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Mary-Ellen Taplin
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Journal Articles

Identification and Management of Pathogenic Variants in BRCA1, BRCA2, and PALB2 in a Tumor-Only Genomic Testing Program

Brittany L. Bychkovsky, Tianyu Li, Jilliane Sotelo, Nabihah Tayob, Joanna Mercado, Israel Gomy, Anu Chittenden, Sarah Kane, Samantha Stokes, Melissa E. Hughes, Ji Seok Kim, Renato Umeton, Mark M. Awad, Panagiotis A. Konstantinopoulos, Matthew B. Yurgelun, Brian M. Wolpin, Mary-Ellen Taplin, Randall E. Newmark, Bruce E. Johnson, Neal I. Lindeman, Laura E. MacConaill, Judy E. Garber, Nancy U. Lin
Journal: Clinical Cancer Research
Clin Cancer Res (2022) 28 (11): 2349–2360.
https://doi.org/10.1158/1078-0432.CCR-21-2861
Published: 01 June 2022
View article titled, Identification and Management of Pathogenic Variants in <em>BRCA1</em>, <em>BRCA2</em>, and <em>PALB2</em> in a Tumor-Only Genomic Testing Program
Open the PDF for Identification and Management of Pathogenic Variants in <em>BRCA1</em>, <em>BRCA2</em>, and <em>PALB2</em> in a Tumor-Only Genomic Testing Program in another window
Includes: Supplementary data
Journal Articles

Detecting Neuroendocrine Prostate Cancer Through Tissue-Informed Cell-Free DNA Methylation Analysis

Jacob E. Berchuck, Sylvan C. Baca, Heather M. McClure, Keegan Korthauer, Harrison K. Tsai, Pier Vitale Nuzzo, Kaitlin M. Kelleher, Monica He, John A. Steinharter, Soumya Zacharia, Sandor Spisak, Ji-Heui Seo, Vincenza Conteduca, Olivier Elemento, Joonghoon Auh, Michael Sigouros, Eva Corey, Michelle S. Hirsch, Mary-Ellen Taplin, Toni K. Choueiri, Mark M. Pomerantz, Himisha Beltran, Matthew L. Freedman
Journal: Clinical Cancer Research
Clin Cancer Res (2022) 28 (5): 928–938.
https://doi.org/10.1158/1078-0432.CCR-21-3762
Published: 03 March 2022
View article titled, Detecting Neuroendocrine Prostate Cancer Through Tissue-Informed Cell-Free DNA Methylation Analysis
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Includes: Supplementary data
Journal Articles

The Effect of Corticosteroids on Prostate Cancer Outcome Following Treatment with Enzalutamide: A Multivariate Analysis of the Phase III AFFIRM Trial

Jimmy L. Zhao, Karim Fizazi, Fred Saad, Kim N. Chi, Mary-Ellen Taplin, Cora N. Sternberg, Andrew J. Armstrong, Johann S. de Bono, William T. Duggan, Howard I. Scher
Journal: Clinical Cancer Research
Clin Cancer Res (2022) 28 (5): 860–869.
https://doi.org/10.1158/1078-0432.CCR-21-1090
Published: 01 March 2022
View article titled, The Effect of Corticosteroids on Prostate Cancer Outcome Following Treatment with Enzalutamide: A Multivariate Analysis of the Phase III AFFIRM Trial
Open the PDF for The Effect of Corticosteroids on Prostate Cancer Outcome Following Treatment with Enzalutamide: A Multivariate Analysis of the Phase III AFFIRM Trial in another window
Includes: Supplementary data
Journal Articles

Circulating and Intratumoral Adrenal Androgens Correlate with Response to Abiraterone in Men with Castration-Resistant Prostate Cancer

