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Journal Articles

Genomic Biomarkers Associated with Response to Induction Chemotherapy in Patients with Localized Pancreatic Ductal Adenocarcinoma

Brett L. Ecker, Alice J. Tao, Quisette P. Janssen, Henry S. Walch, Colin M. Court, Vinod P. Balachandran, Christopher H. Crane, Michael I. D'Angelica, Jeffrey A. Drebin, T. Peter Kingham, Kevin C. Soares, Christine A. Iacobuzio-Donahue, Efsevia Vakiani, Mithat Gonen, Eileen M. O'Reilly, Anna M. Varghese, William R. Jarnagin, Alice C. Wei
Journal: Clinical Cancer Research
Clin Cancer Res (2023) 29 (7): 1368–1374.
https://doi.org/10.1158/1078-0432.CCR-22-3089
Published: 03 April 2023
View article titled, Genomic Biomarkers Associated with Response to Induction Chemotherapy in Patients with Localized Pancreatic Ductal Adenocarcinoma
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Journal Articles

Differences in Prostate Cancer Genomes by Self-reported Race: Contributions of Genetic Ancestry, Modifiable Cancer Risk Factors, and Clinical Factors

Konrad H. Stopsack, Subhiksha Nandakumar, Kanika Arora, Bastien Nguyen, Samantha E. Vasselman, Barbara Nweji, Sean M. McBride, Michael J. Morris, Dana E. Rathkopf, Susan F. Slovin, Daniel C. Danila, Karen A. Autio, Howard I. Scher, Lorelei A. Mucci, David B. Solit, Mithat Gönen, Yu Chen, Michael F. Berger, Nikolaus Schultz, Wassim Abida, Philip W. Kantoff
Journal: Clinical Cancer Research
Clin Cancer Res (2022) 28 (2): 318–326.
https://doi.org/10.1158/1078-0432.CCR-21-2577
Published: 15 January 2022
View article titled, Differences in Prostate Cancer Genomes by Self-reported Race: Contributions of Genetic Ancestry, Modifiable Cancer Risk Factors, and Clinical Factors
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Includes: Supplementary data
Journal Articles

Genome-Derived Classification Signature for Ampullary Adenocarcinoma to Improve Clinical Cancer Care

Saptarshi Chakraborty, Brett L. Ecker, Ken Seier, Victoria G. Aveson, Vinod P. Balachandran, Jeffrey A. Drebin, Michael I. D'Angelica, T. Peter Kingham, Carlie S. Sigel, Kevin C. Soares, Efsevia Vakiani, Alice C. Wei, Rohit Chandwani, Mithat Gonen, Ronglai Shen, William R. Jarnagin
Journal: Clinical Cancer Research
Clin Cancer Res (2021) 27 (21): 5891–5899.
https://doi.org/10.1158/1078-0432.CCR-21-1906
Published: 01 November 2021
View article titled, Genome-Derived Classification Signature for Ampullary Adenocarcinoma to Improve Clinical Cancer Care
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Includes: Supplementary data
Journal Articles

A Grant-Based Experiment to Train Clinical Investigators: The AACR/ASCO Methods in Clinical Cancer Research Workshop

Daniel D. Von Hoff, Gary M. Clark, Charles A. Coltman, Mary L. Disis, S.G. Eckhardt, Lee M. Ellis, Margaret Foti, Elizabeth Garrett-Mayer, Mithat Gönen, Manuel Hidalgo, Susan G. Hilsenbeck, John H. Littlefield, Patricia M. LoRusso, H. Kim Lyerly, Neal J. Meropol, Jyoti D. Patel, Steven Piantadosi, Dean A. Post, Meredith M. Regan, Yu Shyr, Margaret A. Tempero, Joel E. Tepper, Jamie Von Roenn, Louis M. Weiner, Donn C. Young, Nu V. Vu
Journal: Clinical Cancer Research
Clin Cancer Res (2021) 27 (20): 5472–5481.
https://doi.org/10.1158/1078-0432.CCR-21-1799
Published: 15 October 2021
View article titled, A Grant-Based Experiment to Train Clinical Investigators: The AACR/ASCO Methods in Clinical Cancer Research Workshop
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Includes: Supplementary data
Journal Articles

