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Massimo Cristofanilli
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Journal Articles

Genetic Alterations Detected by Circulating Tumor DNA in HER2-Low Metastatic Breast Cancer

Whitney L. Hensing, Lorenzo Gerratana, Katherine Clifton, Arielle J. Medford, Marko Velimirovic, Ami N. Shah, Paolo D'Amico, Carolina Reduzzi, Qiang Zhang, Charles S. Dai, Elyssa N. Denault, Nusayba A. Bagegni, Mateusz Opyrchal, Foluso O. Ademuyiwa, Ron Bose, Amir Behdad, Cynthia X. Ma, Aditya Bardia, Massimo Cristofanilli, Andrew A. Davis
Journal: Clinical Cancer Research
Clin Cancer Res (2023) 29 (16): 3092–3100.
https://doi.org/10.1158/1078-0432.CCR-22-3785
Published: 15 August 2023
View article titled, Genetic Alterations Detected by Circulating Tumor DNA in HER2-Low Metastatic Breast Cancer
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Includes: Supplementary data
Journal Articles

Overall Survival with Palbociclib and Fulvestrant in Women with HR+/HER2− ABC: Updated Exploratory Analyses of PALOMA-3, a Double-blind, Phase III Randomized Study

Massimo Cristofanilli, Hope S. Rugo, Seock-Ah Im, Dennis J. Slamon, Nadia Harbeck, Igor Bondarenko, Norikazu Masuda, Marco Colleoni, Angela DeMichele, Sherene Loi, Hiroji Iwata, Ben O'Leary, Fabrice André, Sibylle Loibl, Eustratios Bananis, Yuan Liu, Xin Huang, Sindy Kim, Maria Jose Lechuga Frean, Nicholas C. Turner
Journal: Clinical Cancer Research
Clin Cancer Res (2022) 28 (16): 3433–3442.
https://doi.org/10.1158/1078-0432.CCR-22-0305
Published: 15 August 2022
View article titled, Overall Survival with Palbociclib and Fulvestrant in Women with HR<sup>+</sup>/HER2<sup>−</sup> ABC: Updated Exploratory Analyses of PALOMA-3, a Double-blind, Phase III Randomized Study
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Includes: Supplementary data
Journal Articles

The Use of Serial Circulating Tumor DNA to Detect Resistance Alterations in Progressive Metastatic Breast Cancer

Saya Jacob, Andrew A. Davis, Lorenzo Gerratana, Marko Velimirovic, Ami N. Shah, Firas Wehbe, Neelima Katam, Qiang Zhang, Lisa Flaum, Kalliopi P. Siziopikou, Leonidas C. Platanias, William J. Gradishar, Amir Behdad, Aditya Bardia, Massimo Cristofanilli
Journal: Clinical Cancer Research
Series: Author Choice
Clin Cancer Res (2021) 27 (5): 1361–1370.
https://doi.org/10.1158/1078-0432.CCR-20-1566
Published: 01 March 2021
View article titled, The Use of Serial Circulating Tumor DNA to Detect Resistance Alterations in Progressive Metastatic Breast Cancer
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Includes: Supplementary data
Journal Articles

Abstract B42: Identification of molecular drivers in circulating tumor cell cluster formation and lung metastasis

Rokana Taftaf, Xia Liu, Salendra Singh, Yuzhi Jia, David Scholten, Massimo Cristofanilli, William A. Muller, Vinay Varadan, Huiping Liu
Journal: Clinical Cancer Research
Clin Cancer Res (2020) 26 (11_Supplement): B42.
https://doi.org/10.1158/1557-3265.LiqBiop20-B42
Published: 01 June 2020
View article titled, Abstract B42: Identification of molecular drivers in circulating tumor cell cluster formation and lung metastasis
Journal Articles

Routine Plasma-Based Genotyping to Comprehensively Detect Germline, Somatic, and Reversion BRCA Mutations among Patients with Advanced Solid Tumors

Neelima Vidula, Thereasa A. Rich, Oliver Sartor, Jennifer Yen, Aaron Hardin, Tracy Nance, Michael B. Lilly, Mohammad Amin Nezami, Sandip P. Patel, Benedito A. Carneiro, Alice C. Fan, Adam M. Brufsky, Barbara A. Parker, Benjamin B. Bridges, Neeraj Agarwal, Benjamin L. Maughan, Victoria M. Raymond, Stephen R. Fairclough, Richard B. Lanman, Aditya Bardia, Massimo Cristofanilli
Journal: Clinical Cancer Research
Clin Cancer Res (2020) 26 (11): 2546–2555.
https://doi.org/10.1158/1078-0432.CCR-19-2933
Published: 01 June 2020
View article titled, Routine Plasma-Based Genotyping to Comprehensively Detect Germline, Somatic, and Reversion <em>BRCA</em> Mutations among Patients with Advanced Solid Tumors
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Includes: Supplementary data
Journal Articles

