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Journal Articles

­­­­­Targeting Acetyl-CoA Carboxylase Suppresses De Novo Lipogenesis and Tumor Cell Growth in Multiple Myeloma

Eugenio Morelli, Caroline Fidalgo. Ribeiro, Silvia D. Rodrigues, Claire Gao, Fabio Socciarelli, Domenico Maisano, Vanessa Favasuli, Na Liu, Katia Todoerti, Chandraditya Chakraborty, Yao Yao, Mariateresa Fulciniti, Mehmet Samur, Anil Aktas-Samur, Nicola Amodio, Marcello Turi, Francesca Barello, Johany Penailillo, Cesarina Giallongo, Alessandra Romano, Annamaria Gulla, Kenneth C. Anderson, Giorgio Inghirami, Nikhil C. Munshi, Massimo Loda
Journal: Clinical Cancer Research
Clin Cancer Res (2025)
https://doi.org/10.1158/1078-0432.CCR-24-2000
Published: 07 March 2025
View article titled, ­­­­­Targeting Acetyl-CoA Carboxylase Suppresses <em>De Novo</em> Lipogenesis and Tumor Cell Growth in Multiple Myeloma
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Includes: Supplementary data
Journal Articles

Framework for the Pathology Workup of Metastatic Castration-Resistant Prostate Cancer Biopsies

Michael C. Haffner, Michael J. Morris, Chien-Kuang C. Ding, Erolcan Sayar, Rohit Mehra, Brian Robinson, Lawrence D. True, Martin Gleave, Tamara L. Lotan, Rahul Aggarwal, Jiaoti Huang, Massimo Loda, Peter S. Nelson, Mark A. Rubin, Himisha Beltran
Journal: Clinical Cancer Research
Clin Cancer Res (2025) 31 (3): 466–478.
https://doi.org/10.1158/1078-0432.CCR-24-2061
Published: 03 February 2025
View article titled, Framework for the Pathology Workup of Metastatic Castration-Resistant Prostate Cancer Biopsies
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Includes: Supplementary data
Journal Articles

Suppression of Tumor Cell Lactate-generating Signaling Pathways Eradicates Murine PTEN/p53-deficient Aggressive-variant Prostate Cancer via Macrophage Phagocytosis

Kiranj Chaudagar, Hanna M. Hieromnimon, Anne Kelley, Brian Labadie, Jordan Shafran, Srikrishnan Rameshbabu, Catherine Drovetsky, Kaela Bynoe, Ani Solanki, Erica Markiewicz, Xiaobing Fan, Massimo Loda, Akash Patnaik
Journal: Clinical Cancer Research
Clin Cancer Res (2023) 29 (23): 4930–4940.
https://doi.org/10.1158/1078-0432.CCR-23-1441
Published: 01 December 2023
View article titled, Suppression of Tumor Cell Lactate-generating Signaling Pathways Eradicates Murine PTEN/p53-deficient Aggressive-variant Prostate Cancer via Macrophage Phagocytosis
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Includes: Supplementary data
Journal Articles

SPOP Mutations Target STING1 Signaling in Prostate Cancer and Create Therapeutic Vulnerabilities to PARP Inhibitor–Induced Growth Suppression

Chuandong Geng, Man-Chao Zhang, Ganiraju C. Manyam, Jody V. Vykoukal, Johannes F. Fahrmann, Shan Peng, Cheng Wu, Sanghee Park, Shakuntala Kondraganti, Daoqi Wang, Brian D. Robinson, Massimo Loda, Christopher E. Barbieri, Timothy A. Yap, Paul G. Corn, Samir Hanash, Bradley M. Broom, Patrick G. Pilié, Timothy C. Thompson
Journal: Clinical Cancer Research
Clin Cancer Res (2023) 29 (21): 4464–4478.
https://doi.org/10.1158/1078-0432.CCR-23-1439
Published: 01 November 2023
View article titled, SPOP Mutations Target STING1 Signaling in Prostate Cancer and Create Therapeutic Vulnerabilities to PARP Inhibitor–Induced Growth Suppression
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Includes: Supplementary data
Journal Articles

