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Paul Nghiem
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Journal Articles

Biomarker Analyses Investigating Disease Biology and Associations with Outcomes in the JAVELIN Merkel 200 Trial of Avelumab in Metastatic Merkel Cell Carcinoma

Sandra P. D’Angelo, Céleste Lebbé, Paul Nghiem, Andrew S. Brohl, Thomas Mrowiec, Trent Leslie, Sara Georges, Gülseren Güzel, Parantu Shah
Journal: Clinical Cancer Research
Clin Cancer Res (2024) 30 (19): 4352–4362.
https://doi.org/10.1158/1078-0432.CCR-23-0395
Published: 01 October 2024
View article titled, Biomarker Analyses Investigating Disease Biology and Associations with Outcomes in the JAVELIN Merkel 200 Trial of Avelumab in Metastatic Merkel Cell Carcinoma
Open the PDF for Biomarker Analyses Investigating Disease Biology and Associations with Outcomes in the JAVELIN Merkel 200 Trial of Avelumab in Metastatic Merkel Cell Carcinoma in another window
Includes: Supplementary data
Journal Articles

Characterization of Immunosuppressive Myeloid Cells in Merkel Cell Carcinoma: Correlation with Resistance to PD-1 Pathway Blockade

Shira Tabachnick-Cherny, Thomas Pulliam, Haroldo J. Rodriguez, Xinyi Fan, Daniel S. Hippe, Daniel C. Jones, Ata S. Moshiri, Kimberly S. Smythe, Rima M. Kulikauskas, Lisa C. Zaba, Kelly G. Paulson, Paul Nghiem
Journal: Clinical Cancer Research
Clin Cancer Res (2024) 30 (6): 1189–1199.
https://doi.org/10.1158/1078-0432.CCR-23-1957
Published: 15 March 2024
View article titled, Characterization of Immunosuppressive Myeloid Cells in Merkel Cell Carcinoma: Correlation with Resistance to PD-1 Pathway Blockade
Open the PDF for Characterization of Immunosuppressive Myeloid Cells in Merkel Cell Carcinoma: Correlation with Resistance to PD-1 Pathway Blockade in another window
Includes: Supplementary data
Journal Articles

Identification of Therapeutic Vulnerabilities in Small-cell Neuroendocrine Prostate Cancer

Alexandra N. Corella, Ma Victoria Andrea Cabiliza Ordonio, Ilsa Coleman, Jared M. Lucas, Arja Kaipainen, Holly M. Nguyen, Daniel Sondheim, Lisha G. Brown, Lawrence D. True, John K. Lee, David MacPherson, Paul Nghiem, Roman Gulati, Colm Morrissey, Eva Corey, Peter S. Nelson
Journal: Clinical Cancer Research
Clin Cancer Res (2020) 26 (7): 1667–1677.
https://doi.org/10.1158/1078-0432.CCR-19-0775
Published: 01 April 2020
View article titled, Identification of Therapeutic Vulnerabilities in Small-cell Neuroendocrine Prostate Cancer
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Includes: Supplementary data
Journal Articles

Intratumoral Delivery of Plasmid IL12 Via Electroporation Leads to Regression of Injected and Noninjected Tumors in Merkel Cell Carcinoma

Shailender Bhatia, Natalie V. Longino, Natalie J. Miller, Rima Kulikauskas, Jayasri G. Iyer, Dafina Ibrani, Astrid Blom, David R. Byrd, Upendra Parvathaneni, Christopher G. Twitty, Jean S. Campbell, Mai H. Le, Sharron Gargosky, Robert H. Pierce, Richard Heller, Adil I. Daud, Paul Nghiem
Journal: Clinical Cancer Research
Series: Author Choice
Clin Cancer Res (2020) 26 (3): 598–607.
https://doi.org/10.1158/1078-0432.CCR-19-0972
Published: 03 February 2020
View article titled, Intratumoral Delivery of Plasmid IL12 Via Electroporation Leads to Regression of Injected and Noninjected Tumors in Merkel Cell Carcinoma
Open the PDF for Intratumoral Delivery of Plasmid IL12 Via Electroporation Leads to Regression of Injected and Noninjected Tumors in Merkel Cell Carcinoma in another window
Includes: Supplementary data
Journal Articles

Intratumoral G100, a TLR4 Agonist, Induces Antitumor Immune Responses and Tumor Regression in Patients with Merkel Cell Carcinoma

Shailender Bhatia, Natalie J. Miller, Hailing Lu, Natalie V. Longino, Dafina Ibrani, Michi M. Shinohara, David R. Byrd, Upendra Parvathaneni, Rima Kulikauskas, Jan ter Meulen, Frank J. Hsu, David M. Koelle, Paul Nghiem
Journal: Clinical Cancer Research
Series: Author Choice
Clin Cancer Res (2019) 25 (4): 1185–1195.
https://doi.org/10.1158/1078-0432.CCR-18-0469
Published: 15 February 2019
View article titled, Intratumoral G100, a TLR4 Agonist, Induces Antitumor Immune Responses and Tumor Regression in Patients with Merkel Cell Carcinoma
Open the PDF for Intratumoral G100, a TLR4 Agonist, Induces Antitumor Immune Responses and Tumor Regression in Patients with Merkel Cell Carcinoma in another window
Includes: Supplementary data
Journal Articles

Circulating Cell-Free miR-375 as Surrogate Marker of Tumor Burden in Merkel Cell Carcinoma

