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Michele Moschetta
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Journal Articles

A Phase I Study Investigating AZD8186, a Potent and Selective Inhibitor of PI3Kβ/δ, in Patients with Advanced Solid Tumors

Open Access
Atish D. Choudhury, Celestia S. Higano, Johann S. de Bono, Natalie Cook, Dana E. Rathkopf, Kari B. Wisinski, Juan Martin-Liberal, Mark Linch, Elisabeth I. Heath, Richard D. Baird, Javier García-Carbacho, Miguel Quintela-Fandino, Simon T. Barry, Elza C. de Bruin, Steve Colebrook, George Hawkins, Teresa Klinowska, Brijesh Maroj, Ganesh Moorthy, Peter G. Mortimer, Michele Moschetta, Myria Nikolaou, Liz Sainsbury, Geoffrey I. Shapiro, Lillian L. Siu, Aaron R. Hansen
Journal: Clinical Cancer Research
Clin Cancer Res (2022) 28 (11): 2257–2269.
https://doi.org/10.1158/1078-0432.CCR-21-3087
Published: 01 June 2022
View articletitled, A Phase I Study Investigating AZD8186, a Potent and Selective Inhibitor of PI3Kβ/δ, in Patients with Advanced Solid Tumors
Open the PDF for A Phase I Study Investigating AZD8186, a Potent and Selective Inhibitor of PI3Kβ/δ, in Patients with Advanced Solid Tumors in another window
Includes: Supplementary data
Journal Articles

A Randomized, Open-label, Presurgical, Window-of-Opportunity Study Comparing the Pharmacodynamic Effects of the Novel Oral SERD AZD9496 with Fulvestrant in Patients with Newly Diagnosed ER+ HER2− Primary Breast Cancer

Free
John F.R. Robertson, Abigail Evans, Stephan Henschen, Cliona C. Kirwan, Ali Jahan, Laura M. Kenny, J. Michael Dixon, Peter Schmid, Ashutosh Kothari, Omar Mohamed, Peter A. Fasching, Kwok-Leung Cheung, Rachel Wuerstlein, Danielle Carroll, Teresa Klinowska, Justin P.O. Lindemann, Alexander MacDonald, Richard Mather, Rhiannon Maudsley, Michele Moschetta, Myria Nikolaou, Martine P. Roudier, Tinnu Sarvotham, Gaia Schiavon, Diansong Zhou, Li Zhou, Nadia Harbeck
Journal: Clinical Cancer Research
Series: Author Choice
Clin Cancer Res (2020) 26 (16): 4242–4249.
https://doi.org/10.1158/1078-0432.CCR-19-3387
Published: 14 August 2020
View articletitled, A Randomized, Open-label, Presurgical, Window-of-Opportunity Study Comparing the Pharmacodynamic Effects of the Novel Oral SERD AZD9496 with Fulvestrant in Patients with Newly Diagnosed ER+ HER2− Primary Breast Cancer
Open the PDF for A Randomized, Open-label, Presurgical, Window-of-Opportunity Study Comparing the Pharmacodynamic Effects of the Novel Oral SERD AZD9496 with Fulvestrant in Patients with Newly Diagnosed ER+ HER2− Primary Breast Cancer in another window
Includes: Supplementary data
Journal Articles

Capivasertib, an AKT Kinase Inhibitor, as Monotherapy or in Combination with Fulvestrant in Patients with AKT1E17K-Mutant, ER-Positive Metastatic Breast Cancer

Free
Lillian M. Smyth, Kenji Tamura, Mafalda Oliveira, Eva M. Ciruelos, Ingrid A. Mayer, Marie-Paule Sablin, Laura Biganzoli, Helen J. Ambrose, Jack Ashton, Alan Barnicle, Des D. Cashell, Claire Corcoran, Elza C. de Bruin, Andrew Foxley, Joana Hauser, Justin P.O. Lindemann, Rhiannon Maudsley, Robert McEwen, Michele Moschetta, Martin Pass, Vicky Rowlands, Gaia Schiavon, Udai Banerji, Maurizio Scaltriti, Barry S. Taylor, Sarat Chandarlapaty, José Baselga, David M. Hyman
Journal: Clinical Cancer Research
Series: Author Choice
Clin Cancer Res (2020) 26 (15): 3947–3957.
https://doi.org/10.1158/1078-0432.CCR-19-3953
Published: 03 August 2020
View articletitled, Capivasertib, an AKT Kinase Inhibitor, as Monotherapy or in Combination with Fulvestrant in Patients with AKT1E17K-Mutant, ER-Positive Metastatic Breast Cancer
Open the PDF for Capivasertib, an AKT Kinase Inhibitor, as Monotherapy or in Combination with Fulvestrant in Patients with AKT1E17K-Mutant, ER-Positive Metastatic Breast Cancer in another window
Includes: Supplementary data
Journal Articles

Platelets Enhance Multiple Myeloma Progression via IL-1β Upregulation

Free
Satoshi Takagi, Shokichi Tsukamoto, Jihye Park, Kelly E. Johnson, Yawara Kawano, Michele Moschetta, Chia-Jen Liu, Yuji Mishima, Katsutoshi Kokubun, Salomon Manier, Karma Z. Salem, Daisy Huynh, Antonio Sacco, Jodi Forward, Aldo M. Roccaro, Elisabeth M. Battinelli, Irene M. Ghobrial
Journal: Clinical Cancer Research
Clin Cancer Res (2018) 24 (10): 2430–2439.
https://doi.org/10.1158/1078-0432.CCR-17-2003
Published: 14 May 2018
View articletitled, Platelets Enhance Multiple Myeloma Progression via IL-1β Upregulation
Open the PDF for Platelets Enhance Multiple Myeloma Progression via IL-1β Upregulation in another window
Includes: Supplementary data
Journal Articles

