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Patrick G. Johnston
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Journal Articles

In-depth Clinical and Biological Exploration of DNA Damage Immune Response as a Biomarker for Oxaliplatin Use in Colorectal Cancer

Free
Sudhir B. Malla, David J. Fisher, Enric Domingo, Andrew Blake, Sylvana Hassanieh, Keara L. Redmond, Susan D. Richman, Michael Youdell, Steven M. Walker, Gemma E. Logan, Aikaterina Chatzipli, Raheleh Amirkhah, Matthew P. Humphries, Stephanie G. Craig, Ultan McDermott, Matthew T. Seymour, Dion G. Morton, Philip Quirke, Nicholas P. West, Manuel Salto-Tellez, Richard D. Kennedy, Patrick G. Johnston, Ian Tomlinson, Viktor H. Koelzer, Letitia Campo, Richard S. Kaplan, Daniel B. Longley, Mark Lawler, Timothy S. Maughan, Louise C. Brown, Philip D. Dunne
Journal: Clinical Cancer Research
Series: Author Choice
Clin Cancer Res (2021) 27 (1): 288–300.
https://doi.org/10.1158/1078-0432.CCR-20-3237
Published: 04 January 2021
View article titled, In-depth Clinical and Biological Exploration of DNA Damage Immune Response as a Biomarker for Oxaliplatin Use in Colorectal Cancer
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Includes: Supplementary data
Journal Articles

A Stepwise Integrated Approach to Personalized Risk Predictions in Stage III Colorectal Cancer

Free
Manuela Salvucci, Maximilian L. Würstle, Clare Morgan, Sarah Curry, Mattia Cremona, Andreas U. Lindner, Orna Bacon, Alexa J. Resler, Áine C. Murphy, Robert O'Byrne, Lorna Flanagan, Sonali Dasgupta, Nadege Rice, Camilla Pilati, Elisabeth Zink, Lisa M. Schöller, Sinead Toomey, Mark Lawler, Patrick G. Johnston, Richard Wilson, Sophie Camilleri-Broët, Manuel Salto-Tellez, Deborah A. McNamara, Elaine W. Kay, Pierre Laurent-Puig, Sandra Van Schaeybroeck, Bryan T. Hennessy, Daniel B. Longley, Markus Rehm, Jochen H.M. Prehn
Journal: Clinical Cancer Research
Clin Cancer Res (2017) 23 (5): 1200–1212.
https://doi.org/10.1158/1078-0432.CCR-16-1084
Published: 28 February 2017
View article titled, A Stepwise Integrated Approach to Personalized Risk Predictions in Stage III Colorectal Cancer
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Includes: Supplementary data
Journal Articles

Challenging the Cancer Molecular Stratification Dogma: Intratumoral Heterogeneity Undermines Consensus Molecular Subtypes and Potential Diagnostic Value in Colorectal Cancer

Free
Philip D. Dunne, Darragh G. McArt, Conor A. Bradley, Paul G. O'Reilly, Helen L. Barrett, Robert Cummins, Tony O'Grady, Ken Arthur, Maurice B. Loughrey, Wendy L. Allen, Simon S. McDade, David J. Waugh, Peter W. Hamilton, Daniel B. Longley, Elaine W. Kay, Patrick G. Johnston, Mark Lawler, Manuel Salto-Tellez, Sandra Van Schaeybroeck
Journal: Clinical Cancer Research
Clin Cancer Res (2016) 22 (16): 4095–4104.
https://doi.org/10.1158/1078-0432.CCR-16-0032
Published: 14 August 2016
View article titled, Challenging the Cancer Molecular Stratification Dogma: Intratumoral Heterogeneity Undermines Consensus Molecular Subtypes and Potential Diagnostic Value in Colorectal Cancer
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Includes: Supplementary data
Journal Articles

EphA2 Expression Is a Key Driver of Migration and Invasion and a Poor Prognostic Marker in Colorectal Cancer

Free
Philip D. Dunne, Sonali Dasgupta, Jaine K. Blayney, Darragh G. McArt, Keara L. Redmond, Jessica-Anne Weir, Conor A. Bradley, Takehiko Sasazuki, Senji Shirasawa, Tingting Wang, Supriya Srivastava, Chee Wee Ong, Ken Arthur, Manuel Salto-Tellez, Richard H. Wilson, Patrick G. Johnston, Sandra Van Schaeybroeck
Journal: Clinical Cancer Research
Clin Cancer Res (2016) 22 (1): 230–242.
https://doi.org/10.1158/1078-0432.CCR-15-0603
Published: 03 January 2016
View article titled, EphA2 Expression Is a Key Driver of Migration and Invasion and a Poor Prognostic Marker in Colorectal Cancer
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Includes: Supplementary data
Journal Articles