Combined Blockade of Activating ERBB2 Mutations and ER Results in Synthetic Lethality of ER+/HER2 Mutant Breast Cancer

Sarah Croessmann, Luigi Formisano, Lisa N. Kinch, Paula I. Gonzalez-Ericsson, Dhivya R. Sudhan, Rebecca J. Nagy, Aju Mathew, Eric H. Bernicker, Massimo Cristofanilli, Jie He, Richard E. Cutler, Jr, Alshad S. Lalani, Vincent A. Miller, Richard B. Lanman, Nick V. Grishin, Carlos L. Arteaga
Journal: Clinical Cancer Research
Clin Cancer Res (2019) 25 (1): 277–289.
https://doi.org/10.1158/1078-0432.CCR-18-1544
Published: 03 January 2019
View article titled, Combined Blockade of Activating <em>ERBB2</em> Mutations and ER Results in Synthetic Lethality of ER+/HER2 Mutant Breast Cancer
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Includes: Supplementary data
Journal Articles

Anaplastic Lymphoma Kinase Mutation (ALK F1174C) in Small Cell Carcinoma of the Prostate and Molecular Response to Alectinib

Benedito A. Carneiro, Sahithi Pamarthy, Ami N. Shah, Vinay Sagar, Kenji Unno, HuiYing Han, Ximing J. Yang, Rubens B. Costa, Rebecca J. Nagy, Richard B. Lanman, Timothy M. Kuzel, Jeffrey S. Ross, Laurie Gay, Julia A. Elvin, Siraj M. Ali, Massimo Cristofanilli, Young K. Chae, Francis J. Giles, Sarki A. Abdulkadir
Journal: Clinical Cancer Research
Clin Cancer Res (2018) 24 (12): 2732–2739.
https://doi.org/10.1158/1078-0432.CCR-18-0332
Published: 14 June 2018
View article titled, Anaplastic Lymphoma Kinase Mutation (<em>ALK</em> F1174C) in Small Cell Carcinoma of the Prostate and Molecular Response to Alectinib
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Includes: Supplementary data
Journal Articles

Cell-Free DNA and Circulating Tumor Cells: Comprehensive Liquid Biopsy Analysis in Advanced Breast Cancer

Giovanna Rossi, Zhaomei Mu, Alfred W. Rademaker, Laura K. Austin, Kimberly S. Strickland, Ricardo Lima Barros Costa, Rebecca J. Nagy, Vittorina Zagonel, Timothy J. Taxter, Amir Behdad, Firas H. Wehbe, Leonidas C. Platanias, William J. Gradishar, Massimo Cristofanilli
Journal: Clinical Cancer Research
Series: Author Choice
Clin Cancer Res (2018) 24 (3): 560–568.
https://doi.org/10.1158/1078-0432.CCR-17-2092
Published: 31 January 2018
View article titled, Cell-Free DNA and Circulating Tumor Cells: Comprehensive Liquid Biopsy Analysis in Advanced Breast Cancer
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Includes: Supplementary data
Journal Articles

Detection of Activating Estrogen Receptor Gene (ESR1) Mutations in Single Circulating Tumor Cells

Carmela Paolillo, Zhaomei Mu, Giovanna Rossi, Matthew J. Schiewer, Thomas Nguyen, Laura Austin, Ettore Capoluongo, Karen Knudsen, Massimo Cristofanilli, Paolo Fortina
Journal: Clinical Cancer Research
Clin Cancer Res (2017) 23 (20): 6086–6093.
https://doi.org/10.1158/1078-0432.CCR-17-1173
Published: 12 October 2017
View article titled, Detection of Activating Estrogen Receptor Gene (<em>ESR1</em>) Mutations in Single Circulating Tumor Cells
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Includes: Supplementary data
Journal Articles

Phase Ib Pilot Study to Evaluate Reparixin in Combination with Weekly Paclitaxel in Patients with HER-2–Negative Metastatic Breast Cancer

Anne F. Schott, Lori J. Goldstein, Massimo Cristofanilli, Pier Adelchi Ruffini, Susan McCanna, James M. Reuben, Raymond P. Perez, Giraldo Kato, Max Wicha
Journal: Clinical Cancer Research
Clin Cancer Res (2017) 23 (18): 5358–5365.
https://doi.org/10.1158/1078-0432.CCR-16-2748
Published: 14 September 2017
View article titled, Phase Ib Pilot Study to Evaluate Reparixin in Combination with Weekly Paclitaxel in Patients with HER-2–Negative Metastatic Breast Cancer
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Includes: Supplementary data
Journal Articles

