatinib Mesylate

Hans Prenen, Jan Cools, Nicole Mentens, Cedric Folens, Raf Sciot, Patrick Schöffski, Allan Van Oosterom, Peter Marynen, Maria Debiec-Rychter
Journal: Clinical Cancer Research
Clin Cancer Res (2006) 12 (8): 2622–2627.
https://doi.org/10.1158/1078-0432.CCR-05-2275
Published: 25 April 2006
View article titled, Efficacy of the Kinase Inhibitor SU11248 against Gastrointestinal Stromal Tumor Mutants Refractory to Imatinib Mesylate
Open the PDF for Efficacy of the Kinase Inhibitor SU11248 against Gastrointestinal Stromal Tumor Mutants Refractory to Imatinib Mesylate in another window
Includes: Supplementary data