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R. Jeffrey Karnes
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Journal Articles

Comparative Genomics Reveals Distinct Immune-oncologic Pathways in African American Men with Prostate Cancer

Shivanshu Awasthi, Anders Berglund, Julieta Abraham-Miranda, Robert J. Rounbehler, Kevin Kensler, Amparo Serna, Adriana Vidal, Sungyong You, Michael R. Freeman, Elai Davicioni, Yang Liu, R. Jeffrey Karnes, Eric A. Klein, Robert B. Den, Bruce J. Trock, Joshua D. Campbell, David J. Einstein, Raavi Gupta, Steven Balk, Priti Lal, Jong Y. Park, John L. Cleveland, Timothy R. Rebbeck, Stephen J. Freedland, Kosj Yamoah
Journal: Clinical Cancer Research
Clin Cancer Res (2021) 27 (1): 320–329.
https://doi.org/10.1158/1078-0432.CCR-20-2925
Published: 04 January 2021
View article titled, Comparative Genomics Reveals Distinct Immune-oncologic Pathways in African American Men with Prostate Cancer
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Includes: Supplementary data
Journal Articles

DNA-Dependent Protein Kinase Drives Prostate Cancer Progression through Transcriptional Regulation of the Wnt Signaling Pathway

Vishal Kothari, Jonathan F. Goodwin, Shuang G. Zhao, Justin M. Drake, Yi Yin, S. Laura Chang, Joseph R. Evans, Kari Wilder-Romans, Kristina Gabbara, Emanuela Dylgjeri, Jonathan Chou, Grace Sun, Scott A. Tomlins, Rohit Mehra, Kristen Hege, Ellen H. Filvaroff, Edward M. Schaeffer, R. Jeffrey Karnes, David A. Quigley, Dana E. Rathkopf, Housheng H. He, Corey Speers, Daniel E. Spratt, Luke A. Gilbert, Alan Ashworth, Arul M. Chinnaiyan, Ganesh V. Raj, Karen E. Knudsen, Felix Y. Feng
Journal: Clinical Cancer Research
Clin Cancer Res (2019) 25 (18): 5608–5622.
https://doi.org/10.1158/1078-0432.CCR-18-2387
Published: 13 September 2019
View article titled, DNA-Dependent Protein Kinase Drives Prostate Cancer Progression through Transcriptional Regulation of the Wnt Signaling Pathway
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Journal Articles

Development and Validation of a Prostate Cancer Genomic Signature that Predicts Early ADT Treatment Response Following Radical Prostatectomy

R. Jeffrey Karnes, Vidit Sharma, Voleak Choeurng, Hussam Al-Deen Ashab, Nicholas Erho, Mohammed Alshalalfa, Bruce Trock, Ashley Ross, Kasra Yousefi, Harrison Tsai, Shuang G. Zhao, Jeffrey J. Tosoian, Zaid Haddad, Mandeep Takhar, S. Laura Chang, Daniel E. Spratt, Firas Abdollah, Robert B. Jenkins, Eric A. Klein, Paul L. Nguyen, Adam P. Dicker, Robert B. Den, Elai Davicioni, Felix Y. Feng, Tamara L. Lotan, Edward M. Schaeffer
Journal: Clinical Cancer Research
Series: Author Choice
Clin Cancer Res (2018) 24 (16): 3908–3916.
https://doi.org/10.1158/1078-0432.CCR-17-2745
Published: 14 August 2018
View article titled, Development and Validation of a Prostate Cancer Genomic Signature that Predicts Early ADT Treatment Response Following Radical Prostatectomy
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Includes: Supplementary data
Journal Articles

PTEN Loss Promotes Intratumoral Androgen Synthesis and Tumor Microenvironment Remodeling via Aberrant Activation of RUNX2 in Castration-Resistant Prostate Cancer

Yinhui Yang, Yang Bai, Yundong He, Yu Zhao, Jiaxiang Chen, Linlin Ma, Yunqian Pan, Michael Hinten, Jun Zhang, R. Jeffrey Karnes, Manish Kohli, Jennifer J. Westendorf, Benyi Li, Runzhi Zhu, Haojie Huang, Wanhai Xu
Journal: Clinical Cancer Research
Series: Author Choice
Clin Cancer Res (2018) 24 (4): 834–846.
https://doi.org/10.1158/1078-0432.CCR-17-2006
Published: 14 February 2018
View article titled, PTEN Loss Promotes Intratumoral Androgen Synthesis and Tumor Microenvironment Remodeling via Aberrant Activation of RUNX2 in Castration-Resistant Prostate Cancer
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Includes: Supplementary data
Journal Articles

