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Padmanee Sharma
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Journal Articles

A Modular Trial of Androgen Signaling Inhibitor Combinations Testing a Risk-Adapted Strategy in Patients with Metastatic Castration–Resistant Prostate Cancer

Ana M. Aparicio, Rebecca S.S. Tidwell, Shalini S. Yadav, Jiun-Sheng Chen, Miao Zhang, Jingjing Liu, Shuai Guo, Patrick G. Pilié, Yao Yu, Xingzhi Song, Haswanth Vundavilli, Sonali Jindal, Keyi Zhu, Paul V. Viscuse, Justin M. Lebenthal, Andrew W. Hahn, Rama Soundararajan, Paul G. Corn, Amado Zurita-Saavedra, Sumit K. Subudhi, Jianhua Zhang, Wenyi Wang, Chad Huff, Patricia Troncoso, James P. Allison, Padmanee Sharma, Christopher J. Logothetis
Journal: Clinical Cancer Research
Clin Cancer Res (2024) 30 (13): 2751–2763.
https://doi.org/10.1158/1078-0432.CCR-23-3740
Published: 01 July 2024
View article titled, A Modular Trial of Androgen Signaling Inhibitor Combinations Testing a Risk-Adapted Strategy in Patients with Metastatic Castration–Resistant Prostate Cancer
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Includes: Supplementary data
Journal Articles

Exercise Training Reduces the Inflammatory Response and Promotes Intestinal Mucosa-Associated Immunity in Lynch Syndrome

Nan Deng, Laura Reyes-Uribe, Johannes F. Fahrmann, Whittney S. Thoman, Mark F. Munsell, Jennifer B. Dennison, Eunice Murage, Ranran Wu, Ernest T. Hawk, Selvi Thirumurthi, Patrick M. Lynch, Christina M. Dieli-Conwright, Alexander J. Lazar, Sonali Jindal, Khoi Chu, Manoj Chelvanambi, Karen Basen-Engquist, Yisheng Li, Jennifer A. Wargo, Florencia McAllister, James P. Allison, Padmanee Sharma, Krishna M. Sinha, Samir Hanash, Susan C. Gilchrist, Eduardo Vilar
Journal: Clinical Cancer Research
Clin Cancer Res (2023) 29 (21): 4361–4372.
https://doi.org/10.1158/1078-0432.CCR-23-0088
Published: 01 November 2023
View article titled, Exercise Training Reduces the Inflammatory Response and Promotes Intestinal Mucosa-Associated Immunity in Lynch Syndrome
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Includes: Supplementary data
Journal Articles

Abstract PO-074: The evolution of the tumor immune microenvironment in immunosuppressed patients with cutaneous squamous cell carcinoma

Mica D. E. Glaun, Frederico O. Gleber-Netto, Priyadharsini Nagarajan, Tongxin Xie, Shamima Akhter, Yu Han Chen, Erez Baruch N. Baruch, Michael K. Wong, Emily Y. Chu, Kenneth Y. Tsai, Elsa R. Flores, Deborah A. Silverman, Ryan P. Goepfert, Murat Cobanoglu, Jared Burks, Padmanee Sharma, James P. Allison, Jeffrey N. Myers, Neil D. Gross, Moran Amit
Journal: Clinical Cancer Research
Clin Cancer Res (2023) 29 (18_Supplement): PO-074.
https://doi.org/10.1158/1557-3265.AACRAHNS23-PO-074
Published: 15 September 2023
View article titled, Abstract PO-074: The evolution of the tumor immune microenvironment in immunosuppressed patients with cutaneous squamous cell carcinoma
Journal Articles

Correction: Pilot Phase II Trial of Neoadjuvant Immunotherapy in Locoregionally Advanced, Resectable Cutaneous Squamous Cell Carcinoma of the Head and Neck

Renata Ferrarotto, Moran Amit, Priyadharsini Nagarajan, M. Laura Rubin, Ying Yuan, Diana Bell, Adel K. El-Naggar, Jason M. Johnson, William H. Morrison, David I. Rosenthal, Bonnie S. Glisson, Faye M. Johnson, Charles Lu, Frank E. Mott, Bita Esmaeli, Eduardo M. Diaz, Jr, Paul W. Gidley, Ryan P. Goepfert, Carol M. Lewis, Randal S. Weber, Jennifer A. Wargo, Sreyashi Basu, Fei Duan, Shalini S. Yadav, Padmanee Sharma, James P. Allison, Jeffrey N. Myers, Neil D. Gross
Journal: Clinical Cancer Research
Clin Cancer Res (2022) 28 (8): 1735.
https://doi.org/10.1158/1078-0432.CCR-22-0468
Published: 14 April 2022
View article titled, Correction: Pilot Phase II Trial of Neoadjuvant Immunotherapy in Locoregionally Advanced, Resectable Cutaneous Squamous Cell Carcinoma of the Head and Neck
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Includes: Supplementary data
Journal Articles

