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Journal Articles

Antitumor Activity and Biomarker Analysis for TROP2 Antibody–Drug Conjugate Datopotamab Deruxtecan in Patient-Derived Breast Cancer Xenograft Models

Open Access
Funda Meric-Bernstam, Erkan Yuca, Kurt W. Evans, Ming Zhao, Takanori Maejima, Tsuyoshi Karibe, Maria Gabriela Raso, Ximing Tang, Xiaofeng Zheng, Yasmeen Qamar Rizvi, Argun Akcakanat, Stephen M. Scott, Bailiang Wang, Lauren A. Byers, Debu Tripathy, Daisuke Okajima, Senthil Damodaran
Journal: Clinical Cancer Research
Clin Cancer Res (2025) 31 (3): 573–587.
https://doi.org/10.1158/1078-0432.CCR-24-1948
Published: 03 February 2025
View articletitled, Antitumor Activity and Biomarker Analysis for TROP2 Antibody–Drug Conjugate Datopotamab Deruxtecan in Patient-Derived Breast Cancer Xenograft Models
Open the PDF for Antitumor Activity and Biomarker Analysis for TROP2 Antibody–Drug Conjugate Datopotamab Deruxtecan in Patient-Derived Breast Cancer Xenograft Models in another window
Includes: Supplementary data
Journal Articles

Utilizing Patient-Derived Xenografts to Model Precision Oncology for Biliary Tract Cancer

Open Access
Timothy P. DiPeri, Kurt W. Evans, Stephen Scott, Xiaofeng Zheng, Kaushik Varadarajan, Lawrence N. Kwong, Michael Kahle, Hop S. Tran Cao, Ching-Wei Tzeng, Thuy Vu, Sunhee Kim, Fei Su, Maria Gabriela Raso, Yasmeen Rizvi, Ming Zhao, Huamin Wang, Sunyoung S. Lee, Timothy A. Yap, Jordi Rodon, Milind Javle, Funda Meric-Bernstam
Journal: Clinical Cancer Research
Clin Cancer Res (2025) 31 (2): 387–402.
https://doi.org/10.1158/1078-0432.CCR-24-1233
Published: 17 January 2025
View articletitled, Utilizing Patient-Derived Xenografts to Model Precision Oncology for Biliary Tract Cancer
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Includes: Supplementary data
Journal Articles

Adavosertib Enhances Antitumor Activity of Trastuzumab Deruxtecan in HER2-Expressing Cancers

Open Access
Timothy P. DiPeri, Kurt W. Evans, Maria Gabriela Raso, Ming Zhao, Yasmeen Q. Rizvi, Xiaofeng Zheng, Bailiang Wang, Bryce P. Kirby, Kathleen Kong, Michael Kahle, Timothy A. Yap, Ecaterina E. Dumbrava, Jaffer A. Ajani, Siqing Fu, Khandan Keyomarsi, Funda Meric-Bernstam
Journal: Clinical Cancer Research
Clin Cancer Res (2023) 29 (21): 4385–4398.
https://doi.org/10.1158/1078-0432.CCR-23-0103
Published: 01 November 2023
View articletitled, Adavosertib Enhances Antitumor Activity of Trastuzumab Deruxtecan in HER2-Expressing Cancers
Open the PDF for Adavosertib Enhances Antitumor Activity of Trastuzumab Deruxtecan in HER2-Expressing Cancers in another window
Includes: Supplementary data
Journal Articles

Large-Scale In Vitro and In Vivo CRISPR-Cas9 Knockout Screens Identify a 16-Gene Fitness Score for Improved Risk Assessment in Acute Myeloid Leukemia

Open Access
Peng Jin, Qiqi Jin, Xiaoling Wang, Ming Zhao, Fangyi Dong, Ge Jiang, Zeyi Li, Jie Shen, Wei Zhang, Shishuang Wu, Ran Li, Yunxiang Zhang, Xiaoyang Li, Junmin Li
Journal: Clinical Cancer Research
Clin Cancer Res (2022) 28 (18): 4033–4044.
https://doi.org/10.1158/1078-0432.CCR-22-1618
Published: 15 September 2022
View articletitled, Large-Scale In Vitro and In Vivo CRISPR-Cas9 Knockout Screens Identify a 16-Gene Fitness Score for Improved Risk Assessment in Acute Myeloid Leukemia
Open the PDF for Large-Scale In Vitro and In Vivo CRISPR-Cas9 Knockout Screens Identify a 16-Gene Fitness Score for Improved Risk Assessment in Acute Myeloid Leukemia in another window
Includes: Supplementary data
Journal Articles

Dose Escalation Data from the Phase 1 Study of the Liposomal Formulation of Eribulin (E7389-LF) in Japanese Patients with Advanced Solid Tumors

