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Michael A. Morse
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Journal Articles

Stimulation of Oncogene-Specific Tumor-Infiltrating T Cells through Combined Vaccine and αPD-1 Enable Sustained Antitumor Responses against Established HER2 Breast Cancer

Erika J. Crosby, Chaitanya R. Acharya, Anthony-Fayez Haddad, Christopher A. Rabiola, Gangjun Lei, Jun-Ping Wei, Xiao-Yi Yang, Tao Wang, Cong-Xiao Liu, Kay U. Wagner, William J. Muller, Lewis A. Chodosh, Gloria Broadwater, Terry Hyslop, Jonathan H. Shepherd, Daniel P. Hollern, Xiaping He, Charles M. Perou, Shengjie Chai, Benjamin K. Ashby, Benjamin G. Vincent, Joshua C. Snyder, Jeremy Force, Michael A. Morse, Herbert K. Lyerly, Zachary C. Hartman
Journal: Clinical Cancer Research
Clin Cancer Res (2020) 26 (17): 4670–4681.
https://doi.org/10.1158/1078-0432.CCR-20-0389
Published: 01 September 2020
View article titled, Stimulation of Oncogene-Specific Tumor-Infiltrating T Cells through Combined Vaccine and αPD-1 Enable Sustained Antitumor Responses against Established HER2 Breast Cancer
Open the PDF for Stimulation of Oncogene-Specific Tumor-Infiltrating T Cells through Combined Vaccine and αPD-1 Enable Sustained Antitumor Responses against Established HER2 Breast Cancer in another window
Includes: Supplementary data
Journal Articles

Phase II Study of Ensituximab, a Novel Chimeric Monoclonal Antibody, in Adults with Unresectable, Metastatic Colorectal Cancer

Richard D. Kim, Nilofer S. Azad, Michael A. Morse, Elizabeth Poplin, Amit Mahipal, Benjamin Tan, Jr, Sharon A. Mavroukakis, Massimo Fantini, Kwong Y. Tsang, Anjum Zaki, Jose Torrealba, Philip M. Arlen, Muhammad S. Beg
Journal: Clinical Cancer Research
Clin Cancer Res (2020) 26 (14): 3557–3564.
https://doi.org/10.1158/1078-0432.CCR-20-0426
Published: 15 July 2020
View article titled, Phase II Study of Ensituximab, a Novel Chimeric Monoclonal Antibody, in Adults with Unresectable, Metastatic Colorectal Cancer
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Journal Articles

Results from a Phase IIb, Randomized, Multicenter Study of GVAX Pancreas and CRS-207 Compared with Chemotherapy in Adults with Previously Treated Metastatic Pancreatic Adenocarcinoma (ECLIPSE Study)

Dung T. Le, Vincent J. Picozzi, Andrew H. Ko, Zev A. Wainberg, Hedy Kindler, Andrea Wang-Gillam, Paul Oberstein, Michael A. Morse, Herbert J. Zeh, III, Colin Weekes, Tony Reid, Erkut Borazanci, Todd Crocenzi, Noelle K. LoConte, Benjamin Musher, Dan Laheru, Aimee Murphy, Chan Whiting, Nitya Nair, Amanda Enstrom, Sandy Ferber, Dirk G. Brockstedt, Elizabeth M. Jaffee
Journal: Clinical Cancer Research
Clin Cancer Res (2019) 25 (18): 5493–5502.
https://doi.org/10.1158/1078-0432.CCR-18-2992
Published: 13 September 2019
View article titled, Results from a Phase IIb, Randomized, Multicenter Study of GVAX Pancreas and CRS-207 Compared with Chemotherapy in Adults with Previously Treated Metastatic Pancreatic Adenocarcinoma (ECLIPSE Study)
Open the PDF for Results from a Phase IIb, Randomized, Multicenter Study of GVAX Pancreas and CRS-207 Compared with Chemotherapy in Adults with Previously Treated Metastatic Pancreatic Adenocarcinoma (ECLIPSE Study) in another window
Includes: Supplementary data
Journal Articles

Vaccine-Induced Memory CD8+ T Cells Provide Clinical Benefit in HER2 Expressing Breast Cancer: A Mouse to Human Translational Study

Erika J. Crosby, William Gwin, Kimberly Blackwell, Paul K. Marcom, Serena Chang, Holden T. Maecker, Gloria Broadwater, Terry Hyslop, Sungjin Kim, Andre Rogatko, Veronica Lubkov, Joshua C. Snyder, Takuya Osada, Amy C. Hobeika, Michael A. Morse, H. Kim Lyerly, Zachary C. Hartman
Journal: Clinical Cancer Research
Clin Cancer Res (2019) 25 (9): 2725–2736.
https://doi.org/10.1158/1078-0432.CCR-18-3102
Published: 01 May 2019
View article titled, Vaccine-Induced Memory CD8<sup>+</sup> T Cells Provide Clinical Benefit in HER2 Expressing Breast Cancer: A Mouse to Human Translational Study
Open the PDF for Vaccine-Induced Memory CD8<sup>+</sup> T Cells Provide Clinical Benefit in HER2 Expressing Breast Cancer: A Mouse to Human Translational Study in another window
Includes: Supplementary data
Journal Articles

