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Michael J. Overman
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Journal Articles

Clinical and Functional Characterization of Atypical KRAS/NRAS Mutations in Metastatic Colorectal Cancer

Jonathan M. Loree, Yucai Wang, Muddassir A. Syed, Alexey V. Sorokin, Oluwadara Coker, Joanne Xiu, Benjamin A. Weinberg, Ari M. Vanderwalde, Anteneh Tesfaye, Victoria M. Raymond, Benjamin Miron, Gabi Tarcic, Ori Zelichov, Russell R. Broaddus, Patrick Kwok Shing Ng, Kang Jin Jeong, Yiu Huen Tsang, Gordon B. Mills, Michael J. Overman, Axel Grothey, John L. Marshall, Scott Kopetz
Journal: Clinical Cancer Research
Clin Cancer Res (2021) 27 (16): 4587–4598.
https://doi.org/10.1158/1078-0432.CCR-21-0180
Published: 15 August 2021
View article titled, Clinical and Functional Characterization of Atypical <em>KRAS</em>/<em>NRAS</em> Mutations in Metastatic Colorectal Cancer
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Includes: Supplementary data
Journal Articles

ZEBRA: A Multicenter Phase II Study of Pembrolizumab in Patients with Advanced Small-Bowel Adenocarcinoma

Katrina S. Pedersen, Nathan R. Foster, Michael J. Overman, Patrick M. Boland, Sunnie S. Kim, Kathryn A. Arrambide, Brandy L. Jaszewski, Tanios Bekaii-Saab, Rondell P. Graham, Jack Welch, Richard H. Wilson, Robert R. McWilliams
Journal: Clinical Cancer Research
Clin Cancer Res (2021) 27 (13): 3641–3648.
https://doi.org/10.1158/1078-0432.CCR-21-0159
Published: 01 July 2021
View article titled, ZEBRA: A Multicenter Phase II Study of Pembrolizumab in Patients with Advanced Small-Bowel Adenocarcinoma
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Includes: Supplementary data
Journal Articles

Development and Validation of a Novel Nomogram for Individualized Prediction of Survival in Cancer of Unknown Primary

Kanwal Raghav, Hyunsoo Hwang, Alexandre A. Jácome, Eric Bhang, Anneleis Willett, Ryan W. Huey, Nishat P. Dhillon, Jignesh Modha, Brandon Smaglo, Aurelio Matamoros, Jr, Jeannelyn S. Estrella, Justin Jao, Michael J. Overman, Xuemei Wang, F. Anthony Greco, Jonathan M. Loree, Gauri R. Varadhachary
Journal: Clinical Cancer Research
Series: Author Choice
Clin Cancer Res (2021) 27 (12): 3414–3421.
https://doi.org/10.1158/1078-0432.CCR-20-4117
Published: 15 June 2021
View article titled, Development and Validation of a Novel Nomogram for Individualized Prediction of Survival in Cancer of Unknown Primary
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Includes: Supplementary data
Journal Articles

Pilot Clinical Trial of Perioperative Durvalumab and Tremelimumab in the Treatment of Resectable Colorectal Cancer Liver Metastases

Preeti Kanikarla Marie, Cara Haymaker, Edwin Roger Parra, Young Uk Kim, Rossana Lazcano, Swati Gite, Daniele Lorenzini, Ignacio I. Wistuba, Rebecca S. Slack Tidwell, Xiaofei Song, Wai Chin Foo, Dipen M. Maru, Yun Shin Chun, Andy Futreal, Bryan Kee, David Menter, Luisa Solis, Ching-Wei Tzeng, Christine Parseghian, Kanwal Raghav, Van Morris, Chia-Chi Chang, Robert Jenq, Alda Tam, Chantale Bernatchez, Scott Kopetz, Jean-Nicolas Vauthey, Michael J. Overman
Journal: Clinical Cancer Research
Clin Cancer Res (2021) 27 (11): 3039–3049.
https://doi.org/10.1158/1078-0432.CCR-21-0163
Published: 01 June 2021
View article titled, Pilot Clinical Trial of Perioperative Durvalumab and Tremelimumab in the Treatment of Resectable Colorectal Cancer Liver Metastases
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Includes: Supplementary data
Journal Articles

ARID1A Mutation May Define an Immunologically Active Subgroup in Patients with Microsatellite Stable Colorectal Cancer