Open Access
Jun Sato, Toshio Shimizu, Takafumi Koyama, Satoru Iwasa, Akihiko Shimomura, Shunsuke Kondo, Shigehisa Kitano, Kan Yonemori, Yutaka Fujiwara, Kenji Tamura, Takuya Suzuki, Takao Takase, Reiko Nagai, Kohei Yamaguchi, Taro Semba, Zi-Ming Zhao, Min Ren, Noboru Yamamoto
Journal: Clinical Cancer Research
Clin Cancer Res (2022) 28 (9): 1783–1791.
https://doi.org/10.1158/1078-0432.CCR-21-3518
Published: 02 May 2022
View articletitled, Dose Escalation Data from the Phase 1 Study of the Liposomal Formulation of Eribulin (E7389-LF) in Japanese Patients with Advanced Solid Tumors
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Includes: Supplementary data
Journal Articles

Combining Neratinib with CDK4/6, mTOR, and MEK Inhibitors in Models of HER2-positive Cancer

Open Access
Ming Zhao, Stephen Scott, Kurt W. Evans, Erkan Yuca, Turcin Saridogan, Xiaofeng Zheng, Heping Wang, Anil Korkut, Christian X. Cruz Pico, Mehmet Demirhan, Bryce Kirby, Scott Kopetz, Irmina Diala, Alshad S. Lalani, Sarina Piha-Paul, Funda Meric-Bernstam
Journal: Clinical Cancer Research
Clin Cancer Res (2021) 27 (6): 1681–1694.
https://doi.org/10.1158/1078-0432.CCR-20-3017
Published: 15 March 2021
View articletitled, Combining Neratinib with CDK4/6, mTOR, and MEK Inhibitors in Models of HER2-positive Cancer
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Includes: Supplementary data
Journal Articles

Whole-body Imaging of Cell Death Provides a Systemic, Minimally Invasive, Dynamic, and Near-real Time Indicator for Chemotherapeutic Drug Toxicity

Available to Purchase
Steven E. Johnson, Andrey Ugolkov, Chad R. Haney, Gennadiy Bondarenko, Lin Li, Emily A. Waters, Raymond Bergan, Andy Tran, Thomas V. O'Halloran, Andrew Mazar, Ming Zhao
Journal: Clinical Cancer Research
Clin Cancer Res (2019) 25 (4): 1331–1342.
https://doi.org/10.1158/1078-0432.CCR-18-1846
Published: 15 February 2019
View articletitled, Whole-body Imaging of Cell Death Provides a Systemic, Minimally Invasive, Dynamic, and Near-real Time Indicator for Chemotherapeutic Drug Toxicity
Open the PDF for Whole-body Imaging of Cell Death Provides a Systemic, Minimally Invasive, Dynamic, and Near-real Time Indicator for Chemotherapeutic Drug Toxicity in another window
Includes: Supplementary data
Journal Articles

A Phase I Trial of Erlotinib and Concurrent Chemoradiotherapy for Stage III and IV (M0) Squamous Cell Carcinoma of the Head and Neck

Available to Purchase
Jill Gilbert, Michelle A. Rudek, Michaela J. Higgins, Ming Zhao, Sara Bienvenu, Nancy Tsottles, Richard Wahl, Arlene Forastiere, Maura Gillison
Journal: Clinical Cancer Research
Clin Cancer Res (2012) 18 (6): 1735–1742.
https://doi.org/10.1158/1078-0432.CCR-11-2544
Published: 14 March 2012
View articletitled, A Phase I Trial of Erlotinib and Concurrent Chemoradiotherapy for Stage III and IV (M0) Squamous Cell Carcinoma of the Head and Neck
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Journal Articles

Metadherin Promotes Hepatocellular Carcinoma Metastasis through Induction of Epithelial–Mesenchymal Transition

Available to Purchase
Kai Zhu, Zhi Dai, Qi Pan, Zheng Wang, Guo-Huan Yang, Lei Yu, Zhen-Bin Ding, Guo-Ming Shi, Ai-Wu Ke, Xin-Rong Yang, Zhong-Hua Tao, Yi-Ming Zhao, Yi Qin, Hai-Ying Zeng, Zhao-You Tang, Jia Fan, Jian Zhou
Journal: Clinical Cancer Research
Clin Cancer Res (2011) 17 (23): 7294–7302.
https://doi.org/10.1158/1078-0432.CCR-11-1327
Published: 30 November 2011
View articletitled, Metadherin Promotes Hepatocellular Carcinoma Metastasis through Induction of Epithelial–Mesenchymal Transition
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Includes: Supplementary data
Journal Articles

TKTL1 Is Activated by Promoter Hypomethylation and Contributes to Head and Neck Squamous Cell Carcinoma Carcinogenesis through Increased Aerobic Glycolysis and HIF1α Stabilization

