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Prafulla C. Gokhale
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Journal Articles

Hyper-Dependence on NHEJ Enables Synergy between DNA-PK Inhibitors and Low-Dose Doxorubicin in Leiomyosarcoma

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Adrian Marino-Enriquez, Jan Philipp Novotny, Doga C. Gulhan, Isabella Klooster, Antuan V. Tran, Macy Kasbo, Meijun Z. Lundberg, Wen-Bin Ou, Derrick L. Tao, Daniel F. Pilco-Janeta, Victor Y. Mao, Frank T. Zenke, Brittaney A. Leeper, Prafulla C. Gokhale, Glenn S. Cowley, Laurence H. Baker, Karla V. Ballman, David E. Root, Joachim Albers, Peter J. Park, Suzanne George, Jonathan A. Fletcher
Journal: Clinical Cancer Research
Clin Cancer Res (2023) 29 (24): 5128–5139.
https://doi.org/10.1158/1078-0432.CCR-23-0998
Published: 15 December 2023
View articletitled, Hyper-Dependence on NHEJ Enables Synergy between DNA-PK Inhibitors and Low-Dose Doxorubicin in Leiomyosarcoma
Open the PDF for Hyper-Dependence on NHEJ Enables Synergy between DNA-PK Inhibitors and Low-Dose Doxorubicin in Leiomyosarcoma in another window
Includes: Supplementary data
Journal Articles

Comparative Analysis and Isoform-Specific Therapeutic Vulnerabilities of KRAS Mutations in Non–Small Cell Lung Cancer

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Biagio Ricciuti, Jieun Son, Jeffrey J. Okoro, Alessia Mira, Enrico Patrucco, Yoonji Eum, Xinan Wang, Raymond Paranal, Haiyun Wang, Mika Lin, Heidi M. Haikala, Jiaqi Li, Yue Xu, Joao Victor Alessi, Chhayheng Chhoeu, Amanda J. Redig, Jens Köhler, Kshiti H. Dholakia, Yunhan Chen, Elodie Richard, Marie-Julie Nokin, David Santamaria, Prafulla C. Gokhale, Mark M. Awad, Pasi A. Jänne, Chiara Ambrogio
Journal: Clinical Cancer Research
Clin Cancer Res (2022) 28 (8): 1640–1650.
https://doi.org/10.1158/1078-0432.CCR-21-2719
Published: 14 April 2022
View articletitled, Comparative Analysis and Isoform-Specific Therapeutic Vulnerabilities of KRAS Mutations in Non–Small Cell Lung Cancer
Open the PDF for Comparative Analysis and Isoform-Specific Therapeutic Vulnerabilities of KRAS Mutations in Non–Small Cell Lung Cancer in another window
Includes: Supplementary data
Journal Articles

Concurrent Dexamethasone Limits the Clinical Benefit of Immune Checkpoint Blockade in Glioblastoma

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J. Bryan Iorgulescu, Prafulla C. Gokhale, Maria C. Speranza, Benjamin K. Eschle, Michael J. Poitras, Margaret K. Wilkens, Kara M. Soroko, Chhayheng Chhoeu, Aine Knott, Yan Gao, Mary Jane Lim-Fat, Gregory J. Baker, Dennis M. Bonal, Quang-Dé Nguyen, Gareth R. L. Grant, Keith L. Ligon, Peter K. Sorger, E. Antonio Chiocca, Ana C. Anderson, Paul T. Kirschmeier, Arlene H. Sharpe, Gordon J. Freeman, David A. Reardon
Journal: Clinical Cancer Research
Clin Cancer Res (2021) 27 (1): 276–287.
https://doi.org/10.1158/1078-0432.CCR-20-2291
Published: 04 January 2021
View articletitled, Concurrent Dexamethasone Limits the Clinical Benefit of Immune Checkpoint Blockade in Glioblastoma
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Includes: Supplementary data
Journal Articles

Rhabdoid Tumors Are Sensitive to the Protein-Translation Inhibitor Homoharringtonine

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Thomas P. Howard, Elaine M. Oberlick, Matthew G. Rees, Taylor E. Arnoff, Minh-Tam Pham, Lisa Brenan, Mariana DoCarmo, Andrew L. Hong, Guillaume Kugener, Hsien-Chao Chou, Yiannis Drosos, Kaeli M. Mathias, Pilar Ramos, Brinton Seashore-Ludlow, Andrew O. Giacomelli, Xiaofeng Wang, Burgess B. Freeman, III, Kaley Blankenship, Lauren Hoffmann, Hong L. Tiv, Prafulla C. Gokhale, Cory M. Johannessen, Elizabeth A. Stewart, Stuart L. Schreiber, William C. Hahn, Charles W.M. Roberts
Journal: Clinical Cancer Research
Clin Cancer Res (2020) 26 (18): 4995–5006.
https://doi.org/10.1158/1078-0432.CCR-19-2717
Published: 15 September 2020
View articletitled, Rhabdoid Tumors Are Sensitive to the Protein-Translation Inhibitor Homoharringtonine
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Includes: Supplementary data
Journal Articles