TOP2A and EZH2 Provide Early Detection of an Aggressive Prostate Cancer Subgroup

David P. Labbé, Christopher J. Sweeney, Myles Brown, Phillip Galbo, Spencer Rosario, Kristine M. Wadosky, Sheng-Yu Ku, Martin Sjöström, Mohammed Alshalalfa, Nicholas Erho, Elai Davicioni, R. Jeffrey Karnes, Edward M. Schaeffer, Robert B. Jenkins, Robert B. Den, Ashley E. Ross, Michaela Bowden, Ying Huang, Kathryn P. Gray, Felix Y. Feng, Daniel E. Spratt, David W. Goodrich, Kevin H. Eng, Leigh Ellis
Journal: Clinical Cancer Research
Clin Cancer Res (2017) 23 (22): 7072–7083.
https://doi.org/10.1158/1078-0432.CCR-17-0413
Published: 14 November 2017
View article titled, TOP2A and EZH2 Provide Early Detection of an Aggressive Prostate Cancer Subgroup
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Includes: Supplementary data
Journal Articles

The Landscape of Prognostic Outlier Genes in High-Risk Prostate Cancer

Shuang G. Zhao, Joseph R. Evans, Vishal Kothari, Grace Sun, Ashley Larm, Victor Mondine, Edward M. Schaeffer, Ashley E. Ross, Eric A. Klein, Robert B. Den, Adam P. Dicker, R. Jeffrey Karnes, Nicholas Erho, Paul L. Nguyen, Elai Davicioni, Felix Y. Feng
Journal: Clinical Cancer Research
Clin Cancer Res (2016) 22 (7): 1777–1786.
https://doi.org/10.1158/1078-0432.CCR-15-1250
Published: 31 March 2016
View article titled, The Landscape of Prognostic Outlier Genes in High-Risk Prostate Cancer
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Includes: Supplementary data
Journal Articles

Germline Variants in Asporin Vary by Race, Modulate the Tumor Microenvironment, and Are Differentially Associated with Metastatic Prostate Cancer

Paula J. Hurley, Debasish Sundi, Brian Shinder, Brian W. Simons, Robert M. Hughes, Rebecca M. Miller, Benjamin Benzon, Sheila F. Faraj, George J. Netto, Ismael A. Vergara, Nicholas Erho, Elai Davicioni, R. Jeffrey Karnes, Guifang Yan, Charles Ewing, Sarah D. Isaacs, David M. Berman, Jennifer R. Rider, Kristina M. Jordahl, Lorelei A. Mucci, Jessie Huang, Steven S. An, Ben H. Park, William B. Isaacs, Luigi Marchionni, Ashley E. Ross, Edward M. Schaeffer
Journal: Clinical Cancer Research
Clin Cancer Res (2016) 22 (2): 448–458.
https://doi.org/10.1158/1078-0432.CCR-15-0256
Published: 14 January 2016
View article titled, Germline Variants in Asporin Vary by Race, Modulate the Tumor Microenvironment, and Are Differentially Associated with Metastatic Prostate Cancer
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Includes: Supplementary data
Journal Articles

Cyclin D1 Loss Distinguishes Prostatic Small-Cell Carcinoma from Most Prostatic Adenocarcinomas

Harrison Tsai, Carlos L. Morais, Mohammed Alshalalfa, Hsueh-Li Tan, Zaid Haddad, Jessica Hicks, Nilesh Gupta, Jonathan I. Epstein, George J. Netto, William B. Isaacs, Jun Luo, Rohit Mehra, Robert L. Vessella, R. Jeffrey Karnes, Edward M. Schaeffer, Elai Davicioni, Angelo M. De Marzo, Tamara L. Lotan
Journal: Clinical Cancer Research
Clin Cancer Res (2015) 21 (24): 5619–5629.
https://doi.org/10.1158/1078-0432.CCR-15-0744
Published: 14 December 2015
View article titled, Cyclin D1 Loss Distinguishes Prostatic Small-Cell Carcinoma from Most Prostatic Adenocarcinomas
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Includes: Supplementary data
Journal Articles

Expression of Immunosuppresive B7-H3 Ligand by Hormone-Treated Prostate Cancer Tumors and Metastases

Grant Chavin, Yuri Sheinin, Paul L. Crispen, Stephen A. Boorjian, Timothy J. Roth, Laureano Rangel, Michael L. Blute, Thomas J. Sebo, Don J. Tindall, Eugene D. Kwon, R. Jeffrey Karnes
Journal: Clinical Cancer Research
Clin Cancer Res (2009) 15 (6): 2174–2180.
https://doi.org/10.1158/1078-0432.CCR-08-2262
Published: 16 March 2009
View article titled, Expression of Immunosuppresive B7-H3 Ligand by Hormone-Treated Prostate Cancer Tumors and Metastases
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Journal Articles

Identification of Prognostic Biomarkers for Prostate Cancer

Farhad Kosari, Jan Marie A. Munz, C. Dilara Savci-Heijink, Craig Spiro, Eric W. Klee, Dagmar Marie Kube, Lori Tillmans, Jeff Slezak, R. Jeffrey Karnes, John C. Cheville, George Vasmatzis
Journal: Clinical Cancer Research
Clin Cancer Res (2008) 14 (6): 1734–1743.
https://doi.org/10.1158/1078-0432.CCR-07-1494
Published: 17 March 2008
View article titled, Identification of Prognostic Biomarkers for Prostate Cancer
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Includes: Supplementary data