HDAC Inhibition Overcomes Acute Resistance to MEK Inhibition in BRAF-Mutant Colorectal Cancer by Downregulation of c-FLIPL

Free
Robbie Carson, Basak Celtikci, Cathy Fenning, Arman Javadi, Nyree Crawford, Lucia Perez-Carbonell, Mark Lawler, Daniel B. Longley, Patrick G. Johnston, Sandra Van Schaeybroeck
Journal: Clinical Cancer Research
Clin Cancer Res (2015) 21 (14): 3230–3240.
https://doi.org/10.1158/1078-0432.CCR-14-2701
Published: 14 July 2015
View article titled, HDAC Inhibition Overcomes Acute Resistance to MEK Inhibition in BRAF-Mutant Colorectal Cancer by Downregulation of c-FLIPL
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Includes: Supplementary data
Journal Articles

AXL Is a Key Regulator of Inherent and Chemotherapy-Induced Invasion and Predicts a Poor Clinical Outcome in Early-Stage Colon Cancer

Free
Philip D. Dunne, Darragh G. McArt, Jaine K. Blayney, Murugan Kalimutho, Samanda Greer, Tingting Wang, Supriya Srivastava, Chee Wee Ong, Ken Arthur, Maurice Loughrey, Keara Redmond, Daniel B. Longley, Manuel Salto-Tellez, Patrick G. Johnston, Sandra Van Schaeybroeck
Journal: Clinical Cancer Research
Clin Cancer Res (2014) 20 (1): 164–175.
https://doi.org/10.1158/1078-0432.CCR-13-1354
Published: 05 January 2014
View article titled, AXL Is a Key Regulator of Inherent and Chemotherapy-Induced Invasion and Predicts a Poor Clinical Outcome in Early-Stage Colon Cancer
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Includes: Supplementary data
Journal Articles

Identification of Galanin and Its Receptor GalR1 as Novel Determinants of Resistance to Chemotherapy and Potential Biomarkers in Colorectal Cancer

Free
Leanne Stevenson, Wendy L. Allen, Richard Turkington, Puthen V. Jithesh, Irina Proutski, Gail Stewart, Heinz-Josef Lenz, Sandra Van Schaeybroeck, Daniel B. Longley, Patrick G. Johnston
Journal: Clinical Cancer Research
Clin Cancer Res (2012) 18 (19): 5412–5426.
https://doi.org/10.1158/1078-0432.CCR-12-1780
Published: 30 September 2012
View article titled, Identification of Galanin and Its Receptor GalR1 as Novel Determinants of Resistance to Chemotherapy and Potential Biomarkers in Colorectal Cancer
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Includes: Supplementary data
Journal Articles

Ran Is a Potential Therapeutic Target for Cancer Cells with Molecular Changes Associated with Activation of the PI3K/Akt/mTORC1 and Ras/MEK/ERK Pathways

Free
Hiu-Fung Yuen, Ka-Kui Chan, Claire Grills, James T. Murray, Angela Platt-Higgins, Osama Sharaf Eldin, Ken O'Byrne, Pasi Janne, Dean A. Fennell, Patrick G. Johnston, Philip S. Rudland, Mohamed El-Tanani
Journal: Clinical Cancer Research
Clin Cancer Res (2012) 18 (2): 380–391.
https://doi.org/10.1158/1078-0432.CCR-11-2035
Published: 16 January 2012
View article titled, Ran Is a Potential Therapeutic Target for Cancer Cells with Molecular Changes Associated with Activation of the PI3K/Akt/mTORC1 and Ras/MEK/ERK Pathways
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Includes: Supplementary data
Journal Articles

Prognostic Significance of TRAIL Signaling Molecules in Stage II and III Colorectal Cancer

Free
Donal P. McLornan, Helen L. Barrett, Robert Cummins, Ultan McDermott, Cliona McDowell, Susie J. Conlon, Victoria M. Coyle, Sandra Van Schaeybroeck, Richard Wilson, Elaine W. Kay, Daniel B. Longley, Patrick G. Johnston
Journal: Clinical Cancer Research
Clin Cancer Res (2010) 16 (13): 3442–3451.
https://doi.org/10.1158/1078-0432.CCR-10-0052
Published: 30 June 2010
View article titled, Prognostic Significance of TRAIL Signaling Molecules in Stage II and III Colorectal Cancer
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Includes: Supplementary data
Journal Articles