Elahe A. Mostaghel, Brett T. Marck, Orpheus Kolokythas, Felix Chew, Evan Y. Yu, Michael T. Schweizer, Heather H. Cheng, Phillip W. Kantoff, Steven P. Balk, Mary-Ellen Taplin, Nima Sharifi, Alvin M. Matsumoto, Peter S. Nelson, R. Bruce Montgomery
Journal: Clinical Cancer Research
Clin Cancer Res (2021) 27 (21): 6001–6011.
https://doi.org/10.1158/1078-0432.CCR-21-1819
Published: 01 November 2021
View article titled, Circulating and Intratumoral Adrenal Androgens Correlate with Response to Abiraterone in Men with Castration-Resistant Prostate Cancer
Open the PDF for Circulating and Intratumoral Adrenal Androgens Correlate with Response to Abiraterone in Men with Castration-Resistant Prostate Cancer in another window
Includes: Supplementary data
Journal Articles

Phase II Multicenter Study of Enzalutamide in Metastatic Castration-Resistant Prostate Cancer to Identify Mechanisms Driving Resistance

Rana R. McKay, Lucia Kwak, Jett P. Crowdis, Jamie M. Sperger, Shuang G. Zhao, Wanling Xie, Lillian Werner, Rosina T. Lis, Zhenwei Zhang, Xiao X. Wei, Joshua M. Lang, Eliezer M. Van Allen, Rupal S. Bhatt, Evan Y. Yu, Peter S. Nelson, Glenn J. Bubley, R. Bruce Montgomery, Mary-Ellen Taplin
Journal: Clinical Cancer Research
Clin Cancer Res (2021) 27 (13): 3610–3619.
https://doi.org/10.1158/1078-0432.CCR-20-4616
Published: 01 July 2021
View article titled, Phase II Multicenter Study of Enzalutamide in Metastatic Castration-Resistant Prostate Cancer to Identify Mechanisms Driving Resistance
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Includes: Supplementary data
Journal Articles

Identification of a Synthetic Lethal Relationship between Nucleotide Excision Repair Deficiency and Irofulven Sensitivity in Urothelial Cancer

Judit Börcsök, Zsofia Sztupinszki, Raie Bekele, Sizhi P. Gao, Miklos Diossy, Amruta S. Samant, Kasia M. Dillon, Viktoria Tisza, Sándor Spisák, Orsolya Rusz, Istvan Csabai, Helle Pappot, Zoë J. Frazier, David J. Konieczkowski, David Liu, Naresh Vasani, James A. Rodrigues, David B. Solit, Jean H. Hoffman-Censits, Elizabeth R. Plimack, Jonathan E. Rosenberg, Jean-Bernard Lazaro, Mary-Ellen Taplin, Gopa Iyer, Søren Brunak, Rita Lozsa, Eliezer M. Van Allen, Dávid Szüts, Kent W. Mouw, Zoltan Szallasi
Journal: Clinical Cancer Research
Clin Cancer Res (2021) 27 (7): 2011–2022.
https://doi.org/10.1158/1078-0432.CCR-20-3316
Published: 01 April 2021
View article titled, Identification of a Synthetic Lethal Relationship between Nucleotide Excision Repair Deficiency and Irofulven Sensitivity in Urothelial Cancer
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Includes: Supplementary data
Journal Articles

Dual Blockade of c-MET and the Androgen Receptor in Metastatic Castration-resistant Prostate Cancer: A Phase I Study of Concurrent Enzalutamide and Crizotinib

Abhishek Tripathi, Jeffrey G. Supko, Kathryn P. Gray, Zachary J. Melnick, Meredith M. Regan, Mary-Ellen Taplin, Atish D. Choudhury, Mark M. Pomerantz, Joaquim Bellmunt, Channing Yu, Zijie Sun, Sandy Srinivas, Philip W. Kantoff, Christopher J. Sweeney, Lauren C. Harshman
Journal: Clinical Cancer Research
Clin Cancer Res (2020) 26 (23): 6122–6131.
https://doi.org/10.1158/1078-0432.CCR-20-2306
Published: 01 December 2020
View article titled, Dual Blockade of c-MET and the Androgen Receptor in Metastatic Castration-resistant Prostate Cancer: A Phase I Study of Concurrent Enzalutamide and Crizotinib
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Includes: Supplementary data
Journal Articles

