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Michael J. Keating
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Journal Articles

AMG-176, an Mcl-1 Antagonist, Shows Preclinical Efficacy in Chronic Lymphocytic Leukemia

Xue Yi, Aloke Sarkar, Gorkem Kismali, Burcu Aslan, Mary Ayres, LaKesla R. Iles, Michael J. Keating, William G. Wierda, James P. Long, Maria Teresa Sabrina Bertilaccio, Varsha Gandhi
Journal: Clinical Cancer Research
Clin Cancer Res (2020) 26 (14): 3856–3867.
https://doi.org/10.1158/1078-0432.CCR-19-1397
Published: 15 July 2020
View article titled, AMG-176, an Mcl-1 Antagonist, Shows Preclinical Efficacy in Chronic Lymphocytic Leukemia
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Includes: Supplementary data
Journal Articles

Comparison of Acalabrutinib, A Selective Bruton Tyrosine Kinase Inhibitor, with Ibrutinib in Chronic Lymphocytic Leukemia Cells

Viralkumar Patel, Kumudha Balakrishnan, Elena Bibikova, Mary Ayres, Michael J. Keating, William G. Wierda, Varsha Gandhi
Journal: Clinical Cancer Research
Clin Cancer Res (2017) 23 (14): 3734–3743.
https://doi.org/10.1158/1078-0432.CCR-16-1446
Published: 13 July 2017
View article titled, Comparison of Acalabrutinib, A Selective Bruton Tyrosine Kinase Inhibitor, with Ibrutinib in Chronic Lymphocytic Leukemia Cells
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Includes: Supplementary data
Journal Articles

Combining Anti-Mir-155 with Chemotherapy for the Treatment of Lung Cancers

Katrien Van Roosbroeck, Francesca Fanini, Tetsuro Setoyama, Cristina Ivan, Cristian Rodriguez-Aguayo, Enrique Fuentes-Mattei, Lianchun Xiao, Ivan Vannini, Roxana S. Redis, Lucilla D'Abundo, Xinna Zhang, Milena S. Nicoloso, Simona Rossi, Vianey Gonzalez-Villasana, Rajesha Rupaimoole, Manuela Ferracin, Fortunato Morabito, Antonino Neri, Peter P. Ruvolo, Vivian R. Ruvolo, Chad V. Pecot, Dino Amadori, Lynne Abruzzo, Steliana Calin, Xuemei Wang, M. James You, Alessandra Ferrajoli, Robert Orlowski, William Plunkett, Tara M. Lichtenberg, Ramana V. Davuluri, Ioana Berindan-Neagoe, Massimo Negrini, Ignacio I. Wistuba, Hagop M. Kantarjian, Anil K. Sood, Gabriel Lopez-Berestein, Michael J. Keating, Muller Fabbri, George A. Calin
Journal: Clinical Cancer Research
Clin Cancer Res (2017) 23 (11): 2891–2904.
https://doi.org/10.1158/1078-0432.CCR-16-1025
Published: 31 May 2017
View article titled, Combining Anti-Mir-155 with Chemotherapy for the Treatment of Lung Cancers
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Includes: Supplementary data
Journal Articles

Long-term Follow-up of Treatment with Ibrutinib and Rituximab in Patients with High-Risk Chronic Lymphocytic Leukemia

Preetesh Jain, Michael J. Keating, William G. Wierda, Mariela Sivina, Philip A. Thompson, Alessandra Ferrajoli, Zeev Estrov, Hagop Kantarjian, Susan O'Brien, Jan A. Burger
Journal: Clinical Cancer Research
Clin Cancer Res (2017) 23 (9): 2154–2158.
https://doi.org/10.1158/1078-0432.CCR-16-1948
Published: 30 April 2017
View article titled, Long-term Follow-up of Treatment with Ibrutinib and Rituximab in Patients with High-Risk Chronic Lymphocytic Leukemia
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Includes: Supplementary data
Journal Articles

Carfilzomib Triggers Cell Death in Chronic Lymphocytic Leukemia by Inducing Proapoptotic and Endoplasmic Reticulum Stress Responses

Betty Lamothe, William G. Wierda, Michael J. Keating, Varsha Gandhi
Journal: Clinical Cancer Research
Clin Cancer Res (2016) 22 (18): 4712–4726.
https://doi.org/10.1158/1078-0432.CCR-15-2522
Published: 15 September 2016
View article titled, Carfilzomib Triggers Cell Death in Chronic Lymphocytic Leukemia by Inducing Proapoptotic and Endoplasmic Reticulum Stress Responses
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Includes: Supplementary data
Journal Articles