Enrichment of PI3K-AKT–mTOR Pathway Activation in Hepatic Metastases from Breast Cancer

Mariaelena Pierobon, Corinne Ramos, Shukmei Wong, K. Alex Hodge, Jessica Aldrich, Sara Byron, Stephen P. Anthony, Nicholas J. Robert, Donald W. Northfelt, Mohammad Jahanzeb, Linda Vocila, Julia Wulfkuhle, Guido Gambara, Rosa I. Gallagher, Bryant Dunetz, Nicholas Hoke, Ting Dong, David W. Craig, Massimo Cristofanilli, Brian Leyland-Jones, Lance A. Liotta, Joyce A. O'Shaughnessy, John D. Carpten, Emanuel F. Petricoin
Journal: Clinical Cancer Research
Clin Cancer Res (2017) 23 (16): 4919–4928.
https://doi.org/10.1158/1078-0432.CCR-16-2656
Published: 14 August 2017
View article titled, Enrichment of PI3K-AKT–mTOR Pathway Activation in Hepatic Metastases from Breast Cancer
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Includes: Supplementary data
Journal Articles

Comparison of circulating tumor cells (CTCs) in metastatic breast cancer (MBC): AdnaTest breast cancer for detection and biological characterization

Eleni Andreopoulou, Diana Urbauer, Savitri Krishnamurthy, James Reuben, Vicente Valero, Massimo Cristofanilli, Herbert Fritsche
Journal: Clinical Cancer Research
Clin Cancer Res (2008) 14 (19_Supplement): A6.
Published: 15 August 2014
View article titled, Comparison of circulating tumor cells (CTCs) in metastatic breast cancer (MBC): <em>AdnaTest breast cancer </em>for detection and biological characterization
Journal Articles

Emergence of Constitutively Active Estrogen Receptor-α Mutations in Pretreated Advanced Estrogen Receptor–Positive Breast Cancer

Rinath Jeselsohn, Roman Yelensky, Gilles Buchwalter, Garrett Frampton, Funda Meric-Bernstam, Ana Maria Gonzalez-Angulo, Jaime Ferrer-Lozano, Jose A. Perez-Fidalgo, Massimo Cristofanilli, Henry Gómez, Carlos L. Arteaga, Jennifer Giltnane, Justin M. Balko, Maureen T. Cronin, Mirna Jarosz, James Sun, Matthew Hawryluk, Doron Lipson, Geoff Otto, Jeffrey S. Ross, Addie Dvir, Lior Soussan-Gutman, Ido Wolf, Tamar Rubinek, Lauren Gilmore, Stuart Schnitt, Steven E. Come, Lajos Pusztai, Philip Stephens, Myles Brown, Vincent A. Miller
Journal: Clinical Cancer Research
Series: Author Choice
Clin Cancer Res (2014) 20 (7): 1757–1767.
https://doi.org/10.1158/1078-0432.CCR-13-2332
Published: 31 March 2014
View article titled, Emergence of Constitutively Active Estrogen Receptor-α Mutations in Pretreated Advanced Estrogen Receptor–Positive Breast Cancer
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Includes: Supplementary data
Journal Articles

Uncovering the Molecular Secrets of Inflammatory Breast Cancer Biology: An Integrated Analysis of Three Distinct Affymetrix Gene Expression Datasets

Steven J. Van Laere, Naoto T. Ueno, Pascal Finetti, Peter Vermeulen, Anthony Lucci, Fredika M. Robertson, Melike Marsan, Takayuki Iwamoto, Savitri Krishnamurthy, Hiroko Masuda, Peter van Dam, Wendy A. Woodward, Patrice Viens, Massimo Cristofanilli, Daniel Birnbaum, Luc Dirix, James M. Reuben, François Bertucci
Journal: Clinical Cancer Research
Clin Cancer Res (2013) 19 (17): 4685–4696.
https://doi.org/10.1158/1078-0432.CCR-12-2549
Published: 02 September 2013
View article titled, Uncovering the Molecular Secrets of Inflammatory Breast Cancer Biology: An Integrated Analysis of Three Distinct Affymetrix Gene Expression Datasets
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Includes: Supplementary data
Journal Articles

Establishment and Validation of Circulating Tumor Cell–Based Prognostic Nomograms in First-Line Metastatic Breast Cancer Patients

