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Journal Articles

Abstract PO-076: Adrenergic regulation of the anti-tumor immune response in p53-deficient tumors

Deborah A. Silverman, Shamima Akhter, Tongxin Xie, Shajedul Islam, Simone Anfossi, Jennifer D. Covello, Frederico O. Gleber-Netto, Elien Doorduijn, Yunfei Wang, Emily L. Ashkin, Jeffrey N. Myers, George A. Calin, Patrick Hwu, Moran Amit
Journal: Clinical Cancer Research
Clin Cancer Res (2023) 29 (18_Supplement): PO-076.
https://doi.org/10.1158/1557-3265.AACRAHNS23-PO-076
Published: 15 September 2023
View article titled, Abstract PO-076: Adrenergic regulation of the anti-tumor immune response in <em>p53</em>-deficient tumors
Journal Articles

Obesity Is Associated with Altered Tumor Metabolism in Metastatic Melanoma

Andrew W. Hahn, Ashley V. Menk, Dayana B. Rivadeneira, Ryan C. Augustin, Mingchu Xu, Jun Li, Xiaogang Wu, Aditya K. Mishra, Tuba N. Gide, Camelia Quek, Yan Zang, Christine N. Spencer, Alexander M. Menzies, Carrie R. Daniel, Courtney W. Hudgens, Theodore Nowicki, Lauren E. Haydu, M.A. Wadud Khan, Vancheswaran Gopalakrishnan, Elizabeth M. Burton, Jared Malke, Julie M. Simon, Chantale Bernatchez, Nagireddy Putluri, Scott E. Woodman, Y.N. Vashisht Gopal, Renato Guerrieri, Grant M. Fischer, Jian Wang, Khalida M. Wani, John F. Thompson, Jeffrey E. Lee, Patrick Hwu, Nadim Ajami, Jeffrey E. Gershenwald, Georgina V. Long, Richard A. Scolyer, Michael T. Tetzlaff, Alexander J. Lazar, Dirk Schadendorf, Jennifer A. Wargo, John M. Kirkwood, Ralph J. DeBerardinis, Han Liang, Andrew Futreal, Jianhua Zhang, James S. Wilmott, Weiyi Peng, Michael A. Davies, Greg M. Delgoffe, Yana G. Najjar, Jennifer L. McQuade
Journal: Clinical Cancer Research
Clin Cancer Res (2023) 29 (1): 154–164.
https://doi.org/10.1158/1078-0432.CCR-22-2661
Published: 04 January 2023
View article titled, Obesity Is Associated with Altered Tumor Metabolism in Metastatic Melanoma
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Includes: Supplementary data
Journal Articles

Genomic Correlates of Outcome in Tumor-Infiltrating Lymphocyte Therapy for Metastatic Melanoma

Caitlin A. Creasy, Yuzhong Jeff Meng, Marie-Andrée Forget, Tatiana Karpinets, Katarzyna Tomczak, Chip Stewart, Carlos A. Torres-Cabala, Shari Pilon-Thomas, Amod A. Sarnaik, James J. Mulé, Levi Garraway, Matias Bustos, Jianhua Zhang, Sapna P. Patel, Adi Diab, Isabella C. Glitza, Cassian Yee, Hussein Tawbi, Michael K. Wong, Jennifer McQuade, Dave S.B. Hoon, Michael A. Davies, Patrick Hwu, Rodabe N. Amaria, Cara Haymaker, Rameen Beroukhim, Chantale Bernatchez
Journal: Clinical Cancer Research
Clin Cancer Res (2022) 28 (9): 1911–1924.
https://doi.org/10.1158/1078-0432.CCR-21-1060
Published: 02 May 2022
View article titled, Genomic Correlates of Outcome in Tumor-Infiltrating Lymphocyte Therapy for Metastatic Melanoma
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Includes: Supplementary data
Journal Articles

Abstract PO015: The impact of the tumor immune microenvironment on response to pembrolizumab in patients with microsatellite instability-high endometrial cancer