Ofatumumab and Lenalidomide for Patients with Relapsed or Refractory Chronic Lymphocytic Leukemia: Correlation between Responses and Immune Characteristics

Candida Vitale, Lorenzo Falchi, Elisa ten Hacken, Hui Gao, Hila Shaim, Katrien Van Roosbroeck, George Calin, Susan O'Brien, Stefan Faderl, Xuemei Wang, William G. Wierda, Katayoun Rezvani, James M. Reuben, Jan A. Burger, Michael J. Keating, Alessandra Ferrajoli
Journal: Clinical Cancer Research
Clin Cancer Res (2016) 22 (10): 2359–2367.
https://doi.org/10.1158/1078-0432.CCR-15-2476
Published: 12 May 2016
View article titled, Ofatumumab and Lenalidomide for Patients with Relapsed or Refractory Chronic Lymphocytic Leukemia: Correlation between Responses and Immune Characteristics
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Includes: Supplementary data
Journal Articles

Pharmacological and Protein Profiling Suggests Venetoclax (ABT-199) as Optimal Partner with Ibrutinib in Chronic Lymphocytic Leukemia

Fabiola Cervantes-Gomez, Betty Lamothe, Jennifer A. Woyach, William G. Wierda, Michael J. Keating, Kumudha Balakrishnan, Varsha Gandhi
Journal: Clinical Cancer Research
Clin Cancer Res (2015) 21 (16): 3705–3715.
https://doi.org/10.1158/1078-0432.CCR-14-2809
Published: 13 August 2015
View article titled, Pharmacological and Protein Profiling Suggests Venetoclax (ABT-199) as Optimal Partner with Ibrutinib in Chronic Lymphocytic Leukemia
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Includes: Supplementary data
Journal Articles

Analysis of human leukemias using extensive immunophenotypes from an antibody microarray

Richard I. Christopherson, Larissa Belov, Stephen P. Mulligan, Nicole Barber, Adrian Woolfson, Mike Scott, Kerryn Stoner, Jeremy S. Chrisp, William A. Sewell, Kenneth F. Bradstock, Linda Bendall, Dana S. Pascovici, Mervyn Thomas, Wendy Erber, Graham AR Young, James S. Wiley, Surender Juneja, William G. Wierda, Anthony R. Green, Michael J. Keating
Journal: Clinical Cancer Research
Clin Cancer Res (2006) 12 (19_Supplement): A12.
Published: 15 August 2014
View article titled, Analysis of human leukemias using extensive immunophenotypes from an antibody microarray
Journal Articles

Targeting DNA Repair in Chronic Lymphocytic Leukemia Cells with a Novel Acyclic Nucleotide Analogue, GS-9219

Cheng-Yu Tsai, Adrian S. Ray, Daniel B. Tumas, Michael J. Keating, Hans Reiser, William Plunkett
Journal: Clinical Cancer Research
Clin Cancer Res (2009) 15 (11): 3760–3769.
https://doi.org/10.1158/1078-0432.CCR-08-2848
Published: 01 June 2009
View article titled, Targeting DNA Repair in Chronic Lymphocytic Leukemia Cells with a Novel Acyclic Nucleotide Analogue, GS-9219
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Includes: Supplementary data
Journal Articles

The Prognostic Significance of Serum β2 Microglobulin Levels in Acute Myeloid Leukemia and Prognostic Scores Predicting Survival: Analysis of 1,180 Patients

Apostolia-Maria Tsimberidou, Hagop M. Kantarjian, Sijin Wen, Susan O'Brien, Jorge Cortes, William G. Wierda, Charles Koller, Sherry Pierce, Mark Brandt, Emil J. Freireich, Michael J. Keating, Elihu H. Estey
Journal: Clinical Cancer Research
Clin Cancer Res (2008) 14 (3): 721–730.
https://doi.org/10.1158/1078-0432.CCR-07-2063
Published: 01 February 2008
View article titled, The Prognostic Significance of Serum β<sub>2</sub> Microglobulin Levels in Acute Myeloid Leukemia and Prognostic Scores Predicting Survival: Analysis of 1,180 Patients
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Journal Articles

Clinical and Pharmacokinetic Study of Clofarabine in Chronic Lymphocytic Leukemia: Strategy for Treatment

