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Journal Articles

PDK1 Mediates NOTCH1-Mutated Head and Neck Squamous Carcinoma Vulnerability to Therapeutic PI3K/mTOR Inhibition

Vaishnavi Sambandam, Mitchell J. Frederick, Li Shen, Pan Tong, Xiayu Rao, Shaohua Peng, Ratnakar Singh, Tuhina Mazumdar, Chenfei Huang, Qiuli Li, Curtis R. Pickering, Jeffery N. Myers, Jing Wang, Faye M. Johnson
Journal: Clinical Cancer Research
Clin Cancer Res (2019) 25 (11): 3329–3340.
https://doi.org/10.1158/1078-0432.CCR-18-3276
Published: 03 June 2019
View article titled, PDK1 Mediates <em>NOTCH1</em>-Mutated Head and Neck Squamous Carcinoma Vulnerability to Therapeutic PI3K/mTOR Inhibition
Open the PDF for PDK1 Mediates <em>NOTCH1</em>-Mutated Head and Neck Squamous Carcinoma Vulnerability to Therapeutic PI3K/mTOR Inhibition in another window
Includes: Supplementary data
Journal Articles

Differential Sensitivity Analysis for Resistant Malignancies (DISARM) Identifies Common Candidate Therapies across Platinum-Resistant Cancers

Carl M. Gay, Pan Tong, Robert J. Cardnell, Triparna Sen, Xiao Su, Jun Ma, Rasha O. Bara, Faye M. Johnson, Chris Wakefield, John V. Heymach, Jing Wang, Lauren A. Byers
Journal: Clinical Cancer Research
Clin Cancer Res (2019) 25 (1): 346–357.
https://doi.org/10.1158/1078-0432.CCR-18-1129
Published: 03 January 2019
View article titled, Differential Sensitivity Analysis for Resistant Malignancies (DISARM) Identifies Common Candidate Therapies across Platinum-Resistant Cancers
Open the PDF for Differential Sensitivity Analysis for Resistant Malignancies (DISARM) Identifies Common Candidate Therapies across Platinum-Resistant Cancers in another window
Includes: Supplementary data
Journal Articles

Targeting AXL and mTOR Pathway Overcomes Primary and Acquired Resistance to WEE1 Inhibition in Small-Cell Lung Cancer

Triparna Sen, Pan Tong, Lixia Diao, Lerong Li, Youhong Fan, Jennifer Hoff, John V. Heymach, Jing Wang, Lauren Averett Byers
Journal: Clinical Cancer Research
Clin Cancer Res (2017) 23 (20): 6239–6253.
https://doi.org/10.1158/1078-0432.CCR-17-1284
Published: 12 October 2017
View article titled, Targeting AXL and mTOR Pathway Overcomes Primary and Acquired Resistance to WEE1 Inhibition in Small-Cell Lung Cancer
Open the PDF for Targeting AXL and mTOR Pathway Overcomes Primary and Acquired Resistance to WEE1 Inhibition in Small-Cell Lung Cancer in another window
Includes: Supplementary data
Journal Articles

KDR Amplification Is Associated with VEGF-Induced Activation of the mTOR and Invasion Pathways but does not Predict Clinical Benefit to the VEGFR TKI Vandetanib

Monique B. Nilsson, Uma Giri, Jayanthi Gudikote, Ximing Tang, Wei Lu, Hai Tran, Youhong Fan, Andrew Koo, Lixia Diao, Pan Tong, Jing Wang, Roy Herbst, Bruce E. Johnson, Andy Ryan, Alan Webster, Philip Rowe, Ignacio I. Wistuba, John V. Heymach
Journal: Clinical Cancer Research
Series: Author Choice
Clin Cancer Res (2016) 22 (8): 1940–1950.
https://doi.org/10.1158/1078-0432.CCR-15-1994
Published: 14 April 2016
View article titled, KDR Amplification Is Associated with VEGF-Induced Activation of the mTOR and Invasion Pathways but does not Predict Clinical Benefit to the VEGFR TKI Vandetanib
Open the PDF for KDR Amplification Is Associated with VEGF-Induced Activation of the mTOR and Invasion Pathways but does not Predict Clinical Benefit to the VEGFR TKI Vandetanib in another window
Includes: Supplementary data
Journal Articles