Jeffrey A. How, Minghao Dao, Elizabeth Euscher, Melinda Yates, Weiyi Peng, Shrina D. Patel, Karen H. Lu, Patrick Hwu, Linghua Wang, Amir A. Jazaeri
Journal: Clinical Cancer Research
Clin Cancer Res (2021) 27 (3_Supplement): PO015.
https://doi.org/10.1158/1557-3265.ENDOMET20-PO015
Published: 01 February 2021
View article titled, Abstract PO015: The impact of the tumor immune microenvironment on response to pembrolizumab in patients with microsatellite instability-high endometrial cancer
Journal Articles

Circulating Tumor Cells and Early Relapse in Node-positive Melanoma

Anthony Lucci, Carolyn S. Hall, Sapna P. Patel, Boomadevi Narendran, Jessica B. Bauldry, Richard E. Royal, Mandar Karhade, Joshua R. Upshaw, Jennifer A. Wargo, Isabella C. Glitza, Michael K.K. Wong, Rodabe N. Amaria, Hussein A. Tawbi, Adi Diab, Michael A. Davies, Jeffrey E. Gershenwald, Jeffrey E. Lee, Patrick Hwu, Merrick I. Ross
Journal: Clinical Cancer Research
Clin Cancer Res (2020) 26 (8): 1886–1895.
https://doi.org/10.1158/1078-0432.CCR-19-2670
Published: 15 April 2020
View article titled, Circulating Tumor Cells and Early Relapse in Node-positive Melanoma
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Includes: Supplementary data
Journal Articles

Anti-OX40 Antibody Directly Enhances The Function of Tumor-Reactive CD8+ T Cells and Synergizes with PI3Kβ Inhibition in PTEN Loss Melanoma

Weiyi Peng, Leila J. Williams, Chunyu Xu, Brenda Melendez, Jodi A. McKenzie, Yuan Chen, Heather L. Jackson, Kui S. Voo, Rina M. Mbofung, Sara Elizabeth Leahey, Jian Wang, Gregory Lizee, Hussein A. Tawbi, Michael A. Davies, Axel Hoos, James Smothers, Roopa Srinivasan, Elaine M. Paul, Niranjan Yanamandra, Patrick Hwu
Journal: Clinical Cancer Research
Series: Author Choice
Clin Cancer Res (2019) 25 (21): 6406–6416.
https://doi.org/10.1158/1078-0432.CCR-19-1259
Published: 01 November 2019
View article titled, Anti-OX40 Antibody Directly Enhances The Function of Tumor-Reactive CD8<sup>+</sup> T Cells and Synergizes with PI3Kβ Inhibition in PTEN Loss Melanoma
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Includes: Supplementary data
Journal Articles

First-in-Class, First-in-Human Study Evaluating LV305, a Dendritic-Cell Tropic Lentiviral Vector, in Sarcoma and Other Solid Tumors Expressing NY-ESO-1

Neeta Somaiah, Matthew S. Block, Joseph W. Kim, Geoffrey I. Shapiro, Khanh T. Do, Patrick Hwu, Joseph P. Eder, Robin L. Jones, Hailing Lu, Jan H. ter Meulen, Chet Bohac, Michael Chen, Frank J. Hsu, Sacha Gnjatic, Seth M. Pollack
Journal: Clinical Cancer Research
Series: Author Choice
Clin Cancer Res (2019) 25 (19): 5808–5817.
https://doi.org/10.1158/1078-0432.CCR-19-1025
Published: 01 October 2019
View article titled, First-in-Class, First-in-Human Study Evaluating LV305, a Dendritic-Cell Tropic Lentiviral Vector, in Sarcoma and Other Solid Tumors Expressing NY-ESO-1
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Includes: Supplementary data
Journal Articles

Radiation Followed by OX40 Stimulation Drives Local and Abscopal Antitumor Effects in an Anti–PD1-Resistant Lung Tumor Model

Sharareh Niknam, Hampartsoum B. Barsoumian, Jonathan E. Schoenhals, Heather L. Jackson, Niranjan Yanamandra, Mauricio S. Caetano, Ailin Li, Ahmed I. Younes, Alexandra Cadena, Taylor R. Cushman, Joe Y. Chang, Quynh N. Nguyen, Daniel R. Gomez, Adi Diab, John V. Heymach, Patrick Hwu, Maria Angelica Cortez, James W. Welsh
Journal: Clinical Cancer Research
Clin Cancer Res (2018) 24 (22): 5735–5743.
https://doi.org/10.1158/1078-0432.CCR-17-3279
Published: 15 November 2018
View article titled, Radiation Followed by OX40 Stimulation Drives Local and Abscopal Antitumor Effects in an Anti–PD1-Resistant Lung Tumor Model
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Includes: Supplementary data
Journal Articles