Intrahepatic Cholangiocarcinoma with Lymph Node Metastasis: Treatment-Related Outcomes and the Role of Tumor Genomics in Patient Selection

Joshua S. Jolissaint, Kevin C. Soares, Kenneth P. Seier, Ritika Kundra, Mithat Gönen, Paul J. Shin, Thomas Boerner, Carlie Sigel, Ramyasree Madupuri, Efsevia Vakiani, Andrea Cercek, James J. Harding, Nancy E. Kemeny, Louise C. Connell, Vinod P. Balachandran, Michael I. D'Angelica, Jeffrey A. Drebin, T. Peter Kingham, Alice C. Wei, William R. Jarnagin
Journal: Clinical Cancer Research
Clin Cancer Res (2021) 27 (14): 4101–4108.
https://doi.org/10.1158/1078-0432.CCR-21-0412
Published: 15 July 2021
View article titled, Intrahepatic Cholangiocarcinoma with Lymph Node Metastasis: Treatment-Related Outcomes and the Role of Tumor Genomics in Patient Selection
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Includes: Supplementary data
Journal Articles

Enhanced Detection of Treatment Effects on Metastatic Colorectal Cancer with Volumetric CT Measurements for Tumor Burden Growth Rate Evaluation

Michael L. Maitland, Julia Wilkerson, Sanja Karovic, Binsheng Zhao, Jessica Flynn, Mengxi Zhou, Patrick Hilden, Firas S. Ahmed, Laurent Dercle, Chaya S. Moskowitz, Ying Tang, Dana E. Connors, Stacey J. Adam, Gary Kelloff, Mithat Gonen, Tito Fojo, Lawrence H. Schwartz, Geoffrey R. Oxnard
Journal: Clinical Cancer Research
Clin Cancer Res (2020) 26 (24): 6464–6474.
https://doi.org/10.1158/1078-0432.CCR-20-1493
Published: 15 December 2020
View article titled, Enhanced Detection of Treatment Effects on Metastatic Colorectal Cancer with Volumetric CT Measurements for Tumor Burden Growth Rate Evaluation
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Includes: Supplementary data
Journal Articles

Molecular Engineering of Ultrasmall Silica Nanoparticle–Drug Conjugates as Lung Cancer Therapeutics

Brian Madajewski, Feng Chen, Barney Yoo, Melik Z. Turker, Kai Ma, Li Zhang, Pei-Ming Chen, Rupa Juthani, Virginia Aragon-Sanabria, Mithat Gonen, Charles M. Rudin, Ulrich Wiesner, Michelle S. Bradbury, Cameron Brennan
Journal: Clinical Cancer Research
Series: Author Choice
Clin Cancer Res (2020) 26 (20): 5424–5437.
https://doi.org/10.1158/1078-0432.CCR-20-0851
Published: 15 October 2020
View article titled, Molecular Engineering of Ultrasmall Silica Nanoparticle–Drug Conjugates as Lung Cancer Therapeutics
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Includes: Supplementary data
Journal Articles

Ultrasmall Core-Shell Silica Nanoparticles for Precision Drug Delivery in a High-Grade Malignant Brain Tumor Model

Rupa Juthani, Brian Madajewski, Barney Yoo, Li Zhang, Pei-Ming Chen, Feng Chen, Melik Z. Turker, Kai Ma, Michael Overholtzer, Valerie A. Longo, Sean Carlin, Virginia Aragon-Sanabria, Jason Huse, Mithat Gonen, Pat Zanzonico, Charles M. Rudin, Ulrich Wiesner, Michelle S. Bradbury, Cameron W. Brennan
Journal: Clinical Cancer Research
Clin Cancer Res (2020) 26 (1): 147–158.
https://doi.org/10.1158/1078-0432.CCR-19-1834
Published: 03 January 2020
View article titled, Ultrasmall Core-Shell Silica Nanoparticles for Precision Drug Delivery in a High-Grade Malignant Brain Tumor Model
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Includes: Multimedia, Supplementary data
Journal Articles

