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Monika E. Hegi
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Journal Articles

MGMT Promoter Methylation Cutoff with Safety Margin for Selecting Glioblastoma Patients into Trials Omitting Temozolomide: A Pooled Analysis of Four Clinical Trials

Monika E. Hegi, Els Genbrugge, Thierry Gorlia, Roger Stupp, Mark R. Gilbert, Olivier L. Chinot, L. Burt Nabors, Greg Jones, Wim Van Criekinge, Josef Straub, Michael Weller
Journal: Clinical Cancer Research
Clin Cancer Res (2019) 25 (6): 1809–1816.
https://doi.org/10.1158/1078-0432.CCR-18-3181
Published: 15 March 2019
View article titled, <em>MGMT</em> Promoter Methylation Cutoff with Safety Margin for Selecting Glioblastoma Patients into Trials Omitting Temozolomide: A Pooled Analysis of Four Clinical Trials
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Includes: Supplementary data
Journal Articles

Phase II Study of Radiotherapy and Temsirolimus versus Radiochemotherapy with Temozolomide in Patients with Newly Diagnosed Glioblastoma without MGMT Promoter Hypermethylation (EORTC 26082)

Wolfgang Wick, Thierry Gorlia, Pierre Bady, Michael Platten, Martin J. van den Bent, Martin J.B. Taphoorn, Jonathan Steuve, Alba A. Brandes, Marie-France Hamou, Antje Wick, Markus Kosch, Michael Weller, Roger Stupp, Patrick Roth, Vassilis Golfinopoulos, Jean-Sebastien Frenel, Mario Campone, Damien Ricard, Christine Marosi, Salvador Villa, Astrid Weyerbrock, Kirsten Hopkins, Krisztian Homicsko, Benoit Lhermitte, Gianfranco Pesce, Monika E. Hegi
Journal: Clinical Cancer Research
Clin Cancer Res (2016) 22 (19): 4797–4806.
https://doi.org/10.1158/1078-0432.CCR-15-3153
Published: 02 October 2016
View article titled, Phase II Study of Radiotherapy and Temsirolimus versus Radiochemotherapy with Temozolomide in Patients with Newly Diagnosed Glioblastoma without <em>MGMT</em> Promoter Hypermethylation (EORTC 26082)
Open the PDF for Phase II Study of Radiotherapy and Temsirolimus versus Radiochemotherapy with Temozolomide in Patients with Newly Diagnosed Glioblastoma without <em>MGMT</em> Promoter Hypermethylation (EORTC 26082) in another window
Includes: Supplementary data
Journal Articles

Extent and Patterns of MGMT Promoter Methylation in Glioblastoma- and Respective Glioblastoma-Derived Spheres

Davide Sciuscio, Annie-Claire Diserens, Kristof van Dommelen, Danielle Martinet, Greg Jones, Robert-Charles Janzer, Claudio Pollo, Marie-France Hamou, Bernd Kaina, Roger Stupp, Marc Levivier, Monika E. Hegi
Journal: Clinical Cancer Research
Clin Cancer Res (2011) 17 (2): 255–266.
https://doi.org/10.1158/1078-0432.CCR-10-1931
Published: 16 January 2011
View article titled, Extent and Patterns of <em>MGMT</em> Promoter Methylation in Glioblastoma- and Respective Glioblastoma-Derived Spheres
Open the PDF for Extent and Patterns of <em>MGMT</em> Promoter Methylation in Glioblastoma- and Respective Glioblastoma-Derived Spheres in another window
Includes: Supplementary data
Journal Articles

Epigenetic Deregulation of DNA Repair and Its Potential for Therapy

Monika E. Hegi, Davide Sciuscio, Anastasia Murat, Marc Levivier, Roger Stupp
Journal: Clinical Cancer Research
Clin Cancer Res (2009) 15 (16): 5026–5031.
https://doi.org/10.1158/1078-0432.CCR-08-1169
Published: 12 August 2009
View article titled, Epigenetic Deregulation of DNA Repair and Its Potential for Therapy
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Journal Articles

Epidermal Growth Factor Receptor Inhibitors in Neuro-oncology: Hopes and Disappointments

Alba A. Brandes, Enrico Franceschi, Alicia Tosoni, Monika E. Hegi, Roger Stupp
Journal: Clinical Cancer Research
Clin Cancer Res (2008) 14 (4): 957–960.
https://doi.org/10.1158/1078-0432.CCR-07-1810
Published: 15 February 2008
View article titled, Epidermal Growth Factor Receptor Inhibitors in Neuro-oncology: Hopes and Disappointments
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Journal Articles

Clinical Trial Substantiates the Predictive Value of O-6-Methylguanine-DNA Methyltransferase Promoter Methylation in Glioblastoma Patients Treated with Temozolomide

Monika E. Hegi, Annie-Claire Diserens, Sophie Godard, Pierre-Yves Dietrich, Luca Regli, Sandrine Ostermann, Philippe Otten, Guy Van Melle, Nicolas de Tribolet, Roger Stupp
Journal: Clinical Cancer Research
Clin Cancer Res (2004) 10 (6): 1871–1874.
https://doi.org/10.1158/1078-0432.CCR-03-0384
Published: 24 March 2004
View article titled, Clinical Trial Substantiates the Predictive Value of <em>O-6-Methylguanine-DNA Methyltransferase</em> Promoter Methylation in Glioblastoma Patients Treated with Temozolomide
Open the PDF for Clinical Trial Substantiates the Predictive Value of <em>O-6-Methylguanine-DNA Methyltransferase</em> Promoter Methylation in Glioblastoma Patients Treated with Temozolomide in another window