Prospective Analysis of Adoptive TIL Therapy in Patients with Metastatic Melanoma: Response, Impact of Anti-CTLA4, and Biomarkers to Predict Clinical Outcome

Marie-Andrée Forget, Cara Haymaker, Kenneth R. Hess, Yuzhong Jeff Meng, Caitlin Creasy, Tatiana Karpinets, Orenthial J. Fulbright, Jason Roszik, Scott E. Woodman, Young Uk Kim, Donastas Sakellariou-Thompson, Ankit Bhatta, Arely Wahl, Esteban Flores, Shawne T. Thorsen, René J. Tavera, Renjith Ramachandran, Audrey M. Gonzalez, Christopher L. Toth, Seth Wardell, Rahmatu Mansaray, Vruti Patel, Destiny Joy Carpio, Carol Vaughn, Chantell M. Farinas, Portia G. Velasquez, Wen-Jen Hwu, Sapna P. Patel, Michael A. Davies, Adi Diab, Isabella C. Glitza, Hussein Tawbi, Michael K. Wong, Suzanne Cain, Merrick I. Ross, Jeffrey E. Lee, Jeffrey E. Gershenwald, Anthony Lucci, Richard Royal, Janice N. Cormier, Jennifer A. Wargo, Laszlo G. Radvanyi, Carlos A. Torres-Cabala, Rameen Beroukhim, Patrick Hwu, Rodabe N. Amaria, Chantale Bernatchez
Journal: Clinical Cancer Research
Clin Cancer Res (2018) 24 (18): 4416–4428.
https://doi.org/10.1158/1078-0432.CCR-17-3649
Published: 14 September 2018
View article titled, Prospective Analysis of Adoptive TIL Therapy in Patients with Metastatic Melanoma: Response, Impact of Anti-CTLA4, and Biomarkers to Predict Clinical Outcome
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Includes: Supplementary data
Journal Articles

The RNA-binding Protein MEX3B Mediates Resistance to Cancer Immunotherapy by Downregulating HLA-A Expression

Lu Huang, Shruti Malu, Jodi A. McKenzie, Miles C. Andrews, Amjad H. Talukder, Trang Tieu, Tatiana Karpinets, Cara Haymaker, Marie-Andrée Forget, Leila J. Williams, Zhe Wang, Rina M. Mbofung, Zhi-Qiang Wang, Richard Eric Davis, Roger S. Lo, Jennifer A. Wargo, Michael A. Davies, Chantale Bernatchez, Timothy Heffernan, Rodabe N. Amaria, Anil Korkut, Weiyi Peng, Jason Roszik, Gregory Lizée, Scott E. Woodman, Patrick Hwu
Journal: Clinical Cancer Research
Series: Author Choice
Clin Cancer Res (2018) 24 (14): 3366–3376.
https://doi.org/10.1158/1078-0432.CCR-17-2483
Published: 15 July 2018
View article titled, The RNA-binding Protein MEX3B Mediates Resistance to Cancer Immunotherapy by Downregulating HLA-A Expression
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Includes: Supplementary data
Journal Articles

T-cell Homing Therapy for Reducing Regulatory T Cells and Preserving Effector T-cell Function in Large Solid Tumors

Jiemiao Hu, Chuang Sun, Chantale Bernatchez, Xueqing Xia, Patrick Hwu, Gianpietro Dotti, Shulin Li
Journal: Clinical Cancer Research
Clin Cancer Res (2018) 24 (12): 2920–2934.
https://doi.org/10.1158/1078-0432.CCR-17-1365
Published: 14 June 2018
View article titled, T-cell Homing Therapy for Reducing Regulatory T Cells and Preserving Effector T-cell Function in Large Solid Tumors
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Includes: Supplementary data
Journal Articles

4-1BB Agonist Focuses CD8+ Tumor-Infiltrating T-Cell Growth into a Distinct Repertoire Capable of Tumor Recognition in Pancreatic Cancer