18FDG-PET Predicts Pharmacodynamic Response to OSI-906, a Dual IGF-1R/IR Inhibitor, in Preclinical Mouse Models of Lung Cancer

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Eliot T. McKinley, Joseph E. Bugaj, Ping Zhao, Saffet Guleryuz, Christine Mantis, Prafulla C. Gokhale, Robert Wild, H. Charles Manning
Journal: Clinical Cancer Research
Clin Cancer Res (2011) 17 (10): 3332–3340.
https://doi.org/10.1158/1078-0432.CCR-10-2274
Published: 15 May 2011
View articletitled, 18FDG-PET Predicts Pharmacodynamic Response to OSI-906, a Dual IGF-1R/IR Inhibitor, in Preclinical Mouse Models of Lung Cancer
Open the PDF for 18FDG-PET Predicts Pharmacodynamic Response to OSI-906, a Dual IGF-1R/IR Inhibitor, in Preclinical Mouse Models of Lung Cancer in another window
Includes: Supplementary data
Journal Articles

Combined Transcriptional and Translational Targeting of EWS/FLI-1 in Ewing's Sarcoma

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Silvia Mateo-Lozano, Prafulla C. Gokhale, Viatcheslav A. Soldatenkov, Anatoly Dritschilo, Oscar M. Tirado, Vicente Notario
Journal: Clinical Cancer Research
Clin Cancer Res (2006) 12 (22): 6781–6790.
https://doi.org/10.1158/1078-0432.CCR-06-0609
Published: 22 November 2006
View articletitled, Combined Transcriptional and Translational Targeting of EWS/FLI-1 in Ewing's Sarcoma
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Journal Articles

Phase I study of liposome-encapsulated c-raf antisense oligodeoxyribonucleotide infusion in combination with radiation therapy in patients with advanced malignancies.

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Anatoly Dritschilo, Chao H Huang, Charles M Rudin, John Marshall, Brian Collins, Jeanne L Dul, Chuanbo Zhang, Deepak Kumar, Prafulla C Gokhale, Ateeq Ahmad, Imran Ahmad, Jeffrey W Sherman, Usha N Kasid
Journal: Clinical Cancer Research
Clin Cancer Res (2006) 12 (4): 1251–1259.
https://doi.org/10.1158/1078-0432.CCR-05-1260
Published: 17 February 2006
View articletitled, Phase I study of liposome-encapsulated c-raf antisense oligodeoxyribonucleotide infusion in combination with radiation therapy in patients with advanced malignancies.
Open the PDF for Phase I study of liposome-encapsulated c-raf antisense oligodeoxyribonucleotide infusion in combination with radiation therapy in patients with advanced malignancies. in another window
Journal Articles

Delivery of a Liposomal c-raf-1 Antisense Oligonucleotide by Weekly Bolus Dosing in Patients with Advanced Solid Tumors: A Phase I Study

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Charles M. Rudin, John L. Marshall, Chao Hui Huang, Hedy L. Kindler, Chuanbo Zhang, Deepak Kumar, Prafulla C. Gokhale, Joyce Steinberg, Steve Wanaski, Usha N. Kasid, Mark J. Ratain
Journal: Clinical Cancer Research
Clin Cancer Res (2004) 10 (21): 7244–7251.
https://doi.org/10.1158/1078-0432.CCR-04-0642
Published: 08 November 2004
View articletitled, Delivery of a Liposomal c-raf-1 Antisense Oligonucleotide by Weekly Bolus Dosing in Patients with Advanced Solid Tumors: A Phase I Study
Open the PDF for Delivery of a Liposomal c-raf-1 Antisense Oligonucleotide by Weekly Bolus Dosing in Patients with Advanced Solid Tumors: A Phase I Study in another window
Journal Articles

Pharmacokinetics, Toxicity, and Efficacy of Ends-modified raf Antisense Oligodeoxyribonucleotide Encapsulated in a Novel Cationic Liposome

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Prafulla C. Gokhale, Chuanbo Zhang, Joseph T. Newsome, Jin Pei, Imran Ahmad, Aquilur Rahman, Anatoly Dritschilo, Usha N. Kasid
Journal: Clinical Cancer Research
Clin Cancer Res (2002) 8 (11): 3611–3621.
Published: 01 November 2002
View articletitled, Pharmacokinetics, Toxicity, and Efficacy of Ends-modified raf Antisense Oligodeoxyribonucleotide Encapsulated in a Novel Cationic Liposome
Open the PDF for Pharmacokinetics, Toxicity, and Efficacy of Ends-modified raf Antisense Oligodeoxyribonucleotide Encapsulated in a Novel Cationic Liposome in another window