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Mitchell J. Frederick
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Journal Articles

Abstract PO-085: Inhibition of ATR as a therapeutic strategy to enhance immunotherapy in head and neck cancer

Free
Abdullah A. Osman, Fabio H. B. da Costa, Adewale A. Adebayo, Mason D. Bartels, Tongxin Xie, Moran Amit, Mutsuki Kawabe, Roberto Rangel, Mitchell J. Frederick, Vlad Sandulache, Andrew G. Sikora, Jeffrey N. Myers
Journal: Clinical Cancer Research
Clin Cancer Res (2023) 29 (18_Supplement): PO-085.
https://doi.org/10.1158/1557-3265.AACRAHNS23-PO-085
Published: 15 September 2023
View article titled, Abstract PO-085: Inhibition of ATR as a therapeutic strategy to enhance immunotherapy in head and neck cancer
Journal Articles

Dysregulation and Epigenetic Reprogramming of NRF2 Signaling Axis Promote Acquisition of Cisplatin Resistance and Metastasis in Head and Neck Squamous Cell Carcinoma

Open Access
Abdullah A. Osman, Emre Arslan, Mason Bartels, Chieko Michikawa, Antje Lindemann, Katarzyna Tomczak, Wangjie Yu, Vlad Sandulache, Wencai Ma, Li Shen, Jing Wang, Anand K. Singh, Mitchell J. Frederick, Nakia D. Spencer, Jeffery Kovacs, Timothy Heffernan, William F. Symmans, Kunal Rai, Jeffrey N. Myers
Journal: Clinical Cancer Research
Clin Cancer Res (2023) 29 (7): 1344–1359.
https://doi.org/10.1158/1078-0432.CCR-22-2747
Published: 03 April 2023
View article titled, Dysregulation and Epigenetic Reprogramming of NRF2 Signaling Axis Promote Acquisition of Cisplatin Resistance and Metastasis in Head and Neck Squamous Cell Carcinoma
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Includes: Supplementary data
Journal Articles

Combined TRIP13 and Aurora Kinase Inhibition Induces Apoptosis in Human Papillomavirus–Driven Cancers

Available to Purchase
Soma Ghosh, Tuhina Mazumdar, Wei Xu, Reid T. Powell, Clifford Stephan, Li Shen, Pooja A. Shah, Curtis R. Pickering, Jeffery N. Myers, Jing Wang, Mitchell J. Frederick, Faye M. Johnson
Journal: Clinical Cancer Research
Clin Cancer Res (2022) 28 (20): 4479–4493.
https://doi.org/10.1158/1078-0432.CCR-22-1627
Published: 14 October 2022
View article titled, Combined TRIP13 and Aurora Kinase Inhibition Induces Apoptosis in Human Papillomavirus–Driven Cancers
Open the PDF for Combined TRIP13 and Aurora Kinase Inhibition Induces Apoptosis in Human Papillomavirus–Driven Cancers in another window
Includes: Supplementary data
Journal Articles

PDK1 Mediates NOTCH1-Mutated Head and Neck Squamous Carcinoma Vulnerability to Therapeutic PI3K/mTOR Inhibition

Free
Vaishnavi Sambandam, Mitchell J. Frederick, Li Shen, Pan Tong, Xiayu Rao, Shaohua Peng, Ratnakar Singh, Tuhina Mazumdar, Chenfei Huang, Qiuli Li, Curtis R. Pickering, Jeffery N. Myers, Jing Wang, Faye M. Johnson
Journal: Clinical Cancer Research
Clin Cancer Res (2019) 25 (11): 3329–3340.
https://doi.org/10.1158/1078-0432.CCR-18-3276
Published: 03 June 2019
View article titled, PDK1 Mediates NOTCH1-Mutated Head and Neck Squamous Carcinoma Vulnerability to Therapeutic PI3K/mTOR Inhibition
Open the PDF for PDK1 Mediates NOTCH1-Mutated Head and Neck Squamous Carcinoma Vulnerability to Therapeutic PI3K/mTOR Inhibition in another window
Includes: Supplementary data
Journal Articles