Epithelial–Mesenchymal Transition Predicts Polo-Like Kinase 1 Inhibitor–Mediated Apoptosis in Non–Small Cell Lung Cancer

Renata Ferrarotto, Ruchitha Goonatilake, Suk Young Yoo, Pan Tong, Uma Giri, Shaohua Peng, John Minna, Luc Girard, Yuehong Wang, Liguang Wang, Lerong Li, Lixia Diao, David H. Peng, Don L. Gibbons, Bonnie S. Glisson, John V. Heymach, Jing Wang, Lauren A. Byers, Faye M. Johnson
Journal: Clinical Cancer Research
Clin Cancer Res (2016) 22 (7): 1674–1686.
https://doi.org/10.1158/1078-0432.CCR-14-2890
Published: 31 March 2016
View article titled, Epithelial–Mesenchymal Transition Predicts Polo-Like Kinase 1 Inhibitor–Mediated Apoptosis in Non–Small Cell Lung Cancer
Open the PDF for Epithelial–Mesenchymal Transition Predicts Polo-Like Kinase 1 Inhibitor–Mediated Apoptosis in Non–Small Cell Lung Cancer in another window
Includes: Supplementary data
Journal Articles

A Patient-Derived, Pan-Cancer EMT Signature Identifies Global Molecular Alterations and Immune Target Enrichment Following Epithelial-to-Mesenchymal Transition

Milena P. Mak, Pan Tong, Lixia Diao, Robert J. Cardnell, Don L. Gibbons, William N. William, Ferdinandos Skoulidis, Edwin R. Parra, Jaime Rodriguez-Canales, Ignacio I. Wistuba, John V. Heymach, John N. Weinstein, Kevin R. Coombes, Jing Wang, Lauren Averett Byers
Journal: Clinical Cancer Research
Clin Cancer Res (2016) 22 (3): 609–620.
https://doi.org/10.1158/1078-0432.CCR-15-0876
Published: 31 January 2016
View article titled, A Patient-Derived, Pan-Cancer EMT Signature Identifies Global Molecular Alterations and Immune Target Enrichment Following Epithelial-to-Mesenchymal Transition
Open the PDF for A Patient-Derived, Pan-Cancer EMT Signature Identifies Global Molecular Alterations and Immune Target Enrichment Following Epithelial-to-Mesenchymal Transition in another window
Includes: Supplementary data
Journal Articles

An Integrated Molecular Analysis of Lung Adenocarcinomas Identifies Potential Therapeutic Targets among TTF1-Negative Tumors, Including DNA Repair Proteins and Nrf2

Robert J.G. Cardnell, Carmen Behrens, Lixia Diao, YouHong Fan, Ximing Tang, Pan Tong, John D. Minna, Gordon B. Mills, John V. Heymach, Ignacio I. Wistuba, Jing Wang, Lauren A. Byers
Journal: Clinical Cancer Research
Clin Cancer Res (2015) 21 (15): 3480–3491.
https://doi.org/10.1158/1078-0432.CCR-14-3286
Published: 02 August 2015
View article titled, An Integrated Molecular Analysis of Lung Adenocarcinomas Identifies Potential Therapeutic Targets among TTF1-Negative Tumors, Including DNA Repair Proteins and Nrf2
Open the PDF for An Integrated Molecular Analysis of Lung Adenocarcinomas Identifies Potential Therapeutic Targets among TTF1-Negative Tumors, Including DNA Repair Proteins and Nrf2 in another window
Includes: Supplementary data