The AACR Journals: Advancing Progress Toward the AACR's 115-Year Mission

Kenneth C. Anderson, Lewis C. Cantley, Riccardo Dalla-Favera, Chi Van Dang, Luis A. Diaz, Raymond N. DuBois, Keith T. Flaherty, Philip D. Greenberg, Massimo Loda, Elaine R. Mardis, Elizabeth A. Platz, Michael N. Pollak, Robert D. Schreiber, Lillian L. Siu, Beverly A. Teicher
Journal: Clinical Cancer Research
Clin Cancer Res (2022) 28 (21): 4593–4599.
https://doi.org/10.1158/1078-0432.CCR-22-3167
Published: 01 November 2022
View article titled, The AACR Journals: Advancing Progress Toward the AACR's 115-Year Mission
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Journal Articles

Pathology: Hub and Integrator of Modern, Multidisciplinary [Precision] Oncology

The AACR Pathology Task Force, Carolyn C. Compton, Angelo M. De Marzo, Jayanta Debnath, Keith D. Eaton, Kojo Elenitoba-Johnson, Michelangelo Fiorentino, Christopher A. French, Thomas J. Fuchs, Felice Giangaspero, Jiaoti Huang, A. John Iafrate, Michael M. Ittmann, Roy A. Jensen, Annette S. Kim, Massimo Loda, Robin G. Lorenz, Tamara L. Lotan, Anirban Maitra, Gerrit A. Meijer, Richard N. Mitchell, Anil V. Parwani, Francesco Pezzella, Eli Pikarsky, Jorge S. Reis-Filho, Andrea L. Richardson, Mark A. Rubin, Lawrence D. True
Journal: Clinical Cancer Research
Clin Cancer Res (2022) 28 (2): 265–270.
https://doi.org/10.1158/1078-0432.CCR-21-1206
Published: 19 January 2022
View article titled, Pathology: Hub and Integrator of Modern, Multidisciplinary [Precision] Oncology
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Journal Articles

Multiplex Immunofluorescence in Formalin-Fixed Paraffin-Embedded Tumor Tissue to Identify Single-Cell–Level PI3K Pathway Activation

Konrad H. Stopsack, Ying Huang, Svitlana Tyekucheva, Travis A. Gerke, Clyde Bango, Habiba Elfandy, Michaela Bowden, Kathryn L. Penney, Thomas M. Roberts, Giovanni Parmigiani, Philip W. Kantoff, Lorelei A. Mucci, Massimo Loda
Journal: Clinical Cancer Research
Clin Cancer Res (2020) 26 (22): 5903–5913.
https://doi.org/10.1158/1078-0432.CCR-20-2000
Published: 13 November 2020
View article titled, Multiplex Immunofluorescence in Formalin-Fixed Paraffin-Embedded Tumor Tissue to Identify Single-Cell–Level PI3K Pathway Activation
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Includes: Supplementary data
Journal Articles

Statin Use Is Associated with Lower Risk of PTEN-Null and Lethal Prostate Cancer

Emma H. Allott, Ericka M. Ebot, Konrad H. Stopsack, Amparo G. Gonzalez-Feliciano, Sarah C. Markt, Kathryn M. Wilson, Thomas U. Ahearn, Travis A. Gerke, Mary K. Downer, Jennifer R. Rider, Stephen J. Freedland, Tamara L. Lotan, Philip W. Kantoff, Elizabeth A. Platz, Massimo Loda, Meir J. Stampfer, Edward Giovannucci, Christopher J. Sweeney, Stephen P. Finn, Lorelei A. Mucci
Journal: Clinical Cancer Research
Clin Cancer Res (2020) 26 (5): 1086–1093.
https://doi.org/10.1158/1078-0432.CCR-19-2853
Published: 02 March 2020
View article titled, Statin Use Is Associated with Lower Risk of PTEN-Null and Lethal Prostate Cancer
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Includes: Supplementary data
Journal Articles