Abstract IA12: An in vivo high throughput shRNA screening platform for identifying ways to target genomic alterations

Free
Tongxin Xie, Ramya L. Parimi, Manish F. Kumar, Liang P. Yang, Jiping Wang, Sahil Seth, Carugo Alessandro, Christopher A. Bristow, Frederick Scott Robinson, Michael D. Peoples, Heath Skinner, Jeffrey N. Myers, Curtis R. Pickering, Mitchell J. Frederick
Journal: Clinical Cancer Research
Clin Cancer Res (2017) 23 (23_Supplement): IA12.
https://doi.org/10.1158/1557-3265.AACRAHNS17-IA12
Published: 30 November 2017
View article titled, Abstract IA12: An in vivo high throughput shRNA screening platform for identifying ways to target genomic alterations
Journal Articles

Abstract 04: Caspase-8 is a novel candidate driver gene in head and neck squamous cell carcinoma

Free
Burak Uzunparmak, Antje Lindemann, Mitchell J. Frederick, Jeffrey N. Myers, Curtis R. Pickering
Journal: Clinical Cancer Research
Clin Cancer Res (2017) 23 (23_Supplement): 04.
https://doi.org/10.1158/1557-3265.AACRAHNS17-04
Published: 30 November 2017
View article titled, Abstract 04: Caspase-8 is a novel candidate driver gene in head and neck squamous cell carcinoma
Journal Articles

Replication Stress Leading to Apoptosis within the S-phase Contributes to Synergism between Vorinostat and AZD1775 in HNSCC Harboring High-Risk TP53 Mutation

Free
Noriaki Tanaka, Ameeta A. Patel, Lin Tang, Natalie L. Silver, Antje Lindemann, Hideaki Takahashi, Roman Jaksik, Xiayu Rao, Nene N. Kalu, Tseng-Cheng Chen, Jiping Wang, Mitchell J. Frederick, Faye Johnson, Frederico O. Gleber-Netto, Siqing Fu, Marek Kimmel, Jing Wang, Walter N. Hittelman, Curtis R. Pickering, Jeffrey N. Myers, Abdullah A. Osman
Journal: Clinical Cancer Research
Series: Author Choice
Clin Cancer Res (2017) 23 (21): 6541–6554.
https://doi.org/10.1158/1078-0432.CCR-17-0947
Published: 31 October 2017
View article titled, Replication Stress Leading to Apoptosis within the S-phase Contributes to Synergism between Vorinostat and AZD1775 in HNSCC Harboring High-Risk TP53 Mutation
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Includes: Multimedia, Supplementary data
Journal Articles

Wee-1 Kinase Inhibition Sensitizes High-Risk HPV+ HNSCC to Apoptosis Accompanied by Downregulation of MCl-1 and XIAP Antiapoptotic Proteins

Free
Noriaki Tanaka, Ameeta A. Patel, Jiping Wang, Mitchell J. Frederick, Nene N. Kalu, Mei Zhao, Alison L. Fitzgerald, Tong-xin Xie, Natalie L. Silver, Carlos Caulin, Ge Zhou, Heath D. Skinner, Faye M. Johnson, Jeffrey N. Myers, Abdullah A. Osman
Journal: Clinical Cancer Research
Series: Author Choice
Clin Cancer Res (2015) 21 (21): 4831–4844.
https://doi.org/10.1158/1078-0432.CCR-15-0279
Published: 01 November 2015
View article titled, Wee-1 Kinase Inhibition Sensitizes High-Risk HPV+ HNSCC to Apoptosis Accompanied by Downregulation of MCl-1 and XIAP Antiapoptotic Proteins
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Includes: Supplementary data
Journal Articles

