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Patricia Troncoso
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Journal Articles

A Modular Trial of Androgen Signaling Inhibitor Combinations Testing a Risk-Adapted Strategy in Patients with Metastatic Castration–Resistant Prostate Cancer

Ana M. Aparicio, Rebecca S.S. Tidwell, Shalini S. Yadav, Jiun-Sheng Chen, Miao Zhang, Jingjing Liu, Shuai Guo, Patrick G. Pilié, Yao Yu, Xingzhi Song, Haswanth Vundavilli, Sonali Jindal, Keyi Zhu, Paul V. Viscuse, Justin M. Lebenthal, Andrew W. Hahn, Rama Soundararajan, Paul G. Corn, Amado Zurita-Saavedra, Sumit K. Subudhi, Jianhua Zhang, Wenyi Wang, Chad Huff, Patricia Troncoso, James P. Allison, Padmanee Sharma, Christopher J. Logothetis
Journal: Clinical Cancer Research
Clin Cancer Res (2024) 30 (13): 2751–2763.
https://doi.org/10.1158/1078-0432.CCR-23-3740
Published: 01 July 2024
View article titled, A Modular Trial of Androgen Signaling Inhibitor Combinations Testing a Risk-Adapted Strategy in Patients with Metastatic Castration–Resistant Prostate Cancer
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Includes: Supplementary data
Journal Articles

Integrative Molecular Analyses of the MD Anderson Prostate Cancer Patient-derived Xenograft (MDA PCa PDX) Series

Nicolas Anselmino, Estefania Labanca, Peter D.A. Shepherd, Jiabin Dong, Jun Yang, Xiaofei Song, Subhiksha Nandakumar, Ritika Kundra, Cindy Lee, Nikolaus Schultz, Jianhua Zhang, John C. Araujo, Ana M. Aparicio, Sumit K. Subudhi, Paul G. Corn, Louis L. Pisters, John F. Ward, John W. Davis, Elba S. Vazquez, Geraldine Gueron, Christopher J. Logothetis, Andrew Futreal, Patricia Troncoso, Yu Chen, Nora M. Navone
Journal: Clinical Cancer Research
Clin Cancer Res (2024) 30 (10): 2272–2285.
https://doi.org/10.1158/1078-0432.CCR-23-2438
Published: 15 May 2024
View article titled, Integrative Molecular Analyses of the MD Anderson Prostate Cancer Patient-derived Xenograft (MDA PCa PDX) Series
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Includes: Supplementary data
Journal Articles

Radium-223 Treatment Increases Immune Checkpoint Expression in Extracellular Vesicles from the Metastatic Prostate Cancer Bone Microenvironment

Ioulia Vardaki, Paul Corn, Emanuela Gentile, Jian H. Song, Namrata Madan, Anh Hoang, Nila Parikh, Leah Guerra, Yu-Chen Lee, Song-Chang Lin, Guoyu Yu, Elmer Santos, Marites P. Melancon, Patricia Troncoso, Nora Navone, Gary E. Gallick, Eleni Efstathiou, Sumit K. Subudhi, Sue-Hwa Lin, Christopher J. Logothetis, Theocharis Panaretakis
Journal: Clinical Cancer Research
Clin Cancer Res (2021) 27 (11): 3253–3264.
https://doi.org/10.1158/1078-0432.CCR-20-4790
Published: 01 June 2021
View article titled, Radium-223 Treatment Increases Immune Checkpoint Expression in Extracellular Vesicles from the Metastatic Prostate Cancer Bone Microenvironment
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Includes: Supplementary data
Journal Articles

The MD Anderson Prostate Cancer Patient-derived Xenograft Series (MDA PCa PDX) Captures the Molecular Landscape of Prostate Cancer and Facilitates Marker-driven Therapy Development

Nallasivam Palanisamy, Jun Yang, Peter D.A. Shepherd, Elsa M. Li-Ning-Tapia, Estefania Labanca, Ganiraju C. Manyam, Murali K. Ravoori, Vikas Kundra, John C. Araujo, Eleni Efstathiou, Louis L. Pisters, Xinhai Wan, Xuemei Wang, Elba S. Vazquez, Ana M. Aparicio, Shannon L. Carskadon, Scott A. Tomlins, Lakshmi P. Kunju, Arul M. Chinnaiyan, Bradley M. Broom, Christopher J. Logothetis, Patricia Troncoso, Nora M. Navone
Journal: Clinical Cancer Research
Series: Author Choice
Clin Cancer Res (2020) 26 (18): 4933–4946.
https://doi.org/10.1158/1078-0432.CCR-20-0479
Published: 15 September 2020
View article titled, The MD Anderson Prostate Cancer Patient-derived Xenograft Series (MDA PCa PDX) Captures the Molecular Landscape of Prostate Cancer and Facilitates Marker-driven Therapy Development
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Includes: Supplementary data
Journal Articles