The Role of Lineage Plasticity in Prostate Cancer Therapy Resistance

Himisha Beltran, Andrew Hruszkewycz, Howard I. Scher, Jeffrey Hildesheim, Jennifer Isaacs, Evan Y. Yu, Kathleen Kelly, Daniel Lin, Adam Dicker, Julia Arnold, Toby Hecht, Max Wicha, Rosalie Sears, David Rowley, Richard White, James L. Gulley, John Lee, Maria Diaz Meco, Eric J. Small, Michael Shen, Karen Knudsen, David W. Goodrich, Tamara Lotan, Amina Zoubeidi, Charles L. Sawyers, Charles M. Rudin, Massimo Loda, Timothy Thompson, Mark A. Rubin, Abdul Tawab-Amiri, William Dahut, Peter S. Nelson
Journal: Clinical Cancer Research
Clin Cancer Res (2019) 25 (23): 6916–6924.
https://doi.org/10.1158/1078-0432.CCR-19-1423
Published: 02 December 2019
View article titled, The Role of Lineage Plasticity in Prostate Cancer Therapy Resistance
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Includes: Supplementary data
Journal Articles

Expression of PD-L1 in Hormone-naïve and Treated Prostate Cancer Patients Receiving Neoadjuvant Abiraterone Acetate plus Prednisone and Leuprolide

Carla Calagua, Joshua Russo, Yue Sun, Rachel Schaefer, Rosina Lis, Zhenwei Zhang, Kathleen Mahoney, Glenn J. Bubley, Massimo Loda, Mary-Ellen Taplin, Steven P. Balk, Huihui Ye
Journal: Clinical Cancer Research
Clin Cancer Res (2017) 23 (22): 6812–6822.
https://doi.org/10.1158/1078-0432.CCR-17-0807
Published: 14 November 2017
View article titled, Expression of PD-L1 in Hormone-naïve and Treated Prostate Cancer Patients Receiving Neoadjuvant Abiraterone Acetate plus Prednisone and Leuprolide
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Includes: Supplementary data
Journal Articles

Association of Tissue Abiraterone Levels and SLCO Genotype with Intraprostatic Steroids and Pathologic Response in Men with High-Risk Localized Prostate Cancer

Elahe A. Mostaghel, Eunpi Cho, Ailin Zhang, Mohammad Alyamani, Arja Kaipainen, Sean Green, Brett T. Marck, Nima Sharifi, Jonathan L. Wright, Roman Gulati, Lawrence D. True, Massimo Loda, Alvin M. Matsumoto, Daniel Tamae, Trevor N. Penning, Steven P. Balk, Phillip W. Kantoff, Peter S. Nelson, Mary-Ellen Taplin, R. Bruce Montgomery
Journal: Clinical Cancer Research
Clin Cancer Res (2017) 23 (16): 4592–4601.
https://doi.org/10.1158/1078-0432.CCR-16-2245
Published: 14 August 2017
View article titled, Association of Tissue Abiraterone Levels and <em>SLCO</em> Genotype with Intraprostatic Steroids and Pathologic Response in Men with High-Risk Localized Prostate Cancer
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Includes: Supplementary data
Journal Articles

Prognostic Utility of a New mRNA Expression Signature of Gleason Score

Jennifer A. Sinnott, Sam F. Peisch, Svitlana Tyekucheva, Travis Gerke, Rosina Lis, Jennifer R. Rider, Michelangelo Fiorentino, Meir J. Stampfer, Lorelei A. Mucci, Massimo Loda, Kathryn L. Penney
Journal: Clinical Cancer Research
Clin Cancer Res (2017) 23 (1): 81–87.
https://doi.org/10.1158/1078-0432.CCR-16-1245
Published: 02 January 2017
View article titled, Prognostic Utility of a New mRNA Expression Signature of Gleason Score
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Includes: Supplementary data
Journal Articles

