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Peter Besmer
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Journal Articles

PD-1/PD-L1 Blockade Enhances T-cell Activity and Antitumor Efficacy of Imatinib in Gastrointestinal Stromal Tumors

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Adrian M. Seifert, Shan Zeng, Jennifer Q. Zhang, Teresa S. Kim, Noah A. Cohen, Michael J. Beckman, Benjamin D. Medina, Joanna H. Maltbaek, Jennifer K. Loo, Megan H. Crawley, Ferdinand Rossi, Peter Besmer, Cristina R. Antonescu, Ronald P. DeMatteo
Journal: Clinical Cancer Research
Clin Cancer Res (2017) 23 (2): 454–465.
https://doi.org/10.1158/1078-0432.CCR-16-1163
Published: 15 January 2017
View articletitled, PD-1/PD-L1 Blockade Enhances T-cell Activity and Antitumor Efficacy of Imatinib in Gastrointestinal Stromal Tumors
Open the PDF for PD-1/PD-L1 Blockade Enhances T-cell Activity and Antitumor Efficacy of Imatinib in Gastrointestinal Stromal Tumors in another window
Includes: Supplementary data
Journal Articles

Increased KIT Inhibition Enhances Therapeutic Efficacy in Gastrointestinal Stromal Tumor

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Teresa S. Kim, Michael J. Cavnar, Noah A. Cohen, Eric C. Sorenson, Jonathan B. Greer, Adrian M. Seifert, Megan H. Crawley, Benjamin L. Green, Rachel Popow, Nagavarakishore Pillarsetty, Darren R. Veach, Anson T. Ku, Ferdinand Rossi, Peter Besmer, Cristina R. Antonescu, Shan Zeng, Ronald P. DeMatteo
Journal: Clinical Cancer Research
Series: Author Choice
Clin Cancer Res (2014) 20 (9): 2350–2362.
https://doi.org/10.1158/1078-0432.CCR-13-3033
Published: 30 April 2014
View articletitled, Increased KIT Inhibition Enhances Therapeutic Efficacy in Gastrointestinal Stromal Tumor
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Includes: Supplementary data
Journal Articles

Mechanisms of Sunitinib Resistance in Gastrointestinal Stromal Tumors Harboring KITAY502-3ins Mutation: An In vitro Mutagenesis Screen for Drug Resistance

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Tianhua Guo, Mihai Hajdu, Narasimhan P. Agaram, Hiroko Shinoda, Darren Veach, Bayard D. Clarkson, Robert G. Maki, Samuel Singer, Ronald P. DeMatteo, Peter Besmer, Cristina R. Antonescu
Journal: Clinical Cancer Research
Clin Cancer Res (2009) 15 (22): 6862–6870.
https://doi.org/10.1158/1078-0432.CCR-09-1315
Published: 11 November 2009
View articletitled, Mechanisms of Sunitinib Resistance in Gastrointestinal Stromal Tumors Harboring KITAY502-3ins Mutation: An In vitro Mutagenesis Screen for Drug Resistance
Open the PDF for Mechanisms of Sunitinib Resistance in Gastrointestinal Stromal Tumors Harboring KITAY502-3ins Mutation: An In vitro Mutagenesis Screen for Drug Resistance in another window
Journal Articles

Molecular Characterization of Pediatric Gastrointestinal Stromal Tumors

Free
Narasimhan P. Agaram, Michael P. Laquaglia, Berrin Ustun, Tianhua Guo, Grace C. Wong, Nicholas D. Socci, Robert G. Maki, Ronald P. DeMatteo, Peter Besmer, Cristina R. Antonescu
Journal: Clinical Cancer Research
Clin Cancer Res (2008) 14 (10): 3204–3215.
https://doi.org/10.1158/1078-0432.CCR-07-1984
Published: 15 May 2008
View articletitled, Molecular Characterization of Pediatric Gastrointestinal Stromal Tumors
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Journal Articles

Sorafenib Inhibits the Imatinib-Resistant KITT670I Gatekeeper Mutation in Gastrointestinal Stromal Tumor

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Tianhua Guo, Narasimhan P. Agaram, Grace C. Wong, Glory Hom, David D'Adamo, Robert G. Maki, Gary K. Schwartz, Darren Veach, Bayard D. Clarkson, Samuel Singer, Ronald P. DeMatteo, Peter Besmer, Cristina R. Antonescu
Journal: Clinical Cancer Research
Clin Cancer Res (2007) 13 (16): 4874–4881.
https://doi.org/10.1158/1078-0432.CCR-07-0484
Published: 15 August 2007
View articletitled, Sorafenib Inhibits the Imatinib-Resistant KITT670I Gatekeeper Mutation in Gastrointestinal Stromal Tumor
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Journal Articles