Autologous Dendritic Cell-Cytokine Induced Killer Cell Immunotherapy Combined with S-1 Plus Cisplatin in Patients with Advanced Gastric Cancer: A Prospective Study

Guoliang Qiao, Xiaoli Wang, Lei Zhou, Xinna Zhou, Yuguang Song, Shuo Wang, Lei Zhao, Michael A. Morse, Amy Hobeika, Jin Song, Xin Yi, Xuefeng Xia, Jun Ren, Herbert Kim Lyerly
Journal: Clinical Cancer Research
Series: Author Choice
Clin Cancer Res (2019) 25 (5): 1494–1504.
https://doi.org/10.1158/1078-0432.CCR-18-2360
Published: 01 March 2019
View article titled, Autologous Dendritic Cell-Cytokine Induced Killer Cell Immunotherapy Combined with S-1 Plus Cisplatin in Patients with Advanced Gastric Cancer: A Prospective Study
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Includes: Supplementary data
Journal Articles

The Role of Angiogenesis in Hepatocellular Carcinoma

Michael A. Morse, Weijing Sun, Richard Kim, Aiwu Ruth He, Paolo B. Abada, Michelle Mynderse, Richard S. Finn
Journal: Clinical Cancer Research
Series: Author Choice
Clin Cancer Res (2019) 25 (3): 912–920.
https://doi.org/10.1158/1078-0432.CCR-18-1254
Published: 01 February 2019
View article titled, The Role of Angiogenesis in Hepatocellular Carcinoma
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Journal Articles

In Vivo Detection of HSP90 Identifies Breast Cancers with Aggressive Behavior

Takuya Osada, Kensuke Kaneko, William R. Gwin, Michael A. Morse, Amy Hobeika, Brian W. Pogue, Zachary C. Hartman, Philip F. Hughes, Timothy Haystead, H. Kim Lyerly
Journal: Clinical Cancer Research
Clin Cancer Res (2017) 23 (24): 7531–7542.
https://doi.org/10.1158/1078-0432.CCR-17-1453
Published: 14 December 2017
View article titled, <em>In Vivo</em> Detection of HSP90 Identifies Breast Cancers with Aggressive Behavior
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Includes: Supplementary data
Journal Articles

Dendritic Cell/Cytokine-Induced Killer Cell Immunotherapy Combined with S-1 in Patients with Advanced Pancreatic Cancer: A Prospective Study

Ni Jiang, Guoliang Qiao, Xiaoli Wang, Michael A. Morse, William R. Gwin, Lei Zhou, Yuguang Song, Yanjie Zhao, Feng Chen, Xinna Zhou, Lefu Huang, Amy Hobeika, Xin Yi, Xuefeng Xia, Yanfang Guan, Jin Song, Jun Ren, H. Kim Lyerly
Journal: Clinical Cancer Research
Clin Cancer Res (2017) 23 (17): 5066–5073.
https://doi.org/10.1158/1078-0432.CCR-17-0492
Published: 31 August 2017
View article titled, Dendritic Cell/Cytokine-Induced Killer Cell Immunotherapy Combined with S-1 in Patients with Advanced Pancreatic Cancer: A Prospective Study
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Includes: Supplementary data
Journal Articles

Phase I Study Utilizing a Novel Antigen-Presenting Cell–Targeted Vaccine with Toll-like Receptor Stimulation to Induce Immunity to Self-antigens in Cancer Patients

Michael A. Morse, Robert Chapman, John Powderly, Kimberly Blackwell, Tibor Keler, Jennifer Green, Renee Riggs, Li-Zhen He, Venky Ramakrishna, Laura Vitale, Biwei Zhao, Stephen A. Butler, Amy Hobeika, Takuya Osada, Thomas Davis, Timothy Clay, H. Kim Lyerly
Journal: Clinical Cancer Research
Clin Cancer Res (2011) 17 (14): 4844–4853.
https://doi.org/10.1158/1078-0432.CCR-11-0891
Published: 17 July 2011
View article titled, Phase I Study Utilizing a Novel Antigen-Presenting Cell–Targeted Vaccine with Toll-like Receptor Stimulation to Induce Immunity to Self-antigens in Cancer Patients
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Includes: Supplementary data
Journal Articles

MHC Class I–Presented Tumor Antigens Identified in Ovarian Cancer by Immunoproteomic Analysis Are Targets for T-Cell Responses against Breast and Ovarian Cancer