Amir Mehrvarz Sarshekeh, Jumanah Alshenaifi, Jason Roszik, Ganiraju C. Manyam, Shailesh M. Advani, Riham Katkhuda, Anuj Verma, Michael Lam, Jason Willis, John Paul Shen, Jeffrey Morris, Jennifer S. Davis, Jonathan M. Loree, Hey Min Lee, Jaffer A. Ajani, Dipen M. Maru, Michael J. Overman, Scott Kopetz
Journal: Clinical Cancer Research
Clin Cancer Res (2021) 27 (6): 1663–1670.
https://doi.org/10.1158/1078-0432.CCR-20-2404
Published: 15 March 2021
View article titled, ARID1A Mutation May Define an Immunologically Active Subgroup in Patients with Microsatellite Stable Colorectal Cancer
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Includes: Supplementary data
Journal Articles

Development and Validation of a Gene Signature Classifier for Consensus Molecular Subtyping of Colorectal Carcinoma in a CLIA-Certified Setting

Jeffrey S. Morris, Rajyalakshmi Luthra, Yusha Liu, Dzifa Y. Duose, Wonyul Lee, Neelima G. Reddy, Justin Windham, Huiqin Chen, Zhimin Tong, Baili Zhang, Wei Wei, Manyam Ganiraju, Bradley M. Broom, Hector A. Alvarez, Alicia Mejia, Omkara Veeranki, Mark J. Routbort, Van K. Morris, Michael J. Overman, David Menter, Riham Katkhuda, Ignacio I. Wistuba, Jennifer S. Davis, Scott Kopetz, Dipen M. Maru
Journal: Clinical Cancer Research
Series: Author Choice
Clin Cancer Res (2021) 27 (1): 120–130.
https://doi.org/10.1158/1078-0432.CCR-20-2403
Published: 04 January 2021
View article titled, Development and Validation of a Gene Signature Classifier for Consensus Molecular Subtyping of Colorectal Carcinoma in a CLIA-Certified Setting
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Includes: Supplementary data
Journal Articles

Germline DNA Sequencing Reveals Novel Mutations Predictive of Overall Survival in a Cohort of Patients with Pancreatic Cancer

Jennifer B. Goldstein, Li Zhao, Xuemei Wang, Yael Ghelman, Michael J. Overman, Milind M. Javle, Rachna T. Shroff, Gauri R. Varadhachary, Robert A. Wolff, Florencia McAllister, Andrew Futreal, David R. Fogelman
Journal: Clinical Cancer Research
Clin Cancer Res (2020) 26 (6): 1385–1394.
https://doi.org/10.1158/1078-0432.CCR-19-0224
Published: 13 March 2020
View article titled, Germline DNA Sequencing Reveals Novel Mutations Predictive of Overall Survival in a Cohort of Patients with Pancreatic Cancer
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Includes: Supplementary data
Journal Articles

Mismatch Repair–Proficient Colorectal Cancer: Finding the Right TiME to Respond

Jason A. Willis, Michael J. Overman, Eduardo Vilar
Journal: Clinical Cancer Research
Clin Cancer Res (2019) 25 (17): 5185–5187.
https://doi.org/10.1158/1078-0432.CCR-19-1447
Published: 03 September 2019
View article titled, Mismatch Repair–Proficient Colorectal Cancer: Finding the Right TiME to Respond
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Journal Articles

DNA Sequencing of Small Bowel Adenocarcinomas Identifies Targetable Recurrent Mutations in the ERBB2 Signaling Pathway

Liana Adam, F. Anthony San Lucas, Richard Fowler, Yao Yu, Wenhui Wu, Yulun Liu, Huamin Wang, David Menter, Michael T. Tetzlaff, Joe Ensor, Jr, Ganiraju Manyam, Stefan T. Arold, Chad Huff, Scott Kopetz, Paul Scheet, Michael J. Overman
Journal: Clinical Cancer Research
Clin Cancer Res (2019) 25 (2): 641–651.
https://doi.org/10.1158/1078-0432.CCR-18-1480
Published: 15 January 2019
View article titled, DNA Sequencing of Small Bowel Adenocarcinomas Identifies Targetable Recurrent Mutations in the ERBB2 Signaling Pathway
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Includes: Supplementary data
Journal Articles

Classifying Colorectal Cancer by Tumor Location Rather than Sidedness Highlights a Continuum in Mutation Profiles and Consensus Molecular Subtypes

Jonathan M. Loree, Allan A.L. Pereira, Michael Lam, Alexandra N. Willauer, Kanwal Raghav, Arvind Dasari, Van. K Morris, Shailesh Advani, David G. Menter, Cathy Eng, Kenna Shaw, Russell Broaddus, Mark J. Routbort, Yusha Liu, Jeffrey S. Morris, Rajyalakshmi Luthra, Funda Meric-Bernstam, Michael J. Overman, Dipen Maru, Scott Kopetz
Journal: Clinical Cancer Research
Clin Cancer Res (2018) 24 (5): 1062–1072.
https://doi.org/10.1158/1078-0432.CCR-17-2484
Published: 28 February 2018
View article titled, Classifying Colorectal Cancer by Tumor Location Rather than Sidedness Highlights a Continuum in Mutation Profiles and Consensus Molecular Subtypes
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Includes: Supplementary data
Journal Articles