Correction: Epigenetic Therapy with Panobinostat Combined with Bicalutamide Rechallenge in Castration-Resistant Prostate Cancer

Anna C. Ferrari, Joshi J. Alumkal, Mark N. Stein, Mary-Ellen Taplin, James Babb, Ethan S. Barnett, Alejandro Gomez-Pinillos, Xiaomei Liu, Dirk Moore, Robert DiPaola, Tomasz M. Beer
Journal: Clinical Cancer Research
Clin Cancer Res (2019) 25 (8): 2672.
https://doi.org/10.1158/1078-0432.CCR-19-0442
Published: 15 April 2019
View article titled, Correction: Epigenetic Therapy with Panobinostat Combined with Bicalutamide Rechallenge in Castration-Resistant Prostate Cancer
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Journal Articles

Epigenetic Therapy with Panobinostat Combined with Bicalutamide Rechallenge in Castration-Resistant Prostate Cancer

Anna C. Ferrari, Joshi J. Alumkal, Mark N. Stein, Mary-Ellen Taplin, James Babb, Ethan S. Barnett, Alejandro Gomez-Pinillos, Xiaomei Liu, Dirk Moore, Robert DiPaola, Tomasz M. Beer
Journal: Clinical Cancer Research
Clin Cancer Res (2019) 25 (1): 52–63.
https://doi.org/10.1158/1078-0432.CCR-18-1589
Published: 03 January 2019
View article titled, Epigenetic Therapy with Panobinostat Combined with Bicalutamide Rechallenge in Castration-Resistant Prostate Cancer
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Includes: Supplementary data
Journal Articles

Muscadine Grape Skin Extract (MPX) in Men with Biochemically Recurrent Prostate Cancer: A Randomized, Multicenter, Placebo-Controlled Clinical Trial

Channing J. Paller, Xian C. Zhou, Elisabeth I. Heath, Mary-Ellen Taplin, Tina Mayer, Mark N. Stein, Glenn J. Bubley, Roberto Pili, Tamaro Hudson, Radhika Kakarla, Muneer M. Abbas, Nicole M. Anders, Donna Dowling, Serina King, Ashley B. Bruns, William D. Wagner, Charles G. Drake, Emmanuel S. Antonarakis, Mario A. Eisenberger, Samuel R. Denmeade, Michelle A. Rudek, Gary L. Rosner, Michael A. Carducci
Journal: Clinical Cancer Research
Clin Cancer Res (2018) 24 (2): 306–315.
https://doi.org/10.1158/1078-0432.CCR-17-1100
Published: 15 January 2018
View article titled, Muscadine Grape Skin Extract (MPX) in Men with Biochemically Recurrent Prostate Cancer: A Randomized, Multicenter, Placebo-Controlled Clinical Trial
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Includes: Supplementary data
Journal Articles

Impact of Therapy on Genomics and Transcriptomics in High-Risk Prostate Cancer Treated with Neoadjuvant Docetaxel and Androgen Deprivation Therapy

Himisha Beltran, Alexander W. Wyatt, Edmund C. Chedgy, Adam Donoghue, Matti Annala, Evan W. Warner, Kevin Beja, Michael Sigouros, Fan Mo, Ladan Fazli, Colin C. Collins, James Eastham, Michael Morris, Mary-Ellen Taplin, Andrea Sboner, Susan Halabi, Martin E. Gleave
Journal: Clinical Cancer Research
Series: Author Choice
Clin Cancer Res (2017) 23 (22): 6802–6811.
https://doi.org/10.1158/1078-0432.CCR-17-1034
Published: 14 November 2017
View article titled, Impact of Therapy on Genomics and Transcriptomics in High-Risk Prostate Cancer Treated with Neoadjuvant Docetaxel and Androgen Deprivation Therapy
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Includes: Supplementary data
Journal Articles

Expression of PD-L1 in Hormone-naïve and Treated Prostate Cancer Patients Receiving Neoadjuvant Abiraterone Acetate plus Prednisone and Leuprolide