A Phase II Study of Cabozantinib and Androgen Ablation in Patients with Hormone-Naïve Metastatic Prostate Cancer

Paul G. Corn, Miao Zhang, Graciela M. Nogueras-Gonzalez, Lianchun Xiao, Amado J. Zurita, Sumit K. Subudhi, Shi-Ming Tu, Ana M. Aparicio, Cristian Coarfa, Kimal Rajapakshe, Shixia Huang, Nora M. Navone, Sue-Hwa Lin, Guocan Wang, Sumankalai Ramachandran, Mark A. Titus, Theocharis Panaretakis, Gary E. Gallick, Eleni Efstathiou, Patricia Troncoso, Christopher Logothetis
Journal: Clinical Cancer Research
Clin Cancer Res (2020) 26 (5): 990–999.
https://doi.org/10.1158/1078-0432.CCR-19-2389
Published: 02 March 2020
View article titled, A Phase II Study of Cabozantinib and Androgen Ablation in Patients with Hormone-Naïve Metastatic Prostate Cancer
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Includes: Supplementary data
Journal Articles

PARP Inhibition Suppresses GR–MYCN–CDK5–RB1–E2F1 Signaling and Neuroendocrine Differentiation in Castration-Resistant Prostate Cancer

Bo Liu, Likun Li, Guang Yang, Chuandong Geng, Yong Luo, Wenhui Wu, Ganiraju C. Manyam, Dimitrios Korentzelos, Sanghee Park, Zhe Tang, Cheng Wu, Zhenyang Dong, Michael Sigouros, Andrea Sboner, Himisha Beltran, Yu Chen, Paul G. Corn, Michael T. Tetzlaff, Patricia Troncoso, Bradley Broom, Timothy C. Thompson
Journal: Clinical Cancer Research
Clin Cancer Res (2019) 25 (22): 6839–6851.
https://doi.org/10.1158/1078-0432.CCR-19-0317
Published: 15 November 2019
View article titled, PARP Inhibition Suppresses GR–MYCN–CDK5–RB1–E2F1 Signaling and Neuroendocrine Differentiation in Castration-Resistant Prostate Cancer
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Includes: Supplementary data
Journal Articles

Targeting the MYCN–PARP–DNA Damage Response Pathway in Neuroendocrine Prostate Cancer

Wei Zhang, Bo Liu, Wenhui Wu, Likun Li, Bradley M. Broom, Spyridon P. Basourakos, Dimitrios Korentzelos, Yang Luan, Jianxiang Wang, Guang Yang, Sanghee Park, Abul Kalam Azad, Xuhong Cao, Jeri Kim, Paul G. Corn, Christopher J. Logothetis, Ana M. Aparicio, Arul M. Chinnaiyan, Nora Navone, Patricia Troncoso, Timothy C. Thompson
Journal: Clinical Cancer Research
Series: Author Choice
Clin Cancer Res (2018) 24 (3): 696–707.
https://doi.org/10.1158/1078-0432.CCR-17-1872
Published: 31 January 2018
View article titled, Targeting the MYCN–PARP–DNA Damage Response Pathway in Neuroendocrine Prostate Cancer
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Includes: Supplementary data
Journal Articles

Paired High-Content Analysis of Prostate Cancer Cells in Bone Marrow and Blood Characterizes Increased Androgen Receptor Expression in Tumor Cell Clusters

Anders Carlsson, Peter Kuhn, Madelyn S. Luttgen, Kevin Keomanee-Dizon, Patricia Troncoso, Paul G. Corn, Anand Kolatkar, James B. Hicks, Christopher J. Logothetis, Amado J. Zurita
Journal: Clinical Cancer Research
Series: Author Choice
Clin Cancer Res (2017) 23 (7): 1722–1732.
https://doi.org/10.1158/1078-0432.CCR-16-1355
Published: 02 April 2017
View article titled, Paired High-Content Analysis of Prostate Cancer Cells in Bone Marrow and Blood Characterizes Increased Androgen Receptor Expression in Tumor Cell Clusters
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Journal Articles

Abstract A03: Analyses of a prostate cancer patient-derived xenografts series, a resource for translational research

Nallasivam Palanisamy, Jun Yang, Xinhai Wan, Elsa M. li Ning Tapia, John C. Araujo, Eleni Efstathiou, Estefania Labanca, Louis Pisters, Ana Aparicio, Ritu Bhalla, Scott Tomlins, Lakshmi P. Kunju, Arul Chinnaiyan, Christopher J. Logothetis, Patricia Troncoso, Nora M. Navone
Journal: Clinical Cancer Research
Clin Cancer Res (2016) 22 (16_Supplement): A03.
https://doi.org/10.1158/1557-3265.PDX16-A03
Published: 15 August 2016
View article titled, Abstract A03: Analyses of a prostate cancer patient-derived xenografts series, a resource for translational research
Journal Articles