Mutational Landscape of Aggressive Cutaneous Squamous Cell Carcinoma

Free
Curtis R. Pickering, Jane H. Zhou, J. Jack Lee, Jennifer A. Drummond, S. Andrew Peng, Rami E. Saade, Kenneth Y. Tsai, Jonathan L. Curry, Michael T. Tetzlaff, Stephen Y. Lai, Jun Yu, Donna M. Muzny, Harshavardhan Doddapaneni, Eve Shinbrot, Kyle R. Covington, Jianhua Zhang, Sahil Seth, Carlos Caulin, Gary L. Clayman, Adel K. El-Naggar, Richard A. Gibbs, Randal S. Weber, Jeffrey N. Myers, David A. Wheeler, Mitchell J. Frederick
Journal: Clinical Cancer Research
Clin Cancer Res (2014) 20 (24): 6582–6592.
https://doi.org/10.1158/1078-0432.CCR-14-1768
Published: 14 December 2014
View article titled, Mutational Landscape of Aggressive Cutaneous Squamous Cell Carcinoma
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Includes: Supplementary data
Journal Articles

Squamous Cell Carcinoma of the Oral Tongue in Young Non-Smokers Is Genomically Similar to Tumors in Older Smokers

Free
Curtis R. Pickering, Jiexin Zhang, David M. Neskey, Mei Zhao, Samar A. Jasser, Jiping Wang, Alexandra Ward, C. Jillian Tsai, Marcus V. Ortega Alves, Jane H. Zhou, Jennifer Drummond, Adel K. El-Naggar, Richard Gibbs, John N. Weinstein, David A. Wheeler, Jing Wang, Mitchell J. Frederick, Jeffrey N. Myers
Journal: Clinical Cancer Research
Clin Cancer Res (2014) 20 (14): 3842–3848.
https://doi.org/10.1158/1078-0432.CCR-14-0565
Published: 14 July 2014
View article titled, Squamous Cell Carcinoma of the Oral Tongue in Young Non-Smokers Is Genomically Similar to Tumors in Older Smokers
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Includes: Supplementary data
Journal Articles

Establishment and Characterization of Novel Cell Lines from Sinonasal Undifferentiated Carcinoma

Free
Yoko Takahashi, Michael E. Kupferman, Diana Bell, Tilahun Jiffar, June Goo Lee, Tong-Xin Xie, Ning-Wei Li, Mei Zhao, Mitchell J. Frederick, Alexander Gelbard, Jeffrey N. Myers, Ehab Y. Hanna
Journal: Clinical Cancer Research
Clin Cancer Res (2012) 18 (22): 6178–6187.
https://doi.org/10.1158/1078-0432.CCR-12-1876
Published: 14 November 2012
View article titled, Establishment and Characterization of Novel Cell Lines from Sinonasal Undifferentiated Carcinoma
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Includes: Supplementary data
Journal Articles

Targeted Therapy of VEGFR2 and EGFR Significantly Inhibits Growth of Anaplastic Thyroid Cancer in an Orthotopic Murine Model

Free
Maria K. Gule, Yunyun Chen, Daisuke Sano, Mitchell J. Frederick, Ge Zhou, Mei Zhao, Zvonimir L. Milas, Chad E. Galer, Ying C. Henderson, Samar A. Jasser, David L. Schwartz, James A. Bankson, Jeffrey N. Myers, Stephen Y. Lai
Journal: Clinical Cancer Research
Clin Cancer Res (2011) 17 (8): 2281–2291.
https://doi.org/10.1158/1078-0432.CCR-10-2762
Published: 14 April 2011
View article titled, Targeted Therapy of VEGFR2 and EGFR Significantly Inhibits Growth of Anaplastic Thyroid Cancer in an Orthotopic Murine Model
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Includes: Supplementary data
Journal Articles

Expression of Apoptosis-related Genes in Human Head and Neck Squamous Cell Carcinomas Undergoing p53-mediated Programmed Cell Death

Free
Mitchell J. Frederick, Paula R. Holton, Mike Hudson, Mary Wang, Gary L. Clayman
Journal: Clinical Cancer Research
Clin Cancer Res (1999) 5 (2): 361–369.
Published: 01 February 1999
View article titled, Expression of Apoptosis-related Genes in Human Head and Neck Squamous Cell Carcinomas Undergoing p53-mediated Programmed Cell Death
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