Available to Purchase
Wenyue Sun, Yan Liu, Chad A. Glazer, Chunbo Shao, Sheetal Bhan, Semra Demokan, Ming Zhao, Michelle A. Rudek, Patrick K. Ha, Joseph A. Califano
Journal: Clinical Cancer Research
Clin Cancer Res (2010) 16 (3): 857–866.
https://doi.org/10.1158/1078-0432.CCR-09-2604
Published: 01 February 2010
View articletitled, TKTL1 Is Activated by Promoter Hypomethylation and Contributes to Head and Neck Squamous Cell Carcinoma Carcinogenesis through Increased Aerobic Glycolysis and HIF1α Stabilization
Open the PDF for TKTL1 Is Activated by Promoter Hypomethylation and Contributes to Head and Neck Squamous Cell Carcinoma Carcinogenesis through Increased Aerobic Glycolysis and HIF1α Stabilization in another window
Includes: Supplementary data
Journal Articles

A Phase I Dose-Finding Study of 5-Azacytidine in Combination with Sodium Phenylbutyrate in Patients with Refractory Solid Tumors

Available to Purchase
Jianqing Lin, Jill Gilbert, Michelle A. Rudek, James A. Zwiebel, Steve Gore, Anchalee Jiemjit, Ming Zhao, Sharyn D. Baker, Richard F. Ambinder, James G. Herman, Ross C. Donehower, Michael A. Carducci
Journal: Clinical Cancer Research
Clin Cancer Res (2009) 15 (19): 6241–6249.
https://doi.org/10.1158/1078-0432.CCR-09-0567
Published: 30 September 2009
View articletitled, A Phase I Dose-Finding Study of 5-Azacytidine in Combination with Sodium Phenylbutyrate in Patients with Refractory Solid Tumors
Open the PDF for A Phase I Dose-Finding Study of 5-Azacytidine in Combination with Sodium Phenylbutyrate in Patients with Refractory Solid Tumors in another window
Includes: Supplementary data
Journal Articles

Interaction of the Multikinase Inhibitors Sorafenib and Sunitinib with Solute Carriers and ATP-Binding Cassette Transporters

Available to Purchase
Shuiying Hu, Zhaoyuan Chen, Ryan Franke, Shelley Orwick, Ming Zhao, Michelle A. Rudek, Alex Sparreboom, Sharyn D. Baker
Journal: Clinical Cancer Research
Clin Cancer Res (2009) 15 (19): 6062–6069.
https://doi.org/10.1158/1078-0432.CCR-09-0048
Published: 30 September 2009
View articletitled, Interaction of the Multikinase Inhibitors Sorafenib and Sunitinib with Solute Carriers and ATP-Binding Cassette Transporters
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Includes: Supplementary data
Journal Articles

Reexpression of Human Somatostatin Receptor Gene 2 Gene Mediated by Oncolytic Adenovirus Increases Antitumor Activity of Tumor Necrosis Factor–Related Apoptosis-Inducing Ligand against Pancreatic Cancer

Available to Purchase
Zhenwei Zhang, Yangbin Huang, Kam Newman, Jinfa Gu, Xuemei Zhang, Hua Wu, Ming Zhao, Zhiqun Xianyu, Xinyuan Liu
Journal: Clinical Cancer Research
Clin Cancer Res (2009) 15 (16): 5154–5160.
https://doi.org/10.1158/1078-0432.CCR-09-0025
Published: 12 August 2009
View articletitled, Reexpression of Human Somatostatin Receptor Gene 2 Gene Mediated by Oncolytic Adenovirus Increases Antitumor Activity of Tumor Necrosis Factor–Related Apoptosis-Inducing Ligand against Pancreatic Cancer
Open the PDF for Reexpression of Human Somatostatin Receptor Gene 2 Gene Mediated by Oncolytic Adenovirus Increases Antitumor Activity of Tumor Necrosis Factor–Related Apoptosis-Inducing Ligand against Pancreatic Cancer in another window
Includes: Supplementary data
Journal Articles

Clinical and Molecular Responses in Lung Cancer Patients Receiving Romidepsin

Available to Purchase
David S. Schrump, Maria R. Fischette, Dao M. Nguyen, Ming Zhao, Xinmin Li, Tricia F. Kunst, Ana Hancox, Julie A. Hong, G. Aaron Chen, Evgeny Kruchin, John J. Wright, Douglas R. Rosing, Alex Sparreboom, William D. Figg, Seth M. Steinberg
Journal: Clinical Cancer Research
Clin Cancer Res (2008) 14 (1): 188–198.
https://doi.org/10.1158/1078-0432.CCR-07-0135
Published: 02 January 2008
View articletitled, Clinical and Molecular Responses in Lung Cancer Patients Receiving Romidepsin
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Journal Articles