Michael A. Morse, Angeles A. Secord, Kimberly Blackwell, Amy C. Hobeika, Gomathinayagam Sinnathamby, Takuya Osada, Julie Hafner, Mohan Philip, Timothy M. Clay, H. Kim Lyerly, Ramila Philip
Journal: Clinical Cancer Research
Clin Cancer Res (2011) 17 (10): 3408–3419.
https://doi.org/10.1158/1078-0432.CCR-10-2614
Published: 15 May 2011
View article titled, MHC Class I–Presented Tumor Antigens Identified in Ovarian Cancer by Immunoproteomic Analysis Are Targets for T-Cell Responses against Breast and Ovarian Cancer
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Journal Articles

An Adenoviral Vaccine Encoding Full-Length Inactivated Human Her2 Exhibits Potent Immunogenicty and Enhanced Therapeutic Efficacy without Oncogenicity

Zachary C. Hartman, Junping Wei, Takuya Osada, Oliver Glass, Gangjun Lei, Xiao-Yi Yang, Sharon Peplinski, Dong-Wan Kim, Wenle Xia, Neil Spector, Jeffrey Marks, William Barry, Amy Hobeika, Gayathri Devi, Andrea Amalfitano, Michael A. Morse, H. Kim Lyerly, Timothy M. Clay
Journal: Clinical Cancer Research
Clin Cancer Res (2010) 16 (5): 1466–1477.
https://doi.org/10.1158/1078-0432.CCR-09-2549
Published: 28 February 2010
View article titled, An Adenoviral Vaccine Encoding Full-Length Inactivated Human Her2 Exhibits Potent Immunogenicty and Enhanced Therapeutic Efficacy without Oncogenicity
Open the PDF for An Adenoviral Vaccine Encoding Full-Length Inactivated Human Her2 Exhibits Potent Immunogenicty and Enhanced Therapeutic Efficacy without Oncogenicity in another window
Includes: Supplementary data
Journal Articles

Induction of Wilms' Tumor Protein (WT1)–Specific Antitumor Immunity Using a Truncated WT1-Expressing Adenovirus Vaccine

Takuya Osada, Christopher Y. Woo, Matthew McKinney, Xiao Yi Yang, Gangjun Lei, Heather G. LaBreche, Zachary C. Hartman, Donna Niedzwiecki, Nelson Chao, Andrea Amalfitano, Michael A. Morse, H. Kim Lyerly, Timothy M. Clay
Journal: Clinical Cancer Research
Clin Cancer Res (2009) 15 (8): 2789–2796.
https://doi.org/10.1158/1078-0432.CCR-08-2589
Published: 15 April 2009
View article titled, Induction of Wilms' Tumor Protein (WT1)–Specific Antitumor Immunity Using a Truncated WT1-Expressing Adenovirus Vaccine
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Journal Articles

Phase I Study of Immunization with Dendritic Cells Modified with Fowlpox Encoding Carcinoembryonic Antigen and Costimulatory Molecules

Michael A. Morse, Timothy M. Clay, Amy C. Hobeika, Takuya Osada, Shubi Khan, Stephen Chui, Donna Niedzwiecki, Dennis Panicali, Jeffrey Schlom, H. Kim Lyerly
Journal: Clinical Cancer Research
Clin Cancer Res (2005) 11 (8): 3017–3024.
https://doi.org/10.1158/1078-0432.CCR-04-2172
Published: 18 April 2005
View article titled, Phase I Study of Immunization with Dendritic Cells Modified with Fowlpox Encoding Carcinoembryonic Antigen and Costimulatory Molecules
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Journal Articles

Assays for Monitoring Cellular Immune Responses to Active Immunotherapy of Cancer

Timothy M. Clay, Amy C. Hobeika, Paul J. Mosca, H. Kim Lyerly, Michael A. Morse
Journal: Clinical Cancer Research
Clin Cancer Res (2001) 7 (5): 1127–1135.
Published: 01 May 2001
View article titled, Assays for Monitoring Cellular Immune Responses to Active Immunotherapy of Cancer
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Journal Articles

A Phase I Study of Active Immunotherapy with Carcinoembryonic Antigen Peptide (CAP-1)-pulsed, Autologous Human Cultured Dendritic Cells in Patients with Metastatic Malignancies Expressing Carcinoembryonic Antigen

Michael A. Morse, Yuping Deng, Doris Coleman, Shelley Hull, Eva Kitrell-Fisher, Smita Nair, Jeffrey Schlom, Mary-Ellen Ryback, H. Kim Lyerly
Journal: Clinical Cancer Research
Clin Cancer Res (1999) 5 (6): 1331–1338.
Published: 01 June 1999
View article titled, A Phase I Study of Active Immunotherapy with Carcinoembryonic Antigen Peptide (CAP-1)-pulsed, Autologous Human Cultured Dendritic Cells in Patients with Metastatic Malignancies Expressing Carcinoembryonic Antigen
Open the PDF for A Phase I Study of Active Immunotherapy with Carcinoembryonic Antigen Peptide (CAP-1)-pulsed, Autologous Human Cultured Dendritic Cells in Patients with Metastatic Malignancies Expressing Carcinoembryonic Antigen in another window