Chemotherapy-Induced Activation of ADAM-17: A Novel Mechanism of Drug Resistance in Colorectal Cancer

Free
Joan N. Kyula, Sandra Van Schaeybroeck, Joanne Doherty, Catherine S. Fenning, Daniel B. Longley, Patrick G. Johnston
Journal: Clinical Cancer Research
Clin Cancer Res (2010) 16 (13): 3378–3389.
https://doi.org/10.1158/1078-0432.CCR-10-0014
Published: 30 June 2010
View article titled, Chemotherapy-Induced Activation of ADAM-17: A Novel Mechanism of Drug Resistance in Colorectal Cancer
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Includes: Supplementary data
Journal Articles

Clinical Determinants of Response to Irinotecan-Based Therapy Derived from Cell Line Models

Free
Wendy L. Allen, Vicky M. Coyle, Puthen V. Jithesh, Irina Proutski, Leanne Stevenson, Cathy Fenning, Daniel B. Longley, Richard H. Wilson, Michael Gordon, Heinz-Josef Lenz, Patrick G. Johnston
Journal: Clinical Cancer Research
Clin Cancer Res (2008) 14 (20): 6647–6655.
https://doi.org/10.1158/1078-0432.CCR-08-0452
Published: 16 October 2008
View article titled, Clinical Determinants of Response to Irinotecan-Based Therapy Derived from Cell Line Models
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Includes: Supplementary data
Journal Articles

BRCA1 mRNA Expression Levels Predict for Overall Survival in Ovarian Cancer after Chemotherapy

Free
Jennifer E. Quinn, Colin R. James, Gail E. Stewart, Jude M. Mulligan, Patricia White, Gary K.F. Chang, Paul B. Mullan, Patrick G. Johnston, Richard H. Wilson, D. Paul Harkin
Journal: Clinical Cancer Research
Clin Cancer Res (2007) 13 (24): 7413–7420.
https://doi.org/10.1158/1078-0432.CCR-07-1083
Published: 19 December 2007
View article titled, BRCA1 mRNA Expression Levels Predict for Overall Survival in Ovarian Cancer after Chemotherapy
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Journal Articles

Nonapical and Cytoplasmic Expression of Interleukin-8, CXCR1, and CXCR2 Correlates with Cell Proliferation and Microvessel Density in Prostate Cancer

Free
Catherine Murphy, Maryalice McGurk, Johanna Pettigrew, Alfredo Santinelli, Roberta Mazzucchelli, Patrick G. Johnston, Rodolfo Montironi, David J.J. Waugh
Journal: Clinical Cancer Research
Clin Cancer Res (2005) 11 (11): 4117–4127.
https://doi.org/10.1158/1078-0432.CCR-04-1518
Published: 01 June 2005
View article titled, Nonapical and Cytoplasmic Expression of Interleukin-8, CXCR1, and CXCR2 Correlates with Cell Proliferation and Microvessel Density in Prostate Cancer
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Journal Articles

Characterization of p53 Wild-Type and Null Isogenic Colorectal Cancer Cell Lines Resistant to 5-Fluorouracil, Oxaliplatin, and Irinotecan

Free
John Boyer, Estelle G. McLean, Somaiah Aroori, Peter Wilson, Andrea McCulla, P. Declan Carey, Daniel B. Longley, Patrick G. Johnston
Journal: Clinical Cancer Research
Clin Cancer Res (2004) 10 (6): 2158–2167.
https://doi.org/10.1158/1078-0432.CCR-03-0362
Published: 24 March 2004
View article titled, Characterization of p53 Wild-Type and Null Isogenic Colorectal Cancer Cell Lines Resistant to 5-Fluorouracil, Oxaliplatin, and Irinotecan
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Journal Articles

Characterization of a Thymidylate Synthase (TS)-inducible Cell Line: A Model System for Studying Sensitivity to TS- and non-TS-targeted Chemotherapies