Combined Tumor Suppressor Defects Characterize Clinically Defined Aggressive Variant Prostate Cancers

Ana M. Aparicio, Li Shen, Elsa Li Ning Tapia, Jing-Fang Lu, Hsiang-Chun Chen, Jiexin Zhang, Guanglin Wu, Xuemei Wang, Patricia Troncoso, Paul Corn, Timothy C. Thompson, Bradley Broom, Keith Baggerly, Sankar N. Maity, Christopher J. Logothetis
Journal: Clinical Cancer Research
Clin Cancer Res (2016) 22 (6): 1520–1530.
https://doi.org/10.1158/1078-0432.CCR-15-1259
Published: 14 March 2016
View article titled, Combined Tumor Suppressor Defects Characterize Clinically Defined Aggressive Variant Prostate Cancers
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Includes: Supplementary data
Journal Articles

Abiraterone Treatment in Castration-Resistant Prostate Cancer Selects for Progesterone Responsive Mutant Androgen Receptors

Eddy J. Chen, Adam G. Sowalsky, Shuai Gao, Changmeng Cai, Olga Voznesensky, Rachel Schaefer, Massimo Loda, Lawrence D. True, Huihui Ye, Patricia Troncoso, Rosina L. Lis, Philip W. Kantoff, Robert B. Montgomery, Peter S. Nelson, Glenn J. Bubley, Steven P. Balk, Mary-Ellen Taplin
Journal: Clinical Cancer Research
Clin Cancer Res (2015) 21 (6): 1273–1280.
https://doi.org/10.1158/1078-0432.CCR-14-1220
Published: 12 March 2015
View article titled, Abiraterone Treatment in Castration-Resistant Prostate Cancer Selects for Progesterone Responsive Mutant Androgen Receptors
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Includes: Supplementary data
Journal Articles

Platinum-Based Chemotherapy for Variant Castrate-Resistant Prostate Cancer

Ana M. Aparicio, Andrea L. Harzstark, Paul G. Corn, Sijin Wen, John C. Araujo, Shi-Ming Tu, Lance C. Pagliaro, Jeri Kim, Randall E. Millikan, Charles Ryan, Nizar M. Tannir, Amado J. Zurita, Paul Mathew, Wadih Arap, Patricia Troncoso, Peter F. Thall, Christopher J. Logothetis
Journal: Clinical Cancer Research
Clin Cancer Res (2013) 19 (13): 3621–3630.
https://doi.org/10.1158/1078-0432.CCR-12-3791
Published: 30 June 2013
View article titled, Platinum-Based Chemotherapy for Variant Castrate-Resistant Prostate Cancer
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Includes: Supplementary data
Journal Articles

Activation of β-Catenin Signaling in Androgen Receptor–Negative Prostate Cancer Cells

Xinhai Wan, Jie Liu, Jing-Fang Lu, Vassiliki Tzelepi, Jun Yang, Michael W. Starbuck, Lixia Diao, Jing Wang, Eleni Efstathiou, Elba S. Vazquez, Patricia Troncoso, Sankar N. Maity, Nora M. Navone
Journal: Clinical Cancer Research
Clin Cancer Res (2012) 18 (3): 726–736.
https://doi.org/10.1158/1078-0432.CCR-11-2521
Published: 31 January 2012
View article titled, Activation of β-Catenin Signaling in Androgen Receptor–Negative Prostate Cancer Cells
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Includes: Supplementary data
Journal Articles

Modeling a Lethal Prostate Cancer Variant with Small-Cell Carcinoma Features

Vassiliki Tzelepi, Jiexin Zhang, Jing-Fang Lu, Brittany Kleb, Guanglin Wu, Xinhai Wan, Anh Hoang, Eleni Efstathiou, Kanishka Sircar, Nora M. Navone, Patricia Troncoso, Shoudan Liang, Christopher J. Logothetis, Sankar N. Maity, Ana M. Aparicio
Journal: Clinical Cancer Research
Clin Cancer Res (2012) 18 (3): 666–677.
https://doi.org/10.1158/1078-0432.CCR-11-1867
Published: 31 January 2012
View article titled, Modeling a Lethal Prostate Cancer Variant with Small-Cell Carcinoma Features
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Includes: Supplementary data
Journal Articles

Preoperative CTLA-4 Blockade: Tolerability and Immune Monitoring in the Setting of a Presurgical Clinical Trial