Pilot Phase II Trial of Neoadjuvant Immunotherapy in Locoregionally Advanced, Resectable Cutaneous Squamous Cell Carcinoma of the Head and Neck

Renata Ferrarotto, Moran Amit, Priyadharsini Nagarajan, M. Laura Rubin, Ying Yuan, Diana Bell, Adel K. El-Naggar, Jason M. Johnson, William H. Morrison, David I. Rosenthal, Bonnie S. Glisson, Faye M. Johnson, Charles Lu, Frank E. Mott, Bita Esmaeli, Eduardo M. Diaz, Jr, Paul W. Gidley, Ryan P. Goepfert, Carol M. Lewis, Randal S. Weber, Jennifer A. Wargo, Sreyashi Basu, Fei Duan, Shalini S. Yadav, Padmanee Sharma, James P. Allison, Jeffrey N. Myers, Neil D. Gross
Journal: Clinical Cancer Research
Clin Cancer Res (2021) 27 (16): 4557–4565.
https://doi.org/10.1158/1078-0432.CCR-21-0585
Published: 15 August 2021
View article titled, Pilot Phase II Trial of Neoadjuvant Immunotherapy in Locoregionally Advanced, Resectable Cutaneous Squamous Cell Carcinoma of the Head and Neck
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Includes: Supplementary data
Journal Articles

Myeloid Cell–associated Resistance to PD-1/PD-L1 Blockade in Urothelial Cancer Revealed Through Bulk and Single-cell RNA Sequencing

Li Wang, John P. Sfakianos, Kristin G. Beaumont, Guray Akturk, Amir Horowitz, Robert P. Sebra, Adam M. Farkas, Sacha Gnjatic, Austin Hake, Sudeh Izadmehr, Peter Wiklund, William K. Oh, Peter M. Szabo, Megan Wind-Rotolo, Keziban Unsal-Kacmaz, Xin Yao, Eric Schadt, Padmanee Sharma, Nina Bhardwaj, Jun Zhu, Matthew D. Galsky
Journal: Clinical Cancer Research
Clin Cancer Res (2021) 27 (15): 4287–4300.
https://doi.org/10.1158/1078-0432.CCR-20-4574
Published: 01 August 2021
View article titled, Myeloid Cell–associated Resistance to PD-1/PD-L1 Blockade in Urothelial Cancer Revealed Through Bulk and Single-cell RNA Sequencing
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Includes: Supplementary data
Journal Articles

Analyses of PD-L1 and Inflammatory Gene Expression Association with Efficacy of Nivolumab ± Ipilimumab in Gastric Cancer/Gastroesophageal Junction Cancer

Ming Lei, Nathan O. Siemers, Dimple Pandya, Han Chang, Teresa Sanchez, Christopher Harbison, Peter M. Szabo, Yelena Janjigian, Patrick A. Ott, Padmanee Sharma, Johanna Bendell, Thomas R. Jeffry Evans, Filippo de Braud, Ian Chau, Zachary Boyd
Journal: Clinical Cancer Research
Series: Author Choice
Clin Cancer Res (2021) 27 (14): 3926–3935.
https://doi.org/10.1158/1078-0432.CCR-20-2790
Published: 15 July 2021
View article titled, Analyses of PD-L1 and Inflammatory Gene Expression Association with Efficacy of Nivolumab ± Ipilimumab in Gastric Cancer/Gastroesophageal Junction Cancer
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Includes: Supplementary data
Journal Articles

First-in-Human Phase I Study of ABBV-085, an Antibody–Drug Conjugate Targeting LRRC15, in Sarcomas and Other Advanced Solid Tumors

George D. Demetri, Jason J. Luke, Antoine Hollebecque, John D. Powderly, II, Alexander I. Spira, Vivek Subbiah, Louie Naumovski, Chris Chen, Hua Fang, Dominic W. Lai, Huibin Yue, Akshanth R. Polepally, James W. Purcell, Randy Robinson, Padmanee Sharma, James P. Allison, Anthony Tolcher, Victor M. Villalobos
Journal: Clinical Cancer Research
Series: Author Choice
Clin Cancer Res (2021) 27 (13): 3556–3566.
https://doi.org/10.1158/1078-0432.CCR-20-4513
Published: 01 July 2021
View article titled, First-in-Human Phase I Study of ABBV-085, an Antibody–Drug Conjugate Targeting LRRC15, in Sarcomas and Other Advanced Solid Tumors
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Includes: Supplementary data
Journal Articles