Stress-Related Signaling Pathways in Lethal and Nonlethal Prostate Cancer

Donghao Lu, Jennifer A. Sinnott, Unnur Valdimarsdóttir, Fang Fang, Travis Gerke, Svitlana Tyekucheva, Michelangelo Fiorentino, Mats Lambe, Howard D. Sesso, Christopher J. Sweeney, Kathryn M. Wilson, Edward L. Giovannucci, Massimo Loda, Lorelei A. Mucci, Katja Fall
Journal: Clinical Cancer Research
Clin Cancer Res (2016) 22 (3): 765–772.
https://doi.org/10.1158/1078-0432.CCR-15-0101
Published: 31 January 2016
View article titled, Stress-Related Signaling Pathways in Lethal and Nonlethal Prostate Cancer
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Includes: Supplementary data
Journal Articles

A Phase I/II Study for Analytic Validation of 89Zr-J591 ImmunoPET as a Molecular Imaging Agent for Metastatic Prostate Cancer

Neeta Pandit-Taskar, Joseph A. O'Donoghue, Jeremy C. Durack, Serge K. Lyashchenko, Sarah M. Cheal, Volkan Beylergil, Robert A. Lefkowitz, Jorge A. Carrasquillo, Danny F. Martinez, Alex Mak Fung, Stephen B. Solomon, Mithat Gönen, Glenn Heller, Massimo Loda, David M. Nanus, Scott T. Tagawa, Jarett L. Feldman, Joseph R. Osborne, Jason S. Lewis, Victor E. Reuter, Wolfgang A. Weber, Neil H. Bander, Howard I. Scher, Steven M. Larson, Michael J. Morris
Journal: Clinical Cancer Research
Clin Cancer Res (2015) 21 (23): 5277–5285.
https://doi.org/10.1158/1078-0432.CCR-15-0552
Published: 30 November 2015
View article titled, A Phase I/II Study for Analytic Validation of <sup>89</sup>Zr-J591 ImmunoPET as a Molecular Imaging Agent for Metastatic Prostate Cancer
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Includes: Supplementary data
Journal Articles

Development and Clinical Validation of an In Situ Biopsy-Based Multimarker Assay for Risk Stratification in Prostate Cancer

Peter Blume-Jensen, David M. Berman, David L. Rimm, Michail Shipitsin, Mathew Putzi, Thomas P. Nifong, Clayton Small, Sibgat Choudhury, Teresa Capela, Louis Coupal, Christina Ernst, Aeron Hurley, Alex Kaprelyants, Hua Chang, Eldar Giladi, Julie Nardone, James Dunyak, Massimo Loda, Eric A. Klein, Cristina Magi-Galluzzi, Mathieu Latour, Jonathan I. Epstein, Philip Kantoff, Fred Saad
Journal: Clinical Cancer Research
Series: Author Choice
Clin Cancer Res (2015) 21 (11): 2591–2600.
https://doi.org/10.1158/1078-0432.CCR-14-2603
Published: 31 May 2015
View article titled, Development and Clinical Validation of an <em>In Situ</em> Biopsy-Based Multimarker Assay for Risk Stratification in Prostate Cancer
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Includes: Supplementary data
Journal Articles

Abiraterone Treatment in Castration-Resistant Prostate Cancer Selects for Progesterone Responsive Mutant Androgen Receptors

Eddy J. Chen, Adam G. Sowalsky, Shuai Gao, Changmeng Cai, Olga Voznesensky, Rachel Schaefer, Massimo Loda, Lawrence D. True, Huihui Ye, Patricia Troncoso, Rosina L. Lis, Philip W. Kantoff, Robert B. Montgomery, Peter S. Nelson, Glenn J. Bubley, Steven P. Balk, Mary-Ellen Taplin
Journal: Clinical Cancer Research
Clin Cancer Res (2015) 21 (6): 1273–1280.
https://doi.org/10.1158/1078-0432.CCR-14-1220
Published: 12 March 2015
View article titled, Abiraterone Treatment in Castration-Resistant Prostate Cancer Selects for Progesterone Responsive Mutant Androgen Receptors
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Includes: Supplementary data
Journal Articles