Free
Daniel B. Longley, Paul R. Ferguson, John Boyer, Tariq Latif, Maria Lynch, Pamela Maxwell, D. Paul Harkin, Patrick G. Johnston
Journal: Clinical Cancer Research
Clin Cancer Res (2001) 7 (11): 3533–3539.
Published: 01 November 2001
View article titled, Characterization of a Thymidylate Synthase (TS)-inducible Cell Line: A Model System for Studying Sensitivity to TS- and non-TS-targeted Chemotherapies
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Journal Articles

Thymidylate Synthase Expression: An Independent Prognostic Factor for Local Recurrence, Distant Metastasis, Disease-free and Overall Survival in Rectal Cancer

Free
David Edler, Marja Hallström, Patrick G. Johnston, Inger Magnusson, Peter Ragnhammar, Henric Blomgren
Journal: Clinical Cancer Research
Clin Cancer Res (2000) 6 (4): 1378–1384.
Published: 01 April 2000
View article titled, Thymidylate Synthase Expression: An Independent Prognostic Factor for Local Recurrence, Distant Metastasis, Disease-free and Overall Survival in Rectal Cancer
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Journal Articles

Immunohistochemically Detected Thymidylate Synthase in Colorectal Cancer: An Independent Prognostic Factor of Survival

Free
David Edler, Ulf Kressner, Peter Ragnhammar, Patrick G. Johnston, Inger Magnusson, Bengt Glimelius, Lars Påhlman, Gudrun Lindmark, Henric Blomgren
Journal: Clinical Cancer Research
Clin Cancer Res (2000) 6 (2): 488–492.
Published: 01 February 2000
View article titled, Immunohistochemically Detected Thymidylate Synthase in Colorectal Cancer: An Independent Prognostic Factor of Survival
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Journal Articles

Prognostic Value of p53, Glutathione S-Transferase π, and Thymidylate Synthase for Neoadjuvant Cisplatin-based Chemotherapy in Head and Neck Cancer

Free
Hideaki Shiga, Elizabeth I. Heath, Audrey A. Rasmussen, Bruce Trock, Patrick G. Johnston, Arlene A. Forastiere, Miles Langmacher, Alfred Baylor, Michele Lee, Kevin J. Cullen
Journal: Clinical Cancer Research
Clin Cancer Res (1999) 5 (12): 4097–4104.
Published: 01 December 1999
View article titled, Prognostic Value of p53, Glutathione S-Transferase π, and Thymidylate Synthase for Neoadjuvant Cisplatin-based Chemotherapy in Head and Neck Cancer
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Journal Articles

A Phase I Study of Raltitrexed, an Antifolate Thymidylate Synthase Inhibitor, in Adult Patients with Advanced Solid Tumors

Free
Jean L. Grem, J. Mel Sorensen, Ellen Cullen, Chris H. Takimoto, Seth M. Steinberg, Alice P. Chen, J. Michael Hamilton, Susan G. Arbuck, Nanette McAtee, David Lawrence, Barry Goldspiel, Patrick G. Johnston, Carmen J. Allegra
Journal: Clinical Cancer Research
Clin Cancer Res (1999) 5 (9): 2381–2391.
Published: 01 September 1999
View article titled, A Phase I Study of Raltitrexed, an Antifolate Thymidylate Synthase Inhibitor, in Adult Patients with Advanced Solid Tumors
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Journal Articles

A Pilot Study of Interferon α-2a, Fluorouracil, and Leucovorin Given with Granulocyte-Macrophage Colony Stimulating Factor in Advanced Gastrointestinal Adenocarcinoma

Free
Jeremy D. Shapiro, Nancy Harold, Chris Takimoto, J. Michael Hamilton, David Vaughn, Alice Chen, Seth M. Steinberg, David Liewehr, Carmen Allegra, Brian Monahan, Alex Lash, Frank Grollman, Donald Flemming, Katherine Behan, Patrick G. Johnston, Daniel Haller, Mary Quinn, Geraldine Morrison, Jean L. Grem
Journal: Clinical Cancer Research
Clin Cancer Res (1999) 5 (9): 2399–2408.
Published: 01 September 1999
View article titled, A Pilot Study of Interferon α-2a, Fluorouracil, and Leucovorin Given with Granulocyte-Macrophage Colony Stimulating Factor in Advanced Gastrointestinal Adenocarcinoma
Open the PDF for A Pilot Study of Interferon α-2a, Fluorouracil, and Leucovorin Given with Granulocyte-Macrophage Colony Stimulating Factor in Advanced Gastrointestinal Adenocarcinoma in another window