Carla Calagua, Joshua Russo, Yue Sun, Rachel Schaefer, Rosina Lis, Zhenwei Zhang, Kathleen Mahoney, Glenn J. Bubley, Massimo Loda, Mary-Ellen Taplin, Steven P. Balk, Huihui Ye
Journal: Clinical Cancer Research
Clin Cancer Res (2017) 23 (22): 6812–6822.
https://doi.org/10.1158/1078-0432.CCR-17-0807
Published: 14 November 2017
View article titled, Expression of PD-L1 in Hormone-naïve and Treated Prostate Cancer Patients Receiving Neoadjuvant Abiraterone Acetate plus Prednisone and Leuprolide
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Includes: Supplementary data
Journal Articles

Association of Tissue Abiraterone Levels and SLCO Genotype with Intraprostatic Steroids and Pathologic Response in Men with High-Risk Localized Prostate Cancer

Elahe A. Mostaghel, Eunpi Cho, Ailin Zhang, Mohammad Alyamani, Arja Kaipainen, Sean Green, Brett T. Marck, Nima Sharifi, Jonathan L. Wright, Roman Gulati, Lawrence D. True, Massimo Loda, Alvin M. Matsumoto, Daniel Tamae, Trevor N. Penning, Steven P. Balk, Phillip W. Kantoff, Peter S. Nelson, Mary-Ellen Taplin, R. Bruce Montgomery
Journal: Clinical Cancer Research
Clin Cancer Res (2017) 23 (16): 4592–4601.
https://doi.org/10.1158/1078-0432.CCR-16-2245
Published: 14 August 2017
View article titled, Association of Tissue Abiraterone Levels and <em>SLCO</em> Genotype with Intraprostatic Steroids and Pathologic Response in Men with High-Risk Localized Prostate Cancer
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Includes: Supplementary data
Journal Articles

Neoadjuvant Enzalutamide Prior to Prostatectomy

Bruce Montgomery, Maria S. Tretiakova, Anthony M. Joshua, Martin E. Gleave, Neil Fleshner, Glenn J. Bubley, Elahe A. Mostaghel, Kim N. Chi, Daniel W. Lin, Martin Sanda, William Novotny, Kenneth Wu, Philip W. Kantoff, Brett T. Marck, Stephen Plymate, Steven P. Balk, Peter S. Nelson, Alvin M. Matsumoto, Rosina T. Lis, Adam Kibel, Gabriel P. Haas, Andrew Krivoshik, Alison Hannah, Mary-Ellen Taplin
Journal: Clinical Cancer Research
Series: Author Choice
Clin Cancer Res (2017) 23 (9): 2169–2176.
https://doi.org/10.1158/1078-0432.CCR-16-1357
Published: 30 April 2017
View article titled, Neoadjuvant Enzalutamide Prior to Prostatectomy
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Includes: Supplementary data
Journal Articles

A Phase II Trial of Abiraterone Combined with Dutasteride for Men with Metastatic Castration-Resistant Prostate Cancer

Rana R. McKay, Lillian Werner, Elahe A. Mostaghel, Rosina Lis, Olga Voznesensky, Zhenwei Zhang, Brett T. Marck, Alvin M. Matsumoto, Liran Domachevsky, Katherine A. Zukotynski, Manoj Bhasin, Glenn J. Bubley, Bruce Montgomery, Philip W. Kantoff, Steven P. Balk, Mary-Ellen Taplin
Journal: Clinical Cancer Research
Clin Cancer Res (2017) 23 (4): 935–945.
https://doi.org/10.1158/1078-0432.CCR-16-0987
Published: 14 February 2017
View article titled, A Phase II Trial of Abiraterone Combined with Dutasteride for Men with Metastatic Castration-Resistant Prostate Cancer
Open the PDF for A Phase II Trial of Abiraterone Combined with Dutasteride for Men with Metastatic Castration-Resistant Prostate Cancer in another window
Includes: Supplementary data
Journal Articles

Abstract A17: Abiraterone metabolism and a novel therapeutic strategy for castration resistant prostate cancer