4-1BB Agonist Focuses CD8+ Tumor-Infiltrating T-Cell Growth into a Distinct Repertoire Capable of Tumor Recognition in Pancreatic Cancer

Donastas Sakellariou-Thompson, Marie-Andrée Forget, Caitlin Creasy, Vincent Bernard, Li Zhao, Young Uk Kim, Mark W. Hurd, Naohiro Uraoka, Edwin Roger Parra, Ya'an Kang, Christopher A. Bristow, Jaime Rodriguez-Canales, Jason B. Fleming, Gauri Varadhachary, Milind Javle, Michael J. Overman, Hector A. Alvarez, Timothy P. Heffernan, Jianhua Zhang, Patrick Hwu, Anirban Maitra, Cara Haymaker, Chantale Bernatchez
Journal: Clinical Cancer Research
Clin Cancer Res (2017) 23 (23): 7263–7275.
https://doi.org/10.1158/1078-0432.CCR-17-0831
Published: 30 November 2017
View article titled, 4-1BB Agonist Focuses CD8<sup>+</sup> Tumor-Infiltrating T-Cell Growth into a Distinct Repertoire Capable of Tumor Recognition in Pancreatic Cancer
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Includes: Supplementary data
Journal Articles

Underreporting of Research Biopsies from Clinical Trials in Oncology

Christine M. Parseghian, Kanwal Raghav, Robert A. Wolff, Joe Ensor, Jr, James Yao, Lee M. Ellis, Alda L. Tam, Michael J. Overman
Journal: Clinical Cancer Research
Clin Cancer Res (2017) 23 (21): 6450–6457.
https://doi.org/10.1158/1078-0432.CCR-17-1449
Published: 31 October 2017
View article titled, Underreporting of Research Biopsies from Clinical Trials in Oncology
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Includes: Supplementary data
Journal Articles

Circulating DNA Demonstrates Convergent Evolution and Common Resistance Mechanisms during Treatment of Colorectal Cancer

Alain R. Thierry, Brice Pastor, Zhi-Qin Jiang, Anastasia D. Katsiampoura, Christine Parseghian, Jonathan M. Loree, Michael J. Overman, Cynthia Sanchez, Safia El Messaoudi, Marc Ychou, Scott Kopetz
Journal: Clinical Cancer Research
Clin Cancer Res (2017) 23 (16): 4578–4591.
https://doi.org/10.1158/1078-0432.CCR-17-0232
Published: 14 August 2017
View article titled, Circulating DNA Demonstrates Convergent Evolution and Common Resistance Mechanisms during Treatment of Colorectal Cancer
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Includes: Supplementary data
Journal Articles

Dual Inhibition of EGFR and c-Src by Cetuximab and Dasatinib Combined with FOLFOX Chemotherapy in Patients with Metastatic Colorectal Cancer

Christine M. Parseghian, Nila U. Parikh, Ji Yuan Wu, Zhi-Qin Jiang, Laura Henderson, Feng Tian, Brice Pastor, Marc Ychou, Kanwal Raghav, Arvind Dasari, David R. Fogelman, Anastasia D. Katsiampoura, David G. Menter, Robert A. Wolff, Cathy Eng, Michael J. Overman, Alain R. Thierry, Gary E. Gallick, Scott Kopetz
Journal: Clinical Cancer Research
Clin Cancer Res (2017) 23 (15): 4146–4154.
https://doi.org/10.1158/1078-0432.CCR-16-3138
Published: 01 August 2017
View article titled, Dual Inhibition of EGFR and c-Src by Cetuximab and Dasatinib Combined with FOLFOX Chemotherapy in Patients with Metastatic Colorectal Cancer
Open the PDF for Dual Inhibition of EGFR and c-Src by Cetuximab and Dasatinib Combined with FOLFOX Chemotherapy in Patients with Metastatic Colorectal Cancer in another window
Includes: Supplementary data
Journal Articles

Epithelial–Mesenchymal Transitioned Circulating Tumor Cells Capture for Detecting Tumor Progression

Arun Satelli, Abhisek Mitra, Zachary Brownlee, Xueqing Xia, Seth Bellister, Michael J. Overman, Scott Kopetz, Lee M. Ellis, Qing H. Meng, Shulin Li
Journal: Clinical Cancer Research
Clin Cancer Res (2015) 21 (4): 899–906.
https://doi.org/10.1158/1078-0432.CCR-14-0894
Published: 16 February 2015
View article titled, Epithelial–Mesenchymal Transitioned Circulating Tumor Cells Capture for Detecting Tumor Progression
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Includes: Supplementary data