Influence of CYP3A4 Inhibition on the Steady-State Pharmacokinetics of Imatinib

Available to Purchase
Nielka P. van Erp, Hans Gelderblom, Mats O. Karlsson, Jing Li, Ming Zhao, Jan Ouwerkerk, Johan W. Nortier, Henk-Jan Guchelaar, Sharyn D. Baker, Alex Sparreboom
Journal: Clinical Cancer Research
Clin Cancer Res (2007) 13 (24): 7394–7400.
https://doi.org/10.1158/1078-0432.CCR-07-0346
Published: 19 December 2007
View articletitled, Influence of CYP3A4 Inhibition on the Steady-State Pharmacokinetics of Imatinib
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Journal Articles

Differential Metabolism of Gefitinib and Erlotinib by Human Cytochrome P450 Enzymes

Available to Purchase
Jing Li, Ming Zhao, Ping He, Manuel Hidalgo, Sharyn D. Baker
Journal: Clinical Cancer Research
Clin Cancer Res (2007) 13 (12): 3731–3737.
https://doi.org/10.1158/1078-0432.CCR-07-0088
Published: 15 June 2007
View articletitled, Differential Metabolism of Gefitinib and Erlotinib by Human Cytochrome P450 Enzymes
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Journal Articles

Phase I Study of Decitabine-Mediated Gene Expression in Patients with Cancers Involving the Lungs, Esophagus, or Pleura

Available to Purchase
David S. Schrump, Maria R. Fischette, Dao M. Nguyen, Ming Zhao, Xinmin Li, Tricia F. Kunst, Ana Hancox, Julie A. Hong, G. Aaron Chen, Vitaliy Pishchik, William D. Figg, Anthony J. Murgo, Seth M. Steinberg
Journal: Clinical Cancer Research
Clin Cancer Res (2006) 12 (19): 5777–5785.
https://doi.org/10.1158/1078-0432.CCR-06-0669
Published: 04 October 2006
View articletitled, Phase I Study of Decitabine-Mediated Gene Expression in Patients with Cancers Involving the Lungs, Esophagus, or Pleura
Open the PDF for Phase I Study of Decitabine-Mediated Gene Expression in Patients with Cancers Involving the Lungs, Esophagus, or Pleura in another window
Includes: Supplementary data
Journal Articles

In vitro and In vivo Clinical Pharmacology of Dimethyl Benzoylphenylurea, a Novel Oral Tubulin-Interactive Agent

Available to Purchase
Michelle A. Rudek, Ming Zhao, Nicola F. Smith, Robert W. Robey, Ping He, Gurulingappa Hallur, Saeed Khan, Manuel Hidalgo, Antonio Jimeno, A. Dimitrios Colevas, Wells A. Messersmith, Antonio C. Wolff, Sharyn D. Baker
Journal: Clinical Cancer Research
Clin Cancer Res (2005) 11 (23): 8503–8511.
https://doi.org/10.1158/1078-0432.CCR-05-1037
Published: 01 December 2005
View articletitled, In vitro and In vivo Clinical Pharmacology of Dimethyl Benzoylphenylurea, a Novel Oral Tubulin-Interactive Agent
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Journal Articles

Effect of Milk Thistle (Silybum marianum) on the Pharmacokinetics of Irinotecan

Available to Purchase
Nielka P.H. van Erp, Sharyn D. Baker, Ming Zhao, Michelle A. Rudek, Henk-Jan Guchelaar, Johan W.R. Nortier, Alex Sparreboom, Hans Gelderblom
Journal: Clinical Cancer Research
Clin Cancer Res (2005) 11 (21): 7800–7806.
https://doi.org/10.1158/1078-0432.CCR-05-1288
Published: 08 November 2005
View articletitled, Effect of Milk Thistle (Silybum marianum) on the Pharmacokinetics of Irinotecan
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Journal Articles

Comparative Pharmacokinetics of Weekly and Every-Three-Weeks Docetaxel

Available to Purchase
Sharyn D. Baker, Ming Zhao, Carlton K. K. Lee, Jaap Verweij, Yelena Zabelina, Julie R. Brahmer, Antonio C. Wolff, Alex Sparreboom, Michael A. Carducci
Journal: Clinical Cancer Research
Clin Cancer Res (2004) 10 (6): 1976–1983.
https://doi.org/10.1158/1078-0432.CCR-0842-03
Published: 24 March 2004
View articletitled, Comparative Pharmacokinetics of Weekly and Every-Three-Weeks Docetaxel
Open the PDF for Comparative Pharmacokinetics of Weekly and Every-Three-Weeks Docetaxel in another window