Antonio Giordano, Brian L. Egleston, David Hajage, Joseph Bland, Gabriel N. Hortobagyi, James M. Reuben, Jean-Yves Pierga, Massimo Cristofanilli, Francois-Clement Bidard
Journal: Clinical Cancer Research
Clin Cancer Res (2013) 19 (6): 1596–1602.
https://doi.org/10.1158/1078-0432.CCR-12-3137
Published: 14 March 2013
View article titled, Establishment and Validation of Circulating Tumor Cell–Based Prognostic Nomograms in First-Line Metastatic Breast Cancer Patients
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Includes: Supplementary data
Journal Articles

Phase II, Randomized Trial to Compare Anastrozole Combined with Gefitinib or Placebo in Postmenopausal Women with Hormone Receptor–Positive Metastatic Breast Cancer

Massimo Cristofanilli, Vicente Valero, Aroop Mangalik, Melanie Royce, Ian Rabinowitz, Francis P. Arena, Joan F. Kroener, Elizabeth Curcio, Claire Watkins, Sarah Bacus, Elsa M. Cora, Elizabeth Anderson, Patrick J. Magill
Journal: Clinical Cancer Research
Clin Cancer Res (2010) 16 (6): 1904–1914.
https://doi.org/10.1158/1078-0432.CCR-09-2282
Published: 14 March 2010
View article titled, Phase II, Randomized Trial to Compare Anastrozole Combined with Gefitinib or Placebo in Postmenopausal Women with Hormone Receptor–Positive Metastatic Breast Cancer
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Includes: Supplementary data
Journal Articles

Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor Reverses Mesenchymal to Epithelial Phenotype and Inhibits Metastasis in Inflammatory Breast Cancer

Dongwei Zhang, Tiffany A. LaFortune, Savitri Krishnamurthy, Francisco J. Esteva, Massimo Cristofanilli, Ping Liu, Anthony Lucci, Balraj Singh, Mien-Chie Hung, Gabriel N. Hortobagyi, Naoto T. Ueno
Journal: Clinical Cancer Research
Clin Cancer Res (2009) 15 (21): 6639–6648.
https://doi.org/10.1158/1078-0432.CCR-09-0951
Published: 02 November 2009
View article titled, Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor Reverses Mesenchymal to Epithelial Phenotype and Inhibits Metastasis in Inflammatory Breast Cancer
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Includes: Supplementary data
Journal Articles

Phase I/II Study of G3139 (Bcl-2 Antisense Oligonucleotide) in Combination with Doxorubicin and Docetaxel in Breast Cancer

Stacy L. Moulder, W. Fraser Symmans, Daniel J. Booser, Timothy L. Madden, Cindy Lipsanen, Linda Yuan, Abenaa M. Brewster, Massimo Cristofanilli, Kelly K. Hunt, Thomas A. Buchholz, James Zwiebel, Vicente Valero, Gabriel N. Hortobagyi, Francisco J. Esteva
Journal: Clinical Cancer Research
Clin Cancer Res (2008) 14 (23): 7909–7916.
https://doi.org/10.1158/1078-0432.CCR-08-1104
Published: 01 December 2008
View article titled, Phase I/II Study of G3139 (Bcl-2 Antisense Oligonucleotide) in Combination with Doxorubicin and Docetaxel in Breast Cancer
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Journal Articles

Prognostic Value of Body Mass Index in Locally Advanced Breast Cancer

Shaheenah Dawood, Kristine Broglio, Ana M. Gonzalez-Angulo, Shu-Wan Kau, Rabiul Islam, Gabriel N. Hortobagyi, Massimo Cristofanilli
Journal: Clinical Cancer Research
Clin Cancer Res (2008) 14 (6): 1718–1725.
https://doi.org/10.1158/1078-0432.CCR-07-1479
Published: 17 March 2008
View article titled, Prognostic Value of Body Mass Index in Locally Advanced Breast Cancer
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Journal Articles

Detection of Circulating Tumor Cells in Peripheral Blood of Patients with Metastatic Breast Cancer: A Validation Study of the CellSearch System

Sabine Riethdorf, Herbert Fritsche, Volkmar Müller, Thomas Rau, Christian Schindlbeck, Brigitte Rack, Wolfgang Janni, Cornelia Coith, Katrin Beck, Fritz Jänicke, Summer Jackson, Terrie Gornet, Massimo Cristofanilli, Klaus Pantel
Journal: Clinical Cancer Research
Clin Cancer Res (2007) 13 (3): 920–928.
https://doi.org/10.1158/1078-0432.CCR-06-1695
Published: 08 February 2007
View article titled, Detection of Circulating Tumor Cells in Peripheral Blood of Patients with Metastatic Breast Cancer: A Validation Study of the CellSearch System
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