Kaiji Fan, Cathrin Ritter, Paul Nghiem, Astrid Blom, Monique E. Verhaegen, Andrzej Dlugosz, Niels Ødum, Anders Woetmann, Richard W. Tothill, Rodney J. Hicks, Michael Sand, David Schrama, Dirk Schadendorf, Selma Ugurel, Jürgen C. Becker
Journal: Clinical Cancer Research
Clin Cancer Res (2018) 24 (23): 5873–5882.
https://doi.org/10.1158/1078-0432.CCR-18-1184
Published: 03 December 2018
View article titled, Circulating Cell-Free miR-375 as Surrogate Marker of Tumor Burden in Merkel Cell Carcinoma
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Includes: Supplementary data
Journal Articles

Targeting Merkel Cell Carcinoma by Engineered T Cells Specific to T-Antigens of Merkel Cell Polyomavirus

Ioannis Gavvovidis, Matthias Leisegang, Gerald Willimsky, Natalie Miller, Paul Nghiem, Thomas Blankenstein
Journal: Clinical Cancer Research
Clin Cancer Res (2018) 24 (15): 3644–3655.
https://doi.org/10.1158/1078-0432.CCR-17-2661
Published: 31 July 2018
View article titled, Targeting Merkel Cell Carcinoma by Engineered T Cells Specific to T-Antigens of Merkel Cell Polyomavirus
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Includes: Supplementary data
Journal Articles

Merkel Cell Carcinoma in the Age of Immunotherapy: Facts and Hopes

Aric Colunga, Thomas Pulliam, Paul Nghiem
Journal: Clinical Cancer Research
Clin Cancer Res (2018) 24 (9): 2035–2043.
https://doi.org/10.1158/1078-0432.CCR-17-0439
Published: 30 April 2018
View article titled, Merkel Cell Carcinoma in the Age of Immunotherapy: Facts and Hopes
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Journal Articles

Merkel Cell Carcinoma Patients Presenting Without a Primary Lesion Have Elevated Markers of Immunity, Higher Tumor Mutation Burden, and Improved Survival

Natalie Vandeven, Christopher W. Lewis, Vladimir Makarov, Nadeem Riaz, Kelly G. Paulson, Daniel Hippe, Amy Bestick, Ryan Doumani, Tessa Marx, Seesha Takagishi, Timothy A. Chan, Jaehyuk Choi, Paul Nghiem
Journal: Clinical Cancer Research
Clin Cancer Res (2018) 24 (4): 963–971.
https://doi.org/10.1158/1078-0432.CCR-17-1678
Published: 14 February 2018
View article titled, Merkel Cell Carcinoma Patients Presenting Without a Primary Lesion Have Elevated Markers of Immunity, Higher Tumor Mutation Burden, and Improved Survival
Open the PDF for Merkel Cell Carcinoma Patients Presenting Without a Primary Lesion Have Elevated Markers of Immunity, Higher Tumor Mutation Burden, and Improved Survival in another window
Includes: Supplementary data
Journal Articles

T-cell Responses to Oncogenic Merkel Cell Polyomavirus Proteins Distinguish Patients with Merkel Cell Carcinoma from Healthy Donors

Rikke Lyngaa, Natasja Wulff Pedersen, David Schrama, Charlotte Albæk Thrue, Dafina Ibrani, Özcan Met, Per thor Straten, Paul Nghiem, Jürgen C. Becker, Sine Reker Hadrup
Journal: Clinical Cancer Research
Series: Author Choice
Clin Cancer Res (2014) 20 (7): 1768–1778.
https://doi.org/10.1158/1078-0432.CCR-13-2697
Published: 31 March 2014
View article titled, T-cell Responses to Oncogenic Merkel Cell Polyomavirus Proteins Distinguish Patients with Merkel Cell Carcinoma from Healthy Donors
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Includes: Supplementary data
Journal Articles

Merkel Polyomavirus-Specific T Cells Fluctuate with Merkel Cell Carcinoma Burden and Express Therapeutically Targetable PD-1 and Tim-3 Exhaustion Markers

Olga K. Afanasiev, Lola Yelistratova, Natalie Miller, Kotaro Nagase, Kelly Paulson, Jayasri G. Iyer, Dafina Ibrani, David M. Koelle, Paul Nghiem
Journal: Clinical Cancer Research
Clin Cancer Res (2013) 19 (19): 5351–5360.
https://doi.org/10.1158/1078-0432.CCR-13-0035
Published: 01 October 2013
View article titled, Merkel Polyomavirus-Specific T Cells Fluctuate with Merkel Cell Carcinoma Burden and Express Therapeutically Targetable PD-1 and Tim-3 Exhaustion Markers
Open the PDF for Merkel Polyomavirus-Specific T Cells Fluctuate with Merkel Cell Carcinoma Burden and Express Therapeutically Targetable PD-1 and Tim-3 Exhaustion Markers in another window
Includes: Supplementary data
Journal Articles

Merkel Cell Polyomavirus-Specific CD8+ and CD4+ T-cell Responses Identified in Merkel Cell Carcinomas and Blood

Jayasri G. Iyer, Olga K. Afanasiev, Christopher McClurkan, Kelly Paulson, Kotaro Nagase, Lichen Jing, Joshua O. Marshak, Lichun Dong, Joseph Carter, Ivy Lai, Erik Farrar, David Byrd, Denise Galloway, Cassian Yee, David M. Koelle, Paul Nghiem
Journal: Clinical Cancer Research
Clin Cancer Res (2011) 17 (21): 6671–6680.
https://doi.org/10.1158/1078-0432.CCR-11-1513
Published: 31 October 2011
View article titled, Merkel Cell Polyomavirus-Specific CD8<sup>+</sup> and CD4<sup>+</sup> T-cell Responses Identified in Merkel Cell Carcinomas and Blood
Open the PDF for Merkel Cell Polyomavirus-Specific CD8<sup>+</sup> and CD4<sup>+</sup> T-cell Responses Identified in Merkel Cell Carcinomas and Blood in another window
Includes: Supplementary data