A HGF/cMET Autocrine Loop Is Operative in Multiple Myeloma Bone Marrow Endothelial Cells and May Represent a Novel Therapeutic Target

Free
Arianna Ferrucci, Michele Moschetta, Maria Antonia Frassanito, Simona Berardi, Ivana Catacchio, Roberto Ria, Vito Racanelli, Antonella Caivano, Antonio Giovanni Solimando, Daniele Vergara, Michele Maffia, Dominga Latorre, Antonia Rizzello, Alfredo Zito, Paolo Ditonno, Eugenio Maiorano, Domenico Ribatti, Angelo Vacca
Journal: Clinical Cancer Research
Series: Author Choice
Clin Cancer Res (2014) 20 (22): 5796–5807.
https://doi.org/10.1158/1078-0432.CCR-14-0847
Published: 13 November 2014
View articletitled, A HGF/cMET Autocrine Loop Is Operative in Multiple Myeloma Bone Marrow Endothelial Cells and May Represent a Novel Therapeutic Target
Open the PDF for A HGF/cMET Autocrine Loop Is Operative in Multiple Myeloma Bone Marrow Endothelial Cells and May Represent a Novel Therapeutic Target in another window
Includes: Supplementary data
Journal Articles

HIF-1α of Bone Marrow Endothelial Cells Implies Relapse and Drug Resistance in Patients with Multiple Myeloma and May Act as a Therapeutic Target

Free
Roberto Ria, Ivana Catacchio, Simona Berardi, Annunziata De Luisi, Antonella Caivano, Claudia Piccoli, Vitalba Ruggieri, Maria Antonia Frassanito, Domenico Ribatti, Beatrice Nico, Tiziana Annese, Simona Ruggieri, Attilio Guarini, Carla Minoia, Paolo Ditonno, Emanuele Angelucci, Daniele Derudas, Michele Moschetta, Franco Dammacco, Angelo Vacca
Journal: Clinical Cancer Research
Clin Cancer Res (2014) 20 (4): 847–858.
https://doi.org/10.1158/1078-0432.CCR-13-1950
Published: 16 February 2014
View articletitled, HIF-1α of Bone Marrow Endothelial Cells Implies Relapse and Drug Resistance in Patients with Multiple Myeloma and May Act as a Therapeutic Target
Open the PDF for HIF-1α of Bone Marrow Endothelial Cells Implies Relapse and Drug Resistance in Patients with Multiple Myeloma and May Act as a Therapeutic Target in another window
Includes: Supplementary data
Journal Articles

Novel Targeting of Phospho-cMET Overcomes Drug Resistance and Induces Antitumor Activity in Multiple Myeloma

Free
Michele Moschetta, Antonio Basile, Arianna Ferrucci, Maria Antonia Frassanito, Luigia Rao, Roberto Ria, Antonio Giovanni Solimando, Nicola Giuliani, Angelina Boccarelli, Fabio Fumarola, Mauro Coluccia, Bernardo Rossini, Simona Ruggieri, Beatrice Nico, Eugenio Maiorano, Domenico Ribatti, Aldo M. Roccaro, Angelo Vacca
Journal: Clinical Cancer Research
Series: Author Choice
Clin Cancer Res (2013) 19 (16): 4371–4382.
https://doi.org/10.1158/1078-0432.CCR-13-0039
Published: 13 August 2013
View articletitled, Novel Targeting of Phospho-cMET Overcomes Drug Resistance and Induces Antitumor Activity in Multiple Myeloma
Open the PDF for Novel Targeting of Phospho-cMET Overcomes Drug Resistance and Induces Antitumor Activity in Multiple Myeloma in another window
Includes: Supplementary data
Journal Articles

Lenalidomide Restrains Motility and Overangiogenic Potential of Bone Marrow Endothelial Cells in Patients with Active Multiple Myeloma

Free
Annunziata De Luisi, Arianna Ferrucci, Addolorata M.L. Coluccia, Roberto Ria, Michele Moschetta, Emanuela de Luca, Luisa Pieroni, Michele Maffia, Andrea Urbani, Giulia Di Pietro, Attilio Guarini, Girolamo Ranieri, Paolo Ditonno, Simona Berardi, Antonella Caivano, Antonio Basile, Nicola Cascavilla, Silvana Capalbo, Giovanni Quarta, Franco Dammacco, Domenico Ribatti, Angelo Vacca
Journal: Clinical Cancer Research
Clin Cancer Res (2011) 17 (7): 1935–1946.
https://doi.org/10.1158/1078-0432.CCR-10-2381
Published: 31 March 2011
View articletitled, Lenalidomide Restrains Motility and Overangiogenic Potential of Bone Marrow Endothelial Cells in Patients with Active Multiple Myeloma
Open the PDF for Lenalidomide Restrains Motility and Overangiogenic Potential of Bone Marrow Endothelial Cells in Patients with Active Multiple Myeloma in another window
Includes: Supplementary data