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Journal Articles

COTI-2, A Novel Thiosemicarbazone Derivative, Exhibits Antitumor Activity in HNSCC through p53-dependent and -independent Mechanisms

Clin Cancer Res (2019) 25 (18): 5650–5662.

DOI: https://doi.org/10.1158/1078-0432.CCR-19-0096

Published: 13 September 2019

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Includes: Multimedia, Supplementary data

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Abstract 73: Gain-of-function mutant p53 promotes the oncogenic potential of head and neck squamous cell carcinoma cell by targeting forkhead transcription factors FOXO3a and FOXM1

Noriaki Tanaka, Mei Zhao, Jiexin Zhang, Jing Wang, Ge Zhou, Jeffrey N. Myers

Clin Cancer Res (2017) 23 (23_Supplement): 73.

DOI: https://doi.org/10.1158/1557-3265.AACRAHNS17-73

Published: 30 November 2017

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Abstract 44: Synergistic antitumor activity of olaparib combined with AZD1775 in head and neck squamous cell carcinoma

Hideaki Takahashi, Antje Lindemann, Ameeta A. Patel, Weiwei Liu, Noriaki Tanaka, Lin Tang, Mei Zhao, Walter N. Hittelman, Jeffrey N. Myers, Abdullah A. Osman

Clin Cancer Res (2017) 23 (23_Supplement): 44.

DOI: https://doi.org/10.1158/1557-3265.AACRAHNS17-44

Published: 30 November 2017

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Journal Articles

Replication Stress Leading to Apoptosis within the S-phase Contributes to Synergism between Vorinostat and AZD1775 in HNSCC Harboring High-Risk TP53 Mutation

Clin Cancer Res (2017) 23 (21): 6541–6554.

DOI: https://doi.org/10.1158/1078-0432.CCR-17-0947

Published: 31 October 2017

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Includes: Multimedia, Supplementary data

Journal Articles

Wee-1 Kinase Inhibition Sensitizes High-Risk HPV⁺ HNSCC to Apoptosis Accompanied by Downregulation of MCl-1 and XIAP Antiapoptotic Proteins

Noriaki Tanaka, Ameeta A. Patel, Jiping Wang, Mitchell J. Frederick, Nene N. Kalu, Mei Zhao, Alison L. Fitzgerald, Tong-xin Xie, Natalie L. Silver, Carlos Caulin, Ge Zhou, Heath D. Skinner, Faye M. Johnson, Jeffrey N. Myers, Abdullah A. Osman

Clin Cancer Res (2015) 21 (21): 4831–4844.

DOI: https://doi.org/10.1158/1078-0432.CCR-15-0279

Published: 01 November 2015

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Includes: Supplementary data

Journal Articles

Dual Tyrosine Kinase Inhibitor for Focal Adhesion Kinase and Insulin-like Growth Factor-I Receptor Exhibits Anticancer Effect in Esophageal Adenocarcinoma In vitro and In vivo

Nobuyuki Watanabe, Munenori Takaoka, Kazufumi Sakurama, Yasuko Tomono, Shinji Hatakeyama, Osamu Ohmori, Takayuki Motoki, Yasuhiro Shirakawa, Tomoki Yamatsuji, Minoru Haisa, Junji Matsuoka, David G. Beer, Hitoshi Nagatsuka, Noriaki Tanaka, Yoshio Naomoto

Clin Cancer Res (2008) 14 (14): 4631–4639.

DOI: https://doi.org/10.1158/1078-0432.CCR-07-4755

Published: 15 July 2008

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Includes: Supplementary data

Journal Articles

Clonal and Parallel Evolution of Primary Lung Cancers and Their Metastases Revealed by Molecular Dissection of Cancer Cells

Kenji Takahashi, Takashi Kohno, Shingo Matsumoto, Yukihiro Nakanishi, Yasuhito Arai, Seiichiro Yamamoto, Toshiyoshi Fujiwara, Noriaki Tanaka, Jun Yokota

Clin Cancer Res (2007) 13 (1): 111–120.