Combined MEK and PI3K Inhibition in a Mouse Model of Pancreatic Cancer

Brinda Alagesan, Gianmarco Contino, Alexander R. Guimaraes, Ryan B. Corcoran, Vikram Deshpande, Gregory R. Wojtkiewicz, Aram F. Hezel, Kwok-Kin Wong, Massimo Loda, Ralph Weissleder, Cyril Benes, Jeffrey A. Engelman, Nabeel Bardeesy
Journal: Clinical Cancer Research
Clin Cancer Res (2015) 21 (2): 396–404.
https://doi.org/10.1158/1078-0432.CCR-14-1591
Published: 14 January 2015
View article titled, Combined MEK and PI3K Inhibition in a Mouse Model of Pancreatic Cancer
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Includes: Supplementary data
Journal Articles

SPINK1 Protein Expression and Prostate Cancer Progression

Richard Flavin, Andreas Pettersson, Whitney K. Hendrickson, Michelangelo Fiorentino, Stephen Finn, Lauren Kunz, Gregory L. Judson, Rosina Lis, Dyane Bailey, Christopher Fiore, Elizabeth Nuttall, Neil E. Martin, Edward Stack, Kathryn L. Penney, Jennifer R. Rider, Jennifer Sinnott, Christopher Sweeney, Howard D. Sesso, Katja Fall, Edward Giovannucci, Philip Kantoff, Meir Stampfer, Massimo Loda, Lorelei A. Mucci
Journal: Clinical Cancer Research
Clin Cancer Res (2014) 20 (18): 4904–4911.
https://doi.org/10.1158/1078-0432.CCR-13-1341
Published: 14 September 2014
View article titled, SPINK1 Protein Expression and Prostate Cancer Progression
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Journal Articles

High-throughput oncogene mutation detection in human cancers by mass spectrometry-based genotyping

Roman K. Thomas, Alissa C. Baker, Ralph DeBiasi, Whei Feng, Thomas LaFramboise, Meng Wang, Jeffrey C. Lee, Richard Nicoletti, Charles Hatton, Liuda Ziagra, Stacey B. Gabriel, Caroline M. Emery, Heidi Greulich, Mark A. Rubin, Massimo Loda, Jonathan Fletcher, Fred J. Kaye, Kenneth C. Anderson, George D. Demetri, Reinhard Dummer, Stephan N. Wagner, Meenhard Herlyn, William R. Sellers, Matthew L. Meyerson, Levi A. Garraway
Journal: Clinical Cancer Research
Clin Cancer Res (2006) 12 (19_Supplement): A106.
Published: 15 August 2014
View article titled, High-throughput oncogene mutation detection in human cancers by mass spectrometry-based genotyping
Journal Articles

Integrative Analysis of 1q23.3 Copy-Number Gain in Metastatic Urothelial Carcinoma

Markus Riester, Lillian Werner, Joaquim Bellmunt, Shamini Selvarajah, Elizabeth A. Guancial, Barbara A. Weir, Edward C. Stack, Rachel S. Park, Robert O'Brien, Fabio A.B. Schutz, Toni K. Choueiri, Sabina Signoretti, Josep Lloreta, Luigi Marchionni, Enrique Gallardo, Federico Rojo, Denise I. Garcia, Yvonne Chekaluk, David J. Kwiatkowski, Bernard H. Bochner, William C. Hahn, Azra H. Ligon, Justine A. Barletta, Massimo Loda, David M. Berman, Philip W. Kantoff, Franziska Michor, Jonathan E. Rosenberg
Journal: Clinical Cancer Research
Clin Cancer Res (2014) 20 (7): 1873–1883.
https://doi.org/10.1158/1078-0432.CCR-13-0759
Published: 31 March 2014
View article titled, Integrative Analysis of 1q23.3 Copy-Number Gain in Metastatic Urothelial Carcinoma
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Includes: Supplementary data