Phase I Trial of Well-Differentiated Neuroendocrine Tumors (NETs) with Radiolabeled Somatostatin Antagonist 177Lu-Satoreotide Tetraxetan

Diane Reidy-Lagunes, Neeta Pandit-Taskar, Joseph A. O'Donoghue, Simone Krebs, Kevin D. Staton, Serge K. Lyashchenko, Jason S. Lewis, Nitya Raj, Mithat Gönen, Christian Lohrmann, Lisa Bodei, Wolfgang A. Weber
Journal: Clinical Cancer Research
Clin Cancer Res (2019) 25 (23): 6939–6947.
https://doi.org/10.1158/1078-0432.CCR-19-1026
Published: 02 December 2019
View article titled, Phase I Trial of Well-Differentiated Neuroendocrine Tumors (NETs) with Radiolabeled Somatostatin Antagonist <sup>177</sup>Lu-Satoreotide Tetraxetan
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Includes: Supplementary data
Journal Articles

Abstract IA13: RNA regulators and the control of self-renewal

Ly Vu, Camila Prieto, Eliana M. Amin, Gerard Minuesa, Sagar Chhangawala, Maria C. Vidal, Andrei Krivtsov, Timothy Chou, Arthur Chow, Trevor Barlowe, James Taggart, Patrick Tivnan, Raquel P. Deering, Lisa P. Chu, Mithat Gonen, Maria E. Figueroa, Elisabeth Paietta, Martin S. Tallman, Ari Melnick, Ross Levine, Fatima Al-Shahrour, Marcus Jaras, Nir Hacohen, Alexia Hwang, Ralph Garippa, Christopher Lengner, Scott Armstrong, Glenn S. Cowley, David Root, John Doench, Leandro Cerchietti, Christina Leslie, Benjamin L. Ebert, Michael G. Kharas
Journal: Clinical Cancer Research
Clin Cancer Res (2017) 23 (24_Supplement): IA13.
https://doi.org/10.1158/1557-3265.HEMMAL17-IA13
Published: 14 December 2017
View article titled, Abstract IA13: RNA regulators and the control of self-renewal
Journal Articles

A Validated Prognostic Multigene Expression Assay for Overall Survival in Resected Colorectal Cancer Liver Metastases

Vinod P. Balachandran, Arshi Arora, Mithat Gönen, Hiromichi Ito, Simon Turcotte, Jinru Shia, Agnes Viale, Nikol Snoeren, Sander R. van Hooff, Inne H.M. Borel Rinkes, René Adam, T. Peter Kingham, Peter J. Allen, Ronald P. DeMatteo, William R. Jarnagin, Michael I. D'Angelica
Journal: Clinical Cancer Research
Clin Cancer Res (2016) 22 (10): 2575–2582.
https://doi.org/10.1158/1078-0432.CCR-15-1071
Published: 12 May 2016
View article titled, A Validated Prognostic Multigene Expression Assay for Overall Survival in Resected Colorectal Cancer Liver Metastases
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Includes: Supplementary data
Journal Articles

A Phase I/II Study for Analytic Validation of 89Zr-J591 ImmunoPET as a Molecular Imaging Agent for Metastatic Prostate Cancer