DOI: https://doi.org/10.1158/1078-0432.CCR-06-0659

Published: 02 January 2007

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Journal Articles

Heparanase Is Involved in Angiogenesis in Esophageal Cancer through Induction of Cyclooxygenase-2

Takaomi Okawa, Yoshio Naomoto, Tetsuji Nobuhisa, Munenori Takaoka, Takayuki Motoki, Yasuhiro Shirakawa, Tomoki Yamatsuji, Hiroyasu Inoue, Mamoru Ouchida, Mehmet Gunduz, Motowo Nakajima, Noriaki Tanaka

Clin Cancer Res (2005) 11 (22): 7995–8005.

DOI: https://doi.org/10.1158/1078-0432.CCR-05-1103

Published: 18 November 2005

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Journal Articles

Human Monocyte-Derived Dendritic Cells Pulsed with Wild-Type p53 Protein Efficiently Induce CTLs against p53 Overexpressing Human Cancer Cells

Naoyuki Tokunaga, Takayoshi Murakami, Yoshikatsu Endo, Masahiko Nishizaki, Shunsuke Kagawa, Noriaki Tanaka, Toshiyoshi Fujiwara

Clin Cancer Res (2005) 11 (3): 1312–1318.

DOI: https://doi.org/10.1158/1078-0432.1312.11.3

Published: 11 February 2005

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Journal Articles

Antitumor Effect of Intratumoral Administration of Bone Marrow-Derived Dendritic Cells Transduced with Wild-Type p53 Gene

Takayoshi Murakami, Naoyuki Tokunaga, Toshihiko Waku, Shinya Gomi, Shunsuke Kagawa, Noriaki Tanaka, Toshiyoshi Fujiwara

Clin Cancer Res (2004) 10 (11): 3871–3880.

DOI: https://doi.org/10.1158/1078-0432.CCR-03-0599

Published: 01 June 2004

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Journal Articles

Allelic Loss of a Common Microsatellite Marker MYCL1 : A Useful Prognostic Factor of Poor Outcomes in Colorectal Cancer

Takeshi Kambara, Gerald B. Sharp, Takeshi Nagasaka, Masanori Takeda, Hiromi Sasamoto, Hitoshi Nakagawa, Hiroshi Isozaki, Donald G. MacPhee, Jeremy R. Jass, Noriaki Tanaka, Nagahide Matsubara

Clin Cancer Res (2004) 10 (5): 1758–1763.

DOI: https://doi.org/10.1158/1078-0432.CCR-0779-3

Published: 10 March 2004

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Journal Articles

Telomerase-Specific Replication-Selective Virotherapy for Human Cancer

Takeshi Kawashima, Shunsuke Kagawa, Naoya Kobayashi, Yoshiko Shirakiya, Tatsuo Umeoka, Fuminori Teraishi, Masaki Taki, Satoru Kyo, Noriaki Tanaka, Toshiyoshi Fujiwara

Clin Cancer Res (2004) 10 (1): 285–292.

DOI: https://doi.org/10.1158/1078-0432.CCR-1075-3

Published: 20 January 2004

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Journal Articles

Hypermethylation of O ⁶-Methylguanine-DNA Methyltransferase Promoter May Predict Nonrecurrence after Chemotherapy in Colorectal Cancer Cases

Takeshi Nagasaka, Gerald B. Sharp, Kenji Notohara, Takeshi Kambara, Hiromi Sasamoto, Hiroshi Isozaki, Donald G. MacPhee, Jeremy R. Jass, Noriaki Tanaka, Nagahide Matsubara

Clin Cancer Res (2003) 9 (14): 5306–5312.

Published: 12 November 2003

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Journal Articles

Induction of Apoptosis in Human Esophageal Cancer Cells by Sequential Transfer of the Wild-Type p53 and E2F-1 Genes: Involvement of p53 Accumulation via ARF-mediated MDM2 Down-Regulation

Takahiro Itoshima, Toshiyoshi Fujiwara, Toshihiko Waku, Jianghua Shao, Masafumi Kataoka, Wendell G. Yarbrough, Ta-Jen Liu, Jack A. Roth, Noriaki Tanaka, Masashi Kodama

Clin Cancer Res (2000) 6 (7): 2851–2859.