Pathologic and Molecular Heterogeneity in Imatinib-Stable or Imatinib-Responsive Gastrointestinal Stromal Tumors

Free
Narasimhan P. Agaram, Peter Besmer, Grace C. Wong, Tianhua Guo, Nicholas D. Socci, Robert G. Maki, Diann DeSantis, Murray F. Brennan, Samuel Singer, Ronald P. DeMatteo, Cristina R. Antonescu
Journal: Clinical Cancer Research
Clin Cancer Res (2007) 13 (1): 170–181.
https://doi.org/10.1158/1078-0432.CCR-06-1508
Published: 02 January 2007
View articletitled, Pathologic and Molecular Heterogeneity in Imatinib-Stable or Imatinib-Responsive Gastrointestinal Stromal Tumors
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Journal Articles

Acquired Resistance to Imatinib in Gastrointestinal Stromal Tumor Occurs Through Secondary Gene Mutation

Free
Cristina R. Antonescu, Peter Besmer, Tianhua Guo, Knarik Arkun, Glory Hom, Beata Koryotowski, Margaret A. Leversha, Philip D. Jeffrey, Diann Desantis, Samuel Singer, Murray F. Brennan, Robert G. Maki, Ronald P. DeMatteo
Journal: Clinical Cancer Research
Clin Cancer Res (2005) 11 (11): 4182–4190.
https://doi.org/10.1158/1078-0432.CCR-04-2245
Published: 01 June 2005
View articletitled, Acquired Resistance to Imatinib in Gastrointestinal Stromal Tumor Occurs Through Secondary Gene Mutation
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Journal Articles

Gene Expression in Gastrointestinal Stromal Tumors Is Distinguished by KIT Genotype and Anatomic Site

Free
Cristina R. Antonescu, Agnes Viale, Lisa Sarran, Sylvia J. Tschernyavsky, Mithat Gonen, Neil H. Segal, Robert G. Maki, Nicholas D. Socci, Ronald P. DeMatteo, Peter Besmer
Journal: Clinical Cancer Research
Clin Cancer Res (2004) 10 (10): 3282–3290.
https://doi.org/10.1158/1078-0432.CCR-03-0715
Published: 24 May 2004
View articletitled, Gene Expression in Gastrointestinal Stromal Tumors Is Distinguished by KIT Genotype and Anatomic Site
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Journal Articles

Pleomorphic Characteristics of a Germ-Line KIT Mutation in a Large Kindred with Gastrointestinal Stromal Tumors, Hyperpigmentation, and Dysphagia

Free
Mark E. Robson, Emily Glogowski, Gunhild Sommer, Cristina R. Antonescu, Khedoudja Nafa, Robert G. Maki, Nathan Ellis, Peter Besmer, Murray Brennan, Kenneth Offit
Journal: Clinical Cancer Research
Clin Cancer Res (2004) 10 (4): 1250–1254.
https://doi.org/10.1158/1078-0432.CCR-03-0110
Published: 20 February 2004
View articletitled, Pleomorphic Characteristics of a Germ-Line KIT Mutation in a Large Kindred with Gastrointestinal Stromal Tumors, Hyperpigmentation, and Dysphagia
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Journal Articles

Association of KIT Exon 9 Mutations with Nongastric Primary Site and Aggressive Behavior: KIT Mutation Analysis and Clinical Correlates of 120 Gastrointestinal Stromal Tumors

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Cristina R. Antonescu, Gunhild Sommer, Lisa Sarran, Sylvia J. Tschernyavsky, Elyn Riedel, James M. Woodruff, Mark Robson, Robert Maki, Murray F. Brennan, Marc Ladanyi, Ronald P. DeMatteo, Peter Besmer
Journal: Clinical Cancer Research
Clin Cancer Res (2003) 9 (9): 3329–3337.
Published: 05 September 2003
View articletitled, Association of KIT Exon 9 Mutations with Nongastric Primary Site and Aggressive Behavior: KIT Mutation Analysis and Clinical Correlates of 120 Gastrointestinal Stromal Tumors
Open the PDF for Association of KIT Exon 9 Mutations with Nongastric Primary Site and Aggressive Behavior: KIT Mutation Analysis and Clinical Correlates of 120 Gastrointestinal Stromal Tumors in another window