Nivolumab in Patients with Advanced Platinum-resistant Urothelial Carcinoma: Efficacy, Safety, and Biomarker Analyses with Extended Follow-up from CheckMate 275

Matthew D. Galsky, Abdel Saci, Peter M. Szabo, G. Celine Han, Gary Grossfeld, Sandra Collette, Arlene Siefker-Radtke, Andrea Necchi, Padmanee Sharma
Journal: Clinical Cancer Research
Clin Cancer Res (2020) 26 (19): 5120–5128.
https://doi.org/10.1158/1078-0432.CCR-19-4162
Published: 01 October 2020
View article titled, Nivolumab in Patients with Advanced Platinum-resistant Urothelial Carcinoma: Efficacy, Safety, and Biomarker Analyses with Extended Follow-up from CheckMate 275
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Includes: Supplementary data
Journal Articles

Efficacy and Tolerability of Tremelimumab in Locally Advanced or Metastatic Urothelial Carcinoma Patients Who Have Failed First-Line Platinum-Based Chemotherapy

Padmanee Sharma, Joohyuk Sohn, Sang Joon Shin, Do-Youn Oh, Bhumsuk Keam, Hyo Jin Lee, Marco Gizzi, Ewa Kalinka, Filip Y.F.L. de Vos, Dario Ruscica, Salvatore Ferro, Feng Xiao, Paul Baverel, Cecil Chi-Keung Chen, Kobby Asubonteng, Nassim Morsli, Luc Dirix
Journal: Clinical Cancer Research
Series: Author Choice
Clin Cancer Res (2020) 26 (1): 61–70.
https://doi.org/10.1158/1078-0432.CCR-19-1635
Published: 03 January 2020
View article titled, Efficacy and Tolerability of Tremelimumab in Locally Advanced or Metastatic Urothelial Carcinoma Patients Who Have Failed First-Line Platinum-Based Chemotherapy
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Includes: Supplementary data
Journal Articles

Characterization and Comparison of GITR Expression in Solid Tumors

Luis Vence, Samantha L. Bucktrout, Irina Fernandez Curbelo, Jorge Blando, Bevin M. Smith, Ashley E. Mahne, John C. Lin, Terrence Park, Edward Pascua, Tao Sai, Javier Chaparro-Riggers, Sumit K. Subudhi, Jorge B. Scutti, Maria G. Higa, Hao Zhao, Shalini S. Yadav, Anirban Maitra, Ignacio I. Wistuba, James P. Allison, Padmanee Sharma
Journal: Clinical Cancer Research
Clin Cancer Res (2019) 25 (21): 6501–6510.
https://doi.org/10.1158/1078-0432.CCR-19-0289
Published: 01 November 2019
View article titled, Characterization and Comparison of GITR Expression in Solid Tumors
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Includes: Supplementary data
Journal Articles

Anti–CTLA-4 Immunotherapy Does Not Deplete FOXP3+ Regulatory T Cells (Tregs) in Human Cancers—Response

Anu Sharma, Sumit K. Subudhi, Jorge Blando, Luis Vence, Jennifer Wargo, James P. Allison, Antoni Ribas, Padmanee Sharma
Journal: Clinical Cancer Research
Clin Cancer Res (2019) 25 (11): 3469–3470.
https://doi.org/10.1158/1078-0432.CCR-19-0402
Published: 03 June 2019
View article titled, Anti–CTLA-4 Immunotherapy Does Not Deplete FOXP3<sup>+</sup> Regulatory T Cells (Tregs) in Human Cancers—Response
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Journal Articles

Anti-CTLA-4 Immunotherapy Does Not Deplete FOXP3+ Regulatory T Cells (Tregs) in Human Cancers

Anu Sharma, Sumit K. Subudhi, Jorge Blando, Jorge Scutti, Luis Vence, Jennifer Wargo, James P. Allison, Antoni Ribas, Padmanee Sharma
Journal: Clinical Cancer Research
Series: Author Choice
Clin Cancer Res (2019) 25 (4): 1233–1238.
https://doi.org/10.1158/1078-0432.CCR-18-0762
Published: 15 February 2019
View article titled, Anti-CTLA-4 Immunotherapy Does Not Deplete FOXP3<sup>+</sup> Regulatory T Cells (Tregs) in Human Cancers
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Includes: Supplementary data
Journal Articles

Ipilimumab plus Lenalidomide after Allogeneic and Autologous Stem Cell Transplantation for Patients with Lymphoid Malignancies

Issa F. Khouri, Irina Fernandez Curbelo, Francesco Turturro, Elias J. Jabbour, Denái R. Milton, Roland L. Bassett, Jr, Luis M. Vence, James P. Allison, Alison M. Gulbis, Padmanee Sharma
Journal: Clinical Cancer Research
Clin Cancer Res (2018) 24 (5): 1011–1018.
https://doi.org/10.1158/1078-0432.CCR-17-2777
Published: 28 February 2018
View article titled, Ipilimumab plus Lenalidomide after Allogeneic and Autologous Stem Cell Transplantation for Patients with Lymphoid Malignancies
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Journal Articles