Neeta Pandit-Taskar, Joseph A. O'Donoghue, Jeremy C. Durack, Serge K. Lyashchenko, Sarah M. Cheal, Volkan Beylergil, Robert A. Lefkowitz, Jorge A. Carrasquillo, Danny F. Martinez, Alex Mak Fung, Stephen B. Solomon, Mithat Gönen, Glenn Heller, Massimo Loda, David M. Nanus, Scott T. Tagawa, Jarett L. Feldman, Joseph R. Osborne, Jason S. Lewis, Victor E. Reuter, Wolfgang A. Weber, Neil H. Bander, Howard I. Scher, Steven M. Larson, Michael J. Morris
Journal: Clinical Cancer Research
Clin Cancer Res (2015) 21 (23): 5277–5285.
https://doi.org/10.1158/1078-0432.CCR-15-0552
Published: 30 November 2015
View article titled, A Phase I/II Study for Analytic Validation of <sup>89</sup>Zr-J591 ImmunoPET as a Molecular Imaging Agent for Metastatic Prostate Cancer
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Includes: Supplementary data
Journal Articles

Targeting antiapoptotic Bcl-2 family memberswith small molecule inhibitors compliments the activity of the proteasome inhibitors bortezomib and carfilzomib in in vitro models of lymphoproliferative malignancies.

Luca Paoluzzi, Mithat Gonen, Owen O'Connor
Journal: Clinical Cancer Research
Clin Cancer Res (2008) 14 (15_Supplement): A33.
Published: 15 August 2014
View article titled, Targeting antiapoptotic Bcl-2 family memberswith small molecule inhibitors compliments the activity of the proteasome inhibitors bortezomib and carfilzomib in in vitro models of lymphoproliferative malignancies.
Journal Articles

Oncogenic Function of SCCRO5/DCUN1D5 Requires Its Neddylation E3 Activity and Nuclear Localization

Claire C. Bommeljé, Víola B. Weeda, Guochang Huang, Kushyup Shah, Sarina Bains, Elizabeth Buss, Manish Shaha, Mithat Gönen, Ronald Ghossein, Suresh Y. Ramanathan, Bhuvanesh Singh
Journal: Clinical Cancer Research
Clin Cancer Res (2014) 20 (2): 372–381.
https://doi.org/10.1158/1078-0432.CCR-13-1252
Published: 16 January 2014
View article titled, Oncogenic Function of SCCRO5/DCUN1D5 Requires Its Neddylation E3 Activity and Nuclear Localization
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Includes: Supplementary data
Journal Articles

Adverse Outcomes in Clear Cell Renal Cell Carcinoma with Mutations of 3p21 Epigenetic Regulators BAP1 and SETD2: A Report by MSKCC and the KIRC TCGA Research Network

A. Ari Hakimi, Irina Ostrovnaya, Boris Reva, Nikolaus Schultz, Ying-Bei Chen, Mithat Gonen, Han Liu, Shugaku Takeda, Martin H. Voss, Satish K. Tickoo, Victor E. Reuter, Paul Russo, Emily H. Cheng, Chris Sander, Robert J. Motzer, James J. Hsieh
Journal: Clinical Cancer Research
Clin Cancer Res (2013) 19 (12): 3259–3267.
https://doi.org/10.1158/1078-0432.CCR-12-3886
Published: 13 June 2013
View article titled, Adverse Outcomes in Clear Cell Renal Cell Carcinoma with Mutations of 3p21 Epigenetic Regulators <em>BAP1</em> and <em>SETD2</em>: A Report by MSKCC and the KIRC TCGA Research Network
Open the PDF for Adverse Outcomes in Clear Cell Renal Cell Carcinoma with Mutations of 3p21 Epigenetic Regulators <em>BAP1</em> and <em>SETD2</em>: A Report by MSKCC and the KIRC TCGA Research Network in another window
Includes: Supplementary data
Journal Articles

A Phase I Clinical Trial of Safingol in Combination with Cisplatin in Advanced Solid Tumors

Mark A. Dickson, Richard D. Carvajal, Alfred H Merrill, Jr, Mithat Gonen, Lauren M. Cane, Gary K. Schwartz
Journal: Clinical Cancer Research
Clin Cancer Res (2011) 17 (8): 2484–2492.
https://doi.org/10.1158/1078-0432.CCR-10-2323
Published: 14 April 2011
View article titled, A Phase I Clinical Trial of Safingol in Combination with Cisplatin in Advanced Solid Tumors
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Journal Articles

