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Journal Articles

Editor's Note: Superior Efficacy of a Combined Epigenetic Therapy against Human Mantle Cell Lymphoma Cells

Warren Fiskus, Rekha Rao, Ramesh Balusu, Siddhartha Ganguly, Jianguo Tao, Eduardo Sotomayor, Uma Mudunuru, Jacqueline E. Smith, Stacey L. Hembruff, Peter Atadja, Victor E. Marquez, Kapil Bhalla
Journal: Clinical Cancer Research
Clin Cancer Res (2024) 30 (9): 1994.
https://doi.org/10.1158/1078-0432.CCR-24-0856
Published: 01 May 2024
View article titled, Editor's Note: Superior Efficacy of a Combined Epigenetic Therapy against Human Mantle Cell Lymphoma Cells
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Journal Articles

Editor's Note: Role of CAAT/Enhancer Binding Protein Homologous Protein in Panobinostat-mediated Potentiation of Bortezomib-induced Lethal Endoplasmic Reticulum Stress in Mantle Cell Lymphoma Cells

Rekha Rao, Srilatha Nalluri, Warren Fiskus, Andrew Savoie, Kathleen M. Buckley, Kyungsoo Ha, Ramesh Balusu, Atul Joshi, Veena Coothankandaswamy, Jianguo Tao, Eduardo Sotomayor, Peter Atadja, Kapil N. Bhalla
Journal: Clinical Cancer Research
Clin Cancer Res (2020) 26 (6): 1531.
https://doi.org/10.1158/1078-0432.CCR-20-0412
Published: 13 March 2020
View article titled, Editor's Note: Role of CAAT/Enhancer Binding Protein Homologous Protein in Panobinostat-mediated Potentiation of Bortezomib-induced Lethal Endoplasmic Reticulum Stress in Mantle Cell Lymphoma Cells
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Journal Articles

Superior Efficacy of a Combined Epigenetic Therapy against Human Mantle Cell Lymphoma Cells

Warren Fiskus, Rekha Rao, Ramesh Balusu, Siddhartha Ganguly, Jianguo Tao, Eduardo Sotomayor, Uma Mudunuru, Jacqueline E. Smith, Stacey L. Hembruff, Peter Atadja, Victor E. Marquez, Kapil Bhalla
Journal: Clinical Cancer Research
Clin Cancer Res (2012) 18 (22): 6227–6238.
https://doi.org/10.1158/1078-0432.CCR-12-0873
Published: 14 November 2012
View article titled, Superior Efficacy of a Combined Epigenetic Therapy against Human Mantle Cell Lymphoma Cells
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Includes: Supplementary data
Journal Articles

The HDAC Inhibitor LBH589 Enhances the Antimyeloma Effects of the IGF-1RTK Inhibitor Picropodophyllin

Miguel Lemaire, Charlotte Fristedt, Prasoon Agarwal, Eline Menu, Els Van Valckenborgh, Elke De Bruyne, Anders Österborg, Peter Atadja, Olle Larsson, Magnus Axelson, Ben Van Camp, Helena Jernberg-Wiklund, Karin Vanderkerken
Journal: Clinical Cancer Research
Clin Cancer Res (2012) 18 (8): 2230–2239.
https://doi.org/10.1158/1078-0432.CCR-11-1764
Published: 16 April 2012
View article titled, The HDAC Inhibitor LBH589 Enhances the Antimyeloma Effects of the IGF-1RTK Inhibitor Picropodophyllin
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Includes: Supplementary data
Journal Articles

Role of CAAT/Enhancer Binding Protein Homologous Protein in Panobinostat-Mediated Potentiation of Bortezomib-Induced Lethal Endoplasmic Reticulum Stress in Mantle Cell Lymphoma Cells