Bradley C. Carthon, Jedd D. Wolchok, Jianda Yuan, Ashish Kamat, Derek S. Ng Tang, Jingjing Sun, Geoffrey Ku, Patricia Troncoso, Christopher J. Logothetis, James P. Allison, Padmanee Sharma
Journal: Clinical Cancer Research
Clin Cancer Res (2010) 16 (10): 2861–2871.
https://doi.org/10.1158/1078-0432.CCR-10-0569
Published: 13 May 2010
View article titled, Preoperative CTLA-4 Blockade: Tolerability and Immune Monitoring in the Setting of a Presurgical Clinical Trial
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Includes: Supplementary data
Journal Articles

Platelet-Derived Growth Factor Receptor Inhibition and Chemotherapy for Castration-Resistant Prostate Cancer with Bone Metastases

Paul Mathew, Peter F. Thall, Corazon D. Bucana, William K. Oh, Michael J. Morris, Donnah M. Jones, Marcella M. Johnson, Sijin Wen, Lance C. Pagliaro, Nizar M. Tannir, Shi-Ming Tu, Anthony A. Meluch, Lon Smith, Lorenzo Cohen, Sun-Jin Kim, Patricia Troncoso, Isaiah J. Fidler, Christopher J. Logothetis
Journal: Clinical Cancer Research
Clin Cancer Res (2007) 13 (19): 5816–5824.
https://doi.org/10.1158/1078-0432.CCR-07-1269
Published: 01 October 2007
View article titled, Platelet-Derived Growth Factor Receptor Inhibition and Chemotherapy for Castration-Resistant Prostate Cancer with Bone Metastases
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Journal Articles

Initial Modulation of the Tumor Microenvironment Accounts for Thalidomide Activity in Prostate Cancer

Eleni Efstathiou, Patricia Troncoso, Sijin Wen, Kim-Anh Do, Curtis A. Pettaway, Louis L. Pisters, Timothy J. McDonnell, Christopher J. Logothetis
Journal: Clinical Cancer Research
Clin Cancer Res (2007) 13 (4): 1224–1231.
https://doi.org/10.1158/1078-0432.CCR-06-1938
Published: 22 February 2007
View article titled, Initial Modulation of the Tumor Microenvironment Accounts for Thalidomide Activity in Prostate Cancer
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Journal Articles

Obesity, Weight Gain, and Risk of Biochemical Failure among Prostate Cancer Patients following Prostatectomy

Sara S. Strom, Xuemei Wang, Curtis A. Pettaway, Christopher J. Logothetis, Yuko Yamamura, Kim-Anh Do, Richard J. Babaian, Patricia Troncoso
Journal: Clinical Cancer Research
Clin Cancer Res (2005) 11 (19): 6889–6894.
https://doi.org/10.1158/1078-0432.CCR-04-1977
Published: 03 October 2005
View article titled, Obesity, Weight Gain, and Risk of Biochemical Failure among Prostate Cancer Patients following Prostatectomy
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Journal Articles

Clinical and Biomarker Correlates of Androgen-Independent, Locally Aggressive Prostate Cancer with Limited Metastatic Potential

Vasily J. Assikis, Kim-Anh Do, Sijin Wen, Xuemei Wang, Jeong Hee Cho-Vega, Shawn Brisbay, Remigio Lopez, Christopher J. Logothetis, Patricia Troncoso, Christos N. Papandreou, Timothy J. McDonnell
Journal: Clinical Cancer Research
Clin Cancer Res (2004) 10 (20): 6770–6778.
https://doi.org/10.1158/1078-0432.CCR-04-0275
Published: 22 October 2004
View article titled, Clinical and Biomarker Correlates of Androgen-Independent, Locally Aggressive Prostate Cancer with Limited Metastatic Potential
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Journal Articles

Evidence That Transfer of Functional p53 Protein Results in Increased Apoptosis in Prostate Cancer

Louis L. Pisters, Curtis A. Pettaway, Patricia Troncoso, Timothy J. McDonnell, L. Clifton Stephens, Christopher G. Wood, Kim-Anh Do, Shawn M. Brisbay, Xuemei Wang, Elizabeth A. Hossan, Robert B. Evans, Cindy Soto, Marc G. Jacobson, Karen Parker, James A. Merritt, Mitchell S. Steiner, Christopher J. Logothetis
Journal: Clinical Cancer Research
Clin Cancer Res (2004) 10 (8): 2587–2593.
https://doi.org/10.1158/1078-0432.CCR-03-0388
Published: 20 April 2004
View article titled, Evidence That Transfer of Functional p53 Protein Results in Increased Apoptosis in Prostate Cancer
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