Varsha Gandhi, William Plunkett, Peter L. Bonate, Min Du, Billie Nowak, Susan Lerner, Michael J. Keating
Journal: Clinical Cancer Research
Clin Cancer Res (2006) 12 (13): 4011–4017.
https://doi.org/10.1158/1078-0432.CCR-05-2664
Published: 03 July 2006
View article titled, Clinical and Pharmacokinetic Study of Clofarabine in Chronic Lymphocytic Leukemia: Strategy for Treatment
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Journal Articles

Mechanisms of Cell Death of Chronic Lymphocytic Leukemia Lymphocytes by RNA-Directed Agent, 8-NH2-Adenosine

Kumudha Balakrishnan, William G. Wierda, Michael J. Keating, Varsha Gandhi
Journal: Clinical Cancer Research
Clin Cancer Res (2005) 11 (18): 6745–6752.
https://doi.org/10.1158/1078-0432.CCR-05-0553
Published: 15 September 2005
View article titled, Mechanisms of Cell Death of Chronic Lymphocytic Leukemia Lymphocytes by RNA-Directed Agent, 8-NH<sub>2</sub>-Adenosine
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Journal Articles

Pharmacokinetics and Pharmacodynamics of Plasma Clofarabine and Cellular Clofarabine Triphosphate in Patients with Acute Leukemias

Varsha Gandhi, Hagop Kantarjian, Stefan Faderl, Peter Bonate, Min Du, Mary Ayres, Mary Beth Rios, Michael J. Keating, William Plunkett
Journal: Clinical Cancer Research
Clin Cancer Res (2003) 9 (17): 6335–6342.
Published: 24 December 2003
View article titled, Pharmacokinetics and Pharmacodynamics of Plasma Clofarabine and Cellular Clofarabine Triphosphate in Patients with Acute Leukemias
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Journal Articles

Effects of Signal Transduction Inhibitor 571 in Acute Myelogenous Leukemia Cells

Barbara Scappini, Francesco Onida, Hagop M. Kantarjian, Li Dong, Srdan Verstovsek, Michael J. Keating, Miloslav Beran
Journal: Clinical Cancer Research
Clin Cancer Res (2001) 7 (12): 3884–3893.
Published: 01 December 2001
View article titled, Effects of Signal Transduction Inhibitor 571 in Acute Myelogenous Leukemia Cells
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Journal Articles

DNA Repair Initiated in Chronic Lymphocytic Leukemia Lymphocytes by 4-Hydroperoxycyclophosphamide Is Inhibited by Fludarabine and Clofarabine

Takahiro Yamauchi, Billie J. Nowak, Michael J. Keating, William Plunkett
Journal: Clinical Cancer Research
Clin Cancer Res (2001) 7 (11): 3580–3589.
Published: 01 November 2001
View article titled, DNA Repair Initiated in Chronic Lymphocytic Leukemia Lymphocytes by 4-Hydroperoxycyclophosphamide Is Inhibited by Fludarabine and Clofarabine
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Journal Articles

High Levels of Vascular Endothelial Growth Factor Receptor-2 Correlate with Shortened Survival in Chronic Lymphocytic Leukemia

Alessandra Ferrajoli, Taghi Manshouri, Zeev Estrov, Michael J. Keating, Susan O’Brien, Susan Lerner, Miloslav Beran, Hagop M. Kantarjian, Emil J. Freireich, Maher Albitar
Journal: Clinical Cancer Research
Clin Cancer Res (2001) 7 (4): 795–799.
Published: 01 April 2001
View article titled, High Levels of Vascular Endothelial Growth Factor Receptor-2 Correlate with Shortened Survival in Chronic Lymphocytic Leukemia
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Journal Articles

Loss of FHIT Expression in Acute Lymphoblastic Leukemia

Cora Hallas, Maher Albitar, Jean Letofsky, Michael J. Keating, Kay Huebner, Carlo M. Croce
Journal: Clinical Cancer Research
Clin Cancer Res (1999) 5 (9): 2409–2414.
Published: 01 September 1999
View article titled, Loss of <em>FHIT</em> Expression in Acute Lymphoblastic Leukemia
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Journal Articles

The Prognostic Impact of BCL2 Protein Expression in Acute Myelogenous Leukemia Varies with Cytogenetics

Steven M. Kornblau, Peter F. Thall, Zeev Estrov, Monica Walterscheid, Shilpen Patel, Alexandra Theriault, Michael J. Keating, Hagop Kantarjian, Elihu Estey, Michael Andreeff
Journal: Clinical Cancer Research
Clin Cancer Res (1999) 5 (7): 1758–1766.
Published: 01 July 1999
View article titled, The Prognostic Impact of BCL2 Protein Expression in Acute Myelogenous Leukemia Varies with Cytogenetics
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