Published: 01 July 2000

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Journal Articles

Topological Analysis of p21^WAF1/CIP1 Expression in Esophageal Squamous Dysplasia

Yasuhiro Shirakawa, Yoshio Naomoto, Masashi Kimura, Ryuichi Kawashima, Tomoki Yamatsuji, Takahiko Tamaki, Madoka Hamada, Minoru Haisa, Noriaki Tanaka

Clin Cancer Res (2000) 6 (2): 541–550.

Published: 01 February 2000

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Journal Articles

Induction of Differentiation-dependent Apoptosis in Human Esophageal Squamous Cell Carcinoma by Adenovirus-mediated p21^sdi1 Gene Transfer

Yoshihiko Kadowaki, Toshiyoshi Fujiwara, Takuya Fukazawa, Jianghua Shao, Tatsuji Yasuda, Takahiro Itoshima, Shunsuke Kagawa, Laurie G. Hudson, Jack A. Roth, Noriaki Tanaka

Clin Cancer Res (1999) 5 (12): 4233–4241.

Published: 01 December 1999

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Journal Articles

Recombinant Adenovirus Expressing Wild-Type p53 Is Antiangiogenic: A Proposed Mechanism for Bystander Effect

Masahiko Nishizaki, Toshiyoshi Fujiwara, Tohru Tanida, Akio Hizuta, Hiroyuki Nishimori, Takashi Tokino, Yusuke Nakamura, Michael Bouvet, Jack A. Roth, Noriaki Tanaka

Clin Cancer Res (1999) 5 (5): 1015–1023.

Published: 01 May 1999

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NARROW

COTI-2, A Novel Thiosemicarbazone Derivative, Exhibits Antitumor Activity in HNSCC through p53-dependent and -independent Mechanisms

Abstract 73: Gain-of-function mutant p53 promotes the oncogenic potential of head and neck squamous cell carcinoma cell by targeting forkhead transcription factors FOXO3a and FOXM1

Abstract 44: Synergistic antitumor activity of olaparib combined with AZD1775 in head and neck squamous cell carcinoma

Replication Stress Leading to Apoptosis within the S-phase Contributes to Synergism between Vorinostat and AZD1775 in HNSCC Harboring High-Risk TP53 Mutation

Wee-1 Kinase Inhibition Sensitizes High-Risk HPV⁺ HNSCC to Apoptosis Accompanied by Downregulation of MCl-1 and XIAP Antiapoptotic Proteins

Dual Tyrosine Kinase Inhibitor for Focal Adhesion Kinase and Insulin-like Growth Factor-I Receptor Exhibits Anticancer Effect in Esophageal Adenocarcinoma In vitro and In vivo

Clonal and Parallel Evolution of Primary Lung Cancers and Their Metastases Revealed by Molecular Dissection of Cancer Cells

Heparanase Is Involved in Angiogenesis in Esophageal Cancer through Induction of Cyclooxygenase-2

Human Monocyte-Derived Dendritic Cells Pulsed with Wild-Type p53 Protein Efficiently Induce CTLs against p53 Overexpressing Human Cancer Cells

Antitumor Effect of Intratumoral Administration of Bone Marrow-Derived Dendritic Cells Transduced with Wild-Type p53 Gene

Allelic Loss of a Common Microsatellite Marker MYCL1 : A Useful Prognostic Factor of Poor Outcomes in Colorectal Cancer

Telomerase-Specific Replication-Selective Virotherapy for Human Cancer

Hypermethylation of O ⁶-Methylguanine-DNA Methyltransferase Promoter May Predict Nonrecurrence after Chemotherapy in Colorectal Cancer Cases

Induction of Apoptosis in Human Esophageal Cancer Cells by Sequential Transfer of the Wild-Type p53 and E2F-1 Genes: Involvement of p53 Accumulation via ARF-mediated MDM2 Down-Regulation

Topological Analysis of p21^WAF1/CIP1 Expression in Esophageal Squamous Dysplasia

Induction of Differentiation-dependent Apoptosis in Human Esophageal Squamous Cell Carcinoma by Adenovirus-mediated p21^sdi1 Gene Transfer

Recombinant Adenovirus Expressing Wild-Type p53 Is Antiangiogenic: A Proposed Mechanism for Bystander Effect

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