Zhenfei Li, Mohammad Alyamani, Jianneng Li, Mary-Ellen Taplin, Nima Sharifi
Journal: Clinical Cancer Research
Clin Cancer Res (2017) 23 (1_Supplement): A17.
https://doi.org/10.1158/1557-3265.PMCCAVULN16-A17
Published: 02 January 2017
View article titled, Abstract A17: Abiraterone metabolism and a novel therapeutic strategy for castration resistant prostate cancer
Journal Articles

ErbB2 Signaling Increases Androgen Receptor Expression in Abiraterone-Resistant Prostate Cancer

Shuai Gao, Huihui Ye, Sean Gerrin, Hongyun Wang, Ankur Sharma, Sen Chen, Akash Patnaik, Adam G. Sowalsky, Olga Voznesensky, Wanting Han, Ziyang Yu, Elahe A. Mostaghel, Peter S. Nelson, Mary-Ellen Taplin, Steven P. Balk, Changmeng Cai
Journal: Clinical Cancer Research
Clin Cancer Res (2016) 22 (14): 3672–3682.
https://doi.org/10.1158/1078-0432.CCR-15-2309
Published: 14 July 2016
View article titled, ErbB2 Signaling Increases Androgen Receptor Expression in Abiraterone-Resistant Prostate Cancer
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Includes: Supplementary data
Journal Articles

Genetic Effect of Chemotherapy Exposure in Children of Testicular Cancer Survivors

Gregory V. Kryukov, Craig M. Bielski, Kaitlin Samocha, Menachem Fromer, Sara Seepo, Carleen Gentry, Benjamin Neale, Levi A. Garraway, Christopher J. Sweeney, Mary-Ellen Taplin, Eliezer M. Van Allen
Journal: Clinical Cancer Research
Series: Author Choice
Clin Cancer Res (2016) 22 (9): 2183–2189.
https://doi.org/10.1158/1078-0432.CCR-15-2317
Published: 01 May 2016
View article titled, Genetic Effect of Chemotherapy Exposure in Children of Testicular Cancer Survivors
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Includes: Supplementary data
Journal Articles

Androgen Receptor Modulation Optimized for Response (ARMOR) Phase I and II Studies: Galeterone for the Treatment of Castration-Resistant Prostate Cancer

Bruce Montgomery, Mario A. Eisenberger, Matthew B. Rettig, Franklin Chu, Roberto Pili, Joseph J. Stephenson, Nicholas J. Vogelzang, Alan J. Koletsky, Luke T. Nordquist, William J. Edenfield, Khalid Mamlouk, Karen J. Ferrante, Mary-Ellen Taplin
Journal: Clinical Cancer Research
Clin Cancer Res (2016) 22 (6): 1356–1363.
https://doi.org/10.1158/1078-0432.CCR-15-1432
Published: 14 March 2016
View article titled, Androgen Receptor Modulation Optimized for Response (ARMOR) Phase I and II Studies: Galeterone for the Treatment of Castration-Resistant Prostate Cancer
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Includes: Supplementary data
Journal Articles

Abiraterone Treatment in Castration-Resistant Prostate Cancer Selects for Progesterone Responsive Mutant Androgen Receptors

Eddy J. Chen, Adam G. Sowalsky, Shuai Gao, Changmeng Cai, Olga Voznesensky, Rachel Schaefer, Massimo Loda, Lawrence D. True, Huihui Ye, Patricia Troncoso, Rosina L. Lis, Philip W. Kantoff, Robert B. Montgomery, Peter S. Nelson, Glenn J. Bubley, Steven P. Balk, Mary-Ellen Taplin
Journal: Clinical Cancer Research
Clin Cancer Res (2015) 21 (6): 1273–1280.
https://doi.org/10.1158/1078-0432.CCR-14-1220
Published: 12 March 2015
View article titled, Abiraterone Treatment in Castration-Resistant Prostate Cancer Selects for Progesterone Responsive Mutant Androgen Receptors
Open the PDF for Abiraterone Treatment in Castration-Resistant Prostate Cancer Selects for Progesterone Responsive Mutant Androgen Receptors in another window
Includes: Supplementary data