Donastas Sakellariou-Thompson, Marie-Andrée Forget, Caitlin Creasy, Vincent Bernard, Li Zhao, Young Uk Kim, Mark W. Hurd, Naohiro Uraoka, Edwin Roger Parra, Ya'an Kang, Christopher A. Bristow, Jaime Rodriguez-Canales, Jason B. Fleming, Gauri Varadhachary, Milind Javle, Michael J. Overman, Hector A. Alvarez, Timothy P. Heffernan, Jianhua Zhang, Patrick Hwu, Anirban Maitra, Cara Haymaker, Chantale Bernatchez
Journal: Clinical Cancer Research
Clin Cancer Res (2017) 23 (23): 7263–7275.
https://doi.org/10.1158/1078-0432.CCR-17-0831
Published: 30 November 2017
View article titled, 4-1BB Agonist Focuses CD8<sup>+</sup> Tumor-Infiltrating T-Cell Growth into a Distinct Repertoire Capable of Tumor Recognition in Pancreatic Cancer
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Includes: Supplementary data
Journal Articles

Multifaceted Role of BTLA in the Control of CD8+ T-cell Fate after Antigen Encounter

Krit Ritthipichai, Cara L. Haymaker, Melisa Martinez, Andrew Aschenbrenner, Xiaohui Yi, Minying Zhang, Charuta Kale, Luis M. Vence, Jason Roszik, Yared Hailemichael, Willem W. Overwijk, Navin Varadarajan, Roza Nurieva, Laszlo G. Radvanyi, Patrick Hwu, Chantale Bernatchez
Journal: Clinical Cancer Research
Clin Cancer Res (2017) 23 (20): 6151–6164.
https://doi.org/10.1158/1078-0432.CCR-16-1217
Published: 12 October 2017
View article titled, Multifaceted Role of BTLA in the Control of CD8<sup>+</sup> T-cell Fate after Antigen Encounter
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Includes: Multimedia, Supplementary data
Journal Articles

AACR Cancer Progress Report 2016

Nancy E. Davidson, Scott A. Armstrong, Lisa M. Coussens, Marcia R. Cruz-Correa, Ralph J. DeBerardinis, James H. Doroshow, Margaret Foti, Patrick Hwu, Thomas W. Kensler, Monica Morrow, Charles G. Mulligan, William Pao, Elizabeth A. Platz, Thomas J. Smith, Cheryl L. Willman
Journal: Clinical Cancer Research
Clin Cancer Res (2016) 22 (19_Supplement): S1–S137.
https://doi.org/10.1158/1078-0432.CCR-16-1993
Published: 02 October 2016
View article titled, AACR Cancer Progress Report 2016
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Journal Articles

Epithelial–Mesenchymal Transition Is Associated with a Distinct Tumor Microenvironment Including Elevation of Inflammatory Signals and Multiple Immune Checkpoints in Lung Adenocarcinoma

Yanyan Lou, Lixia Diao, Edwin Roger Parra Cuentas, Warren L. Denning, Limo Chen, You Hong Fan, Lauren A. Byers, Jing Wang, Vassiliki A. Papadimitrakopoulou, Carmen Behrens, Jaime Canales Rodriguez, Patrick Hwu, Ignacio I. Wistuba, John V. Heymach, Don L. Gibbons
Journal: Clinical Cancer Research
Series: Author Choice
Clin Cancer Res (2016) 22 (14): 3630–3642.
https://doi.org/10.1158/1078-0432.CCR-15-1434
Published: 14 July 2016
View article titled, Epithelial–Mesenchymal Transition Is Associated with a Distinct Tumor Microenvironment Including Elevation of Inflammatory Signals and Multiple Immune Checkpoints in Lung Adenocarcinoma
Open the PDF for Epithelial–Mesenchymal Transition Is Associated with a Distinct Tumor Microenvironment Including Elevation of Inflammatory Signals and Multiple Immune Checkpoints in Lung Adenocarcinoma in another window
Includes: Supplementary data
Journal Articles

Correlation of BRAF Mutation Status in Circulating-Free DNA and Tumor and Association with Clinical Outcome across Four BRAFi and MEKi Clinical Trials