Rekha Rao, Srilatha Nalluri, Warren Fiskus, Andrew Savoie, Kathleen M. Buckley, Kyungsoo Ha, Ramesh Balusu, Atul Joshi, Veena Coothankandaswamy, Jianguo Tao, Eduardo Sotomayor, Peter Atadja, Kapil N. Bhalla
Journal: Clinical Cancer Research
Clin Cancer Res (2010) 16 (19): 4742–4754.
https://doi.org/10.1158/1078-0432.CCR-10-0529
Published: 29 September 2010
View article titled, Role of CAAT/Enhancer Binding Protein Homologous Protein in Panobinostat-Mediated Potentiation of Bortezomib-Induced Lethal Endoplasmic Reticulum Stress in Mantle Cell Lymphoma Cells
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Journal Articles

High Efficacy of Panobinostat Towards Human Gastrointestinal Stromal Tumors in a Xenograft Mouse Model

Giuseppe Floris, Maria Debiec-Rychter, Raf Sciot, Cristiana Stefan, Steffen Fieuws, Kathleen Machiels, Peter Atadja, Agnieszka Wozniak, Gavino Faa, Patrick Schöffski
Journal: Clinical Cancer Research
Clin Cancer Res (2009) 15 (12): 4066–4076.
https://doi.org/10.1158/1078-0432.CCR-08-2588
Published: 15 June 2009
View article titled, High Efficacy of Panobinostat Towards Human Gastrointestinal Stromal Tumors in a Xenograft Mouse Model
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Includes: Supplementary data
Journal Articles

Phase I Pharmacokinetic and Pharmacodynamic Study of LAQ824, a Hydroxamate Histone Deacetylase Inhibitor with a Heat Shock Protein-90 Inhibitory Profile, in Patients with Advanced Solid Tumors

Johann S. de Bono, Rebecca Kristeleit, Anthony Tolcher, Peter Fong, Simon Pacey, Vasilios Karavasilis, Monica Mita, Heather Shaw, Paul Workman, Stan Kaye, Eric K. Rowinsky, Wynne Aherne, Peter Atadja, Jeffrey W. Scott, Amita Patnaik
Journal: Clinical Cancer Research
Clin Cancer Res (2008) 14 (20): 6663–6673.
https://doi.org/10.1158/1078-0432.CCR-08-0376
Published: 16 October 2008
View article titled, Phase I Pharmacokinetic and Pharmacodynamic Study of LAQ824, a Hydroxamate Histone Deacetylase Inhibitor with a Heat Shock Protein-90 Inhibitory Profile, in Patients with Advanced Solid Tumors
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Journal Articles

Histone Deacetylase Inhibitor Panobinostat Induces Clinical Responses with Associated Alterations in Gene Expression Profiles in Cutaneous T-Cell Lymphoma

Leigh Ellis, Yan Pan, Gordon K. Smyth, Daniel J. George, Chris McCormack, Roxanne Williams-Truax, Monica Mita, Joachim Beck, Howard Burris, Gail Ryan, Peter Atadja, Dale Butterfoss, Margaret Dugan, Kenneth Culver, Ricky W. Johnstone, H. Miles Prince
Journal: Clinical Cancer Research
Clin Cancer Res (2008) 14 (14): 4500–4510.
https://doi.org/10.1158/1078-0432.CCR-07-4262
Published: 15 July 2008
View article titled, Histone Deacetylase Inhibitor Panobinostat Induces Clinical Responses with Associated Alterations in Gene Expression Profiles in Cutaneous T-Cell Lymphoma
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Includes: Supplementary data
Journal Articles

Combination Strategy Targeting the Hypoxia Inducible Factor-1α with Mammalian Target of Rapamycin and Histone Deacetylase Inhibitors

Henk M.W. Verheul, Brenda Salumbides, Karen Van Erp, Hans Hammers, David Z. Qian, Tolib Sanni, Peter Atadja, Roberto Pili
Journal: Clinical Cancer Research
Clin Cancer Res (2008) 14 (11): 3589–3597.
https://doi.org/10.1158/1078-0432.CCR-07-4306
Published: 02 June 2008
View article titled, Combination Strategy Targeting the Hypoxia Inducible Factor-1α with Mammalian Target of Rapamycin and Histone Deacetylase Inhibitors
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Journal Articles

Epigenetic Silencing of the Tetraspanin CD9 during Disease Progression in Multiple Myeloma Cells and Correlation with Survival