Ipilimumab with Stereotactic Ablative Radiation Therapy: Phase I Results and Immunologic Correlates from Peripheral T Cells

Chad Tang, James W. Welsh, Patricia de Groot, Erminia Massarelli, Joe Y. Chang, Kenneth R. Hess, Sreyashi Basu, Michael A. Curran, Maria E. Cabanillas, Vivek Subbiah, Siqing Fu, Apostolia M. Tsimberidou, Daniel Karp, Daniel R. Gomez, Adi Diab, Ritsuko Komaki, John V. Heymach, Padmanee Sharma, Aung Naing, David S. Hong
Journal: Clinical Cancer Research
Clin Cancer Res (2017) 23 (6): 1388–1396.
https://doi.org/10.1158/1078-0432.CCR-16-1432
Published: 14 March 2017
View article titled, Ipilimumab with Stereotactic Ablative Radiation Therapy: Phase I Results and Immunologic Correlates from Peripheral T Cells
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Includes: Supplementary data
Journal Articles

A Pilot Study of Preoperative Single-Dose Ipilimumab and/or Cryoablation in Women with Early-Stage Breast Cancer with Comprehensive Immune Profiling

Heather L. McArthur, Adi Diab, David B. Page, Jianda Yuan, Stephen B. Solomon, Virgilio Sacchini, Christopher Comstock, Jeremy C. Durack, Majid Maybody, Janice Sung, Arielle Ginsberg, Phillip Wong, Afsar Barlas, Zhiwan Dong, Chunjun Zhao, Brian Blum, Sujata Patil, Deirdre Neville, Elizabeth A. Comen, Elizabeth A. Morris, Alan Kotin, Edi Brogi, Y. Hannah Wen, Monica Morrow, Mario E. Lacouture, Padmanee Sharma, James P. Allison, Clifford A. Hudis, Jedd D. Wolchok, Larry Norton
Journal: Clinical Cancer Research
Series: Author Choice
Clin Cancer Res (2016) 22 (23): 5729–5737.
https://doi.org/10.1158/1078-0432.CCR-16-0190
Published: 30 November 2016
View article titled, A Pilot Study of Preoperative Single-Dose Ipilimumab and/or Cryoablation in Women with Early-Stage Breast Cancer with Comprehensive Immune Profiling
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Journal Articles

Preoperative CTLA-4 Blockade: Tolerability and Immune Monitoring in the Setting of a Presurgical Clinical Trial

Bradley C. Carthon, Jedd D. Wolchok, Jianda Yuan, Ashish Kamat, Derek S. Ng Tang, Jingjing Sun, Geoffrey Ku, Patricia Troncoso, Christopher J. Logothetis, James P. Allison, Padmanee Sharma
Journal: Clinical Cancer Research
Clin Cancer Res (2010) 16 (10): 2861–2871.
https://doi.org/10.1158/1078-0432.CCR-10-0569
Published: 13 May 2010
View article titled, Preoperative CTLA-4 Blockade: Tolerability and Immune Monitoring in the Setting of a Presurgical Clinical Trial
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Includes: Supplementary data
Journal Articles

NY-ESO-1 DNA Vaccine Induces T-Cell Responses That Are Suppressed by Regulatory T Cells

Sacha Gnjatic, Nasser K. Altorki, Derek Ng Tang, Shi-Ming Tu, Vikas Kundra, Gerd Ritter, Lloyd J. Old, Christopher J. Logothetis, Padmanee Sharma
Journal: Clinical Cancer Research
Clin Cancer Res (2009) 15 (6): 2130–2139.
https://doi.org/10.1158/1078-0432.CCR-08-2632
Published: 16 March 2009
View article titled, NY-ESO-1 DNA Vaccine Induces T-Cell Responses That Are Suppressed by Regulatory T Cells
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Includes: Supplementary data
Journal Articles

Cancer-Testis Antigens: Expression and Correlation with Survival in Human Urothelial Carcinoma

Padmanee Sharma, Yu Shen, Sijin Wen, Dean F. Bajorin, Victor E. Reuter, Lloyd J. Old, Achim A. Jungbluth
Journal: Clinical Cancer Research
Clin Cancer Res (2006) 12 (18): 5442–5447.
https://doi.org/10.1158/1078-0432.CCR-06-0527
Published: 25 September 2006
View article titled, Cancer-Testis Antigens: Expression and Correlation with Survival in Human Urothelial Carcinoma
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Includes: Supplementary data