Ademi Santiago-Walker, Robert Gagnon, Jolly Mazumdar, Michelle Casey, Georgina V. Long, Dirk Schadendorf, Keith Flaherty, Richard Kefford, Axel Hauschild, Patrick Hwu, Patricia Haney, Anne O'Hagan, Jennifer Carver, Vicki Goodman, Jeffrey Legos, Anne-Marie Martin
Journal: Clinical Cancer Research
Series: Author Choice
Clin Cancer Res (2016) 22 (3): 567–574.
https://doi.org/10.1158/1078-0432.CCR-15-0321
Published: 31 January 2016
View article titled, Correlation of <em>BRAF</em> Mutation Status in Circulating-Free DNA and Tumor and Association with Clinical Outcome across Four BRAFi and MEKi Clinical Trials
Open the PDF for Correlation of <em>BRAF</em> Mutation Status in Circulating-Free DNA and Tumor and Association with Clinical Outcome across Four BRAFi and MEKi Clinical Trials in another window
Includes: Supplementary data
Journal Articles

CCR 20th Anniversary Commentary: Chimeric Antigen Receptors—From Model T to the Tesla

Patrick Hwu
Journal: Clinical Cancer Research
Clin Cancer Res (2015) 21 (14): 3099–3101.
https://doi.org/10.1158/1078-0432.CCR-14-2560
Published: 14 July 2015
View article titled, <em>CCR</em> 20<sup>th</sup> Anniversary Commentary: Chimeric Antigen Receptors—From Model T to the Tesla
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Journal Articles

Manipulating the Tumor Microenvironment Ex Vivo for Enhanced Expansion of Tumor-Infiltrating Lymphocytes for Adoptive Cell Therapy

Jessica Ann Chacon, Amod A. Sarnaik, Jie Qing Chen, Caitlin Creasy, Charuta Kale, John Robinson, Jeffrey Weber, Patrick Hwu, Shari Pilon-Thomas, Laszlo Radvanyi
Journal: Clinical Cancer Research
Series: Author Choice
Clin Cancer Res (2015) 21 (3): 611–621.
https://doi.org/10.1158/1078-0432.CCR-14-1934
Published: 01 February 2015
View article titled, Manipulating the Tumor Microenvironment <em>Ex Vivo</em> for Enhanced Expansion of Tumor-Infiltrating Lymphocytes for Adoptive Cell Therapy
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Includes: Supplementary data
Journal Articles

Complete Loss of PTEN Protein Expression Correlates with Shorter Time to Brain Metastasis and Survival in Stage IIIB/C Melanoma Patients with BRAFV600 Mutations

Amanda D. Bucheit, Guo Chen, Alan Siroy, Michael Tetzlaff, Russell Broaddus, Denai Milton, Patricia Fox, Roland Bassett, Patrick Hwu, Jeffrey E. Gershenwald, Alexander J. Lazar, Michael A. Davies
Journal: Clinical Cancer Research
Clin Cancer Res (2014) 20 (21): 5527–5536.
https://doi.org/10.1158/1078-0432.CCR-14-1027
Published: 30 October 2014
View article titled, Complete Loss of PTEN Protein Expression Correlates with Shorter Time to Brain Metastasis and Survival in Stage IIIB/C Melanoma Patients with <em>BRAF</em><sup>V600</sup> Mutations
Open the PDF for Complete Loss of PTEN Protein Expression Correlates with Shorter Time to Brain Metastasis and Survival in Stage IIIB/C Melanoma Patients with <em>BRAF</em><sup>V600</sup> Mutations in another window
Includes: Supplementary data
Journal Articles

Antagonist Antibodies to PD-1 and B7-H1 (PD-L1) in the Treatment of Advanced Human Cancer—Letter

Laszlo Radvanyi, Shari Pilon-Thomas, Weiyi Peng, Amod Sarnaik, James J. Mulé, Jeffrey Weber, Patrick Hwu
Journal: Clinical Cancer Research
Clin Cancer Res (2013) 19 (19): 5541.
https://doi.org/10.1158/1078-0432.CCR-13-1054
Published: 01 October 2013
View article titled, Antagonist Antibodies to PD-1 and B7-H1 (PD-L1) in the Treatment of Advanced Human Cancer—Letter
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