Elke De Bruyne, Tomas Jan Bos, Kewal Asosingh, Isabelle Vande Broek, Eline Menu, Els Van Valckenborgh, Peter Atadja, Valérie Coiteux, Xavier Leleu, Kris Thielemans, Ben Van Camp, Karin Vanderkerken, Ivan Van Riet
Journal: Clinical Cancer Research
Clin Cancer Res (2008) 14 (10): 2918–2926.
https://doi.org/10.1158/1078-0432.CCR-07-4489
Published: 15 May 2008
View article titled, Epigenetic Silencing of the Tetraspanin CD9 during Disease Progression in Multiple Myeloma Cells and Correlation with Survival
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Journal Articles

Hydroxamic Acid Analogue Histone Deacetylase Inhibitors Attenuate Estrogen Receptor-α Levels and Transcriptional Activity: A Result of Hyperacetylation and Inhibition of Chaperone Function of Heat Shock Protein 90

Warren Fiskus, Yuan Ren, Alex Mohapatra, Purva Bali, Aditya Mandawat, Rekha Rao, Bryan Herger, Yonghua Yang, Peter Atadja, Jie Wu, Kapil Bhalla
Journal: Clinical Cancer Research
Clin Cancer Res (2007) 13 (16): 4882–4890.
https://doi.org/10.1158/1078-0432.CCR-06-3093
Published: 15 August 2007
View article titled, Hydroxamic Acid Analogue Histone Deacetylase Inhibitors Attenuate Estrogen Receptor-α Levels and Transcriptional Activity: A Result of Hyperacetylation and Inhibition of Chaperone Function of Heat Shock Protein 90
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Journal Articles

Abrogation of MAPK and Akt Signaling by AEE788 Synergistically Potentiates Histone Deacetylase Inhibitor-Induced Apoptosis through Reactive Oxygen Species Generation

Chunrong Yu, Bret B. Friday, Jin-Ping Lai, Andrea McCollum, Peter Atadja, Lewis R. Roberts, Alex A. Adjei
Journal: Clinical Cancer Research
Clin Cancer Res (2007) 13 (4): 1140–1148.
https://doi.org/10.1158/1078-0432.CCR-06-1751
Published: 22 February 2007
View article titled, Abrogation of MAPK and Akt Signaling by AEE788 Synergistically Potentiates Histone Deacetylase Inhibitor-Induced Apoptosis through Reactive Oxygen Species Generation
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Journal Articles

Targeting Tumor Angiogenesis with Histone Deacetylase Inhibitors: the Hydroxamic Acid Derivative LBH589

David Z. Qian, Yukihiko Kato, Shabana Shabbeer, Yongfeng Wei, Hendrik M.W. Verheul, Brenda Salumbides, Tolib Sanni, Peter Atadja, Roberto Pili
Journal: Clinical Cancer Research
Clin Cancer Res (2006) 12 (2): 634–642.
https://doi.org/10.1158/1078-0432.CCR-05-1132
Published: 20 January 2006
View article titled, Targeting Tumor Angiogenesis with Histone Deacetylase Inhibitors: the Hydroxamic Acid Derivative LBH589
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Journal Articles

Superior Activity of the Combination of Histone Deacetylase Inhibitor LAQ824 and the FLT-3 Kinase Inhibitor PKC412 against Human Acute Myelogenous Leukemia Cells with Mutant FLT-3

Purva Bali, Prince George, Pamela Cohen, Jianguo Tao, Fei Guo, Celia Sigua, Anasuya Vishvanath, Anna Scuto, Srinivas Annavarapu, Warren Fiskus, Lynn Moscinski, Peter Atadja, Kapil Bhalla
Journal: Clinical Cancer Research
Clin Cancer Res (2004) 10 (15): 4991–4997.
https://doi.org/10.1158/1078-0432.CCR-04-0210
Published: 05 August 2004
View article titled, Superior Activity of the Combination of Histone Deacetylase Inhibitor LAQ824 and the FLT-3 Kinase Inhibitor PKC412 against Human Acute Myelogenous Leukemia Cells with Mutant FLT-3
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