Prognostic Value of Baseline [18F] Fluorodeoxyglucose Positron Emission Tomography and 99mTc-MDP Bone Scan in Progressing Metastatic Prostate Cancer

Gustavo S.P. Meirelles, Heiko Schöder, Gregory C. Ravizzini, Mithat Gönen, Josef J. Fox, John Humm, Michael J. Morris, Howard I. Scher, Steven M. Larson
Journal: Clinical Cancer Research
Clin Cancer Res (2010) 16 (24): 6093–6099.
https://doi.org/10.1158/1078-0432.CCR-10-1357
Published: 16 December 2010
View article titled, Prognostic Value of Baseline [<sup>18</sup>F] Fluorodeoxyglucose Positron Emission Tomography and <sup>99m</sup>Tc-MDP Bone Scan in Progressing Metastatic Prostate Cancer
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Journal Articles

Time to Treatment Response in Patients with Follicular Lymphoma Treated with Bortezomib Is Longer Compared with Other Histologic Subtypes

Owen A. O'Connor, Carol Portlock, Craig Moskowitz, Paul Hamlin, David Straus, John Gerecitano, Mithat Gonen, Otilia Dumitrescu, Debra Sarasohn, John Butos, Ellen Neylon, Barbara Mac-Gregor Cortelli, Susan Blumel, Andrew M. Evens, Andrew D. Zelenetz, John Wright, Brenda Cooper, Jane Winter, Julie Vose
Journal: Clinical Cancer Research
Clin Cancer Res (2010) 16 (2): 719–726.
https://doi.org/10.1158/1078-0432.CCR-08-2647
Published: 14 January 2010
View article titled, Time to Treatment Response in Patients with Follicular Lymphoma Treated with Bortezomib Is Longer Compared with Other Histologic Subtypes
Open the PDF for Time to Treatment Response in Patients with Follicular Lymphoma Treated with Bortezomib Is Longer Compared with Other Histologic Subtypes in another window
Journal Articles

Phase I Study of Flavopiridol with Oxaliplatin and Fluorouracil/Leucovorin in Advanced Solid Tumors

Dana Rathkopf, Mark A. Dickson, Darren R. Feldman, Richard D. Carvajal, Manish A. Shah, Nian Wu, Robert Lefkowitz, Mithat Gonen, Lauren M. Cane, Heather J. Dials, Jennifer L. Winkelmann, George J. Bosl, Gary K. Schwartz
Journal: Clinical Cancer Research
Clin Cancer Res (2009) 15 (23): 7405–7411.
https://doi.org/10.1158/1078-0432.CCR-09-1502
Published: 30 November 2009
View article titled, Phase I Study of Flavopiridol with Oxaliplatin and Fluorouracil/Leucovorin in Advanced Solid Tumors
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Journal Articles

A Phase 1 Dose-Escalation Study of Irinotecan in Combination with 17-Allylamino-17-Demethoxygeldanamycin in Patients with Solid Tumors

Archie N. Tse, David S. Klimstra, Mithat Gonen, Manish Shah, Tahir Sheikh, Rachel Sikorski, Richard Carvajal, Janet Mui, Caroll Tipian, Eileen O'Reilly, Ki Chung, Robert Maki, Robert Lefkowitz, Karen Brown, Katia Manova-Todorova, Nian Wu, Merrill J. Egorin, David Kelsen, Gary K. Schwartz
Journal: Clinical Cancer Research
Clin Cancer Res (2008) 14 (20): 6704–6711.
https://doi.org/10.1158/1078-0432.CCR-08-1006
Published: 16 October 2008
View article titled, A Phase 1 Dose-Escalation Study of Irinotecan in Combination with 17-Allylamino-17-Demethoxygeldanamycin in Patients with Solid Tumors
Open the PDF for A Phase 1 Dose-Escalation Study of Irinotecan in Combination with 17-Allylamino-17-Demethoxygeldanamycin in Patients with Solid Tumors in another window
Includes: Supplementary data